{"id":"https://openalex.org/W2123851052","doi":"https://doi.org/10.1126/scisignal.aaa2710","title":"Neuregulin 1\u2013activated ERBB4 as a \u201cdedicated\u201d receptor for the Hippo-YAP pathway","display_name":"Neuregulin 1\u2013activated ERBB4 as a \u201cdedicated\u201d receptor for the Hippo-YAP pathway","publication_year":2014,"publication_date":"2014-12-09","ids":{"openalex":"https://openalex.org/W2123851052","doi":"https://doi.org/10.1126/scisignal.aaa2710","mag":"2123851052","pmid":"https://pubmed.ncbi.nlm.nih.gov/25492964"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.aaa2710","doi":"https://doi.org/10.1126/scisignal.aaa2710","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.aaa2710","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058298248","display_name":"Marius Sudol","orcid":"https://orcid.org/0000-0003-3051-6406","observed_orcids":["https://orcid.org/0000-0003-3051-6406"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Marius Sudol","raw_affiliation_strings":["Department of Physiology, National University of Singapore, Laboratory of Cancer Signaling and Domainopathies, Yong Loo Li School of Medicine, Block MD9, 2 Medical Drive 04-01, Singapore 117597, Republic of Singapore","Institute of Molecular and Cell Biology A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore","Mechanobiology Institute, T-Lab, 5-01, 5A Engineering Drive 1, Singapore 117411, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, National University of Singapore, Laboratory of Cancer Signaling and Domainopathies, Yong Loo Li School of Medicine, Block MD9, 2 Medical Drive 04-01, Singapore 117597, Republic of Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology A*STAR, 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Mechanobiology Institute, T-Lab, 5-01, 5A Engineering Drive 1, Singapore 117411, Republic of Singapore","institution_ids":["https://openalex.org/I4405277086"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058298248"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I165932596","https://openalex.org/I4405277086","https://openalex.org/I75573869"],"apc_list":null,"apc_paid":null,"fwci":0.6644,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.68100603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"355","first_page":"pe29","last_page":"pe29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.8740000128746033},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.6769999861717224},{"id":"https://openalex.org/keywords/receptor-identification","display_name":"receptor identification","score":0.3409999907016754},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cell-to-cell-junctions","display_name":"cell-to-cell junctions","score":0.8429999947547913},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.7063971757888794},{"id":"https://openalex.org/C185323287","wikidata":"https://www.wikidata.org/wiki/Q59252204","display_name":"Neuregulin","level":3,"score":0.6297541260719299},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.581249475479126},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5287534594535828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4515992999076843},{"id":"https://openalex.org/C2778560701","wikidata":"https://www.wikidata.org/wiki/Q14914188","display_name":"Neuregulin 1","level":3,"score":0.42997249960899353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.325390100479126},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32361680269241333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12416785955429077}],"mesh":[{"descriptor_ui":"D000090683","descriptor_name":"Hippo Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066247","descriptor_name":"Receptor, ErbB-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066247","descriptor_name":"Receptor, ErbB-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/scisignal.aaa2710","doi":"https://doi.org/10.1126/scisignal.aaa2710","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.aaa2710","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"pmid:25492964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25492964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1969579081","https://openalex.org/W1995160678","https://openalex.org/W1998563859","https://openalex.org/W2006778392","https://openalex.org/W2023775321","https://openalex.org/W2040430549","https://openalex.org/W2057989196","https://openalex.org/W2072677891","https://openalex.org/W2079828953","https://openalex.org/W2109838283","https://openalex.org/W2161491446","https://openalex.org/W2327188447"],"related_works":["https://openalex.org/W2327188447","https://openalex.org/W2066244404","https://openalex.org/W2905340293","https://openalex.org/W1998563859","https://openalex.org/W4232365105","https://openalex.org/W2109838283","https://openalex.org/W1965670855","https://openalex.org/W3214741565","https://openalex.org/W1969579081","https://openalex.org/W2375517147"],"abstract_inverted_index":{"The":[0],"Hippo":[1,16],"tumor-suppressor":[2],"pathway":[3,28,51,80],"is":[4],"regulated":[5],"by":[6,66,81],"several":[7],"multicomponent":[8],"complexes":[9],"of":[10,61,77,117,123],"cell":[11],"polarity":[12],"and":[13,38,85,137,146],"cell-to-cell":[14],"junctions.":[15],"kinases":[17],"inhibit":[18],"the":[19,26,33,46,48,115,129,133,138],"transcription":[20],"coactivator":[21],"YAP.":[22],"In":[23,58],"contrast":[24],"to":[25,44,74],"orthologous":[27],"in":[29,31],"Drosophila,":[30],"which":[32],"single":[34],"transmembrane":[35],"receptor":[36,88,93,108,122],"Fat":[37],"its":[39,86],"ligand":[40],"Dachsous":[41],"are":[42],"\"dedicated\"":[43],"trigger":[45],"pathway,":[47],"mammalian":[49],"Hippo-YAP":[50,139],"was":[52],"without":[53],"such":[54],"a":[55,64,106,120],"dedicated":[56],"receptor.":[57],"this":[59,75],"issue":[60],"Science":[62],"Signaling,":[63],"study":[65],"Haskins":[67],"et":[68],"al.":[69],"has":[70],"brought":[71],"an":[72,78],"end":[73],"scenario":[76],"\"orphaned\"":[79],"identifying":[82],"neuregulin":[83],"1":[84],"cognate":[87],"ERBB4":[89,118],"[epidermal":[90],"growth":[91],"factor":[92],"(EGFR)":[94],"family":[95],"member":[96],"v-erb-b2":[97],"avian":[98],"erythroblastic":[99],"leukemia":[100],"viral":[101],"oncogene":[102],"homolog":[103],"4]":[104],"as":[105,119],"major":[107],"complex":[109],"that":[110],"activates":[111],"YAP":[112,124],"activity.":[113],"Moreover,":[114],"identification":[116],"dominant":[121],"signaling":[125,130,135],"brings":[126],"into":[127],"focus":[128],"interface":[131],"between":[132],"EGFR":[134],"axis":[136],"network,":[140],"with":[141],"numerous":[142],"implications":[143],"for":[144],"basic":[145],"applied":[147],"cancer":[148],"research.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}