{"id":"https://openalex.org/W2123698136","doi":"https://doi.org/10.1093/ndt/15.10.1562","title":"Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury","display_name":"Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2123698136","doi":"https://doi.org/10.1093/ndt/15.10.1562","mag":"2123698136","pmid":"https://pubmed.ncbi.nlm.nih.gov/11007823"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/15.10.1562","doi":"https://doi.org/10.1093/ndt/15.10.1562","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/15.10.1562","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076282187","display_name":"Dirk Ysebaert","orcid":"https://orcid.org/0000-0002-3350-6994","observed_orcids":["https://orcid.org/0000-0002-3350-6994"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dirk K. Ysebaert","raw_affiliation_strings":["Departments of Experimental Surgery, University of Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Experimental Surgery, University of Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107974564","display_name":"Kathleen E. De Greef","orcid":"https://orcid.org/0000-0003-2870-5646","observed_orcids":["https://orcid.org/0000-0003-2870-5646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen E. De Greef","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568519","display_name":"Sven R. Vercauteren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sven R. Vercauteren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059003811","display_name":"Manuela Ghielli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuela Ghielli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109169655","display_name":"Gert A. Verpooten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gert A. Verpooten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024310088","display_name":"E Eyskens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik J. Eyskens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109063352","display_name":"Marc E. De Broe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc E. De Broe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":10.4414,"has_fulltext":true,"cited_by_count":373,"citation_normalized_percentile":{"value":0.98884707,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"15","issue":"10","first_page":"1562","last_page":"1574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9639999866485596},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.7829999923706055},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.796999990940094},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9340000152587891},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tubular-regeneration","display_name":"tubular regeneration","score":0.6869999766349792},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.6769999861717224},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ed1","display_name":"ED1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.753000020980835},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.4000000059604645},{"id":"https://openalex.org/keywords/unilateral-nephrectomy","display_name":"unilateral nephrectomy","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7277653813362122},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.642341136932373},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6152447462081909},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.598400890827179},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4982776641845703},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.49499958753585815},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.46279168128967285},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.44340789318084717},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4202101230621338},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4157589375972748},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.30375662446022034},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27062252163887024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1980280876159668},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001773","descriptor_name":"Blood Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ndt/15.10.1562","doi":"https://doi.org/10.1093/ndt/15.10.1562","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/15.10.1562","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:11007823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11007823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W9410167","https://openalex.org/W63028927","https://openalex.org/W99713136","https://openalex.org/W1505149221","https://openalex.org/W1969658990","https://openalex.org/W1971917696","https://openalex.org/W1979892541","https://openalex.org/W1980074141","https://openalex.org/W1997127851","https://openalex.org/W1998200062","https://openalex.org/W2004365737","https://openalex.org/W2005659566","https://openalex.org/W2009520704","https://openalex.org/W2020358486","https://openalex.org/W2023956699","https://openalex.org/W2036755333","https://openalex.org/W2046149192","https://openalex.org/W2051354793","https://openalex.org/W2051955042","https://openalex.org/W2060984566","https://openalex.org/W2062138291","https://openalex.org/W2063123103","https://openalex.org/W2067709564","https://openalex.org/W2070892241","https://openalex.org/W2074976340","https://openalex.org/W2077357748","https://openalex.org/W2086417798","https://openalex.org/W2092711749","https://openalex.org/W2095957966","https://openalex.org/W2125727879","https://openalex.org/W2127684770","https://openalex.org/W2137646911","https://openalex.org/W2140892076","https://openalex.org/W2151567849","https://openalex.org/W2164437042","https://openalex.org/W2215726651","https://openalex.org/W2273994439","https://openalex.org/W2274433470","https://openalex.org/W2324449307","https://openalex.org/W2396396576","https://openalex.org/W2398550861","https://openalex.org/W2410873308","https://openalex.org/W2417127099","https://openalex.org/W2417520842","https://openalex.org/W3184628723","https://openalex.org/W4248586959"],"related_works":["https://openalex.org/W2143379277","https://openalex.org/W23360501","https://openalex.org/W2050916570","https://openalex.org/W2415856485","https://openalex.org/W2014554613","https://openalex.org/W2051955042","https://openalex.org/W1980232824","https://openalex.org/W1998226806","https://openalex.org/W2382135199","https://openalex.org/W2017518622"],"abstract_inverted_index":{"BACKGROUND:":[0],"Leukocyte":[1],"adhesion/infiltration":[2,252],"in":[3,27,80,221,339,388,397,429,436],"response":[4],"to":[5,42,74,156],"renal":[6,45,50,55,326,351],"ischaemia/reperfusion":[7],"(I/R)":[8],"injury":[9,29],"is":[10],"a":[11,218,298,328,343,378],"well-known":[12],"but":[13,315,347],"poorly":[14],"understood":[15],"phenomenon.":[16],"The":[17,144,405],"identification,":[18],"kinetics,":[19],"and":[20,30,118,170,225,240,283,365,373,383],"exact":[21],"role":[22],"of":[23,35,49,76,84,110,123,173,200,342,357,376,381,394,407,434],"these":[24,174],"inflammatory":[25,360],"cells":[26,79,290,306,361,363,385],"I/R":[28,201,325],"regeneration":[31,377],"are":[32],"still":[33],"matters":[34],"debate.":[36],"METHODS:":[37],"Uninephrectomized":[38],"rats":[39],"were":[40,88,133,308,319],"submitted":[41],"60":[43],"min":[44],"ischaemia":[46],"by":[47,167,213],"clamping":[48],"vessels.":[51],"RESULTS:":[52],"Severe":[53],"acute":[54,330],"failure":[56],"was":[57,183],"observed,":[58],"with":[59,142,176,348,390,424],"maximum":[60,104,195,299],"functional":[61],"impairment":[62],"on":[63,106,114],"day":[64,107,137,275,295,301],"2.":[65],"By":[66],"12":[67,198],"h":[68,189,199,229,261,338],"after":[69,100,119,197,230,286],"the":[70,81,115,171,177,207,231,244,257,335,340,355,358,371,391,398,401,408,427,432],"ischaemic":[71,232],"event,":[72],"up":[73],"80%":[75],"proximal":[77],"tubular":[78,111,331],"outer":[82,85],"stripe":[83],"medulla":[86],"(OSOM)":[87,375],"already":[89,134,184],"severely":[90],"damaged.":[91],"Proliferation":[92],"(proliferating":[93],"cell":[94],"nuclear":[95],"antigen":[96],"(PCNA)":[97],"staining)":[98,132,254],"started":[99,113],"24":[101,228,260,264],"h,":[102,265],"reaching":[103,193,297],"activity":[105,182,196],"3.":[108],"Regeneration":[109],"morphology":[112],"3rd":[116],"day,":[117],"10":[120,246,287],"days":[121,311],"50%":[122],"tubules":[124],"had":[125],"regenerated":[126],"completely.":[127],"Interstitial":[128],"leukocytes":[129],"(OX-1":[130],"immunohistochemical":[131],"prominent":[135,273],"at":[136,187,227,256,259,274,300,370],"1,":[138],"thereafter":[139],"gradually":[140,292],"increasing":[141],"time.":[143],"so-called":[145,409],"neutrophil-specific":[146,410],"identification":[147,411],"methods":[148,412],"(myeloperoxidase":[149],"(MPO),":[150],"chloroacetate":[151,417],"esterase,":[152,418],"mAb":[153,420],"HIS-48)":[154],"proved":[155],"be":[157],"non-specific,":[158],"since":[159],"they":[160],"also":[161],"stained":[162],"for":[163],"macrophages,":[164],"as":[165],"demonstrated":[166],"flow":[168],"cytometry":[169],"combination":[172],"stainings":[175],"macrophage-specific":[178],"ED-1":[179],"staining.":[180],"MPO":[181,352],"significantly":[185],"increased":[186,293],"1":[188],"post-I/R":[190],"(439+/-34%,":[191],"P<0.005),":[192],"its":[194],"(1159+/-138%,":[202],"P<0.0005),":[203],"declining":[204],"thereafter.":[205],"On":[206],"other":[208],"hand,":[209],"neutrophil":[210],"presence":[211],"investigated":[212],"H&E":[214],"staining":[215],"revealed":[216],"only":[217],"few":[219,304],"neutrophils":[220,395],"glomeruli,":[222],"medullary":[223],"rays,":[224],"OSOM":[226,258],"event":[233],"(4.7+/-4.2":[234],"cells/mm(2)":[235,238,267,270,278,281],"vs":[236,279],"controls=2.3+/-2.0":[237],"(n.s.)),":[239],"remained":[241],"unchanged":[242],"over":[243],"next":[245],"days.":[247,288],"In":[248],"contrast,":[249],"significant":[250],"monocyte/macrophage":[251],"(ED-1":[253],"occurred":[255],"post-ischaemia":[262],"(at":[263],"120+/-46":[266],"vs.":[268],"sham=18+/-4":[269],"(P<0.05)),":[271,282],"became":[272],"5":[276],"(1034+/-161":[277],"sham=18+/-18":[280],"almost":[284],"disappeared":[285],"CD4(+)":[289],"(W3/25)":[291],"from":[294,310],"5,":[296],"10.":[302],"A":[303],"CD8(+)":[305],"(OX-8)":[307],"apparent":[309],"3":[312],"until":[313],"10,":[314],"no":[316],"B-cells":[317],"(OX-33)":[318],"observed.":[320],"CONCLUSIONS:":[321],"After":[322],"severe":[323],"warm":[324],"injury,":[327],"pronounced":[329],"necrosis":[332],"occurs":[333],"during":[334,400],"first":[336],"12-24":[337],"absence":[341],"marked":[344],"cellular":[345],"infiltrate,":[346],"an":[349],"important":[350],"activity,":[353,414],"reflecting":[354],"activation":[356],"adhering":[359],"(polymorphonuclear":[362],"(PMNs)":[364],"mainly":[366],"monocytes/macrophages).":[367],"Only":[368],"later":[369],"time":[372],"site":[374],"sequential":[379],"accumulation":[380],"monocytes/macrophages":[382],"T":[384],"becomes":[386],"prominent,":[387],"contrast":[389],"low":[392],"number":[393,433],"found":[396],"kidney":[399],"10-day":[402],"post-ischaemic":[403,437],"period.":[404],"non-specificity":[406],"(MPO":[413],"naphthol":[415],"AS-D":[416],"or":[419],"HIS-48":[421],"staining),":[422],"cross-reacting":[423],"monocytes/macrophages,":[425],"explains":[426],"controversy":[428],"literature":[430],"concerning":[431],"PMNs":[435],"injury.":[438]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}