{"id":"https://openalex.org/W21236616","doi":null,"title":"Dysregulated biological pathways in major depression: An examination of the antidepressant effects of curcumin","display_name":"Dysregulated biological pathways in major depression: An examination of the antidepressant effects of curcumin","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W21236616","mag":"21236616"},"language":"en","primary_location":{"id":"pmh:oai:alma.61MUN_INST:11137340900007891","doi":null,"is_oa":true,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/doctoral/Dysregulated-biological-pathways-in-major-depression/991005545997507891","pdf_url":"https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12137340890007891/13137355870007891","source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12137340890007891/13137355870007891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019688979","display_name":"Adrian L. Lopresti","orcid":"https://orcid.org/0000-0002-6409-7839","observed_orcids":["https://orcid.org/0000-0002-6409-7839"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adrian L. Lopresti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6409-7839","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019688979"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.20960000157356262,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9340000152587891},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neurotransmitter-imbalance","display_name":"neurotransmitter imbalance","score":0.7850000262260437},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7239999771118164},{"id":"https://openalex.org/keywords/lifestyle-factors","display_name":"lifestyle factors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.8830000162124634},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9879999756813049},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.906000018119812},{"id":"https://openalex.org/keywords/trauma-and-stress","display_name":"stress and trauma","score":0.7609999775886536},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9879999756813049},{"id":"https://openalex.org/keywords/peripheral-biomarkers","display_name":"peripheral biomarkers","score":0.7649999856948853},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.8849999904632568},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.984000027179718},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.909810483455658},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6079745888710022},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5495457053184509},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.512815535068512},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5101338028907776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.509458601474762},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38042038679122925},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35288184881210327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3364694118499756},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.333798348903656},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:alma.61MUN_INST:11137340900007891","doi":null,"is_oa":true,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/doctoral/Dysregulated-biological-pathways-in-major-depression/991005545997507891","pdf_url":"https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12137340890007891/13137355870007891","source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:24167","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.murdoch.edu.au/id/eprint/24167/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lopresti, A.L. &lt;https://researchrepository.murdoch.edu.au/view/author/Lopresti, Adrian.html&gt;ORCID: 0000-0002-6409-7839 &lt;http://orcid.org/0000-0002-6409-7839&gt; (2014) Dysregulated biological pathways in major depression: An examination of the antidepressant effects of curcumin. PhD thesis, Murdoch University.","raw_type":"Thesis"},{"id":"mag:21236616","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.murdoch.edu.au/id/eprint/24167/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:alma.61MUN_INST:11137340900007891","doi":null,"is_oa":true,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/doctoral/Dysregulated-biological-pathways-in-major-depression/991005545997507891","pdf_url":"https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12137340890007891/13137355870007891","source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W21236616.pdf","grobid_xml":"https://content.openalex.org/works/W21236616.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1560004065","https://openalex.org/W1596389679","https://openalex.org/W1972072530","https://openalex.org/W1973788838","https://openalex.org/W1984336722","https://openalex.org/W1990487655","https://openalex.org/W2008971294","https://openalex.org/W2014860670","https://openalex.org/W2014881669","https://openalex.org/W2036024220","https://openalex.org/W2040785820","https://openalex.org/W2048082192","https://openalex.org/W2048536263","https://openalex.org/W2068080380","https://openalex.org/W2069240179","https://openalex.org/W2069889736","https://openalex.org/W2081356986","https://openalex.org/W2083254291","https://openalex.org/W2093759195","https://openalex.org/W2102204071","https://openalex.org/W2106362422","https://openalex.org/W2122305679","https://openalex.org/W2127000564","https://openalex.org/W2144948677","https://openalex.org/W2146921470","https://openalex.org/W2154679373","https://openalex.org/W2155899994","https://openalex.org/W2166211384","https://openalex.org/W2262705777","https://openalex.org/W4239517296"],"related_works":["https://openalex.org/W2048063648","https://openalex.org/W4210316733","https://openalex.org/W1993028853","https://openalex.org/W3108712879","https://openalex.org/W2022700222","https://openalex.org/W2783516642","https://openalex.org/W2048646100","https://openalex.org/W2059326912","https://openalex.org/W3034903248","https://openalex.org/W2059991182"],"abstract_inverted_index":{"Major":[0],"depression":[1,261],"is":[2],"associated":[3,60,245,330,346,353],"with":[4,61,123,183,199,246,331,347,354],"multiple":[5],"dysregulated":[6,55,141],"biological":[7,20,56,142],"pathways":[8,143],"which":[9],"are":[10,166,358,365],"influenced":[11],"by":[12],"an":[13,173],"array":[14],"of":[15,43,102,134,153,170,192,204,256,270,295,309,340],"lifestyle,":[16],"psychological,":[17],"environmental":[18],"and":[19,51,70,75,88,90,115,118,128,136,209,221,229,262,282,301,326,343,360],"factors.":[21],"Nutraceuticals":[22],"including":[23],"curcumin,":[24],"derived":[25],"from":[26,232,237,315],"the":[27,33,41,82,100,150,253,274,293,355],"Indian":[28],"spice":[29],"turmeric,":[30],"also":[31,145,319],"have":[32],"potential":[34,125,254,275],"to":[35,126,216,234,240,276,311],"influence":[36,101,133,294],"these":[37,95,140],"depressogenic":[38,96],"pathways.":[39,97],"Consequently,":[40],"aims":[42],"this":[44],"thesis":[45],"were":[46,120,214,223,329,345],"to:":[47],"\\n":[48,77,147,250,351],"\\n1.":[49],"Review":[50,79,252],"integrate":[52],"research":[53,80,364],"on":[54,81,94,139,297],"pathways,":[57],"namely":[58],"those":[59],"neurotransmitter":[62],"imbalances,":[63],"immuno-inflammatory":[64],"processes,":[65],"hypothalamus-pituitary-adrenal":[66],"axis":[67],"dysregulation,":[68],"oxidative":[69],"nitrosative":[71],"stress,":[72],"mitochondrial":[73],"dysfunction":[74],"neuroprogression.":[76],"\\n2.":[78],"relationship":[83],"between":[84],"several":[85,298],"lifestyle-based":[86],"factors":[87],"depression,":[89],"examine":[91,263],"their":[92,124],"effects":[93,152],"More":[98],"specifically,":[99],"diet,":[103],"exercise,":[104],"sleep,":[105],"vitamin":[106],"D,":[107],"omega":[108],"3":[109],"essential":[110],"fatty":[111],"acid":[112],"deficiency,":[113],"stress":[114],"trauma,":[116],"obesity":[117],"smoking":[119],"appraised":[121],"along":[122],"prevent":[127],"treat":[129],"major":[130,185,260],"depression.":[131],"The":[132,168,202,307],"psychological":[135],"pharmaceutical":[137],"interventions":[138],"was":[144,179,197,244,305,318],"reviewed.":[146],"\\n3.":[148],"Examine":[149],"antidepressant":[151,161,248],"curcumin.":[154],"In":[155,286],"animal-based":[156],"models,":[157],"curcumin":[158,171,242,267,296,316,334],"has":[159,273],"demonstrated":[160],"effects,":[162],"although":[163],"clinical":[164,356],"studies":[165,357],"lacking.":[167],"efficacy":[169,308,314],"in":[172,181,226,259],"8-week,":[174],"randomised,":[175,288],"double-blind,":[176,289],"placebo-controlled":[177],"study":[178],"examined":[180],"people":[182],"a":[184,190,200,287],"depressive":[186,228],"disorder.":[187],"Curcumin":[188,220],"at":[189],"dose":[191],"500":[193],"mg,":[194],"twice":[195],"daily,":[196],"compared":[198],"placebo.":[201],"Inventory":[203,213],"Depressive":[205],"Symptomatology-Self":[206],"Report":[207],"(IDS-SR30)":[208],"Spielberger":[210],"State-Trait":[211],"Anxiety":[212],"used":[215],"assess":[217],"symptomatic":[218],"change.":[219],"placebo":[222,290],"equally":[224],"effective":[225],"lowering":[227],"anxiety":[230],"symptomatology":[231],"baseline":[233,338],"week,":[235],"but":[236],"weeks":[238],"4":[239],"8":[241],"supplementation":[243],"superior":[247],"efficacy.":[249,350],"\\n4.":[251],"role":[255],"peripheral":[257,271,303],"biomarkers":[258,272,304,310],"biomarker":[264],"changes":[265,332],"following":[266,333],"supplementation.":[268],"Measurement":[269],"enhance":[277],"diagnosis,":[278],"evaluate":[279],"treatment":[280,284,313,349],"progress":[281],"facilitate":[283],"matching.":[285],"controlled":[291],"study,":[292],"urinary,":[299],"plasma":[300,341],"salivary":[302],"examined.":[306,320],"predict":[312],"administration":[317],"Urinary":[321],"leukotriene":[322],"B4,":[323],"thromboxane":[324],"B2":[325],"substance":[327],"P":[328],"treatment,":[335],"while":[336],"higher":[337],"concentrations":[339],"endothelin-1":[342],"leptin":[344],"greater":[348],"\\nLimitations":[352],"reviewed":[359],"recommendations":[361],"for":[362],"future":[363],"provided.":[366]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
