{"id":"https://openalex.org/W2123620482","doi":"https://doi.org/10.3109/07357909909021419","title":"Second-Line Chemotherapy with 96-Hour Infusional Paclitaxel in Refractory Non-Small Cell Lung Cancer: Report of a Phase II Trial","display_name":"Second-Line Chemotherapy with 96-Hour Infusional Paclitaxel in Refractory Non-Small Cell Lung Cancer: Report of a Phase II Trial","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2123620482","doi":"https://doi.org/10.3109/07357909909021419","mag":"2123620482","pmid":"https://pubmed.ncbi.nlm.nih.gov/10099656"},"language":"en","primary_location":{"id":"doi:10.3109/07357909909021419","doi":"https://doi.org/10.3109/07357909909021419","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357909909021419","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078629724","display_name":"Mark A. Socinski","orcid":"https://orcid.org/0000-0003-2915-9325","observed_orcids":["https://orcid.org/0000-0003-2915-9325","https://orcid.org/0000-0002-8213-0137"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Socinski","raw_affiliation_strings":["Multidisciplinary Thoracic Oncology Program, University of North Carolina at Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Thoracic Oncology Program, University of North Carolina at Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032418111","display_name":"Ann Steagall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Steagall","raw_affiliation_strings":["Multidisciplinary Thoracic Oncology Program and Division of Hernatology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Thoracic Oncology Program and Division of Hernatology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111783900","display_name":"Heidi H. Gillenwater","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi Gillenwater","raw_affiliation_strings":["Multidisciplinary Thoracic Oncology Program and Division of Hernatology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Thoracic Oncology Program and Division of Hernatology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":7.6639,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.97562276,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"17","issue":"3","first_page":"181","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/second-line-chemotherapy","display_name":"second-line chemotherapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8939999938011169},{"id":"https://openalex.org/keywords/prolonged-infusion","display_name":"prolonged infusion","score":0.5889999866485596},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cisplatin-refractory-disease","display_name":"cisplatin-refractory disease","score":0.6959999799728394},{"id":"https://openalex.org/keywords/stable-disease","display_name":"stable disease","score":0.7049999833106995},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.48399999737739563},{"id":"https://openalex.org/keywords/central-venous-catheters","display_name":"central venous catheters","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9060627222061157},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7402678728103638},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.7337308526039124},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6814272999763489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6113939881324768},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5716633796691895},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5658990740776062},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5592571496963501},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5278817415237427},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.5136355757713318},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.41818541288375854},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3771476447582245},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007260","descriptor_name":"Infusion Pumps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/07357909909021419","doi":"https://doi.org/10.3109/07357909909021419","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357909909021419","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},{"id":"pmid:10099656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10099656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer investigation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1879303306","https://openalex.org/W1880426265","https://openalex.org/W1883066466","https://openalex.org/W1909306097","https://openalex.org/W1917502393","https://openalex.org/W1922104747","https://openalex.org/W1934698255","https://openalex.org/W1963786241","https://openalex.org/W1967832506","https://openalex.org/W1976128207","https://openalex.org/W1993310964","https://openalex.org/W1995686464","https://openalex.org/W2001996041","https://openalex.org/W2003562529","https://openalex.org/W2011447881","https://openalex.org/W2013582820","https://openalex.org/W2014725195","https://openalex.org/W2017062373","https://openalex.org/W2026848003","https://openalex.org/W2036475994","https://openalex.org/W2057157978","https://openalex.org/W2083131128","https://openalex.org/W2086370927","https://openalex.org/W2098076970","https://openalex.org/W2128746268","https://openalex.org/W2129793485","https://openalex.org/W2133514662","https://openalex.org/W2240623839","https://openalex.org/W2253177453","https://openalex.org/W2323531161","https://openalex.org/W2345356837","https://openalex.org/W2466065312","https://openalex.org/W4231647528"],"related_works":["https://openalex.org/W2043570236","https://openalex.org/W2460850608","https://openalex.org/W1934698255","https://openalex.org/W2157794621","https://openalex.org/W201862443","https://openalex.org/W2101705825","https://openalex.org/W2243915795","https://openalex.org/W426726271","https://openalex.org/W2018404630","https://openalex.org/W2084203448"],"abstract_inverted_index":{"Advanced":[0],"metastatic":[1],"non-small":[2],"cell":[3],"lung":[4],"cancer":[5,55],"(NSCLC)":[6],"that":[7],"has":[8,14,42],"progressed":[9,73],"on":[10,74,216],"initial":[11,77],"cisplatin-based":[12,40],"chemotherapy":[13,78],"a":[15,96,101,120,144],"poor":[16],"prognosis.":[17],"Although":[18],"paclitaxel":[19,33,49,83],"is":[20],"an":[21],"active":[22],"agent":[23],"in":[24,34,53,160,203,218],"the":[25,176],"first-line":[26,39],"therapy":[27],"of":[28,32,48,62,112,115,123,133,140,147,163,171,179,205,226],"NSCLC,":[29],"24-hr":[30],"infusion":[31,98],"patients":[35,56,68,105,130,220],"with":[36,69,81,188,211],"NSCLC":[37,71],"failing":[38],"regimens":[41],"shown":[43,51],"minimal":[44],"activity.":[45],"Prolonged":[46],"infusions":[47,61,92],"have":[50,58],"activity":[52],"breast":[54],"who":[57,72],"failed":[59],"short":[60],"paclitaxel.":[63],"In":[64,192],"this":[65],"study,":[66],"13":[67],"refractory":[70],"or":[75,109,223],"after":[76],"were":[79,183,198],"treated":[80],"96-hr":[82],"(140":[84],"mg/m2":[85],"over":[86],"96":[87],"hr":[88],"every":[89],"3":[90,124],"weeks)":[91],"as":[93],"outpatients":[94],"using":[95,175],"CADD":[97],"pump":[99],"via":[100],"central":[102],"catheter.":[103],"Nine":[104],"received":[106],"only":[107],"one":[108],"two":[110,136,222],"cycles":[111,139,225],"treatment":[113,141,190],"because":[114],"disease":[116,134,200],"progression":[117],"and":[118,142,156,165,187],"had":[119,131,143],"median":[121,145],"survival":[122,146],"months":[125,149],"(range,":[126,150],"1-5":[127],"months).":[128,152],"Four":[129],"stabilization":[132,201],"for":[135],"to":[137],"six":[138],"8":[148],"8-12+":[151],"Grade":[153],"3-4":[154],"hematologic":[155],"nonhematologic":[157],"toxicity":[158,208],"occurred":[159,202],"<":[161],"10%":[162],"cycles,":[164],"no":[166,195,212],"treatment-related":[167],"hospitalizations":[168],"occurred.":[169],"Quality":[170],"life":[172],"(QOL)":[173],"assessments":[174],"Functional":[177],"Assessment":[178],"Cancer":[180],"Therapy-Lung":[181],"questionnaire":[182],"performed":[184],"at":[185],"baseline":[186],"each":[189],"cycle.":[191],"conclusion,":[193],"although":[194],"objective":[196],"responses":[197],"seen,":[199],"31%":[204],"patients.":[206],"Overall":[207],"was":[209],"tolerable":[210],"major":[213],"negative":[214],"impact":[215],"QOL":[217],"those":[219],"receiving":[221],"more":[224],"treatment.":[227]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
