{"id":"https://openalex.org/W2123577795","doi":"https://doi.org/10.1093/ageing/26.5.359","title":"Effect of intermittent cyclical disodium etidronate therapy on bone mineral density in men with vertebral fractures","display_name":"Effect of intermittent cyclical disodium etidronate therapy on bone mineral density in men with vertebral fractures","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2123577795","doi":"https://doi.org/10.1093/ageing/26.5.359","mag":"2123577795","pmid":"https://pubmed.ncbi.nlm.nih.gov/9351480"},"language":"en","primary_location":{"id":"doi:10.1093/ageing/26.5.359","doi":"https://doi.org/10.1093/ageing/26.5.359","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ageing/26.5.359","pdf_url":null,"source":{"id":"https://openalex.org/S31768639","display_name":"Age and Ageing","issn_l":"0002-0729","issn":["0002-0729","1468-2834"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Age and Ageing","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109238559","display_name":"Frazer H. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"FRAZER H. ANDERSON","raw_affiliation_strings":["Freeman Hospital, High Heaton, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Freeman Hospital, High Heaton, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084283624","display_name":"Roger M. Francis","orcid":"https://orcid.org/0000-0002-0853-7342","observed_orcids":["https://orcid.org/0000-0002-0853-7342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ROGER M. FRANCIS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014943415","display_name":"Janine Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JANINE C. BISHOP","raw_affiliation_strings":["Department of Medical Statistics, Medical School Framlington Place, Newcastle upon Tyne NEI 2DH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics, Medical School Framlington Place, Newcastle upon Tyne NEI 2DH, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":null,"display_name":"DAVID J. RAWLINGS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DAVID J. RAWLINGS","raw_affiliation_strings":["Regional Medical Physics Department, Newcastle General Hospital Westgate Road, Newcastle upon Tyne NE4 6BE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Medical Physics Department, Newcastle General Hospital Westgate Road, Newcastle upon Tyne NE4 6BE, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109238559"],"corresponding_institution_ids":["https://openalex.org/I2801924861"],"apc_list":{"value":2805,"currency":"GBP","value_usd":3699},"apc_paid":null,"fwci":6.0239,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.96614082,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"26","issue":"5","first_page":"359","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etidronate-disodium","display_name":"etidronate disodium","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9229999780654907},{"id":"https://openalex.org/keywords/idiopathic-osteoporosis","display_name":"idiopathic osteoporosis","score":0.746999979019165},{"id":"https://openalex.org/keywords/vertebral-fractures","display_name":"vertebral fractures","score":0.9070000052452087},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lumbar-spine","display_name":"lumbar spine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/femoral-neck","display_name":"femoral neck","score":0.9629999995231628},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6740000247955322},{"id":"https://openalex.org/keywords/calcium-supplementation","display_name":"calcium supplementation","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.927028477191925},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.7222640514373779},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6638613343238831},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6443079113960266},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.5537741780281067},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5334810018539429},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4637857675552368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46315139532089233},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.44922298192977905},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3669421076774597}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005598","descriptor_name":"Fractures, Spontaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012968","descriptor_name":"Etidronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012968","descriptor_name":"Etidronic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019355","descriptor_name":"Calcium Citrate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ageing/26.5.359","doi":"https://doi.org/10.1093/ageing/26.5.359","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ageing/26.5.359","pdf_url":null,"source":{"id":"https://openalex.org/S31768639","display_name":"Age and Ageing","issn_l":"0002-0729","issn":["0002-0729","1468-2834"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Age and Ageing","raw_type":"journal-article"},{"id":"pmid:9351480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9351480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Age and ageing","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315469","display_name":"Hologic","ror":"https://ror.org/02td4ph55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W115187101","https://openalex.org/W1968418396","https://openalex.org/W1968645046","https://openalex.org/W1970093445","https://openalex.org/W1972172282","https://openalex.org/W1974424899","https://openalex.org/W1977368739","https://openalex.org/W1980271798","https://openalex.org/W1980596434","https://openalex.org/W1982707245","https://openalex.org/W2013043118","https://openalex.org/W2034377417","https://openalex.org/W2038050797","https://openalex.org/W2062229770","https://openalex.org/W2062701351","https://openalex.org/W2064496052","https://openalex.org/W2153245935","https://openalex.org/W2336678594","https://openalex.org/W2414941139"],"related_works":["https://openalex.org/W2062229770","https://openalex.org/W2336678594","https://openalex.org/W1968418396","https://openalex.org/W2320458466","https://openalex.org/W4244430802","https://openalex.org/W2289596691","https://openalex.org/W2074615691","https://openalex.org/W2026347829","https://openalex.org/W1985914690","https://openalex.org/W2032946274"],"abstract_inverted_index":{"OBJECTIVES:":[0],"to":[1,183,208,219,229],"investigate":[2],"the":[3,90,144,161,205,222],"effects":[4],"of":[5,53,61,89,134,168,173,188,190,192,210,226,270],"oral":[6,64,75],"intermittent":[7,254],"cyclical":[8,255],"etidronate":[9,66,256],"therapy":[10,257],"on":[11],"bone":[12,32,104],"mineral":[13],"density":[14],"(BMD)":[15],"in":[16,49,201,221,244,266,281],"men":[17,36,123,271],"with":[18,41,63,272],"idiopathic":[19],"vertebral":[20,43,274],"osteoporosis.":[21],"DESIGN:":[22],"consecutive":[23],"case":[24],"series.":[25],"SETTING:":[26],"regional":[27],"specialist":[28],"clinic":[29],"for":[30,70,82,127,136,143],"metabolic":[31],"disease.":[33],"SUBJECTS:":[34],"42":[35,122],"aged":[37],"35-81":[38],"(median":[39],"60.5)":[40],"established":[42],"crush":[44],"fractures":[45],"and":[46,93,111,114,132,237,241],"back":[47],"pain,":[48],"whom":[50],"secondary":[51],"causes":[52],"osteoporosis":[54],"had":[55],"been":[56,125],"excluded.":[57],"INTERVENTION:":[58],"repeated":[59],"cycles":[60],"treatment":[62,155,277],"disodium":[65],"400":[67],"mg":[68,78],"daily":[69,81],"14":[71],"days":[72],"followed":[73],"by":[74,96,165],"calcium":[76,236],"500":[77],"as":[79,146],"citrate":[80],"76":[83],"days.":[84],"OUTCOME":[85],"MEASURES:":[86],"BMD":[87,159,203,261],"measurement":[88],"lumbar":[91,162,259],"spine":[92,163,260],"femoral":[94],"neck":[95],"dual":[97],"energy":[98],"x-ray":[99],"absorptiometry":[100],"at":[101,117,160,204,232],"6-12-month":[102],"intervals;":[103],"biochemistry":[105],"(serum":[106],"calcium,":[107],"phosphate,":[108],"alkaline":[109,216],"phosphatase":[110,217],"urine":[112],"calcium/creatinine":[113,246],"hydroxyproline/creatinine":[115,249],"ratios)":[116],"6-month":[118],"intervals.":[119],"RESULTS:":[120],"all":[121],"have":[124],"treated":[126],"more":[128,137],"than":[129,138],"18":[130],"months,":[131],"35":[133],"them":[135],"24":[139],"months.":[140],"Median":[141],"follow-up":[142,174],"group":[145,269],"a":[147,166,197,263,282],"whole":[148],"is":[149,181],"31":[150],"months":[151,225],"(range":[152],"18-45).":[153],"The":[154],"was":[156,196,251],"well":[157],"tolerated.":[158],"increased":[164,258],"mean":[167,202],"0.024":[169],"g/cm2":[170],"per":[171,213],"year":[172],"(95%":[175],"confidence":[176],"interval":[177],"0.017-0.032":[178],"g/cm2).":[179],"This":[180,276],"equivalent":[182,207],"an":[184,267],"average":[185],"annual":[186],"rate":[187],"change":[189],"3.2%":[191],"baseline":[193,211,230],"values.":[194],"There":[195],"small,":[198],"non-significant":[199],"rise":[200],"hip":[206],"0.7%":[209],"values":[212,231],"year.":[214],"Serum":[215,235],"tended":[218],"fall":[220],"first":[223],"6":[224],"treatment,":[227],"returning":[228],"2":[233],"years.":[234],"phosphate":[238],"were":[239],"unchanged":[240],"no":[242],"decrease":[243],"urinary":[245],"ratio":[247,250],"or":[248],"seen.":[252],"CONCLUSIONS:":[253],"over":[262],"2-year":[264],"period":[265],"unselected":[268],"osteoporotic":[273],"fractures.":[275],"warrants":[278],"further":[279],"evaluation":[280],"randomized":[283],"controlled":[284],"trial.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
