{"id":"https://openalex.org/W2123540409","doi":"https://doi.org/10.5507/bp.155.2011.004","title":"ADDITION OF SPIRONOLACTONE IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION (ASPIRANT) - STUDY PROTOCOL","display_name":"ADDITION OF SPIRONOLACTONE IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION (ASPIRANT) - STUDY PROTOCOL","publication_year":2011,"publication_date":"2011-02-08","ids":{"openalex":"https://openalex.org/W2123540409","doi":"https://doi.org/10.5507/bp.155.2011.004","mag":"2123540409","pmid":"https://pubmed.ncbi.nlm.nih.gov/21804623"},"language":"en","primary_location":{"id":"doi:10.5507/bp.155.2011.004","doi":"https://doi.org/10.5507/bp.155.2011.004","is_oa":true,"landing_page_url":"https://doi.org/10.5507/bp.155.2011.004","pdf_url":"http://biomed.papers.upol.cz/doi/10.5507/bp.155.2011.004.pdf","source":{"id":"https://openalex.org/S4210187759","display_name":"Biomedical Papers","issn_l":"1213-8118","issn":["1213-8118","1804-7521"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319874","host_organization_name":"Palack\u00fd University Olomouc","host_organization_lineage":["https://openalex.org/P4310319874"],"host_organization_lineage_names":["Palack\u00fd University Olomouc"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Papers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://biomed.papers.upol.cz/doi/10.5507/bp.155.2011.004.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072939562","display_name":"Jan V\u00e1clav\u00edk","orcid":"https://orcid.org/0000-0001-7847-0967","observed_orcids":["https://orcid.org/0000-0001-7847-0967"]},"institutions":[{"id":"https://openalex.org/I4210107161","display_name":"University Hospital Olomouc","ror":"https://ror.org/01jxtne23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210107161"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Vaclavik","raw_affiliation_strings":["1st Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. vaclavik.j@centrum.cz","1st Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. vaclavik.j@centrum.cz","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]},{"raw_affiliation_string":"1st Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113672441","display_name":"Richard Sedl\u00e1k","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Sedlak","raw_affiliation_strings":["Department of Internal Medicine, Prostejov Hospital, Prostejov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Prostejov Hospital, Prostejov","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002498199","display_name":"Martin Plach\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107161","display_name":"University Hospital Olomouc","ror":"https://ror.org/01jxtne23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210107161"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Martin Plachy","raw_affiliation_strings":["st Department of Internal Medicine , University Hospital Olomouc and Faculty of Medicine and Dentistry , Palacky University Olomouc , Czech Republic","Department of Internal Medicine, St. Anne's University Hospital, Brno","Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"st Department of Internal Medicine , University Hospital Olomouc and Faculty of Medicine and Dentistry , Palacky University Olomouc , Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]},{"raw_affiliation_string":"Department of Internal Medicine, St. Anne's University Hospital, Brno","institution_ids":["https://openalex.org/I4210136987"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022626848","display_name":"Karel Navr\u00e1til","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karel Navratil","raw_affiliation_strings":["Department of Internal Medicine, Military Hospital, Olomouc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Military Hospital, Olomouc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069048681","display_name":"Ji\u0159\u00ed Pl\u00e1\u0161ek","orcid":"https://orcid.org/0000-0002-5183-9557","observed_orcids":["https://orcid.org/0000-0002-5183-9557"]},"institutions":[{"id":"https://openalex.org/I4210088935","display_name":"University Hospital Ostrava","ror":"https://ror.org/00a6yph09","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210088935"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jiri Plasek","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Ostrava"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Ostrava","institution_ids":["https://openalex.org/I4210088935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037502132","display_name":"Roman Hus\u00e1r","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman Husar","raw_affiliation_strings":["Department of Internal Medicine, Hranice Hospital, Hranice na Morave"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hranice Hospital, Hranice na Morave","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032060686","display_name":"Eva Koci\u00e1nov\u00e1","orcid":"https://orcid.org/0000-0003-2183-957X","observed_orcids":["https://orcid.org/0000-0003-2183-957X"]},"institutions":[{"id":"https://openalex.org/I4210107161","display_name":"University Hospital Olomouc","ror":"https://ror.org/01jxtne23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210107161"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Eva Kocianova","raw_affiliation_strings":["st Department of Internal Medicine , University Hospital Olomouc and Faculty of Medicine and Dentistry , Palacky University Olomouc , Czech Republic","Department of Internal Medicine, St. Anne's University Hospital, Brno","Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"st Department of Internal Medicine , University Hospital Olomouc and Faculty of Medicine and Dentistry , Palacky University Olomouc , Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]},{"raw_affiliation_string":"Department of Internal Medicine, St. Anne's University Hospital, Brno","institution_ids":["https://openalex.org/I4210136987"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083791579","display_name":"Milo\u0161 T\u00e1borsk\u00fd","orcid":"https://orcid.org/0000-0002-5036-2347","observed_orcids":["https://orcid.org/0000-0002-5036-2347"]},"institutions":[{"id":"https://openalex.org/I4210107161","display_name":"University Hospital Olomouc","ror":"https://ror.org/01jxtne23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210107161"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Milos Taborsky","raw_affiliation_strings":["st Department of Internal Medicine , University Hospital Olomouc and Faculty of Medicine and Dentistry , Palacky University Olomouc , Czech Republic","Department of Internal Medicine, St. Anne's University Hospital, Brno","Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"st Department of Internal Medicine , University Hospital Olomouc and Faculty of Medicine and Dentistry , Palacky University Olomouc , Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]},{"raw_affiliation_string":"Department of Internal Medicine, St. Anne's University Hospital, Brno","institution_ids":["https://openalex.org/I4210136987"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":600,"currency":"EUR","value_usd":591},"apc_paid":{"value":600,"currency":"EUR","value_usd":591},"fwci":1.2324,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79408096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"155","issue":"2","first_page":"143","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.29269999265670776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spironolactone","display_name":"spironolactone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/resistant-hypertension","display_name":"resistant hypertension","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9520000219345093},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure-monitoring","display_name":"ambulatory blood pressure monitoring","score":0.9100000262260437},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.8289999961853027},{"id":"https://openalex.org/keywords/aldosterone-to-renin-ratio","display_name":"aldosterone-renin ratio","score":0.7239999771118164},{"id":"https://openalex.org/keywords/serum-potassium","display_name":"serum potassium","score":0.7419999837875366},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.6700000166893005},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776379505","wikidata":"https://www.wikidata.org/wiki/Q422188","display_name":"Spironolactone","level":3,"score":0.9455606937408447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8331851959228516},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.803960919380188},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.6921825408935547},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.6238012909889221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5142592787742615},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.49910426139831543},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47429683804512024},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.46092483401298523},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.43630069494247437},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.423615425825119},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000451","descriptor_name":"Mineralocorticoid Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013148","descriptor_name":"Spironolactone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.5507/bp.155.2011.004","doi":"https://doi.org/10.5507/bp.155.2011.004","is_oa":true,"landing_page_url":"https://doi.org/10.5507/bp.155.2011.004","pdf_url":"http://biomed.papers.upol.cz/doi/10.5507/bp.155.2011.004.pdf","source":{"id":"https://openalex.org/S4210187759","display_name":"Biomedical Papers","issn_l":"1213-8118","issn":["1213-8118","1804-7521"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319874","host_organization_name":"Palack\u00fd University Olomouc","host_organization_lineage":["https://openalex.org/P4310319874"],"host_organization_lineage_names":["Palack\u00fd University Olomouc"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Papers","raw_type":"journal-article"},{"id":"pmid:21804623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21804623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.997.961","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.997.961","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biomed.papers.upol.cz/pdfs/bio/2011/02/06.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.5507/bp.155.2011.004","doi":"https://doi.org/10.5507/bp.155.2011.004","is_oa":true,"landing_page_url":"https://doi.org/10.5507/bp.155.2011.004","pdf_url":"http://biomed.papers.upol.cz/doi/10.5507/bp.155.2011.004.pdf","source":{"id":"https://openalex.org/S4210187759","display_name":"Biomedical Papers","issn_l":"1213-8118","issn":["1213-8118","1804-7521"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319874","host_organization_name":"Palack\u00fd University Olomouc","host_organization_lineage":["https://openalex.org/P4310319874"],"host_organization_lineage_names":["Palack\u00fd University Olomouc"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Papers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2123540409.pdf","grobid_xml":"https://content.openalex.org/works/W2123540409.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1987919111","https://openalex.org/W1999826744","https://openalex.org/W2014072417","https://openalex.org/W2031135412","https://openalex.org/W2036366805","https://openalex.org/W2039340766","https://openalex.org/W2041502303","https://openalex.org/W2042552892","https://openalex.org/W2063753451","https://openalex.org/W2064320461","https://openalex.org/W2064532153","https://openalex.org/W2072074888","https://openalex.org/W2076224641","https://openalex.org/W2076609670","https://openalex.org/W2103596506","https://openalex.org/W2119642449","https://openalex.org/W2129950671","https://openalex.org/W2137408480","https://openalex.org/W2145849370","https://openalex.org/W2146282879","https://openalex.org/W2156121263","https://openalex.org/W2172086404","https://openalex.org/W2323458614","https://openalex.org/W2328926651","https://openalex.org/W2470108114","https://openalex.org/W2562329777","https://openalex.org/W4245704696","https://openalex.org/W4247606505","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7099463372","https://openalex.org/W2150734413","https://openalex.org/W1993050502","https://openalex.org/W2042529705","https://openalex.org/W2040758605","https://openalex.org/W1834354955","https://openalex.org/W2608505166","https://openalex.org/W2135100154","https://openalex.org/W2161975266","https://openalex.org/W7099680474"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"is":[2,33],"currently":[3],"limited":[4],"data":[5],"on":[6,47,180],"which":[7],"drug":[8],"should":[9],"be":[10],"used":[11],"to":[12,35,95,116],"improve":[13],"blood":[14,48,134,161],"pressure":[15,49,135,162],"control":[16],"in":[17,51,85,122,163,166,201],"patients":[18,52,202],"with":[19,53,59,74,203],"resistant":[20,54,204],"hypertension.":[21,56,206],"Recent":[22],"observational":[23],"trials":[24],"reported":[25],"spironolactone":[26,46,97,140,191],"as":[27],"having":[28],"good":[29],"effects.":[30],"This":[31],"study":[32],"designed":[34],"assess":[36],"the":[37,40,107,123,139,167,197],"effect":[38],"of":[39,42,45,104,109,125,147,153,169,184,199],"addition":[41],"25":[43],"mg":[44],"(BP)":[50],"arterial":[55,205],"METHODS:":[57],"Patients":[58,91],"office":[60],"systolic":[61,128],"BP":[62,68,131,175],">":[63,69],"140":[64],"mmHg":[65,71],"or":[66,98],"diastolic":[67,130],"90":[70],"despite":[72],"treatment":[73,177,200],"at":[75,101],"least":[76],"3":[77],"antihypertensive":[78],"drugs":[79],"including":[80],"a":[81,99,102,118],"diuretic,":[82],"are":[83,92,115,151],"enrolled":[84],"this":[86],"double-blind,":[87],"placebo-controlled,":[88],"multicentre":[89],"trial.":[90],"randomly":[93],"assigned":[94],"receive":[96],"placebo":[100,142],"ratio":[103],"1:1":[105],"by":[106,132],"method":[108],"simple":[110],"randomisation.":[111],"Our":[112],"primary":[113],"endpoints":[114],"show":[117],"statistically":[119],"significant":[120],"difference":[121,165],"fall":[124,168],"mean":[126,170],"day-time":[127],"and":[129,141,172,176,186],"ambulatory":[133],"monitoring":[136],"(ABPM),":[137],"between":[138],"groups,":[143],"after":[144],"8":[145],"weeks":[146],"treatment.":[148],"Secondary":[149],"outcomes":[150],"changes":[152],"serum":[154],"potassium,":[155],"natrium,":[156],"creatinine,":[157],"body":[158],"weight,":[159],"casual":[160],"office,":[164],"night-time":[171],"24-hour":[173],"ABPM":[174],"response":[178],"depending":[179],"different":[181],"baseline":[182],"levels":[183],"aldosterone":[185],"aldosterone/PRA":[187],"ratio.":[188],"DISCUSSION:":[189],"If":[190],"proves":[192],"effective,":[193],"it":[194],"might":[195],"become":[196],"standard":[198]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
