{"id":"https://openalex.org/W2123518080","doi":"https://doi.org/10.3109/07357907.2011.636115","title":"Serum Profiling to Distinguish Early- and Late-Stage Ovarian Cancer Patients from Disease-Free Individuals","display_name":"Serum Profiling to Distinguish Early- and Late-Stage Ovarian Cancer Patients from Disease-Free Individuals","publication_year":2011,"publication_date":"2011-12-07","ids":{"openalex":"https://openalex.org/W2123518080","doi":"https://doi.org/10.3109/07357907.2011.636115","mag":"2123518080","pmid":"https://pubmed.ncbi.nlm.nih.gov/22149058"},"language":"en","primary_location":{"id":"doi:10.3109/07357907.2011.636115","doi":"https://doi.org/10.3109/07357907.2011.636115","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357907.2011.636115","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013349626","display_name":"James Randolph Sanders Hocker","orcid":"https://orcid.org/0000-0002-7111-9119","observed_orcids":["https://orcid.org/0000-0002-7111-9119"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Hocker","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA","Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA,","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037854945","display_name":"Erin A. Bishop","orcid":"https://orcid.org/0000-0002-9914-4754","observed_orcids":["https://orcid.org/0000-0002-9914-4754"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin A. Bishop","raw_affiliation_strings":["Departments of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059170204","display_name":"Stan A. Lightfoot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stan A. Lightfoot","raw_affiliation_strings":["Departments of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043870806","display_name":"Megan R. Lerner","orcid":"https://orcid.org/0000-0003-2645-8311","observed_orcids":["https://orcid.org/0000-0003-2645-8311"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan R. Lerner","raw_affiliation_strings":["Departments of Surgery, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113567686","display_name":"Marvin D. Peyton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marvin D. Peyton","raw_affiliation_strings":["Departments of Surgery, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109126432","display_name":"Daniel J. Brackett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Brackett","raw_affiliation_strings":["Departments of Surgery, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046881948","display_name":"Rushie J. Hanas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rushie J. Hanas","raw_affiliation_strings":["Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108555243","display_name":"Donald Scott McMeekin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Scott McMeekin","raw_affiliation_strings":["Departments of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053990407","display_name":"Joan L. Walker","orcid":"https://orcid.org/0000-0002-5034-4309","observed_orcids":["https://orcid.org/0000-0002-5034-4309"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan L. Walker","raw_affiliation_strings":["Departments of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060206799","display_name":"Jay S. Hanas","orcid":"https://orcid.org/0000-0003-1922-5333","observed_orcids":["https://orcid.org/0000-0003-1922-5333"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jay S. Hanas","raw_affiliation_strings":["Non-aligned"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non-aligned","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060206799"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6554,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72114361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"30","issue":"2","first_page":"189","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"mass spectrometry","score":0.8740000128746033},{"id":"https://openalex.org/keywords/early-stage-cancer-detection","display_name":"early-stage cancer detection","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.8169999718666077},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7609999775886536},{"id":"https://openalex.org/keywords/diagnostic-sensitivity","display_name":"diagnostic sensitivity","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8746720552444458},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6886082887649536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6365786194801331},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5624368190765381},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5383075475692749},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4848800599575043},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48483026027679443},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.320163756608963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13231253623962402},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/07357907.2011.636115","doi":"https://doi.org/10.3109/07357907.2011.636115","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357907.2011.636115","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},{"id":"pmid:22149058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22149058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W166169566","https://openalex.org/W1536912963","https://openalex.org/W1537494447","https://openalex.org/W1575982426","https://openalex.org/W1644997609","https://openalex.org/W1928099527","https://openalex.org/W1976167707","https://openalex.org/W1977226390","https://openalex.org/W1978004240","https://openalex.org/W1986295696","https://openalex.org/W2026542164","https://openalex.org/W2027913086","https://openalex.org/W2029113441","https://openalex.org/W2033204893","https://openalex.org/W2035654246","https://openalex.org/W2051866318","https://openalex.org/W2053338365","https://openalex.org/W2054343221","https://openalex.org/W2086664362","https://openalex.org/W2119908867","https://openalex.org/W2122430069","https://openalex.org/W2129355295","https://openalex.org/W2145639723","https://openalex.org/W2151429141","https://openalex.org/W2157492758"],"related_works":["https://openalex.org/W2093126354","https://openalex.org/W4220886549","https://openalex.org/W2371246887","https://openalex.org/W2385028518","https://openalex.org/W2140562544","https://openalex.org/W1537494447","https://openalex.org/W2243610691","https://openalex.org/W2360301681","https://openalex.org/W2590462198","https://openalex.org/W2565871317"],"abstract_inverted_index":{"Sera":[0,36],"mass":[1],"spectrometry":[2],"(MS)":[3],"peak":[4],"differences":[5],"were":[6,67],"analyzed":[7],"from":[8,82],"35":[9],"ovarian":[10,32,44,61,84],"cancer":[11,27,33,45,62,85],"patients":[12,46],"and":[13,31,41,56,65,69,87],"16":[14],"disease-free":[15],"individuals.":[16],"\"Leave":[17],"one":[18],"out\"":[19],"cross":[20],"validation":[21],"was":[22],"used":[23],"to":[24],"assign":[25],"\"%":[26],"peaks\"":[28],"in":[29],"control":[30],"sera":[34,81],"samples.":[35],"MS":[37,76],"discriminated":[38],"stage":[39,42,63],"I/II":[40,64],"III/V":[43,66],"versus":[47],"controls":[48],"with":[49],"ROC":[50],"curve":[51],"area":[52],"values":[53],"of":[54,96],"0.82":[55],"0.92.":[57],"Test":[58],"sensitivities":[59],"for":[60,79,93],"80%":[68],"93%":[70],"respectively.":[71],"These":[72],"results":[73],"indicate":[74],"that":[75],"is":[77],"useful":[78],"distinguishing":[80],"early-stage":[83],"patients,":[86],"has":[88],"potential":[89],"as":[90],"a":[91],"test":[92],"early":[94],"detection":[95],"this":[97],"disease.":[98]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}