{"id":"https://openalex.org/W2123504278","doi":"https://doi.org/10.1534/genetics.107.083154","title":"A Thermodynamic Switch for Chromosome Colocalization","display_name":"A Thermodynamic Switch for Chromosome Colocalization","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2123504278","doi":"https://doi.org/10.1534/genetics.107.083154","mag":"2123504278","pmid":"https://pubmed.ncbi.nlm.nih.gov/18493085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2390650"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.107.083154","doi":"https://doi.org/10.1534/genetics.107.083154","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.107.083154","pdf_url":"https://academic.oup.com/genetics/article-pdf/179/1/717/42192463/genetics0717.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/genetics/article-pdf/179/1/717/42192463/genetics0717.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044366692","display_name":"Mario Nicodemi","orcid":"https://orcid.org/0000-0002-8416-6416","observed_orcids":["https://orcid.org/0000-0002-8416-6416"]},"institutions":[{"id":"https://openalex.org/I160013858","display_name":"Istituto Nazionale di Fisica Nucleare","ror":"https://ror.org/005ta0471","country_code":"IT","type":"government","lineage":["https://openalex.org/I160013858"]},{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]},{"id":"https://openalex.org/I4210108560","display_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Napoli","ror":"https://ror.org/015kcdd40","country_code":"IT","type":"facility","lineage":["https://openalex.org/I160013858","https://openalex.org/I4210108560"]}],"countries":["GB","IT"],"is_corresponding":true,"raw_author_name":"Mario Nicodemi","raw_affiliation_strings":["Department of Physics and Complexity Science, University of Warwick, Coventry CV4 7AL, United Kingdom","Istituto Nazionale Fisica Nucleare, I-80125 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Complexity Science, University of Warwick, Coventry CV4 7AL, United Kingdom","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Istituto Nazionale Fisica Nucleare, I-80125 Napoli, Italy","institution_ids":["https://openalex.org/I160013858","https://openalex.org/I4210108560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047663657","display_name":"Barbara Panning","orcid":"https://orcid.org/0000-0002-8301-1172","observed_orcids":["https://orcid.org/0000-0002-8301-1172"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Panning","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158 and","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034908531","display_name":"Antonella Prisco","orcid":"https://orcid.org/0000-0001-8061-0068","observed_orcids":["https://orcid.org/0000-0001-8061-0068"]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Prisco","raw_affiliation_strings":["Consiglio Nazionale delle Ricerche, Institute of Genetics and Biophysics, 80131 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consiglio Nazionale delle Ricerche, Institute of Genetics and Biophysics, 80131 Napoli, Italy","institution_ids":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044366692"],"corresponding_institution_ids":["https://openalex.org/I160013858","https://openalex.org/I39555362","https://openalex.org/I4210108560"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.3519,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78977408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"179","issue":"1","first_page":"717","last_page":"721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.49729999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.49729999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.1282999962568283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homologous-dna-pairing","display_name":"homologous DNA pairing","score":0.7749999761581421},{"id":"https://openalex.org/keywords/thermodynamic-modeling","display_name":"thermodynamic modeling","score":0.6480000019073486},{"id":"https://openalex.org/keywords/phase-switching","display_name":"phase switching","score":0.47099998593330383},{"id":"https://openalex.org/keywords/dna-binding-affinity","display_name":"DNA binding affinity","score":0.35100001096725464},{"id":"https://openalex.org/keywords/dna-concentration","display_name":"DNA concentration","score":0.4320000112056732},{"id":"https://openalex.org/keywords/meiotic-recombination","display_name":"meiotic recombination","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.9153680801391602},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.781352162361145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.728026270866394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6141486167907715},{"id":"https://openalex.org/C14103023","wikidata":"https://www.wikidata.org/wiki/Q11681459","display_name":"Pairing","level":3,"score":0.5802881717681885},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.575537919998169},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.5282986164093018},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5269642472267151},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3446239233016968},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3310352861881256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3107362985610962},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16969886422157288},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C54101563","wikidata":"https://www.wikidata.org/wiki/Q124131","display_name":"Superconductivity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1534/genetics.107.083154","doi":"https://doi.org/10.1534/genetics.107.083154","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.107.083154","pdf_url":"https://academic.oup.com/genetics/article-pdf/179/1/717/42192463/genetics0717.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2390650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2390650","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmid:18493085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18493085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:0809.4788","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/0809.4788","pdf_url":"https://arxiv.org/pdf/0809.4788","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.0809.4788","doi":"https://doi.org/10.48550/arxiv.0809.4788","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.0809.4788","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1534/genetics.107.083154","doi":"https://doi.org/10.1534/genetics.107.083154","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.107.083154","pdf_url":"https://academic.oup.com/genetics/article-pdf/179/1/717/42192463/genetics0717.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G637476367","display_name":"Xist RNA and Regulation of Chromatin Structure","funder_award_id":"R01GM063671","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2123504278.pdf","grobid_xml":"https://content.openalex.org/works/W2123504278.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1540380506","https://openalex.org/W1774151066","https://openalex.org/W1991518938","https://openalex.org/W1997250578","https://openalex.org/W2001758397","https://openalex.org/W2006460442","https://openalex.org/W2032464841","https://openalex.org/W2049427149","https://openalex.org/W2054661742","https://openalex.org/W2078852136","https://openalex.org/W2087985833","https://openalex.org/W2098549100","https://openalex.org/W2100822763","https://openalex.org/W2109584264","https://openalex.org/W2118117928","https://openalex.org/W2124789443","https://openalex.org/W2138847882","https://openalex.org/W2139231693","https://openalex.org/W2151011799","https://openalex.org/W2155324891","https://openalex.org/W2171582839","https://openalex.org/W2594550962","https://openalex.org/W3003303647"],"related_works":["https://openalex.org/W1989014809","https://openalex.org/W2078143253","https://openalex.org/W2163913809","https://openalex.org/W2027224271","https://openalex.org/W4226081724","https://openalex.org/W2092950915","https://openalex.org/W1989650370","https://openalex.org/W1982621957","https://openalex.org/W2563536859","https://openalex.org/W1969930767"],"abstract_inverted_index":{"A":[0],"general":[1],"model":[2],"for":[3],"the":[4,21,32],"early":[5],"recognition":[6],"and":[7,34],"colocalization":[8,53],"of":[9,36,54],"homologous":[10,25],"DNA":[11,26],"sequences":[12,27],"is":[13,28],"proposed.":[14],"We":[15],"show,":[16],"on":[17],"thermodynamic":[18],"grounds,":[19],"how":[20],"distance":[22],"between":[23,46],"two":[24,47],"spontaneously":[29],"regulated":[30],"by":[31],"concentration":[33],"affinity":[35],"diffusible":[37],"mediators":[38],"binding":[39],"them,":[40],"which":[41],"act":[42],"as":[43],"a":[44],"switch":[45],"phases":[48],"corresponding":[49],"to":[50],"independence":[51],"or":[52],"pairing":[55],"regions.":[56]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}