{"id":"https://openalex.org/W2123460554","doi":"https://doi.org/10.3390/m566","title":"N-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl (N-Dde) Lipoamino Acids","display_name":"N-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl (N-Dde) Lipoamino Acids","publication_year":2008,"publication_date":"2008-08-15","ids":{"openalex":"https://openalex.org/W2123460554","doi":"https://doi.org/10.3390/m566","mag":"2123460554"},"language":"en","primary_location":{"id":"doi:10.3390/m566","doi":"https://doi.org/10.3390/m566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/m566","pdf_url":"https://www.mdpi.com/1422-8599/2008/2/M566/pdf?version=1234949567","source":{"id":"https://openalex.org/S51894404","display_name":"Molbank","issn_l":"1422-8599","issn":["1422-8599"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molbank","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-8599/2008/2/M566/pdf?version=1234949567","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065560675","display_name":"Benjamin P. Ross","orcid":"https://orcid.org/0000-0002-1899-8484","observed_orcids":["https://orcid.org/0000-0002-1899-8484"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Benjamin Ross","raw_affiliation_strings":["School of Pharmacy, The University of Queensland, Brisbane, Queensland 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, The University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003171365","display_name":"Robert A. Falconer","orcid":"https://orcid.org/0000-0002-6426-4430","observed_orcids":["https://orcid.org/0000-0002-6426-4430"]},"institutions":[{"id":"https://openalex.org/I139894009","display_name":"University of Bradford","ror":"https://ror.org/00vs8d940","country_code":"GB","type":"education","lineage":["https://openalex.org/I139894009"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Falconer","raw_affiliation_strings":["Institute of Cancer Therapeutics, School of Life Sciences, University of Bradford, West Yorkshire, BD7 1DP, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Therapeutics, School of Life Sciences, University of Bradford, West Yorkshire, BD7 1DP, United Kingdom","institution_ids":["https://openalex.org/I139894009"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008581557","display_name":"Istv\u00e1n T\u00f3th","orcid":"https://orcid.org/0000-0002-4572-397X","observed_orcids":["https://orcid.org/0000-0002-4572-397X","https://orcid.org/0000-0002-6771-4388"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Istvan Thot","raw_affiliation_strings":["School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia","School of Pharmacy, The University of Queensland, Brisbane, Queensland 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"School of Pharmacy, The University of Queensland, Brisbane, Queensland 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008581557"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":500,"currency":"CHF","value_usd":603},"apc_paid":{"value":500,"currency":"CHF","value_usd":603},"fwci":0.0,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.12980769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2008","issue":"2","first_page":"M566","last_page":"M566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.38179999589920044,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.38179999589920044,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.2939000129699707,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoamino-acids","display_name":"lipoamino acids","score":0.9829999804496765},{"id":"https://openalex.org/keywords/drug-conjugation","display_name":"drug conjugation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/steric-protection","display_name":"steric protection","score":0.6970000267028809},{"id":"https://openalex.org/keywords/enzymatic-degradation","display_name":"enzymatic degradation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9689300656318665},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.9308375120162964},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7392075061798096},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.6109830737113953},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5297414064407349},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.43982887268066406},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.37178927659988403},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21726274490356445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/m566","doi":"https://doi.org/10.3390/m566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/m566","pdf_url":"https://www.mdpi.com/1422-8599/2008/2/M566/pdf?version=1234949567","source":{"id":"https://openalex.org/S51894404","display_name":"Molbank","issn_l":"1422-8599","issn":["1422-8599"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molbank","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.852.7722","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.852.7722","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1422-8599/2008/2/M566/pdf/","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3390/m566","doi":"https://doi.org/10.3390/m566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/m566","pdf_url":"https://www.mdpi.com/1422-8599/2008/2/M566/pdf?version=1234949567","source":{"id":"https://openalex.org/S51894404","display_name":"Molbank","issn_l":"1422-8599","issn":["1422-8599"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molbank","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2123460554.pdf","grobid_xml":"https://content.openalex.org/works/W2123460554.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1518071796","https://openalex.org/W1974607009","https://openalex.org/W1976600333","https://openalex.org/W1978692324","https://openalex.org/W1987519042","https://openalex.org/W1991711350","https://openalex.org/W1995044016","https://openalex.org/W1995233420","https://openalex.org/W2008494805","https://openalex.org/W2018857922","https://openalex.org/W2023132559","https://openalex.org/W2028640930","https://openalex.org/W2065566578","https://openalex.org/W2069963367","https://openalex.org/W2075638208","https://openalex.org/W2083130353","https://openalex.org/W2096176556","https://openalex.org/W2109280631","https://openalex.org/W2145299059"],"related_works":["https://openalex.org/W1978344987","https://openalex.org/W2157363396","https://openalex.org/W2994712850","https://openalex.org/W2469529300","https://openalex.org/W3093819014","https://openalex.org/W7117162525","https://openalex.org/W65702625","https://openalex.org/W67413893","https://openalex.org/W1645608","https://openalex.org/W1989384182"],"abstract_inverted_index":{"The":[0],"conjugation":[1],"of":[2],"a":[3],"drug":[4,20,36],"with":[5],"one":[6],"or":[7],"more":[8],"lipoamino":[9],"acids":[10],"(LAAs;":[11],"2-aminoalkanoic":[12],"acids;":[13],"e.g.":[14],"3)":[15],"can":[16],"impart":[17],"upon":[18],"the":[19],"steric":[21],"protection":[22],"from":[23],"enzymatic":[24],"degradation,":[25],"increased":[26,28],"lipophilicity,":[27],"passive":[29],"membrane":[30],"diffusion":[31],"and":[32],"therefore":[33],"may":[34],"improve":[35],"bioavailability":[37],"[1].[...]":[38]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}