{"id":"https://openalex.org/W2123440662","doi":"https://doi.org/10.4172/2332-0877.1000208","title":"Is Drug Resistance in First-Line Therapy against All Antiretroviral Agents Inevitable?","display_name":"Is Drug Resistance in First-Line Therapy against All Antiretroviral Agents Inevitable?","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2123440662","doi":"https://doi.org/10.4172/2332-0877.1000208","mag":"2123440662"},"language":"en","primary_location":{"id":"doi:10.4172/2332-0877.1000208","doi":"https://doi.org/10.4172/2332-0877.1000208","is_oa":true,"landing_page_url":"https://doi.org/10.4172/2332-0877.1000208","pdf_url":null,"source":{"id":"https://openalex.org/S2764874173","display_name":"Journal of Infectious Diseases and Therapy","issn_l":"2332-0877","issn":["2332-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4172/2332-0877.1000208","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029881635","display_name":"Mark A. Wainberg","orcid":"https://orcid.org/0000-0002-0272-1317","observed_orcids":["https://orcid.org/0000-0002-0272-1317"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Mark A Wainberg","raw_affiliation_strings":["McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029881635"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08590338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"03","issue":"02","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.8960000276565552},{"id":"https://openalex.org/keywords/first-line-antiretroviral-therapy","display_name":"first-line antiretroviral therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dolutegravir","display_name":"dolutegravir","score":0.996999979019165},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/resistance-mutations","display_name":"resistance mutations","score":0.8109999895095825},{"id":"https://openalex.org/keywords/viral-replication-capacity","display_name":"viral replication capacity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hiv-treatment","display_name":"HIV treatment","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2779502633","wikidata":"https://www.wikidata.org/wiki/Q937224","display_name":"Dolutegravir","level":5,"score":0.9959706664085388},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.8203350901603699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7065964937210083},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.697202205657959},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6966262459754944},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6831356883049011},{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.6196151375770569},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5583827495574951},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.508590817451477},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4850582182407379},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.42388951778411865},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.4103962481021881},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1977546215057373},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.19176819920539856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13688474893569946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07953467965126038}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4172/2332-0877.1000208","doi":"https://doi.org/10.4172/2332-0877.1000208","is_oa":true,"landing_page_url":"https://doi.org/10.4172/2332-0877.1000208","pdf_url":null,"source":{"id":"https://openalex.org/S2764874173","display_name":"Journal of Infectious Diseases and Therapy","issn_l":"2332-0877","issn":["2332-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases and Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4172/2332-0877.1000208","doi":"https://doi.org/10.4172/2332-0877.1000208","is_oa":true,"landing_page_url":"https://doi.org/10.4172/2332-0877.1000208","pdf_url":null,"source":{"id":"https://openalex.org/S2764874173","display_name":"Journal of Infectious Diseases and Therapy","issn_l":"2332-0877","issn":["2332-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1990828872","https://openalex.org/W1993363443","https://openalex.org/W2057925552","https://openalex.org/W2062514953","https://openalex.org/W2094811879","https://openalex.org/W2110471430","https://openalex.org/W2121720236","https://openalex.org/W2132585743","https://openalex.org/W2139430929","https://openalex.org/W2139497502","https://openalex.org/W2144255757","https://openalex.org/W2145467751","https://openalex.org/W2151050670","https://openalex.org/W2152505869","https://openalex.org/W2166733691","https://openalex.org/W2170463669","https://openalex.org/W2314461521","https://openalex.org/W2318124317"],"related_works":["https://openalex.org/W1966567607","https://openalex.org/W2022787293","https://openalex.org/W2463348369","https://openalex.org/W2185595601","https://openalex.org/W4388015553","https://openalex.org/W2397560420","https://openalex.org/W2071348779","https://openalex.org/W2531633101","https://openalex.org/W2094303174","https://openalex.org/W2415914350"],"abstract_inverted_index":{"Drug":[0,44],"resistance":[1,63],"has":[2,59],"been":[3,13],"observed":[4],"in":[5,26,46,50,65,118],"regard":[6],"to":[7,21,82,89,109,115],"all":[8],"anti-retroviral":[9],"drugs":[10],"that":[11,35,58,78,105,112],"have":[12,76],"studied":[14],"until":[15],"now.":[16],"The":[17],"most":[18],"recent":[19],"drug":[20,57],"be":[22],"approved":[23,37],"for":[24,38,62],"use":[25],"HIV":[27,32,56],"therapy":[28,39],"is":[29,53,80],"dolutegravir,":[30],"an":[31],"integrase":[33,91],"inhibitor,":[34],"was":[36],"by":[40],"the":[41,47,54,66,83,90,101],"Food":[42],"and":[43,111],"Administration":[45],"United":[48],"States":[49],"2013.":[51],"Dolutegravir":[52],"only":[55],"not":[60],"selected":[61],"mutations":[64],"clinic":[67],"when":[68],"used":[69],"as":[70,93,95],"part":[71,102],"of":[72,87,103],"first-line":[73],"therapy.":[74],"We":[75],"hypothesized":[77],"this":[79],"due":[81],"long":[84],"binding":[85],"time":[86],"dolutegravir":[88,110],"enzyme":[92],"well":[94],"greatly":[96],"diminished":[97],"replication":[98],"capacity":[99],"on":[100],"viruses":[104],"might":[106],"become":[107],"resistant":[108],"are":[113],"unable":[114],"successfully":[116],"replicate":[117],"infected":[119],"individuals.":[120]},"counts_by_year":[],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2016-06-24T00:00:00"}
