{"id":"https://openalex.org/W2123427895","doi":"https://doi.org/10.1074/jbc.m804372200","title":"Exendin-(9\u201339) Corrects Fasting Hypoglycemia in SUR-1\u2013/\u2013 Mice by Lowering cAMP in Pancreatic \u03b2-Cells and Inhibiting Insulin Secretion","display_name":"Exendin-(9\u201339) Corrects Fasting Hypoglycemia in SUR-1\u2013/\u2013 Mice by Lowering cAMP in Pancreatic \u03b2-Cells and Inhibiting Insulin Secretion","publication_year":2008,"publication_date":"2008-07-18","ids":{"openalex":"https://openalex.org/W2123427895","doi":"https://doi.org/10.1074/jbc.m804372200","mag":"2123427895","pmid":"https://pubmed.ncbi.nlm.nih.gov/18635551","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3258866"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m804372200","doi":"https://doi.org/10.1074/jbc.m804372200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m804372200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m804372200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051617679","display_name":"Diva D. De Le\u00f3n","orcid":"https://orcid.org/0000-0003-1225-8087","observed_orcids":["https://orcid.org/0000-0003-1225-8087"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diva D. De Le\u00f3n","raw_affiliation_strings":["Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. deleon@email.chop.edu","Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. deleon@email.chop.edu","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100773998","display_name":"Changhong Li","orcid":"https://orcid.org/0000-0003-0699-8900","observed_orcids":["https://orcid.org/0000-0003-0699-8900","https://orcid.org/0000-0003-0513-1459"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changhong Li","raw_affiliation_strings":["Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075600128","display_name":"Madeleine I. Delson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeleine I. Delson","raw_affiliation_strings":["Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050182252","display_name":"Franz M. Matschinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franz M. Matschinsky","raw_affiliation_strings":["Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073631988","display_name":"Charles A. Stanley","orcid":"https://orcid.org/0000-0003-4881-9392","observed_orcids":["https://orcid.org/0000-0003-4881-9392"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Stanley","raw_affiliation_strings":["Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013723938","display_name":"Doris A. Stoffers","orcid":"https://orcid.org/0000-0003-2626-2124","observed_orcids":["https://orcid.org/0000-0003-2626-2124","https://orcid.org/0000-0002-2410-8951"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Doris A. Stoffers","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104","Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013723938","https://openalex.org/A5051617679"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.025,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.86989033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"283","issue":"38","first_page":"25786","last_page":"25793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exendin-9-39","display_name":"exendin-9-39","score":0.9800000190734863},{"id":"https://openalex.org/keywords/congenital-hyperinsulinism","display_name":"congenital hyperinsulinism","score":0.9039999842643738},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.7549999952316284},{"id":"https://openalex.org/keywords/kir6-2","display_name":"Kir6.2","score":0.8880000114440918},{"id":"https://openalex.org/keywords/fasting-hypoglycemia","display_name":"fasting hypoglycemia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9639999866485596},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.5099999904632568},{"id":"https://openalex.org/keywords/islet-perifusion","display_name":"islet perifusion","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9132900238037109},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8982803821563721},{"id":"https://openalex.org/C2777368190","wikidata":"https://www.wikidata.org/wiki/Q477390","display_name":"Hyperinsulinism","level":4,"score":0.6853500604629517},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6506222486495972},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.586318850517273},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5841034650802612},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.521628201007843},{"id":"https://openalex.org/C144855686","wikidata":"https://www.wikidata.org/wiki/Q6042245","display_name":"Insulin oscillation","level":4,"score":0.507358729839325},{"id":"https://openalex.org/C2775858560","wikidata":"https://www.wikidata.org/wiki/Q11612732","display_name":"Hyperinsulinemic hypoglycemia","level":4,"score":0.4810366928577423},{"id":"https://openalex.org/C2777643638","wikidata":"https://www.wikidata.org/wiki/Q5160437","display_name":"Congenital hyperinsulinism","level":5,"score":0.4784303307533264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47566503286361694},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.18216660618782043}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064233","descriptor_name":"Sulfonylurea Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m804372200","doi":"https://doi.org/10.1074/jbc.m804372200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m804372200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2266908","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3258866","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3258866","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3258866","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:18635551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18635551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m804372200","doi":"https://doi.org/10.1074/jbc.m804372200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m804372200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4353942866","display_name":"Role of GLP-1 in disorders of carbohydrate metabolism in children","funder_award_id":"K23DK073663","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7533653669","display_name":"Molecular Basis of a New Form of Hyperinsulinism","funder_award_id":"R01DK053012","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G854368093","display_name":"Ped Endocrine Career Development in Diabetes Research","funder_award_id":"K12DK063682","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000878197","display_name":"University of Pennsylvania Diabetes Research Center","funder_award_id":"P30DK019525","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W23355599","https://openalex.org/W1559132754","https://openalex.org/W1571595997","https://openalex.org/W1667518818","https://openalex.org/W1968498807","https://openalex.org/W1970958676","https://openalex.org/W1975863794","https://openalex.org/W1977017927","https://openalex.org/W1983286754","https://openalex.org/W1988196562","https://openalex.org/W1993038809","https://openalex.org/W1994867775","https://openalex.org/W2013658326","https://openalex.org/W2041442731","https://openalex.org/W2055054551","https://openalex.org/W2073235659","https://openalex.org/W2074501705","https://openalex.org/W2074511950","https://openalex.org/W2082036487","https://openalex.org/W2082763759","https://openalex.org/W2101695647","https://openalex.org/W2104214122","https://openalex.org/W2110015701","https://openalex.org/W2111242088","https://openalex.org/W2125036135","https://openalex.org/W2126461698","https://openalex.org/W2128167237","https://openalex.org/W2128902735","https://openalex.org/W2137364215","https://openalex.org/W2145811259","https://openalex.org/W2146581079","https://openalex.org/W2152557643","https://openalex.org/W2153361294","https://openalex.org/W2156627717","https://openalex.org/W2164561590","https://openalex.org/W2165848705","https://openalex.org/W2167479225","https://openalex.org/W2171483278","https://openalex.org/W2428583472"],"related_works":["https://openalex.org/W2107040844","https://openalex.org/W1808254183","https://openalex.org/W2104214122","https://openalex.org/W2101695647","https://openalex.org/W2042595191","https://openalex.org/W2096867745","https://openalex.org/W2110015701","https://openalex.org/W2098899089","https://openalex.org/W2126461698","https://openalex.org/W2795336314"],"abstract_inverted_index":{"Congenital":[0],"hyperinsulinism":[1],"is":[2,74,175,224],"a":[3,212,242,252],"disorder":[4],"of":[5,19,36,51,105],"pancreatic":[6],"beta-cell":[7],"function":[8],"characterized":[9],"by":[10,189,196],"failure":[11],"to":[12,58,67,117],"suppress":[13],"insulin":[14,160,172,217,246],"secretion":[15,218],"in":[16,22,31,97,111,126,136,178,184,215,227,238],"the":[17,32,45,68,71,87,103,221],"setting":[18],"hypoglycemia,":[20],"resulting":[21],"brain":[23],"damage":[24],"or":[25,120],"death":[26],"if":[27],"untreated.":[28],"Loss-of-function":[29],"mutations":[30],"K(ATP)":[33,257],"channel":[34],"(composed":[35],"two":[37],"subunits:":[38],"Kir6.2":[39],"and":[40,48,62,78,139,152,159,193,219],"SUR-1)":[41],"are":[42,56],"responsible":[43],"for":[44,256],"most":[46],"common":[47],"severe":[49],"form":[50],"congenital":[52],"hyperinsulinism.":[53,258],"Most":[54],"patients":[55],"unresponsive":[57],"available":[59],"medical":[60],"therapy":[61],"require":[63],"palliative":[64],"pancreatectomy.":[65],"Similar":[66],"human":[69],"condition,":[70],"SUR-1(-/-)":[72,112,127,179,185,228,239],"mouse":[73],"hypoglycemic":[75],"when":[76,80,194],"fasted":[77],"hyperglycemic":[79],"glucose-loaded.":[81],"We":[82],"have":[83],"previously":[84],"reported":[85],"that":[86,167,209,220,233],"glucagon-like":[88],"peptide-1":[89],"receptor":[90,223],"antagonist":[91],"exendin-(9-39)":[92,106,119,131,168,190,234,250],"raises":[93],"fasting":[94,108,236],"blood":[95,109,123],"glucose":[96,110,124,150],"normal":[98],"mice.":[99,113],"Here":[100],"we":[101],"examine":[102],"effect":[104,155,244],"on":[107,156,245],"Mice":[114],"were":[115,132,203],"randomized":[116],"receive":[118],"vehicle.":[121],"Fasting":[122],"levels":[125,202],"mice":[128,138,240],"treated":[129],"with":[130],"significantly":[133],"higher":[134],"than":[135],"vehicle-treated":[137],"not":[140,147,204],"different":[141],"from":[142],"wild-type":[143],"littermates.":[144],"Exendin-(9-39)":[145],"did":[146],"further":[148],"worsen":[149],"tolerance":[151],"had":[153],"no":[154],"body":[157],"weight":[158],"sensitivity.":[161],"Isolated":[162],"islet":[163],"perifusion":[164],"studies":[165],"demonstrated":[166],"blocked":[169],"amino":[170,197],"acid-stimulated":[171],"secretion,":[173,247],"which":[174],"abnormally":[176],"increased":[177],"islets.":[180],"Furthermore,":[181],"cAMP":[182,210],"content":[183],"islets":[186],"was":[187],"reduced":[188],"both":[191],"basally":[192],"stimulated":[195],"acids,":[198],"whereas":[199],"cytosolic":[200],"calcium":[201],"affected.":[205],"These":[206],"findings":[207,231],"suggest":[208],"plays":[211],"key":[213],"role":[214],"K(ATP)-independent":[216],"GLP-1":[222],"constitutively":[225],"active":[226],"beta-cells.":[229],"Our":[230],"indicate":[232],"normalizes":[235],"hypoglycemia":[237],"via":[241],"direct":[243],"thereby":[248],"raising":[249],"as":[251],"potential":[253],"therapeutic":[254],"agent":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
