{"id":"https://openalex.org/W2123344644","doi":"https://doi.org/10.1093/toxsci/kfq055","title":"Hematopoietic Cell Kinase Associates with the 40S Ribosomal Subunit and Mediates the Ribotoxic Stress Response to Deoxynivalenol in Mononuclear Phagocytes","display_name":"Hematopoietic Cell Kinase Associates with the 40S Ribosomal Subunit and Mediates the Ribotoxic Stress Response to Deoxynivalenol in Mononuclear Phagocytes","publication_year":2010,"publication_date":"2010-02-24","ids":{"openalex":"https://openalex.org/W2123344644","doi":"https://doi.org/10.1093/toxsci/kfq055","mag":"2123344644","pmid":"https://pubmed.ncbi.nlm.nih.gov/20181660","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2902856"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfq055","doi":"https://doi.org/10.1093/toxsci/kfq055","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfq055","pdf_url":"https://academic.oup.com/toxsci/article-pdf/115/2/444/16682416/kfq055.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/toxsci/article-pdf/115/2/444/16682416/kfq055.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053853419","display_name":"Heekyong R. Bae","orcid":"https://orcid.org/0000-0003-2205-9700","observed_orcids":["https://orcid.org/0000-0003-2205-9700"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heekyong Bae","raw_affiliation_strings":["Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824-1224, USA","Center for Integrative Toxicology","Department of Food Science and Human Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824-1224, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Center for Integrative Toxicology","institution_ids":[]},{"raw_affiliation_string":"Department of Food Science and Human Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer S. Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer S. Gray","raw_affiliation_strings":["Center for Integrative Toxicology","Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-1224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Toxicology","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-1224","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072512393","display_name":"Maoxiang Li","orcid":"https://orcid.org/0009-0006-0502-6842","observed_orcids":["https://orcid.org/0009-0006-0502-6842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maoxiang Li","raw_affiliation_strings":["Center for Integrative Toxicology","Department of Food Science and Human Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Toxicology","institution_ids":[]},{"raw_affiliation_string":"Department of Food Science and Human Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074523344","display_name":"Laura L. Vines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Vines","raw_affiliation_strings":["Center for Integrative Toxicology","Department of Food Science and Human Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Toxicology","institution_ids":[]},{"raw_affiliation_string":"Department of Food Science and Human Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100662521","display_name":"Joon Kim","orcid":"https://orcid.org/0000-0003-0914-4273","observed_orcids":["https://orcid.org/0000-0003-0914-4273"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joon Kim","raw_affiliation_strings":["Laboratory of Biochemistry, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060677752","display_name":"James J. Pestka","orcid":"https://orcid.org/0000-0003-4689-2756","observed_orcids":["https://orcid.org/0000-0003-4689-2756"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Pestka","raw_affiliation_strings":["Center for Integrative Toxicology , \u2020Department of Food Science and Human Nutrition and \u2021Department of Microbiology and Molecular Genetics , Michigan State University , East Lansing , Michigan 48824-1224 ; and","Center for Integrative Toxicology","Department of Food Science and Human Nutrition","Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-1224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Toxicology , \u2020Department of Food Science and Human Nutrition and \u2021Department of Microbiology and Molecular Genetics , Michigan State University , East Lansing , Michigan 48824-1224 ; and","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Center for Integrative Toxicology","institution_ids":[]},{"raw_affiliation_string":"Department of Food Science and Human Nutrition","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824-1224","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":9.2275,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.97994609,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"115","issue":"2","first_page":"444","last_page":"452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.20520000159740448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deoxynivalenol","display_name":"deoxynivalenol","score":0.9589999914169312},{"id":"https://openalex.org/keywords/trichothecenes","display_name":"trichothecenes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hematopoietic-cell-kinase","display_name":"hematopoietic cell kinase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pkr","display_name":"PKR","score":0.6620000004768372},{"id":"https://openalex.org/keywords/40s-ribosomal-subunit","display_name":"40S ribosomal subunit","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ribotoxic-stress","display_name":"ribotoxic stress","score":0.7960000038146973},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mononuclear-phagocytes","display_name":"mononuclear phagocytes","score":0.824999988079071},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8579999804496765},{"id":"https://openalex.org/keywords/rps3","display_name":"ribosomal protein S3","score":0.8759999871253967},{"id":"https://openalex.org/keywords/2-aminopurine","display_name":"2-aminopurine","score":0.843999981880188},{"id":"https://openalex.org/keywords/pp2","display_name":"PP2","score":0.43299999833106995},{"id":"https://openalex.org/keywords/ask1","display_name":"ASK1","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C161238802","wikidata":"https://www.wikidata.org/wiki/Q14905690","display_name":"Protein kinase R","level":5,"score":0.7889857888221741},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5853583216667175},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5240923762321472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5143950581550598},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4952060282230377},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4703778624534607},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.3305302858352661},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32478249073028564}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010586","descriptor_name":"Phagocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010586","descriptor_name":"Phagocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051572","descriptor_name":"Proto-Oncogene Proteins c-hck","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051572","descriptor_name":"Proto-Oncogene Proteins c-hck","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054682","descriptor_name":"Ribosome Subunits, Small, Eukaryotic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D054682","descriptor_name":"Ribosome Subunits, Small, Eukaryotic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/toxsci/kfq055","doi":"https://doi.org/10.1093/toxsci/kfq055","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfq055","pdf_url":"https://academic.oup.com/toxsci/article-pdf/115/2/444/16682416/kfq055.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2902856","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2902856","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Sci","raw_type":"Text"},{"id":"pmid:20181660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20181660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/toxsci/kfq055","doi":"https://doi.org/10.1093/toxsci/kfq055","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfq055","pdf_url":"https://academic.oup.com/toxsci/article-pdf/115/2/444/16682416/kfq055.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2951544504","display_name":"Dietary lipids and Experimental IgA Nephropathy","funder_award_id":"R01DK058833","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G598354566","display_name":"Trichothecene Toxicity and the Ribotoxic Stress Response","funder_award_id":"R01ES003358","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7797760064","display_name":null,"funder_award_id":"ES03553","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2123344644.pdf","grobid_xml":"https://content.openalex.org/works/W2123344644.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W74224146","https://openalex.org/W112912425","https://openalex.org/W1504003784","https://openalex.org/W1523792532","https://openalex.org/W1549105044","https://openalex.org/W1920673175","https://openalex.org/W1963500867","https://openalex.org/W1967333602","https://openalex.org/W1982485185","https://openalex.org/W1990122501","https://openalex.org/W1990868866","https://openalex.org/W1993250698","https://openalex.org/W1994601555","https://openalex.org/W1996639520","https://openalex.org/W2001338730","https://openalex.org/W2002473468","https://openalex.org/W2004808033","https://openalex.org/W2015422987","https://openalex.org/W2023831963","https://openalex.org/W2030912425","https://openalex.org/W2031116438","https://openalex.org/W2031240856","https://openalex.org/W2031495829","https://openalex.org/W2037087465","https://openalex.org/W2043442231","https://openalex.org/W2046907602","https://openalex.org/W2053897938","https://openalex.org/W2059769519","https://openalex.org/W2088839978","https://openalex.org/W2093658250","https://openalex.org/W2111304767","https://openalex.org/W2119928295","https://openalex.org/W2120013569","https://openalex.org/W2135793835","https://openalex.org/W2140796894","https://openalex.org/W2146644929","https://openalex.org/W2149422934","https://openalex.org/W2151419807","https://openalex.org/W2159648100","https://openalex.org/W2161057270","https://openalex.org/W2172297330","https://openalex.org/W2285747988","https://openalex.org/W4313144828"],"related_works":["https://openalex.org/W2146644929","https://openalex.org/W7100926566","https://openalex.org/W1984253264","https://openalex.org/W2140796894","https://openalex.org/W7099570188","https://openalex.org/W1967333602","https://openalex.org/W2120013569","https://openalex.org/W1993355443","https://openalex.org/W7098118837","https://openalex.org/W2106435800"],"abstract_inverted_index":{"The":[0],"trichothecene":[1],"deoxynivalenol":[2],"(DON)":[3],"binds":[4],"to":[5,57,102,219],"eukaryotic":[6],"ribosomes":[7],"and":[8,28,43,67,97,127,143,168,197,213,227],"triggers":[9],"p38-driven":[10,68,242],"proinflammatory":[11,243],"gene":[12],"expression":[13,72,99],"in":[14,53,73,135,170,184],"the":[15,41,47,74,131,166],"macrophage-a":[16],"response":[17],"that":[18,38,125,150],"is":[19],"dependent":[20],"on":[21],"both":[22,110],"double-stranded":[23],"RNA-activated":[24],"protein":[25,155,215],"kinase":[26,31,211,216],"(PKR)":[27],"hematopoietic":[29],"cell":[30,78],"(Hck).":[32],"Here":[33],"we":[34],"elucidated":[35],"critical":[36,230],"linkages":[37],"exist":[39],"among":[40],"ribosome":[42,167],"these":[44],"kinases":[45],"during":[46],"course":[48],"of":[49,93,119,181,202,222,235],"DON-induced":[50,94,179,200,232],"ribotoxic":[51],"stress":[52],"mononuclear":[54],"phagocytes.":[55],"Similar":[56],"PKR":[58,86,126,226],"inhibitors,":[59],"Hck":[60,128,151,183,228],"inhibitor":[61],"4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine":[62],"(PP2)":[63],"suppressed":[64,191],"p38":[65,95,163,203],"activation":[66,96],"interleukin":[69],"8":[70],"(IL-8)":[71],"U937":[75,80,159],"human":[76],"monocyte":[77],"line.":[79],"cells":[81,103,148],"stably":[82],"transfected":[83,104],"with":[84,105,109,130,146,153,158,165],"a":[85],"antisense":[87],"vector":[88,107],"(U9K-A1)":[89],"displayed":[90],"marked":[91],"reduction":[92],"IL-8":[98],"as":[100,204,206],"compared":[101],"empty":[106],"(U9K-C2),":[108],"responses":[111],"being":[112],"completely":[113],"ablated":[114],"by":[115,192],"PP2.":[116],"Western":[117],"analysis":[118],"sucrose":[120],"density":[121],"gradient":[122],"fractions":[123],"revealed":[124],"interacted":[129,152],"40S":[132],"ribosomal":[133,154,233],"subunit":[134],"U9K-C2":[136],"but":[137,175],"not":[138,176],"U9K-A1":[139],"cells.":[140],"Subsequent":[141],"transfection":[142],"immunoprecipitation":[144],"studies":[145],"HeLa":[147],"indicated":[149],"S3.":[156],"Consistent":[157],"cells,":[160],"DON":[161],"induced":[162],"association":[164],"phosphorylation":[169,180,201],"peritoneal":[171],"macrophages":[172,188],"from":[173],"wild-type":[174],"PKR-deficient":[177],"mice.":[178],"ribosome-associated":[182],"RAW":[185],"264.7":[186],"murine":[187],"was":[189],"also":[190],"2-aminopurine":[193],"(2-AP).":[194],"Both":[195],"2-AP":[196],"PP2":[198],"inhibited":[199],"well":[205],"two":[207],"kinases,":[208],"apoptosis":[209],"signal-regulating":[210],"1":[212],"mitogen-activated":[214],"3/6,":[217],"known":[218],"be":[220],"upstream":[221],"p38.":[223],"Taken":[224],"together,":[225],"were":[229],"for":[231],"recruitment":[234],"p38,":[236],"its":[237],"subsequent":[238],"phosphorylation,":[239],"and,":[240],"ultimately,":[241],"cytokine":[244],"expression.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
