{"id":"https://openalex.org/W2123308243","doi":"https://doi.org/10.1002/ptr.2650070307","title":"Influence of Padma 28 on patients with chronic active hepatitis B","display_name":"Influence of Padma 28 on patients with chronic active hepatitis B","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W2123308243","doi":"https://doi.org/10.1002/ptr.2650070307","mag":"2123308243"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.2650070307","doi":"https://doi.org/10.1002/ptr.2650070307","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.2650070307","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103682061","display_name":"Andrzej G\u0142adysz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej G\u0142adysz","raw_affiliation_strings":["Department of Infectious Diseases, Medical Academy, Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Medical Academy, Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000323022","display_name":"Jacek Juszczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jacek Juszczyk","raw_affiliation_strings":["Department of Infectious Diseases, Medical Academy, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Medical Academy, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075204301","display_name":"W Brzosko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Witold J. Brzosko","raw_affiliation_strings":["Center of Natural Medicine, 00\u2013790 Warsaw, Willowa 8/10, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Natural Medicine, 00\u2013790 Warsaw, Willowa 8/10, Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075204301"],"corresponding_institution_ids":[],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.19080308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"7","issue":"3","first_page":"244","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/padma-28","display_name":"Padma 28","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chronic-active-hepatitis-b","display_name":"chronic active hepatitis B","score":0.8740000128746033},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immunocorrective-therapy","display_name":"immunocorrective therapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hbsag-seroconversion","display_name":"HBsAg seroconversion","score":0.7250000238418579},{"id":"https://openalex.org/keywords/hbeag-seroconversion","display_name":"HBeAg seroconversion","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hbv-dna","display_name":"HBV DNA","score":0.5870000123977661},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.7710000276565552},{"id":"https://openalex.org/keywords/t-cell-count","display_name":"T-cell count","score":0.8050000071525574},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.9409999847412109},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2775940106","wikidata":"https://www.wikidata.org/wiki/Q10478733","display_name":"HBeAg","level":5,"score":0.814272403717041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7868156433105469},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.7183579206466675},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.7021143436431885},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5840485095977783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5667750239372253},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5051713585853577},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.48689189553260803},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4614066183567047},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4239368140697479},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2837403118610382},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.23193076252937317}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ptr.2650070307","doi":"https://doi.org/10.1002/ptr.2650070307","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.2650070307","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1492617591","https://openalex.org/W1880062466","https://openalex.org/W1950099322","https://openalex.org/W1975978239","https://openalex.org/W1985319773","https://openalex.org/W1992454992","https://openalex.org/W2052128395","https://openalex.org/W2058659182","https://openalex.org/W2092219032","https://openalex.org/W2139764438","https://openalex.org/W2144026533","https://openalex.org/W2415229180","https://openalex.org/W2419159901"],"related_works":["https://openalex.org/W4246499910","https://openalex.org/W2080528055","https://openalex.org/W2417373983","https://openalex.org/W4247466912","https://openalex.org/W2369937981","https://openalex.org/W2376437295","https://openalex.org/W2253067938","https://openalex.org/W2938110563","https://openalex.org/W2370178263","https://openalex.org/W1992337527"],"abstract_inverted_index":{"Abstract":[0],"Thirty\u2010four":[1],"patients":[2,21,46,73,93,96,110,123,139,167],"with":[3,11,17,124,163,168],"chronic":[4],"active":[5],"hepatitis":[6],"B":[7],"(CAH\u2010B)":[8],"were":[9,22],"treated":[10],"Padma":[12,78,144,164],"28,":[13],"a":[14,130],"herbal":[15],"remedy":[16],"immunocorrective":[18],"properties.":[19],"The":[20],"monitored":[23],"by":[24,32],"clinical":[25],"and":[26,35,62,102,113,115,127,135,191],"biochemical":[27,52],"testing,":[28],"as":[29,31,54,56],"well":[30,55],"serological,":[33],"immunological":[34],"histological":[36],"techniques.":[37],"After":[38],"treatment":[39,162],"lasting":[40],"1":[41],"year":[42],"26":[43,90],"of":[44,77,84,91,97,104,117,133,143,149,166,172,180,187,189,195],"34":[45,92,98],"(76.5%)":[47],"improved":[48],"or":[49],"normalized":[50],"in":[51,57,67,71,89],"parameters":[53],"total":[58],"T\u2010cell":[59],"count":[60],"(CD3)":[61],"CD4/CD8":[63],"index.":[64],"An":[65,75],"improvement":[66],"histology":[68],"was":[69,87,152],"seen":[70,88,153],"19":[72],"(55.9%).":[74],"influence":[76,142],"28":[79,145,165],"on":[80,146],"the":[81,155,173,181,185,193],"serological":[82,147],"markers":[83,148],"HBV":[85,150,190],"infection":[86,151],"(76.5%).":[94],"Six":[95],"eliminated":[99,111],"HBsAg":[100,134],"(17.6%)":[101],"four":[103],"them":[105,118],"seroconverted":[106,119],"to":[107,120],"anti\u2010HBs.":[108],"Eleven":[109],"HBeAg":[112],"HBV\u2010DNA,":[114],"eight":[116,138],"anti\u2010HBe.":[121],"Eight":[122],"persistent":[125],"HBs":[126],"HBe\u2010antigenaemia":[128],"had":[129],"decreased":[131],"titre":[132],"HBeAg.":[136],"In":[137],"(23.5%)":[140],"no":[141],"throughout":[154],"observation":[156],"period.":[157],"These":[158],"observations":[159],"indicate":[160],"that":[161],"CAH\u2010B":[169],"fulfils":[170],"two":[171],"most":[174],"important":[175],"tasks":[176],"for":[177],"drug":[178],"therapy":[179],"disease,":[182],"it":[183],"influences":[184],"activity":[186],"genes":[188],"stops":[192],"progression":[194],"liver":[196],"inflammation.":[197]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}