{"id":"https://openalex.org/W2123294643","doi":"https://doi.org/10.2460/ajvr.75.2.117","title":"Evaluation of thermal antinociceptive effects after oral administration of tramadol hydrochloride to American kestrels (Falco sparverius)","display_name":"Evaluation of thermal antinociceptive effects after oral administration of tramadol hydrochloride to American kestrels (Falco sparverius)","publication_year":2014,"publication_date":"2014-01-28","ids":{"openalex":"https://openalex.org/W2123294643","doi":"https://doi.org/10.2460/ajvr.75.2.117","mag":"2123294643","pmid":"https://pubmed.ncbi.nlm.nih.gov/24471747"},"language":"en","primary_location":{"id":"doi:10.2460/ajvr.75.2.117","doi":"https://doi.org/10.2460/ajvr.75.2.117","is_oa":false,"landing_page_url":"https://doi.org/10.2460/ajvr.75.2.117","pdf_url":null,"source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057717436","display_name":"David S\u00e1nchez-Migall\u00f3n Guzman","orcid":"https://orcid.org/0000-0001-5858-5142","observed_orcids":["https://orcid.org/0000-0001-5858-5142"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Sanchez-Migallon Guzman","raw_affiliation_strings":["Veterinary Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061804424","display_name":"Tracy L. Drazenovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy L. Drazenovich","raw_affiliation_strings":["University of California at Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Davis","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089906339","display_name":"Glenn H. Olsen","orcid":"https://orcid.org/0000-0002-7188-6203","observed_orcids":["https://orcid.org/0000-0002-7188-6203"]},"institutions":[{"id":"https://openalex.org/I1286329397","display_name":"United States Geological Survey","ror":"https://ror.org/035a68863","country_code":"US","type":"government","lineage":["https://openalex.org/I1286329397","https://openalex.org/I1335927249"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn H. Olsen","raw_affiliation_strings":["United States Geological Survey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Geological Survey","institution_ids":["https://openalex.org/I1286329397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065995748","display_name":"Neil H. Willits","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil H. Willits","raw_affiliation_strings":["University of California at Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Davis","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037343432","display_name":"Joanne Paul\u2010Murphy","orcid":"https://orcid.org/0000-0002-4828-0991","observed_orcids":["https://orcid.org/0000-0002-4828-0991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanne R. Paul-Murphy","raw_affiliation_strings":["Medicine and Epidemiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Epidemiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.3572,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.97786981,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"75","issue":"2","first_page":"117","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10838","display_name":"Animal Behavior and Welfare Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tramadol-hydrochloride","display_name":"tramadol hydrochloride","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.847000002861023},{"id":"https://openalex.org/keywords/thermal-nociception","display_name":"thermal nociception","score":0.9309999942779541},{"id":"https://openalex.org/keywords/american-kestrel","display_name":"Falco sparverius","score":0.9490000009536743},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5600000023841858},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5260000228881836},{"id":"https://openalex.org/keywords/duration-of-action","display_name":"duration of action","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.8756904602050781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7794725298881531},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.7692829370498657},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6911625862121582},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6166452765464783},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.6001874208450317},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5964517593383789},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.5174344182014465},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4384869635105133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31630516052246094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1279958188533783},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046093","descriptor_name":"Falconiformes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2460/ajvr.75.2.117","doi":"https://doi.org/10.2460/ajvr.75.2.117","is_oa":false,"landing_page_url":"https://doi.org/10.2460/ajvr.75.2.117","pdf_url":null,"source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},{"id":"pmid:24471747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24471747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of veterinary research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W86750102","https://openalex.org/W190189085","https://openalex.org/W1503834335","https://openalex.org/W1597294279","https://openalex.org/W1615330761","https://openalex.org/W1933363599","https://openalex.org/W1951082951","https://openalex.org/W1964980514","https://openalex.org/W1965248892","https://openalex.org/W1969384722","https://openalex.org/W1969700502","https://openalex.org/W1973489138","https://openalex.org/W1979165070","https://openalex.org/W1981811701","https://openalex.org/W1984047657","https://openalex.org/W1984668826","https://openalex.org/W1989827366","https://openalex.org/W1999572454","https://openalex.org/W2006780200","https://openalex.org/W2011561000","https://openalex.org/W2011645297","https://openalex.org/W2015304870","https://openalex.org/W2024260173","https://openalex.org/W2026595123","https://openalex.org/W2026930606","https://openalex.org/W2029508377","https://openalex.org/W2031416719","https://openalex.org/W2031737952","https://openalex.org/W2032433889","https://openalex.org/W2032966687","https://openalex.org/W2037075166","https://openalex.org/W2038950635","https://openalex.org/W2040234989","https://openalex.org/W2040764855","https://openalex.org/W2045730050","https://openalex.org/W2058962735","https://openalex.org/W2060865384","https://openalex.org/W2063286778","https://openalex.org/W2066348684","https://openalex.org/W2074350939","https://openalex.org/W2089713777","https://openalex.org/W2090839691","https://openalex.org/W2119679642","https://openalex.org/W2126785129","https://openalex.org/W2132187590","https://openalex.org/W2140627532","https://openalex.org/W2140956490","https://openalex.org/W2150877927","https://openalex.org/W2157639922","https://openalex.org/W2163076934","https://openalex.org/W2163086347","https://openalex.org/W2167917925","https://openalex.org/W2171285944","https://openalex.org/W2183479091","https://openalex.org/W2199966823","https://openalex.org/W2207775649","https://openalex.org/W2395245197","https://openalex.org/W6636586598"],"related_works":["https://openalex.org/W2126785129","https://openalex.org/W2011561000","https://openalex.org/W184803490","https://openalex.org/W2150877927","https://openalex.org/W4411791997","https://openalex.org/W2119223589","https://openalex.org/W2132187590","https://openalex.org/W2163076934","https://openalex.org/W2395437161","https://openalex.org/W2153117055"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2,236],"the":[3,98,237],"thermal":[4,56,84,99,137,188],"antinociceptive":[5,214],"and":[6,9,34,37,64,69,115,132,149,170,201,228,239,246],"sedative":[7],"effects":[8,241],"duration":[10],"of":[11,13,91,130,181,184,221,226,242],"action":[12],"tramadol":[14,92,169,243],"hydrochloride":[15],"after":[16,72,108,121,142,154],"oral":[17,179],"administration":[18,180],"to":[19,54,79,105,118,151,234],"American":[20,28],"kestrels":[21,192,245],"(Falco":[22],"sparverius).":[23],"ANIMALS:":[24],"12":[25],"healthy":[26],"3-year-old":[27],"kestrels.":[29],"PROCEDURES:":[30],"Tramadol":[31,127],"(5,":[32],"15,":[33],"30":[35,133],"mg/kg)":[36,95],"a":[38,45,55,198],"control":[39,112,146,171,199],"suspension":[40],"were":[41,76,166],"administered":[42],"orally":[43],"in":[44,163,211,244],"masked":[46],"randomized":[47],"crossover":[48],"experimental":[49],"design.":[50],"Foot":[51],"withdrawal":[52,101],"response":[53],"stimulus":[57,85],"was":[58],"determined":[59,77],"1":[60],"hour":[61],"before":[62,82],"(baseline)":[63],"0.5,":[65],"1.5,":[66],"3,":[67],"6,":[68],"9":[70,119,202],"hours":[71,107,120,141,153],"treatment.":[73],"Agitation-sedation":[74],"scores":[75,165],"3":[78,152],"5":[80,182],"minutes":[81],"each":[83],"test.":[86],"RESULTS:":[87],"The":[88],"lowest":[89],"dose":[90],"evaluated":[93],"(5":[94],"significantly":[96,135,186],"increased":[97,136,187],"foot":[100],"thresholds":[102,138,190],"for":[103,116,191,193],"up":[104,117,150],"1.5":[106,194],"administration,":[109,122,143,155,227],"compared":[110,123,144,156,196,204],"with":[111,124,145,157,197,205,218],"treatment":[113,147],"values,":[114,148],"baseline":[125,158,206],"values.":[126,159],"at":[128,139],"doses":[129,209],"15":[131],"mg/kg":[134],"0.5":[140],"No":[160],"significant":[161],"differences":[162],"agitation-sedation":[164],"detected":[167],"between":[168],"treatments.":[172],"CONCLUSIONS":[173],"AND":[174],"CLINICAL":[175],"RELEVANCE:":[176],"Results":[177],"indicated":[178],"mg":[183],"tramadol/kg":[185],"nociception":[189],"hours,":[195,203],"treatment,":[200],"values;":[207],"higher":[208],"resulted":[210],"less":[212],"pronounced":[213],"effects.":[215],"Additional":[216],"studies":[217],"other":[219,247],"types":[220],"stimulation,":[222],"formulations,":[223],"dosages,":[224],"routes":[225],"testing":[229],"times":[230],"would":[231],"be":[232],"needed":[233],"fully":[235],"analgesic":[238],"adverse":[240],"avian":[248],"species.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}