{"id":"https://openalex.org/W2123268109","doi":"https://doi.org/10.2174/157488809788167373","title":"Targeting Stem Cells-Clinical Implications for Cancer Therapy","display_name":"Targeting Stem Cells-Clinical Implications for Cancer Therapy","publication_year":2009,"publication_date":"2009-04-30","ids":{"openalex":"https://openalex.org/W2123268109","doi":"https://doi.org/10.2174/157488809788167373","mag":"2123268109","pmid":"https://pubmed.ncbi.nlm.nih.gov/19442199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3034385"},"language":"en","primary_location":{"id":"doi:10.2174/157488809788167373","doi":"https://doi.org/10.2174/157488809788167373","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157488809788167373","pdf_url":null,"source":{"id":"https://openalex.org/S4210223497","display_name":"Current Stem Cell Research & Therapy","issn_l":"1574-888X","issn":["1574-888X","2212-3946"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3034385","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058028050","display_name":"Lan N. Tu","orcid":"https://orcid.org/0000-0002-6362-8554","observed_orcids":["https://orcid.org/0000-0002-6362-8554"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Tu","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA 98103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA 98103, USA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041970501","display_name":"Greg Foltz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Foltz","raw_affiliation_strings":["Institute for Systems Biology, 1441 N 34 Street, Seattle, WA 98103, USA","Swedish Neuroscience Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, 1441 N 34 Street, Seattle, WA 98103, USA","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Swedish Neuroscience Institute, Seattle, WA","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112771093","display_name":"Edward H. Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Lin","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, 98109, USA","Fred Hutchinson Cancer Research Center, 825 Eastlake Ave East, Seattle, WA 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, 98109, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, 825 Eastlake Ave East, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085306431","display_name":"Leroy Hood","orcid":"https://orcid.org/0000-0001-7158-3678","observed_orcids":["https://orcid.org/0000-0001-7158-3678"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leroy Hood","raw_affiliation_strings":["Institute for Systems Biology, 1441 N 34 Street, Seattle, WA 98103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, 1441 N 34 Street, Seattle, WA 98103, USA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101438829","display_name":"Qiang Tian","orcid":"https://orcid.org/0000-0002-1924-6217","observed_orcids":["https://orcid.org/0000-0002-1924-6217"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Tian","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, 98109, USA","Institute for Systems Biology, 1441 N 34 Street, Seattle, WA 98103, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, 98109, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Systems Biology, 1441 N 34 Street, Seattle, WA 98103, USA","institution_ids":["https://openalex.org/I3148997608"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8255,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.93872054,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"2","first_page":"147","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-surface-markers","display_name":"cell surface markers","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":1.0},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pi3-kinase-pathway","display_name":"PI3 kinase pathway","score":0.8309999704360962},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.675000011920929},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.6629999876022339},{"id":"https://openalex.org/keywords/intestinal-stem-cells","display_name":"intestinal stem cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/radiotherapy-resistance","display_name":"radiotherapy resistance","score":0.828000009059906},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7950000166893005},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6179999709129333},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7571766376495361},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.741223156452179},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7030539512634277},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.678377091884613},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6472128629684448},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6002810001373291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4843117296695709},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44786351919174194},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.43228524923324585},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4246067702770233},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37981972098350525},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2788313627243042},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16092568635940552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/157488809788167373","doi":"https://doi.org/10.2174/157488809788167373","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157488809788167373","pdf_url":null,"source":{"id":"https://openalex.org/S4210223497","display_name":"Current Stem Cell Research & Therapy","issn_l":"1574-888X","issn":["1574-888X","2212-3946"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"pmid:19442199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19442199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3034385","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3034385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Stem Cell Res Ther","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.688.3903","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.688.3903","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://personaloncology.org/pdf/Scientific/Targeting_stem_cells-clinical_implications_for_cancer_therapy.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3034385","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3034385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Stem Cell Res Ther","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3049806640","display_name":null,"funder_award_id":"U54-CA119347","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4676348261","display_name":"National Center for Integrative Biomedical Informatics(RMI)","funder_award_id":"U54DA021519","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G50212507","display_name":"NanoSystems Biology Cancer Center","funder_award_id":"5u54ca119347-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8969253236","display_name":"Quantitative Systems Biology","funder_award_id":"P50GM076547","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1553919822","https://openalex.org/W1564808156","https://openalex.org/W1584701201","https://openalex.org/W1596376889","https://openalex.org/W1603313604","https://openalex.org/W1947016183","https://openalex.org/W1964923097","https://openalex.org/W1965124339","https://openalex.org/W1969589143","https://openalex.org/W1970200774","https://openalex.org/W1971611000","https://openalex.org/W1974936391","https://openalex.org/W1976359234","https://openalex.org/W1977015486","https://openalex.org/W1982649435","https://openalex.org/W1983075270","https://openalex.org/W1989387813","https://openalex.org/W2000035739","https://openalex.org/W2001992345","https://openalex.org/W2002764864","https://openalex.org/W2009886857","https://openalex.org/W2010069797","https://openalex.org/W2011842366","https://openalex.org/W2013734740","https://openalex.org/W2018671779","https://openalex.org/W2030074887","https://openalex.org/W2036041106","https://openalex.org/W2048160969","https://openalex.org/W2048252195","https://openalex.org/W2048385227","https://openalex.org/W2052116910","https://openalex.org/W2053662322","https://openalex.org/W2057880610","https://openalex.org/W2058155210","https://openalex.org/W2059281433","https://openalex.org/W2060449515","https://openalex.org/W2060551076","https://openalex.org/W2066757270","https://openalex.org/W2073759231","https://openalex.org/W2076534093","https://openalex.org/W2080643515","https://openalex.org/W2080838269","https://openalex.org/W2081479450","https://openalex.org/W2088575158","https://openalex.org/W2092642151","https://openalex.org/W2096214657","https://openalex.org/W2098278242","https://openalex.org/W2102085111","https://openalex.org/W2102752109","https://openalex.org/W2105223153","https://openalex.org/W2105241495","https://openalex.org/W2110046876","https://openalex.org/W2110301828","https://openalex.org/W2116542269","https://openalex.org/W2117767331","https://openalex.org/W2119999174","https://openalex.org/W2121625674","https://openalex.org/W2121788572","https://openalex.org/W2123922022","https://openalex.org/W2127053639","https://openalex.org/W2127107445","https://openalex.org/W2134987819","https://openalex.org/W2137956382","https://openalex.org/W2140254135","https://openalex.org/W2147745959","https://openalex.org/W2147863207","https://openalex.org/W2149430154","https://openalex.org/W2157769714","https://openalex.org/W2161972823","https://openalex.org/W2163102268","https://openalex.org/W2167650288","https://openalex.org/W2167960944","https://openalex.org/W2170107010","https://openalex.org/W2170140374","https://openalex.org/W2171648963","https://openalex.org/W2224027383","https://openalex.org/W2287398810"],"related_works":["https://openalex.org/W4388292855","https://openalex.org/W4389508910","https://openalex.org/W4285280999","https://openalex.org/W901978","https://openalex.org/W2566522894","https://openalex.org/W2109678171","https://openalex.org/W4393023774","https://openalex.org/W2435661928","https://openalex.org/W343229533","https://openalex.org/W2116504531"],"abstract_inverted_index":{"Cancer":[0],"stem":[1,111,174],"cells":[2,8,20],"(CSC),":[3],"also":[4],"called":[5],"tumor":[6,19,31,93,122,171],"initiating":[7],"(TIC),":[9],"are":[10],"considered":[11],"to":[12,38,60,105],"be":[13],"the":[14,30,73,100,117,121,151,181,186],"origin":[15],"of":[16,24,102,120,139,150,188],"replicating":[17],"malignant":[18],"in":[21,29,127,130],"a":[22,178],"variety":[23],"human":[25],"cancers.":[26],"Their":[27],"presence":[28],"may":[32,50,191],"herald":[33],"malignancy":[34],"potential,":[35],"mediate":[36],"resistance":[37],"conventional":[39,162],"chemotherapy":[40],"or":[41],"radiotherapy,":[42],"and":[43,72,133,159,172,184,198],"confer":[44],"poor":[45],"survival":[46,75],"outcomes.":[47],"Thus,":[48],"CSC":[49,63,89,108,144,155,189],"serve":[51,192],"as":[52,85,88,193],"critical":[53,118],"cellular":[54],"targets":[55],"for":[56,91,99,195],"treatment.":[57],"The":[58,136],"ability":[59],"therapeutically":[61],"target":[62],"hinges":[64],"upon":[65],"identifying":[66],"their":[67],"unique":[68],"cell":[69,175],"surface":[70],"markers":[71,90,104],"underlying":[74],"signaling":[76],"pathways.":[77],"While":[78],"accumulating":[79],"evidence":[80],"suggests":[81],"cell-surface":[82],"antigens":[83],"(such":[84],"CD44,":[86],"CD133)":[87],"several":[92],"tissues,":[94],"emerging":[95],"clinical":[96],"needs":[97],"exist":[98],"identification":[101],"new":[103],"completely":[106],"separate":[107],"from":[109,161,169],"normal":[110],"cells.":[112],"Recent":[113],"studies":[114],"have":[115],"demonstrated":[116],"role":[119],"suppressor":[123],"PTEN/PI3":[124],"kinase":[125],"pathway":[126],"regulating":[128],"TIC":[129],"leukemia,":[131],"brain,":[132],"intestinal":[134,173],"tissues.":[135],"successful":[137],"eradication":[138],"tumors":[140],"by":[141],"therapies":[142],"targeting":[143],"will":[145],"require":[146],"an":[147],"in-depth":[148],"understanding":[149],"molecular":[152],"mechanisms":[153],"governing":[154],"self":[156],"renewal,":[157],"differentiation,":[158],"escape":[160],"therapy.":[163],"Here":[164],"we":[165],"review":[166],"recent":[167],"progress":[168],"brain":[170],"research":[176],"with":[177],"focus":[179],"on":[180],"PTEN-Akt-Wnt":[182],"pathway,":[183],"how":[185],"components":[187],"pathways":[190],"biomarkers":[194],"diagnosis,":[196],"prognosis,":[197],"therapeutics.":[199]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}