{"id":"https://openalex.org/W2123226751","doi":"https://doi.org/10.1152/ajpcell.00417.2008","title":"TGF-\u03b2 suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB","display_name":"TGF-\u03b2 suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB","publication_year":2009,"publication_date":"2009-10-22","ids":{"openalex":"https://openalex.org/W2123226751","doi":"https://doi.org/10.1152/ajpcell.00417.2008","mag":"2123226751","pmid":"https://pubmed.ncbi.nlm.nih.gov/19846754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2806150"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00417.2008","doi":"https://doi.org/10.1152/ajpcell.00417.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00417.2008","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2806150","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048847559","display_name":"George Mitchell Risinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Risinger","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014146234","display_name":"Dawn L. Updike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn L. Updike","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111515356","display_name":"Elizabeth C. Bullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth C. Bullen","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065215101","display_name":"James J. Tomasek","orcid":"https://orcid.org/0000-0001-9370-4792","observed_orcids":["https://orcid.org/0000-0001-9370-4792"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Tomasek","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104145635","display_name":"Eric W. Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric W. Howard","raw_affiliation_strings":["Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","Non-aligned"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Non-aligned","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5104145635"],"corresponding_institution_ids":["https://openalex.org/I49332381"],"apc_list":null,"apc_paid":null,"fwci":1.5975,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.82216069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"298","issue":"1","first_page":"C191","last_page":"C201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.9679999947547913},{"id":"https://openalex.org/keywords/smooth-muscle-cell-dedifferentiation","display_name":"smooth muscle cell dedifferentiation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/contractile-phenotype","display_name":"contractile phenotype","score":0.8640000224113464},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tgf-beta-isoforms","display_name":"TGF-beta isoforms","score":0.8159999847412109},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.6740000247955322},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9940000176429749},{"id":"https://openalex.org/keywords/smooth-muscle-alpha-actin","display_name":"smooth muscle actin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.9575120210647583},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.7694423198699951},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7187250852584839},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6633052229881287},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6382541656494141},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.6012588739395142},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5572627782821655},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5378695130348206},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4871620833873749},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4391344487667084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4168210029602051},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3856157064437866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38296592235565186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3744531273841858},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14307469129562378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10850846767425537},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.08500039577484131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07030344009399414},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04564666748046875}],"mesh":[{"descriptor_ui":"D000077214","descriptor_name":"Becaplermin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016762","descriptor_name":"Genes, fos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019716","descriptor_name":"Tissue Inhibitor of Metalloproteinase-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpcell.00417.2008","doi":"https://doi.org/10.1152/ajpcell.00417.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00417.2008","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2806150","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2806150","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Cell Physiol","raw_type":"Text"},{"id":"pmid:19846754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19846754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2806150","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2806150","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Cell Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4512652279","display_name":null,"funder_award_id":"GM-63638","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5584256610","display_name":"Regulation of Angiogenesis During Wound Healing","funder_award_id":"5r01gm063638-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5727168833","display_name":"Fibroblast Differentiation in Wound Healing","funder_award_id":"R01GM060651","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G976053597","display_name":null,"funder_award_id":"GM-60651","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W64666574","https://openalex.org/W1244702794","https://openalex.org/W1503388237","https://openalex.org/W1529117373","https://openalex.org/W1555806697","https://openalex.org/W1905104097","https://openalex.org/W1912592877","https://openalex.org/W1964820861","https://openalex.org/W1967487834","https://openalex.org/W1968084778","https://openalex.org/W1968338931","https://openalex.org/W1968374269","https://openalex.org/W1971652814","https://openalex.org/W1971922636","https://openalex.org/W1975522586","https://openalex.org/W1976377667","https://openalex.org/W1984344088","https://openalex.org/W1988307856","https://openalex.org/W1991779158","https://openalex.org/W1992159395","https://openalex.org/W1994778563","https://openalex.org/W1994965373","https://openalex.org/W1995592152","https://openalex.org/W1995827857","https://openalex.org/W1998417413","https://openalex.org/W1999182913","https://openalex.org/W2002796681","https://openalex.org/W2010645787","https://openalex.org/W2017176305","https://openalex.org/W2018545886","https://openalex.org/W2021218223","https://openalex.org/W2022189167","https://openalex.org/W2023521724","https://openalex.org/W2030620101","https://openalex.org/W2032729680","https://openalex.org/W2034705232","https://openalex.org/W2034911624","https://openalex.org/W2035657192","https://openalex.org/W2039458025","https://openalex.org/W2044522714","https://openalex.org/W2046694960","https://openalex.org/W2047431499","https://openalex.org/W2047470479","https://openalex.org/W2051104359","https://openalex.org/W2059159422","https://openalex.org/W2059937333","https://openalex.org/W2064061791","https://openalex.org/W2065736677","https://openalex.org/W2071835246","https://openalex.org/W2072578620","https://openalex.org/W2072674109","https://openalex.org/W2074644169","https://openalex.org/W2076014090","https://openalex.org/W2076520247","https://openalex.org/W2078962878","https://openalex.org/W2083536576","https://openalex.org/W2085163154","https://openalex.org/W2092671785","https://openalex.org/W2093723806","https://openalex.org/W2094184267","https://openalex.org/W2096334465","https://openalex.org/W2102049381","https://openalex.org/W2105846876","https://openalex.org/W2110121929","https://openalex.org/W2115321880","https://openalex.org/W2115390024","https://openalex.org/W2115515762","https://openalex.org/W2121822802","https://openalex.org/W2124051484","https://openalex.org/W2125302698","https://openalex.org/W2130213654","https://openalex.org/W2141582826","https://openalex.org/W2150615178","https://openalex.org/W2150682250","https://openalex.org/W2156606731","https://openalex.org/W2156945761","https://openalex.org/W2163220652","https://openalex.org/W2166920557","https://openalex.org/W2169199162","https://openalex.org/W2408799644","https://openalex.org/W2412394777","https://openalex.org/W2418086052","https://openalex.org/W4240948184"],"related_works":["https://openalex.org/W2357052066","https://openalex.org/W2047431499","https://openalex.org/W2386887440","https://openalex.org/W2042259396","https://openalex.org/W2417443534","https://openalex.org/W2000132670","https://openalex.org/W2392718938","https://openalex.org/W2102049381","https://openalex.org/W2043677317","https://openalex.org/W2022189167"],"abstract_inverted_index":{"During":[0],"platelet-derived":[1],"growth":[2,92],"factor":[3,93],"(PDGF)-BB-mediated":[4],"recruitment":[5],"to":[6,18,52,84,98,120,126,156],"neovascular":[7],"sprouts,":[8],"vascular":[9],"smooth":[10,31],"muscle":[11,32],"cells":[12],"(VSMCs)":[13],"dedifferentiate":[14],"from":[15],"a":[16,19,66,127,157,181,191],"contractile":[17,27,101,192],"migratory":[20],"phenotype.":[21],"This":[22],"involves":[23,57],"the":[24,36,76,85,100,109,161,167,197],"downregulation":[25],"of":[26,38,48,90,111,169,184,199],"markers":[28],"such":[29,41],"as":[30,42],"(SM)":[33],"alpha-actin":[34],"and":[35,56,60,88,114,152],"upregulation":[37,80,168,198],"promigration":[39],"genes":[40],"matrix":[43],"metalloproteinase":[44],"(MMP)-2.":[45],"The":[46],"regulation":[47],"MMP-2":[49,79,176],"in":[50,65,69,78,103,160,166,188],"response":[51],"PDGF-BB":[53,106,144],"is":[54,96,178],"complex":[55],"both":[58],"stimulatory":[59],"inhibitory":[61],"signaling":[62,136],"pathways,":[63],"resulting":[64,165],"significant":[67],"delay":[68,77],"upregulation.":[70],"Here,":[71],"we":[72],"provide":[73],"evidence":[74],"that":[75,175,195],"may":[81],"be":[82],"due":[83],"autocrine":[86],"expression":[87,177],"activation":[89],"transforming":[91],"(TGF)-beta,":[94],"which":[95,187],"known":[97],"promote":[99],"phenotype":[102,194],"VSMCs.":[104],"Whereas":[105],"could":[107],"induce":[108],"loss":[110],"stress":[112],"fibers":[113],"focal":[115],"adhesions,":[116],"TGF-beta":[117,130,163],"was":[118],"able":[119],"block":[121],"or":[122],"reverse":[123],"this":[124],"transition":[125],"noncontractile":[128],"state.":[129],"did":[131],"not,":[132],"however,":[133],"suppress":[134],"early":[135],"events":[137],"stimulated":[138],"by":[139,180],"PDGF-BB.":[140],"Over":[141],"time,":[142],"though":[143],"induced":[145],"increased":[146],"TGF-beta1":[147],"levels,":[148],"it":[149],"suppressed":[150,179],"TGF-beta2":[151],"TGF-beta3":[153],"expression,":[154],"leading":[155],"net":[158],"decrease":[159],"total":[162],"pool,":[164],"MMP-2.":[170,200],"Together,":[171],"these":[172],"findings":[173],"indicate":[174],"threshold":[182],"level":[183],"active":[185],"TGF-beta,":[186],"turn":[189],"promotes":[190],"VSMC":[193],"prevents":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
