{"id":"https://openalex.org/W2123152147","doi":null,"title":"Zebularine suppresses TGF-beta-induced lens epithelial cell-myofibroblast transdifferentiation by inhibiting MeCP2.","display_name":"Zebularine suppresses TGF-beta-induced lens epithelial cell-myofibroblast transdifferentiation by inhibiting MeCP2.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2123152147","mag":"2123152147","pmid":"https://pubmed.ncbi.nlm.nih.gov/22065925","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3209433"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2212536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3209433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3209433","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085189920","display_name":"Peng Zhou","orcid":"https://orcid.org/0000-0002-1744-5167","observed_orcids":["https://orcid.org/0000-0002-1744-5167"]},"institutions":[{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhou","raw_affiliation_strings":["Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210112065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034171571","display_name":"Yi Lu","orcid":"https://orcid.org/0000-0001-9182-853X","observed_orcids":["https://orcid.org/0000-0001-9182-853X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108244101","display_name":"Xinghuai Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xing-Huai Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4794,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.91679336,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":null,"first_page":"2717","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebularine","display_name":"zebularine","score":1.0},{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/myofibroblast-transdifferentiation","display_name":"myofibroblast transdifferentiation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/posterior-capsule-opacification","display_name":"posterior capsule opacification","score":0.9739999771118164},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cataract-surgery-complications","display_name":"cataract surgery complications","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.94159334897995},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.7691168189048767},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.47453486919403076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4494374692440033},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4387805163860321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.434379518032074},{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.4299493730068207},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.41601261496543884},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3953368365764618},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3371170163154602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3353925347328186},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23043420910835266},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21276524662971497},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.16360929608345032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1197543740272522},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07208824157714844},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002387","descriptor_name":"Cataract Extraction","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003562","descriptor_name":"Cytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003562","descriptor_name":"Cytidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003562","descriptor_name":"Cytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054338","descriptor_name":"Cell Transdifferentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D057852","descriptor_name":"Posterior Capsule of the Lens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D057852","descriptor_name":"Posterior Capsule of the Lens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057852","descriptor_name":"Posterior Capsule of the Lens","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058442","descriptor_name":"Capsule Opacification","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058628","descriptor_name":"Myofibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058628","descriptor_name":"Myofibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058628","descriptor_name":"Myofibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2212536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3209433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22065925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22065925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3209433","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3209433/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.288.6345","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.288.6345","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/34/90/Mol_Vis_2011_Oct_19_17_2717-2723.tar.gz","raw_type":"text"},{"id":"mag:2123152147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22065925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2212536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3209433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1482786452","https://openalex.org/W1583538898","https://openalex.org/W1972204639","https://openalex.org/W1975791071","https://openalex.org/W1985373686","https://openalex.org/W1989167457","https://openalex.org/W2009036920","https://openalex.org/W2013095759","https://openalex.org/W2016635764","https://openalex.org/W2021424812","https://openalex.org/W2026639078","https://openalex.org/W2029332643","https://openalex.org/W2039276157","https://openalex.org/W2045066457","https://openalex.org/W2062375341","https://openalex.org/W2066092045","https://openalex.org/W2070928313","https://openalex.org/W2099678391","https://openalex.org/W2111041465","https://openalex.org/W2111542200","https://openalex.org/W2113377321","https://openalex.org/W2133124834","https://openalex.org/W2141066321","https://openalex.org/W2150361016","https://openalex.org/W2158582055","https://openalex.org/W2409852129"],"related_works":["https://openalex.org/W7095495433","https://openalex.org/W7096581396","https://openalex.org/W1996095832","https://openalex.org/W2323231913","https://openalex.org/W1913053306","https://openalex.org/W2588786207","https://openalex.org/W2035704620","https://openalex.org/W2095998865","https://openalex.org/W3030531239","https://openalex.org/W2540711947"],"abstract_inverted_index":{"PURPOSE:":[0],"Posterior":[1],"capsular":[2],"opacification":[3],"(PCO)":[4],"is":[5,24,39],"a":[6,20,113,159],"common":[7],"long-term":[8],"complication":[9],"of":[10,31,36,44,57,103,115,119],"modern":[11],"cataract":[12],"surgery.":[13],"Remnant":[14],"lens":[15,155,180],"epithelial":[16,156,181],"cells":[17,157],"(LECs)":[18],"undergo":[19],"myofibroblast":[21],"transdifferentiation":[22],"that":[23,80],"thought":[25],"to":[26,40],"be":[27],"the":[28,42,186],"initial":[29],"step":[30],"PCO":[32,71,138,199],"pathogenesis.":[33],"The":[34,54,78,101,117],"purpose":[35],"this":[37],"study":[38],"determine":[41],"effects":[43],"zebularine":[45,104,120,195],"on":[46,105,121],"transforming":[47],"growth":[48],"factor-\u03b2":[49],"(TGF\u03b2)-induced,":[50],"LEC-myofibroblast":[51],"transdifferentiation.":[52],"METHODS:":[53],"expression":[55,86,107,124,153,178,189],"levels":[56],"methyl":[58],"CpG":[59],"binding":[60],"protein":[61],"2":[62],"(MeCP2)":[63],"and":[64,94,133,161,164],"\u03b1-smooth":[65],"muscle":[66],"actin":[67],"(\u03b1-SMA)":[68],"in":[69,83,136,154,158,175,179],"human":[70,137],"membranes":[72],"were":[73],"evaluated":[74],"by":[75,89,127,190],"confocal":[76],"microscopy.":[77],"role":[79,174],"MeCP2":[81,96,106,132,141,152,170,192],"played":[82],"TGF\u03b22-induced":[84,122,166,176,187],"\u03b1-SMA":[85,123,134,148,167,177,188],"was":[87,108,125,142],"analyzed":[88,109],"western":[90,128],"blotting":[91],"both":[92],"before":[93],"after":[95],"knockdown":[97],"with":[98],"MeCP2-specific":[99],"siRNA.":[100],"effect":[102,118],"over":[110],"time":[111],"using":[112],"variety":[114],"dosages.":[116],"determined":[126],"blot":[129],"analysis.":[130],"RESULTS:":[131],"co-localized":[135],"membranes.":[139],"When":[140],"depleted,":[143],"TGF\u03b22":[144],"could":[145,184,196],"not":[146],"induce":[147],"expression.":[149,168,193],"Zebularine":[150,183],"decreased":[151],"time-":[160],"dose-dependent":[162],"pattern":[163],"reversed":[165],"CONCLUSIONS:":[169],"plays":[171],"an":[172],"important":[173],"cells.":[182],"reverse":[185],"inhibiting":[191],"Therefore,":[194],"potentially":[197],"prevent":[198],"formation.":[200]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}