{"id":"https://openalex.org/W2123102785","doi":"https://doi.org/10.1161/01.cir.0000147829.78357.c5","title":"Overexpression of Brain Natriuretic Peptide Facilitates Neutrophil Infiltration and Cardiac Matrix Metalloproteinase-9 Expression After Acute Myocardial Infarction","display_name":"Overexpression of Brain Natriuretic Peptide Facilitates Neutrophil Infiltration and Cardiac Matrix Metalloproteinase-9 Expression After Acute Myocardial Infarction","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2123102785","doi":"https://doi.org/10.1161/01.cir.0000147829.78357.c5","mag":"2123102785","pmid":"https://pubmed.ncbi.nlm.nih.gov/15545516"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000147829.78357.c5","doi":"https://doi.org/10.1161/01.cir.0000147829.78357.c5","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000147829.78357.c5","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085513622","display_name":"Rika Kawakami","orcid":"https://orcid.org/0000-0002-2904-4993","observed_orcids":["https://orcid.org/0000-0002-2904-4993"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rika Kawakami","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066956159","display_name":"Yoshihiko Saito","orcid":"https://orcid.org/0000-0001-5574-3571","observed_orcids":["https://orcid.org/0000-0001-5574-3571"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Saito","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002254054","display_name":"Ichiro Kishimoto","orcid":"https://orcid.org/0000-0002-8322-0230","observed_orcids":["https://orcid.org/0000-0002-8322-0230"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Kishimoto","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102028817","display_name":"Masaki Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Harada","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021147223","display_name":"Koichiro Kuwahara","orcid":"https://orcid.org/0000-0003-2670-7170","observed_orcids":["https://orcid.org/0000-0003-2670-7170"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichiro Kuwahara","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110244414","display_name":"Nobuki Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuki Takahashi","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019825512","display_name":"Yasuaki Nakagawa","orcid":"https://orcid.org/0000-0002-5664-963X","observed_orcids":["https://orcid.org/0000-0002-5664-963X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuaki Nakagawa","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061934624","display_name":"Michio Nakanishi","orcid":"https://orcid.org/0000-0001-5720-0722","observed_orcids":["https://orcid.org/0000-0001-5720-0722"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Nakanishi","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075163529","display_name":"Keiji Tanimoto","orcid":"https://orcid.org/0000-0003-1971-6546","observed_orcids":["https://orcid.org/0000-0003-1971-6546"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiji Tanimoto","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035544496","display_name":"Satoru Usami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Usami","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112639050","display_name":"Shinji Yasuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Yasuno","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017612062","display_name":"Hideyuki Kinoshita","orcid":"https://orcid.org/0000-0002-0515-088X","observed_orcids":["https://orcid.org/0000-0002-0515-088X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Kinoshita","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083459785","display_name":"Hideki Chusho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Chusho","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014616303","display_name":"Naohisa Tamura","orcid":"https://orcid.org/0000-0003-4000-6215","observed_orcids":["https://orcid.org/0000-0003-4000-6215"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohisa Tamura","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074060371","display_name":"Yoshihiro Ogawa","orcid":"https://orcid.org/0000-0002-0834-2836","observed_orcids":["https://orcid.org/0000-0002-0834-2836"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Ogawa","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105832217","display_name":"Kazuwa Nakao","orcid":"https://orcid.org/0000-0003-3483-4196","observed_orcids":["https://orcid.org/0000-0003-3483-4196"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuwa Nakao","raw_affiliation_strings":["From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. Dr Saito is now at the First Department of Internal Medicine, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I64926303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9723,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.95633122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"110","issue":"21","first_page":"3306","last_page":"3312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.7009999752044678},{"id":"https://openalex.org/keywords/infarct-healing","display_name":"infarct healing","score":0.8500000238418579},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/nesiritide","display_name":"nesiritide","score":0.8619999885559082},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8966661691665649},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7657589912414551},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.6992231607437134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.648513913154602},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.554487407207489},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5372355580329895},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.49988436698913574},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.47133946418762207},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.46166637539863586},{"id":"https://openalex.org/C2775965246","wikidata":"https://www.wikidata.org/wiki/Q4531845","display_name":"Tissue inhibitor of metalloproteinase","level":3,"score":0.4325272738933563},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4250726103782654},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.42079344391822815},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.cir.0000147829.78357.c5","doi":"https://doi.org/10.1161/01.cir.0000147829.78357.c5","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000147829.78357.c5","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:15545516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15545516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1024.9150","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1024.9150","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/110/21/3306.full.pdf","raw_type":"text"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/144486","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2433/144486","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W57890890","https://openalex.org/W1557058411","https://openalex.org/W1559091327","https://openalex.org/W1977152294","https://openalex.org/W1979659033","https://openalex.org/W1980357510","https://openalex.org/W1987197699","https://openalex.org/W1994590258","https://openalex.org/W1995588722","https://openalex.org/W2005804926","https://openalex.org/W2008490829","https://openalex.org/W2011780678","https://openalex.org/W2021002154","https://openalex.org/W2028147914","https://openalex.org/W2053561973","https://openalex.org/W2059717704","https://openalex.org/W2062630420","https://openalex.org/W2107933519","https://openalex.org/W2119455028","https://openalex.org/W2121815042","https://openalex.org/W2122450538","https://openalex.org/W2131036882","https://openalex.org/W2132106701","https://openalex.org/W2136348600","https://openalex.org/W2136418621","https://openalex.org/W2143425349","https://openalex.org/W2148117025","https://openalex.org/W2164006129","https://openalex.org/W2176503073","https://openalex.org/W2268016673","https://openalex.org/W2325727928","https://openalex.org/W2328167306","https://openalex.org/W3139636154"],"related_works":["https://openalex.org/W7100267399","https://openalex.org/W2350152905","https://openalex.org/W1976110338","https://openalex.org/W2382427210","https://openalex.org/W2037154455","https://openalex.org/W2978904165","https://openalex.org/W2262908072","https://openalex.org/W2150487735","https://openalex.org/W1973281599","https://openalex.org/W2355815028"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"clinical":[2],"trials":[3],"have":[4],"shown":[5],"that":[6,27,158,189,213],"systemic":[7],"infusion":[8],"of":[9,85,92,99,117,142,164,178,196,206,222],"nesiritide,":[10],"a":[11,30,38,216],"recombinant":[12],"human":[13],"brain":[14],"natriuretic":[15],"peptide":[16],"(BNP),":[17],"improves":[18],"hemodynamic":[19],"parameters":[20],"in":[21,96,126,150,182,219],"acutely":[22],"decompensated":[23],"hearts.":[24],"This":[25,211],"suggests":[26,212],"BNP":[28,62,68,192,214],"exerts":[29],"direct":[31],"cardioprotective":[32],"effect":[33,174],"and":[34,66,74,87,90,103,139,202,226],"might":[35],"thus":[36],"be":[37],"useful":[39],"therapeutic":[40],"agent":[41],"with":[42,59],"which":[43],"to":[44,63,70],"treat":[45],"acute":[46,113,233],"myocardial":[47],"infarction":[48],"(MI).":[49],"In":[50,133],"the":[51,83,88,97,109,120,136,161,165,179,197,204,207,220,229],"present":[52],"study,":[53],"we":[54],"used":[55],"BNP-transgenic":[56],"(BNP-Tg)":[57],"mice":[58,102,128],"elevated":[60,190],"plasma":[61,191],"determine":[64],"whether":[65],"how":[67],"contributes":[69],"left":[71],"ventricular":[72],"remodeling":[73,225],"healing":[75],"after":[76,112,131,200,232],"MI.":[77,114,132,234],"METHODS":[78],"AND":[79],"RESULTS:":[80],"We":[81],"examined":[82],"accumulation":[84],"neutrophils":[86,118,159],"expression":[89,138],"activation":[91],"matrix":[93,224],"metalloproteinase":[94],"(MMP)-9":[95],"ventricles":[98],"male":[100],"BNP-Tg":[101,127,151,183],"their":[104],"nontransgenic":[105],"(non-Tg)":[106],"littermates":[107],"during":[108,228],"early":[110,230],"phase":[111,231],"The":[115],"numbers":[116],"infiltrating":[119],"infarcted":[121,180,198],"area":[122,181,199],"were":[123,147],"significantly":[124,148],"increased":[125],"3":[129],"days":[130],"addition,":[134],"both":[135],"gene":[137],"zymographic":[140],"activity":[141,205],"MMP-9,":[143,166],"but":[144],"not":[145],"MMP-2,":[146],"higher":[149],"than":[152],"non-Tg":[153],"mice.":[154,184],"Double":[155],"immunostaining":[156],"revealed":[157],"are":[160],"main":[162],"source":[163],"although":[167],"doxycycline,":[168],"an":[169],"MMP":[170],"inhibitor,":[171],"had":[172],"no":[173],"on":[175],"neutrophil":[176,194],"infiltration":[177,195],"CONCLUSIONS:":[185],"These":[186],"results":[187],"demonstrate":[188],"facilitates":[193],"MI":[201],"increases":[203],"MMP-9":[208],"they":[209],"produce.":[210],"plays":[215],"key":[217],"role":[218],"processes":[221],"extracellular":[223],"wound-healing":[227]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}