{"id":"https://openalex.org/W2123088795","doi":"https://doi.org/10.1158/1538-7445.chtme14-a68","title":"Abstract A68: GPCRs as potential therapeutic targets in pancreatic cancer-associated fibroblasts","display_name":"Abstract A68: GPCRs as potential therapeutic targets in pancreatic cancer-associated fibroblasts","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2123088795","doi":"https://doi.org/10.1158/1538-7445.chtme14-a68","mag":"2123088795"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.chtme14-a68","doi":"https://doi.org/10.1158/1538-7445.chtme14-a68","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.chtme14-a68","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103625121","display_name":"Shu Min Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Zhou","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108567563","display_name":"Randall P. French","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall French","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089839809","display_name":"Andrew M. Lowy","orcid":"https://orcid.org/0000-0002-7106-0735","observed_orcids":["https://orcid.org/0000-0002-7106-0735"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Lowy","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055677266","display_name":"Paul A. Insel","orcid":"https://orcid.org/0000-0001-8521-5315","observed_orcids":["https://orcid.org/0000-0001-8521-5315"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Insel","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"1_Supplement","first_page":"A68","last_page":"A68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8040000200271606},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.4359999895095825},{"id":"https://openalex.org/keywords/stellate-cells","display_name":"stellate cells","score":0.5450000166893005},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8270548582077026},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.764374852180481},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7497836351394653},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.6662915349006653},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5936676859855652},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5045064687728882},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49654918909072876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4962065815925598},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.44767865538597107},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42534974217414856},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3703761696815491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34982746839523315},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.1962379813194275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1687287986278534},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1303832232952118},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08449572324752808}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.chtme14-a68","doi":"https://doi.org/10.1158/1538-7445.chtme14-a68","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.chtme14-a68","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2915346251","https://openalex.org/W1605608183","https://openalex.org/W2303137618","https://openalex.org/W2971660417","https://openalex.org/W3176350919","https://openalex.org/W2767115634","https://openalex.org/W4389022781","https://openalex.org/W4389026868","https://openalex.org/W1573445593","https://openalex.org/W2741431014"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"is":[5],"characterized":[6],"by":[7,63,95,182,200],"a":[8,33,49],"dense":[9],"fibrotic":[10],"stromal":[11],"matrix,":[12],"composed":[13],"of":[14,36,113,141,145,150,179,192],"activated":[15],"fibroblasts/stellate":[16],"cells,":[17],"inflammatory":[18],"cells":[19],"and":[20,39,90,134,175,196,206],"other":[21],"cell":[22],"types.":[23],"This":[24],"unique":[25],"tumor":[26,45],"microenvironment":[27],"has":[28],"been":[29],"increasingly":[30],"recognized":[31],"as":[32,226],"key":[34],"mediator":[35],"PDAC":[37],"progression":[38],"drug":[40],"resistance.":[41],"Thus,":[42],"targeting":[43],"the":[44,92,110,127,142,151,160,163,177,186,244],"stroma":[46],"may":[47,68,202],"be":[48,69,207],"novel":[50,208],"therapeutic":[51,71,209,228],"approach":[52,87],"for":[53,73,211],"PDAC.":[54,74,212],"We":[55,98,166],"hypothesized":[56],"that":[57,137,191],"G":[58,146],"protein-coupled":[59],"receptors":[60],"(GPCRs)":[61],"expressed":[62,94,181,199],"pancreatic":[64,96,132,183,194,231],"cancer-associated":[65,232],"fibroblasts":[66,133,195],"(CAFs)":[67],"potential":[70,227],"targets":[72,210,229],"To":[75],"begin":[76],"to":[77,88,130,139],"test":[78],"this":[79],"hypothesis,":[80],"we":[81],"used":[82],"an":[83],"unbiased":[84],"GPCRomic":[85,170],"array":[86,171],"identify":[89,174],"quantify":[91,176],"GPCRs":[93,136,155,180,198,225],"CAFs.":[97],"found":[99],"125":[100],"GPCRs,":[101,118],"whose":[102],"expression":[103,125],"was":[104],"shared":[105],"in":[106,126,230,243],"CAFs":[107,128,201],"obtained":[108],"from":[109,162,190],"primary":[111],"tumors":[112],"five":[114],"patients.":[115],"Among":[116],"those":[117],"35":[119],"had":[120],"at":[121],"least":[122],"two-fold":[123],"higher":[124],"compared":[129],"normal":[131,193],"included":[135],"link":[138],"each":[140],"major":[143],"classes":[144],"proteins.":[147],"RT-PCR":[148],"analysis":[149,172],"10":[152],"most":[153],"up-regulated":[154],"correlated":[156],"well":[157],"(r2=0.88)":[158],"with":[159],"data":[161],"GPCR":[164],"array.":[165],"conclude":[167],"that:":[168],"1)":[169],"can":[173],"profile":[178,188],"CAFs;":[184],"2)":[185],"CAF-expressed":[187],"differs":[189],"3)":[197],"have":[203],"functional":[204],"roles":[205],"Citation":[213],"Format:":[214],"Shu":[215],"Zhou,":[216],"Randall":[217],"French,":[218],"Andrew":[219],"M.":[220],"Lowy,":[221],"Paul":[222],"A.":[223],"Insel.":[224],"fibroblasts.":[233],"[abstract].":[234],"In:":[235],"Abstracts:":[236],"AACR":[237],"Special":[238],"Conference":[239],"on":[240],"Cellular":[241],"Heterogeneity":[242],"Tumor":[245],"Microenvironment;":[246],"2014":[247],"Feb":[248],"26-Mar":[249],"1;":[250],"San":[251],"Diego,":[252],"CA.":[253],"Philadelphia":[254],"(PA):":[255],"AACR;":[256],"Cancer":[257],"Res":[258],"2015;75(1":[259],"Suppl):Abstract":[260],"nr":[261],"A68.":[262],"doi:10.1158/1538-7445.CHTME14-A68":[263]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
