{"id":"https://openalex.org/W2123074232","doi":null,"title":"Inositol safety: clinical evidences.","display_name":"Inositol safety: clinical evidences.","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2123074232","mag":"2123074232","pmid":"https://pubmed.ncbi.nlm.nih.gov/21845803"},"language":"en","primary_location":{"id":"pmid:21845803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21845803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059290297","display_name":"G Carlomagno","orcid":"https://orcid.org/0000-0001-6950-1530","observed_orcids":["https://orcid.org/0000-0001-6950-1530"]},"institutions":[{"id":"https://openalex.org/I4210147004","display_name":"Agunco","ror":"https://ror.org/052w8rh87","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210147004"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Carlomagno","raw_affiliation_strings":["AGUNCO Obstetrics & Gynecology Center, Rome, Italy. Gianfranco.carlomagno@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGUNCO Obstetrics & Gynecology Center, Rome, Italy. Gianfranco.carlomagno@gmail.com","institution_ids":["https://openalex.org/I4210147004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061261875","display_name":"Vittorio Unfer","orcid":"https://orcid.org/0000-0002-1805-3181","observed_orcids":["https://orcid.org/0000-0002-1805-3181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Unfer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.005,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.90116986,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"15","issue":"8","first_page":"931","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8230000138282776},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.8420000076293945},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9200000166893005},{"id":"https://openalex.org/keywords/insulin-sensitizers","display_name":"insulin sensitizers","score":0.8450000286102295},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.5540000200271606},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.8489049077033997},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.7218065857887268},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.704857587814331},{"id":"https://openalex.org/C2778523565","wikidata":"https://www.wikidata.org/wiki/Q3008453","display_name":"Cyclitol","level":4,"score":0.6710305213928223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5330867767333984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4105965495109558},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.351936399936676},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33939194679260254},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.260966956615448},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1772496998310089},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08622604608535767}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018849","descriptor_name":"Controlled Clinical Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21845803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21845803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2123074232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21845803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W190002334","https://openalex.org/W1709914984","https://openalex.org/W1974941767","https://openalex.org/W1984828425","https://openalex.org/W1990462691","https://openalex.org/W2001727662","https://openalex.org/W2006350589","https://openalex.org/W2016233524","https://openalex.org/W2043219605","https://openalex.org/W2045232429","https://openalex.org/W2063776412","https://openalex.org/W2065958896","https://openalex.org/W2097100082","https://openalex.org/W2097130421","https://openalex.org/W2099129833","https://openalex.org/W2109728298","https://openalex.org/W2110818559","https://openalex.org/W2118600958","https://openalex.org/W2125639857","https://openalex.org/W2126784703","https://openalex.org/W2127991037","https://openalex.org/W2144939832","https://openalex.org/W2154026691","https://openalex.org/W2159969434","https://openalex.org/W2165385898","https://openalex.org/W2165846997","https://openalex.org/W2171177397","https://openalex.org/W2185437024","https://openalex.org/W2414963813","https://openalex.org/W2417717865"],"related_works":["https://openalex.org/W2246316638","https://openalex.org/W1972948495","https://openalex.org/W2411189367","https://openalex.org/W82029137","https://openalex.org/W2103198067","https://openalex.org/W7165800702","https://openalex.org/W2051689101","https://openalex.org/W7052409905","https://openalex.org/W4312462115","https://openalex.org/W4294902162"],"abstract_inverted_index":{"Myo-inositol":[0,15],"is":[1,26,45],"a":[2],"six":[3],"carbon":[4],"cyclitol":[5],"that":[6,83],"contains":[7],"five":[8],"equatorial":[9],"and":[10,24,65,76,101],"one":[11],"axial":[12],"hydroxyl":[13],"groups.":[14],"has":[16],"been":[17],"classified":[18],"as":[19,98],"an":[20],"insulin":[21],"sensitizing":[22],"agent":[23],"it":[25],"commonly":[27],"used":[28],"in":[29,74],"the":[30,33,50,59,70,85,112],"treatment":[31],"of":[32,58,88,105],"Polycystic":[34],"Ovary":[35],"Syndrome":[36],"(PCOS).":[37],"However,":[38],"despite":[39],"its":[40],"wide":[41],"clinical":[42,77],"use,":[43],"there":[44],"still":[46],"scarce":[47],"information":[48],"on":[49,69],"myo-inositol":[51,71,89],"safety":[52,72],"and/or":[53],"side":[54,95,106],"effects.":[55],"The":[56,79,103],"aim":[57],"present":[60],"review":[61],"was":[62,82],"to":[63],"summarize":[64],"discuss":[66],"available":[67],"data":[68],"both":[73],"non-clinical":[75],"settings.":[78],"main":[80],"outcome":[81],"only":[84],"highest":[86],"dose":[87],"(12":[90],"g/day)":[91],"induced":[92],"mild":[93],"gastrointestinal":[94],"effects":[96,107],"such":[97],"nausea,":[99],"flatus":[100],"diarrhea.":[102],"severity":[104],"did":[108],"not":[109],"increase":[110],"with":[111],"dosage.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}