{"id":"https://openalex.org/W2123010887","doi":null,"title":"Induction of undifferentiated brain tumors in rats by a human polyomavirus (JC virus).","display_name":"Induction of undifferentiated brain tumors in rats by a human polyomavirus (JC virus).","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2123010887","mag":"2123010887","pmid":"https://pubmed.ncbi.nlm.nih.gov/2991057"},"language":"en","primary_location":{"id":"pmid:2991057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2991057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029883361","display_name":"Shozo Ohsumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Ohsumi","raw_affiliation_strings":["Department of Pathology, Okayama University Medical School*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Medical School*","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091480625","display_name":"Ikuko Ikehara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I Ikehara","raw_affiliation_strings":["Department of Pathology, Okayama University Medical School*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Medical School*","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113684939","display_name":"Makoto Motoi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Motoi","raw_affiliation_strings":["Department of Pathology, Okayama University Medical School*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Medical School*","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110007284","display_name":"Katsuo Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Ogawa","raw_affiliation_strings":["Department of Pathology, Okayama University Medical School*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Okayama University Medical School*","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840696","display_name":"Kazuo Nagashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Nagashima","raw_affiliation_strings":["*Department of Pathology, Faculty of Medicine, University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Faculty of Medicine, University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100866106","display_name":"Kotaro Yasui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yasui","raw_affiliation_strings":["Department of Microbiology, Tokyo Metropolitan Institute for Neurosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tokyo Metropolitan Institute for Neurosciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2984,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.57810026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"76","issue":"6","first_page":"429","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jc-virus","display_name":"JC virus","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neuroectodermal-tumors","display_name":"neuroectodermal tumors","score":0.9049999713897705},{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"progressive multifocal leukoencephalopathy","score":0.925000011920929},{"id":"https://openalex.org/keywords/viral-tumor-induction","display_name":"viral tumor induction","score":0.6050000190734863},{"id":"https://openalex.org/keywords/intracranial-inoculation","display_name":"intracranial inoculation","score":0.875},{"id":"https://openalex.org/keywords/cerebrum","display_name":"cerebrum","score":0.7139999866485596},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5049999952316284},{"id":"https://openalex.org/keywords/neurotropism","display_name":"neurotropism","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.863379716873169},{"id":"https://openalex.org/C533869091","wikidata":"https://www.wikidata.org/wiki/Q75855","display_name":"Cerebrum","level":3,"score":0.8061310648918152},{"id":"https://openalex.org/C2779150272","wikidata":"https://www.wikidata.org/wiki/Q1676563","display_name":"JC virus","level":4,"score":0.7999967336654663},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7715166807174683},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.6324455142021179},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5597314238548279},{"id":"https://openalex.org/C2778583010","wikidata":"https://www.wikidata.org/wiki/Q3237081","display_name":"Leukoencephalopathy","level":3,"score":0.5297722816467285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4540357291698456},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.42980656027793884},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4092629849910736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3791278302669525},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.27739498019218445},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06747636198997498},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007577","descriptor_name":"JC Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2991057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2991057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},{"id":"mag:2123010887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2991057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W66172177","https://openalex.org/W1575101242","https://openalex.org/W1969355897","https://openalex.org/W2025561456","https://openalex.org/W2055390759","https://openalex.org/W2063270572","https://openalex.org/W2076499694","https://openalex.org/W2079281464","https://openalex.org/W2414680044","https://openalex.org/W2414701905"],"related_works":["https://openalex.org/W2084843924","https://openalex.org/W21992390","https://openalex.org/W66172177","https://openalex.org/W2076499694","https://openalex.org/W2162230249","https://openalex.org/W2063270572","https://openalex.org/W2064720995","https://openalex.org/W1575101242","https://openalex.org/W2056882100","https://openalex.org/W2077735507"],"abstract_inverted_index":{"Newborn":[0],"SD":[1],"rats":[2,33],"were":[3],"inoculated":[4],"intracranially":[5],"with":[6,21],"JC":[7],"virus":[8],"(Tokyo-1),":[9],"a":[10,19],"human":[11],"polyomavirus,":[12],"isolated":[13],"from":[14],"the":[15,37,42,49],"autopsied":[16],"brain":[17],"of":[18,31,48],"patient":[20],"progressive":[22],"multifocal":[23],"leukoencephalopathy.":[24],"Twenty-one":[25],"to":[26],"61":[27],"weeks":[28],"later,":[29],"20":[30],"27":[32],"developed":[34],"tumors":[35,50],"in":[36,41],"cerebrum,":[38],"but":[39],"not":[40],"cerebellum.":[43],"The":[44],"undifferentiated":[45],"neuroectodermal":[46],"nature":[47],"was":[51],"histologically,":[52],"immunohistochemically":[53],"and":[54],"ultrastructurally":[55],"confirmed.":[56]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}