{"id":"https://openalex.org/W2122909430","doi":"https://doi.org/10.1038/423498a","title":"BSE in sheep bred for resistance to infection","display_name":"BSE in sheep bred for resistance to infection","publication_year":2003,"publication_date":"2003-05-28","ids":{"openalex":"https://openalex.org/W2122909430","doi":"https://doi.org/10.1038/423498a","mag":"2122909430","pmid":"https://pubmed.ncbi.nlm.nih.gov/12774113"},"language":"en","primary_location":{"id":"doi:10.1038/423498a","doi":"https://doi.org/10.1038/423498a","is_oa":false,"landing_page_url":"https://doi.org/10.1038/423498a","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111923866","display_name":"Fiona E. Houston","orcid":"https://orcid.org/0000-0002-4082-2274","observed_orcids":["https://orcid.org/0000-0002-4082-2274"]},"institutions":[{"id":"https://openalex.org/I1287548271","display_name":"The Pirbright Institute","ror":"https://ror.org/04xv01a59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1287548271","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Fiona Houston","raw_affiliation_strings":["Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK. fiona.houston@bbsrc.sc.uk","Institute for Animal Health, Compton, Newbury, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK. fiona.houston@bbsrc.sc.uk","institution_ids":["https://openalex.org/I1287548271"]},{"raw_affiliation_string":"Institute for Animal Health, Compton, Newbury, UK","institution_ids":["https://openalex.org/I1287548271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017463196","display_name":"Wilfred Goldmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilfred Goldmann","raw_affiliation_strings":["IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","IAH Neuropathogenesis Unit, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","institution_ids":[]},{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Edinburgh, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113512236","display_name":"Angela Chong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela Chong","raw_affiliation_strings":["IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","IAH Neuropathogenesis Unit, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","institution_ids":[]},{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Edinburgh, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113454253","display_name":"Martin Jeffrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Jeffrey","raw_affiliation_strings":["Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, EH26 0PZ, Midlothian, UK","Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, EH26 0PZ, Midlothian, UK","institution_ids":["https://openalex.org/I174729306"]},{"raw_affiliation_string":"Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, UK","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109234328","display_name":"Lorenzo Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174729306","display_name":"Animal and Plant Health Agency","ror":"https://ror.org/0378g3743","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I174729306","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lorenzo Gonz\u00e1lez","raw_affiliation_strings":["Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, EH26 0PZ, Midlothian, UK","Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, EH26 0PZ, Midlothian, UK","institution_ids":["https://openalex.org/I174729306"]},{"raw_affiliation_string":"Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Penicuik, UK","institution_ids":["https://openalex.org/I174729306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081734448","display_name":"James D. Foster","orcid":"https://orcid.org/0000-0002-5595-0623","observed_orcids":["https://orcid.org/0000-0002-5595-0623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Foster","raw_affiliation_strings":["IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","IAH Neuropathogenesis Unit, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","institution_ids":[]},{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Edinburgh, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054887673","display_name":"David Parnham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Parnham","raw_affiliation_strings":["IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","IAH Neuropathogenesis Unit, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","institution_ids":[]},{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Edinburgh, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102747981","display_name":"Nora Hunter","orcid":"https://orcid.org/0000-0002-2663-148X","observed_orcids":["https://orcid.org/0000-0002-2663-148X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nora Hunter","raw_affiliation_strings":["IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","IAH Neuropathogenesis Unit, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Ogston Building, Edinburgh, EH9 3JF, UK","institution_ids":[]},{"raw_affiliation_string":"IAH Neuropathogenesis Unit, Edinburgh, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111923866"],"corresponding_institution_ids":["https://openalex.org/I1287548271"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":6.5513,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.97920558,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"423","issue":"6939","first_page":"498","last_page":"498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/scrapie","display_name":"scrapie","score":0.953000009059906},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.9390000104904175},{"id":"https://openalex.org/keywords/disease-resistance","display_name":"disease resistance","score":0.8799999952316284},{"id":"https://openalex.org/keywords/selective-breeding","display_name":"selective breeding","score":0.8629999756813049},{"id":"https://openalex.org/keywords/genotypes","display_name":"genotypes","score":0.5709999799728394},{"id":"https://openalex.org/keywords/intracerebral-injection","display_name":"intracerebral injection","score":0.9070000052452087},{"id":"https://openalex.org/keywords/prion-infection","display_name":"prion infection","score":0.7269999980926514},{"id":"https://openalex.org/keywords/disease-eradication","display_name":"disease eradication","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.8662371635437012},{"id":"https://openalex.org/C134215735","wikidata":"https://www.wikidata.org/wiki/Q120997","display_name":"Flock","level":2,"score":0.858193039894104},{"id":"https://openalex.org/C2781131914","wikidata":"https://www.wikidata.org/wiki/Q154666","display_name":"Bovine spongiform encephalopathy","level":4,"score":0.8331257104873657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6686879992485046},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6520206928253174},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6366150379180908},{"id":"https://openalex.org/C2776797465","wikidata":"https://www.wikidata.org/wiki/Q703961","display_name":"Transmissible spongiform encephalopathy","level":5,"score":0.617043137550354},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5533450245857239},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.4618804156780243},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.4280685484409332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24391457438468933},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.2111477553844452},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1598052680492401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07808169722557068},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0634966790676117},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.046338796615600586}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001947","descriptor_name":"Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034561","descriptor_name":"Sheep, Domestic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/423498a","doi":"https://doi.org/10.1038/423498a","is_oa":false,"landing_page_url":"https://doi.org/10.1038/423498a","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:12774113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12774113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:423:y:2003:i:6939:d:10.1038_423498a","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/423498a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6875},{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1901543726","display_name":null,"funder_award_id":"BBS/E/I/00001152","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1685359092","https://openalex.org/W1964712424","https://openalex.org/W1971887653","https://openalex.org/W1995198702","https://openalex.org/W2029323775","https://openalex.org/W2049724475","https://openalex.org/W2058503712","https://openalex.org/W2096757743","https://openalex.org/W2113473342","https://openalex.org/W2128667083","https://openalex.org/W2142880647","https://openalex.org/W2160322119"],"related_works":["https://openalex.org/W2021326765","https://openalex.org/W4319736233","https://openalex.org/W1973595985","https://openalex.org/W2125135541","https://openalex.org/W1978390328","https://openalex.org/W4297984037","https://openalex.org/W2424556786","https://openalex.org/W2181035973","https://openalex.org/W2416271596","https://openalex.org/W1992997987"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
