{"id":"https://openalex.org/W2122901410","doi":null,"title":"Understanding the Impact of an HIV Intervention Package for Adolescents","display_name":"Understanding the Impact of an HIV Intervention Package for Adolescents","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2122901410","mag":"2122901410"},"language":"en","primary_location":{"id":"pmh:oai:scholar.sun.ac.za:10019.1/85666","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10019.1/85666","pdf_url":"http://hdl.handle.net/10019.1/85666","source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10019.1/85666","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040826232","display_name":"Faikah Bruce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Faikah Bruce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040826232"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10327","display_name":"Adolescent Sexual and Reproductive Health","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adolescent-hiv-prevention","display_name":"adolescent HIV prevention","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hiv-incidence","display_name":"HIV incidence","score":0.7400000095367432},{"id":"https://openalex.org/keywords/combination-prevention","display_name":"combination prevention","score":0.47999998927116394},{"id":"https://openalex.org/keywords/medical-male-circumcision","display_name":"medical male circumcision","score":0.8899999856948853},{"id":"https://openalex.org/keywords/oral-pre-exposure-prophylaxis","display_name":"oral pre-exposure prophylaxis","score":0.890999972820282},{"id":"https://openalex.org/keywords/vaginal-microbicides","display_name":"vaginal microbicides","score":0.8700000047683716},{"id":"https://openalex.org/keywords/stochastic-individual-based-model","display_name":"stochastic individual-based model","score":0.7710000276565552},{"id":"https://openalex.org/keywords/age-and-sex-stratification","display_name":"age and sex stratification","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.9096505641937256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7200538516044617},{"id":"https://openalex.org/C2779496540","wikidata":"https://www.wikidata.org/wiki/Q7239230","display_name":"Pre-exposure prophylaxis","level":5,"score":0.7100598216056824},{"id":"https://openalex.org/C97228660","wikidata":"https://www.wikidata.org/wiki/Q7908502","display_name":"Vaginal microbicide","level":5,"score":0.6856212615966797},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6661861538887024},{"id":"https://openalex.org/C117214928","wikidata":"https://www.wikidata.org/wiki/Q7905570","display_name":"Microbicides for sexually transmitted diseases","level":4,"score":0.6389862298965454},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5773573517799377},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5681991577148438},{"id":"https://openalex.org/C2779755712","wikidata":"https://www.wikidata.org/wiki/Q1927779","display_name":"Vaginal ring","level":5,"score":0.5443233847618103},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.47866401076316833},{"id":"https://openalex.org/C2776939746","wikidata":"https://www.wikidata.org/wiki/Q853451","display_name":"Men who have sex with men","level":4,"score":0.29182350635528564},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.27443093061447144},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.2591800093650818},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2385084629058838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22043061256408691},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.21364110708236694},{"id":"https://openalex.org/C2779076696","wikidata":"https://www.wikidata.org/wiki/Q1280670","display_name":"Family planning","level":4,"score":0.1522224247455597},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.10316789150238037},{"id":"https://openalex.org/C2986740045","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health services","level":3,"score":0.07865080237388611},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07776284217834473},{"id":"https://openalex.org/C2986817661","wikidata":"https://www.wikidata.org/wiki/Q185698","display_name":"Research methodology","level":3,"score":0.0673876404762268},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:scholar.sun.ac.za:10019.1/85666","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10019.1/85666","pdf_url":"http://hdl.handle.net/10019.1/85666","source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/91022","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/91022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/91028","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/91028","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters"},{"id":"mag:2122901410","doi":null,"is_oa":false,"landing_page_url":"https://scholar.sun.ac.za:443/bitstream/10019.1/85666/2/bruce_adolescent_2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholar.sun.ac.za:10019.1/85666","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10019.1/85666","pdf_url":"http://hdl.handle.net/10019.1/85666","source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122901410.pdf","grobid_xml":"https://content.openalex.org/works/W2122901410.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W932380384","https://openalex.org/W1499271638","https://openalex.org/W1967626101","https://openalex.org/W1972828904","https://openalex.org/W1973540642","https://openalex.org/W1975920443","https://openalex.org/W1976028120","https://openalex.org/W1976202980","https://openalex.org/W1976460573","https://openalex.org/W1977900451","https://openalex.org/W1979325857","https://openalex.org/W1979468458","https://openalex.org/W1980136429","https://openalex.org/W1982600050","https://openalex.org/W1982769349","https://openalex.org/W1982855578","https://openalex.org/W1985999222","https://openalex.org/W1986445745","https://openalex.org/W1990628777","https://openalex.org/W1991949170","https://openalex.org/W1995920680","https://openalex.org/W1998933853","https://openalex.org/W2002570479","https://openalex.org/W2003767967","https://openalex.org/W2005947177","https://openalex.org/W2006570999","https://openalex.org/W2007856240","https://openalex.org/W2010236134","https://openalex.org/W2015176800","https://openalex.org/W2015768353","https://openalex.org/W2017037891","https://openalex.org/W2019632798","https://openalex.org/W2019710337","https://openalex.org/W2023562891","https://openalex.org/W2024213191","https://openalex.org/W2025338300","https://openalex.org/W2027291049","https://openalex.org/W2028649510","https://openalex.org/W2029104750","https://openalex.org/W2032231409","https://openalex.org/W2035200144","https://openalex.org/W2037087763","https://openalex.org/W2038573911","https://openalex.org/W2038662816","https://openalex.org/W2046141153","https://openalex.org/W2047690132","https://openalex.org/W2047957979","https://openalex.org/W2050108634","https://openalex.org/W2050935656","https://openalex.org/W2055300508","https://openalex.org/W2055331855","https://openalex.org/W2056366136","https://openalex.org/W2057014262","https://openalex.org/W2059169937","https://openalex.org/W2066902718","https://openalex.org/W2068081534","https://openalex.org/W2068943402","https://openalex.org/W2069089571","https://openalex.org/W2079580813","https://openalex.org/W2083459343","https://openalex.org/W2083903201","https://openalex.org/W2089104699","https://openalex.org/W2089635115","https://openalex.org/W2091357851","https://openalex.org/W2093219399","https://openalex.org/W2094069456","https://openalex.org/W2094674887","https://openalex.org/W2095687684","https://openalex.org/W2098100768","https://openalex.org/W2100206933","https://openalex.org/W2103564870","https://openalex.org/W2103920597","https://openalex.org/W2110138914","https://openalex.org/W2110649747","https://openalex.org/W2110932543","https://openalex.org/W2112791146","https://openalex.org/W2113262346","https://openalex.org/W2113950488","https://openalex.org/W2115373328","https://openalex.org/W2116870694","https://openalex.org/W2117057469","https://openalex.org/W2119835296","https://openalex.org/W2119989719","https://openalex.org/W2121617938","https://openalex.org/W2123519394","https://openalex.org/W2129175449","https://openalex.org/W2131473815","https://openalex.org/W2131976757","https://openalex.org/W2133053181","https://openalex.org/W2134642396","https://openalex.org/W2142356600","https://openalex.org/W2143071104","https://openalex.org/W2145947789","https://openalex.org/W2146428988","https://openalex.org/W2146634980","https://openalex.org/W2147600982","https://openalex.org/W2148207513","https://openalex.org/W2149472590","https://openalex.org/W2153375241","https://openalex.org/W2154441926","https://openalex.org/W2155799700","https://openalex.org/W2157366101","https://openalex.org/W2159263888","https://openalex.org/W2159477638","https://openalex.org/W2160614567","https://openalex.org/W2161961104","https://openalex.org/W2162226934","https://openalex.org/W2163164462","https://openalex.org/W2165184562","https://openalex.org/W2168251450","https://openalex.org/W2168764709","https://openalex.org/W2171094389","https://openalex.org/W2171820290","https://openalex.org/W2242557303","https://openalex.org/W2299246196","https://openalex.org/W2306800444","https://openalex.org/W2432158033","https://openalex.org/W2589667254","https://openalex.org/W2608877821","https://openalex.org/W2613770596"],"related_works":["https://openalex.org/W2321142317","https://openalex.org/W7162185493","https://openalex.org/W6979719878","https://openalex.org/W3111665853","https://openalex.org/W2914380287","https://openalex.org/W2946734845","https://openalex.org/W3048440126","https://openalex.org/W2015453406","https://openalex.org/W2736504712","https://openalex.org/W2266203147"],"abstract_inverted_index":{"Adolescents":[0],"are":[1,103],"regarded":[2],"as":[3,228],"a":[4,27,49,56,84,88,105,108,126,134,143,158,167,183,187,193,201],"high":[5],"risk":[6,150,174,208,219],"group":[7],"in":[8,20,29,38,53,83,100,164,189],"South":[9],"Africa":[10],"with":[11,166,200],"the":[12,31,39,45,71,131,179,190,217,222,229,235],"highest":[13],"human":[14],"immunodeficiency":[15],"virus":[16],"(HIV)":[17],"incidence":[18,79,140,163],"occurring":[19],"this":[21,67],"group.Prevention":[22],"among":[23,80],"adolescents":[24,81,102],"is":[25,94,212,226,231],"therefore":[26],"key":[28],"decreasing":[30],"HIV":[32,78,139,162,176,210],"burden.This":[33],"thesis":[34],"aims":[35],"to":[36,69,233],"assist":[37],"design":[40],"of":[41,48,73,107,133,153,175,181,192,209],"trials":[42],"by":[43,61],"simulating":[44],"potential":[46],"outcomes":[47],"combination":[50,152],"prevention":[51,75,109,136],"trial":[52,86,92],"adolescents.We":[54],"develop":[55],"stochastic":[57],"individual-based":[58],"model":[59,68],"stratified":[60],"sex":[62],"and":[63,120,125,155],"age.We":[64],"then":[65],"use":[66],"determine":[70],"impact":[72,132,160],"various":[74],"packages":[76],"on":[77,138,161],"participating":[82],"hypothetical":[85],"over":[87],"three":[89],"year":[90],"period.The":[91],"that":[93,130],"simulated":[95],"involves":[96],"an":[97],"intervention":[98],"arm,":[99],"which":[101],"offered":[104],"choice":[106,180],"methods":[110],"(including":[111],"medical":[112],"male":[113],"circumcision":[114],"(MMC),":[115],"oral":[116],"pre-exposure":[117],"prophylaxis":[118],"(PrEP)":[119],"antiretroviral-based":[121],"vaginal":[122,194,223],"microbicides":[123],"(ARV-VM)),":[124],"control":[127],"arm.We":[128],"predict":[129],"full":[135],"package":[137],"would":[141,196],"be":[142,197,234],"46%":[144],"per":[145],"personyear(PPY)":[146],"(95%":[147,170,204],"CI":[148,171,205],"45-47%)":[149],"reduction.The":[151],"MMC":[154],"PrEP":[156],"has":[157],"substantial":[159],"males,":[165],"51%":[168],"PPY":[169,203],"49-53%)":[172],"relative":[173,207,218],"infection.Offering":[177],"women":[178],"PrEP,":[182],"microbicide":[184,188],"gel":[185],"or":[186],"form":[191],"ring":[195,224,230],"less":[198],"effective,":[199],"57%":[202],"56-58%)":[206],"acquisition.This":[211],"not":[213],"substantially":[214],"different":[215],"from":[216],"estimated":[220],"when":[221],"alone":[225],"offered,":[227],"assumed":[232],"most":[236],"acceptii":[237]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}