{"id":"https://openalex.org/W2122828787","doi":"https://doi.org/10.1093/emboj/18.19.5389","title":"Ligand\u2010induced recruitment of a histone deacetylase in the negative\u2010feedback regulation of the thyrotropin \u03b2 gene","display_name":"Ligand\u2010induced recruitment of a histone deacetylase in the negative\u2010feedback regulation of the thyrotropin \u03b2 gene","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2122828787","doi":"https://doi.org/10.1093/emboj/18.19.5389","mag":"2122828787","pmid":"https://pubmed.ncbi.nlm.nih.gov/10508171","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1171608"},"language":"en","primary_location":{"id":"doi:10.1093/emboj/18.19.5389","doi":"https://doi.org/10.1093/emboj/18.19.5389","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/18.19.5389","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/18.19.5389","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/18.19.5389","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018682603","display_name":"Shigekazu Sasaki","orcid":"https://orcid.org/0000-0001-8081-6402","observed_orcids":["https://orcid.org/0000-0001-8081-6402"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I13491362","display_name":"Hamamatsu University","ror":"https://ror.org/057vy9683","country_code":"JP","type":"education","lineage":["https://openalex.org/I13491362"]},{"id":"https://openalex.org/I3123035732","display_name":"Hamamatsu University School of Medicine","ror":"https://ror.org/00ndx3g44","country_code":"JP","type":"education","lineage":["https://openalex.org/I3123035732"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shigekazu Sasaki","raw_affiliation_strings":["Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2753, USA","Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development","Present address: Second Department of Internal Medicine, Hamamatsu University, School of Medicine, 3600 Handa\u2010cho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2753, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development","institution_ids":["https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Present address: Second Department of Internal Medicine, Hamamatsu University, School of Medicine, 3600 Handa\u2010cho","institution_ids":["https://openalex.org/I13491362","https://openalex.org/I3123035732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047780873","display_name":"Leslie A. Lesoon\u2010Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie A. Lesoon\u2010Wood","raw_affiliation_strings":["Molecular Carcinogenesis, Cancer Research Center of Hawaii, University of Hawaii HI 96813 USA","Molecular Carcinogenesis, Cancer Research Center of Hawaii, University of Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Carcinogenesis, Cancer Research Center of Hawaii, University of Hawaii HI 96813 USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Molecular Carcinogenesis, Cancer Research Center of Hawaii, University of Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016696610","display_name":"Anup Dey","orcid":"https://orcid.org/0000-0001-5866-3075","observed_orcids":["https://orcid.org/0000-0001-5866-3075"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anup Dey","raw_affiliation_strings":["Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development","institution_ids":["https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046439279","display_name":"Takeshi Kuwata","orcid":"https://orcid.org/0000-0003-0044-953X","observed_orcids":["https://orcid.org/0000-0003-0044-953X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takeshi Kuwata","raw_affiliation_strings":["Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development","institution_ids":["https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112067957","display_name":"Bruce D. Weintraub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Weintraub","raw_affiliation_strings":["Division of Endocrinology, University of Maryland, School of Medicine and Laboratory of Molecular Endocrinology, Institute of Human Virology Baltimore MD 21201 USA","Division of Endocrinology, University of Maryland, School of Medicine and Laboratory of Molecular Endocrinology, Institute of Human Virology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, University of Maryland, School of Medicine and Laboratory of Molecular Endocrinology, Institute of Human Virology Baltimore MD 21201 USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Endocrinology, University of Maryland, School of Medicine and Laboratory of Molecular Endocrinology, Institute of Human Virology","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059458188","display_name":"Glen W. Humphrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glen Humphrey","raw_affiliation_strings":["Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development","institution_ids":["https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010411205","display_name":"Wen\u2010Ming Yang","orcid":"https://orcid.org/0000-0002-5871-5979","observed_orcids":["https://orcid.org/0000-0002-5871-5979"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen\u2010Ming Yang","raw_affiliation_strings":["H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida Tampa FL 33612 USA","H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida Tampa FL 33612 USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]},{"raw_affiliation_string":"H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004256523","display_name":"Edward Seto","orcid":"https://orcid.org/0000-0001-7562-7316","observed_orcids":["https://orcid.org/0000-0001-7562-7316"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Seto","raw_affiliation_strings":["H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida Tampa FL 33612 USA","H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida Tampa FL 33612 USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]},{"raw_affiliation_string":"H.Lee Moffitt Cancer Center and Research Institute, Department of Medical Microbiology and Immunology, University of South Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015934115","display_name":"Paul M. Yen","orcid":"https://orcid.org/0000-0002-3790-8114","observed_orcids":["https://orcid.org/0000-0002-3790-8114"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Yen","raw_affiliation_strings":["Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda MD 20892-2753 USA","Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda MD 20892-2753 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047591792","display_name":"Bruce H. Howard","orcid":"https://orcid.org/0000-0001-9988-9724","observed_orcids":["https://orcid.org/0000-0001-9988-9724"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce H. Howard","raw_affiliation_strings":["Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development","institution_ids":["https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033861845","display_name":"Keiko Ozato","orcid":"https://orcid.org/0000-0001-7013-2728","observed_orcids":["https://orcid.org/0000-0001-7013-2728"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keiko Ozato","raw_affiliation_strings":["Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development Bethesda MD 20892-2753 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development","institution_ids":["https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5033861845"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":3.5827,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.93810433,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"19","first_page":"5389","last_page":"5398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4004000127315521,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8450000286102295},{"id":"https://openalex.org/keywords/negative-feedback-regulation","display_name":"negative feedback regulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-beta","display_name":"thyroid hormone receptor beta","score":0.9789999723434448},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.48500001430511475},{"id":"https://openalex.org/keywords/promoter-repression","display_name":"promoter repression","score":0.6290000081062317},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.8349999785423279},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pituitary-thyroid-axis","display_name":"pituitary-thyroid axis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gh3-cells","display_name":"GH3 cells","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.8102407455444336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7643616199493408},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.7490954399108887},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6920053362846375},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.6182815432548523},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5019893646240234},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.48769721388816833},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.4658903181552887},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.4642205238342285},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4441480040550232},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.4365481734275818},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3599851131439209},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3548082709312439},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2278754711151123},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1919969618320465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17963427305221558}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/emboj/18.19.5389","doi":"https://doi.org/10.1093/emboj/18.19.5389","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/18.19.5389","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/18.19.5389","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:95093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1171608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1171608","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1171608","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:10508171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10508171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/emboj/18.19.5389","doi":"https://doi.org/10.1093/emboj/18.19.5389","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/18.19.5389","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/18.19.5389","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310131","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122828787.pdf","grobid_xml":"https://content.openalex.org/works/W2122828787.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W52542474","https://openalex.org/W135983215","https://openalex.org/W1486257535","https://openalex.org/W1511815964","https://openalex.org/W1513279281","https://openalex.org/W1517784889","https://openalex.org/W1520441844","https://openalex.org/W1556768294","https://openalex.org/W1563624749","https://openalex.org/W1580606703","https://openalex.org/W1635667563","https://openalex.org/W1646199134","https://openalex.org/W1665024321","https://openalex.org/W1784857457","https://openalex.org/W1825997706","https://openalex.org/W1960503626","https://openalex.org/W1970316586","https://openalex.org/W1973313721","https://openalex.org/W1974112332","https://openalex.org/W1979698007","https://openalex.org/W1982676504","https://openalex.org/W1985063313","https://openalex.org/W1987271093","https://openalex.org/W1987395855","https://openalex.org/W1990939350","https://openalex.org/W1998904806","https://openalex.org/W2004458209","https://openalex.org/W2011184703","https://openalex.org/W2011467252","https://openalex.org/W2011990607","https://openalex.org/W2016567695","https://openalex.org/W2026441085","https://openalex.org/W2029816768","https://openalex.org/W2036639816","https://openalex.org/W2037287388","https://openalex.org/W2038092316","https://openalex.org/W2042315437","https://openalex.org/W2043102727","https://openalex.org/W2044177812","https://openalex.org/W2047202332","https://openalex.org/W2052594397","https://openalex.org/W2054696920","https://openalex.org/W2056724579","https://openalex.org/W2058506354","https://openalex.org/W2060696024","https://openalex.org/W2061484507","https://openalex.org/W2069532898","https://openalex.org/W2074562704","https://openalex.org/W2083804971","https://openalex.org/W2084938642","https://openalex.org/W2085615781","https://openalex.org/W2094558395","https://openalex.org/W2103567375","https://openalex.org/W2104788426","https://openalex.org/W2106900373","https://openalex.org/W2112414494","https://openalex.org/W2118516988","https://openalex.org/W2119725374","https://openalex.org/W2143241514","https://openalex.org/W2144319241","https://openalex.org/W2145221641","https://openalex.org/W2155754912","https://openalex.org/W2172212006","https://openalex.org/W2428539104","https://openalex.org/W4229958257","https://openalex.org/W4247970123","https://openalex.org/W6605946895"],"related_works":["https://openalex.org/W2153997114","https://openalex.org/W2015795642","https://openalex.org/W2034071735","https://openalex.org/W2044216374","https://openalex.org/W2126943357","https://openalex.org/W2007851111","https://openalex.org/W2149113463","https://openalex.org/W2749834132","https://openalex.org/W2047332277","https://openalex.org/W2020126297"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}