{"id":"https://openalex.org/W2122695751","doi":"https://doi.org/10.1002/14651858.cd001040","title":"Progestagens for endometrial cancer","display_name":"Progestagens for endometrial cancer","publication_year":1999,"publication_date":"1999-10-25","ids":{"openalex":"https://openalex.org/W2122695751","doi":"https://doi.org/10.1002/14651858.cd001040","mag":"2122695751","pmid":"https://pubmed.ncbi.nlm.nih.gov/10796737"},"language":"en","primary_location":{"id":"doi:10.1002/14651858.cd001040","doi":"https://doi.org/10.1002/14651858.cd001040","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd001040","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"reference-entry"},"volume":null,"type":"reference-entry","is_traditional":false,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104053256","display_name":"Pierre PL Martin-Hirsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293129422","display_name":"Lancashire Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/02j7n9748","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293129422"]},{"id":"https://openalex.org/I4210154214","display_name":"Royal Preston Hospital","ror":"https://ror.org/05kpx1157","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293129422","https://openalex.org/I4210154214"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pierre PL Martin-Hirsch","raw_affiliation_strings":["Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust","Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Gynaecological Oncology Unit, Preston, Lancashire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust","institution_ids":["https://openalex.org/I1293129422","https://openalex.org/I4210154214"]},{"raw_affiliation_string":"Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Gynaecological Oncology Unit, Preston, Lancashire, UK","institution_ids":["https://openalex.org/I1293129422","https://openalex.org/I4210154214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053212192","display_name":"Gerry G Jarvis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["GB","IE"],"is_corresponding":false,"raw_author_name":"Gerry G Jarvis","raw_affiliation_strings":["St James' Hospital","St James' Hospital, Department of Obstetrics and Gynaecology, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James' Hospital","institution_ids":["https://openalex.org/I4210154619"]},{"raw_affiliation_string":"St James' Hospital, Department of Obstetrics and Gynaecology, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008419054","display_name":"Henry Charles Kitchener","orcid":"https://orcid.org/0000-0001-5791-7838","observed_orcids":["https://orcid.org/0000-0001-5791-7838"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210087748","display_name":"St Mary's Hospital","ror":"https://ror.org/001x4vz59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800602287","https://openalex.org/I4210087748","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henry C Kitchener","raw_affiliation_strings":["St. Mary's Hospital","St. Mary's Hospital, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Mary's Hospital","institution_ids":[]},{"raw_affiliation_string":"St. Mary's Hospital, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210087748"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024646212","display_name":"Richard James Lilford","orcid":"https://orcid.org/0000-0002-0634-984X","observed_orcids":["https://orcid.org/0000-0002-0634-984X"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Lilford","raw_affiliation_strings":["University of Birmingham","University of Birmingham, Department of Public Health and Epidemiology, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"University of Birmingham, Department of Public Health and Epidemiology, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"2","first_page":"CD001040","last_page":"CD001040"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/recurrence-prevention","display_name":"recurrence prevention","score":0.7099999785423279},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9179999828338623},{"id":"https://openalex.org/keywords/primary-surgery","display_name":"primary surgery","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9248892068862915},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.8902884721755981},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.5751525163650513},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5711339116096497},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.549055814743042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5373666882514954},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.480686753988266},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4436799883842468},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44339635968208313},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.420939177274704}],"mesh":[{"descriptor_ui":"D000077713","descriptor_name":"17 alpha-Hydroxyprogesterone Caproate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006908","descriptor_name":"Hydroxyprogesterones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011372","descriptor_name":"Progestins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017258","descriptor_name":"Medroxyprogesterone Acetate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/14651858.cd001040","doi":"https://doi.org/10.1002/14651858.cd001040","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd001040","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"reference-entry"},{"id":"pmid:10796737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10796737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cochrane database of systematic reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W53250911","https://openalex.org/W1687334315","https://openalex.org/W1968253256","https://openalex.org/W1986095928","https://openalex.org/W2057806510","https://openalex.org/W2104742468","https://openalex.org/W2227417480","https://openalex.org/W2340522505","https://openalex.org/W2433082452","https://openalex.org/W2460999166","https://openalex.org/W4256240877"],"related_works":["https://openalex.org/W1519719924","https://openalex.org/W2000593806","https://openalex.org/W1968253256","https://openalex.org/W2227417480","https://openalex.org/W1986095928","https://openalex.org/W1964466078","https://openalex.org/W3113526453","https://openalex.org/W2054317525","https://openalex.org/W4306910798","https://openalex.org/W2409275621"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Progestagen":[1],"therapy":[2,31,58,120,141,182],"following":[3],"primary":[4,185],"surgery":[5,64],"for":[6,65],"endometrial":[7,33,66,188],"cancer":[8,129,156],"has":[9],"been":[10],"advocated":[11],"to":[12,24,49,126,136],"reduce":[13],"the":[14,26,39,177,184],"risk":[15],"of":[16,20,28,56,133,179,187],"recurrence.":[17],"The":[18],"objective":[19],"this":[21],"review":[22],"was":[23,74,114],"assess":[25],"effect":[27],"adjuvant":[29,118,180],"progestagen":[30,57,119,140,181],"in":[32,59,162,183],"cancer.":[34,67,189],"SEARCH":[35],"STRATEGY:":[36],"We":[37],"searched":[38],"Cochrane":[40],"Gynaecological":[41],"Cancer":[42],"Group":[43],"trials":[44,55,85,92],"register":[45],"and":[46,76,131,147],"MEDLINE":[47],"up":[48],"May":[50],"1999.":[51],"SELECTION":[52],"CRITERIA:":[53],"Randomised":[54],"women":[60,88,94,103,163],"who":[61],"have":[62],"had":[63],"DATA":[68],"COLLECTION":[69],"AND":[70],"ANALYSIS:":[71],"Trial":[72],"quality":[73],"assessed":[75],"two":[77],"reviewers":[78],"abstracted":[79],"data":[80],"independently.":[81],"MAIN":[82],"RESULTS:":[83],"Six":[84],"involving":[86],"4351":[87],"were":[89,159],"identified.":[90],"Three":[91],"included":[93,102],"with":[95,104,165],"stage":[96],"one":[97],"disease":[98,134],"only,":[99],"whereas":[100],"three":[101],"more":[105,160],"advanced":[106],"disease.":[107],"Based":[108],"on":[109],"five":[110],"trials,":[111],"overall":[112],"survival":[113],"not":[115,175],"improved":[116],"by":[117,139],"(OR":[121],"1.05,":[122],"95%":[123,144,150],"CI":[124,145,151],"0.88":[125,143],"1.24).":[127],"Endometrial":[128],"deaths":[130,158],"relapse":[132],"appears":[135],"be":[137],"reduced":[138],"OR":[142,167],"(0.71-1.1)":[146],"0.":[148],"81":[149],"(0.65-1.01)":[152],"respectively.":[153],"However,":[154],"non-endometrial":[155],"related":[157],"common":[161],"treated":[164],"progestagens":[166],"1.33":[168],"(1.02-1.73).":[169],"REVIEWER'S":[170],"CONCLUSIONS:":[171],"Current":[172],"evidence":[173],"does":[174],"support":[176],"use":[178],"treatment":[186]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}