{"id":"https://openalex.org/W21226852","doi":null,"title":"In vitro and ex vivo expression of nucleolar proteins B23 and p120 in benign and malignant epithelial lesions of the prostate.","display_name":"In vitro and ex vivo expression of nucleolar proteins B23 and p120 in benign and malignant epithelial lesions of the prostate.","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W21226852","mag":"21226852","pmid":"https://pubmed.ncbi.nlm.nih.gov/7542384"},"language":"en","primary_location":{"id":"pmid:7542384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7542384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109179275","display_name":"Tina Bocker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Bocker","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110159501","display_name":"A. Bittinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Bittinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045651628","display_name":"Wolf Ferdinand Wieland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Wieland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112456022","display_name":"Ralf Buettner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Buettner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000047117","display_name":"G Fauser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Fauser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001362374","display_name":"Ferdinand Hofstaedter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Hofstaedter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083603266","display_name":"Jan H. R\u00fcschoff","orcid":"https://orcid.org/0000-0002-1936-6606","observed_orcids":["https://orcid.org/0000-0002-1936-6606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R\u00fcschoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2725,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.78631402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":"3","first_page":"226","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5781000256538391,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.14489999413490295,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.1363999992609024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleolar-proteins","display_name":"nucleolar proteins","score":0.8399999737739563},{"id":"https://openalex.org/keywords/nucleophosmin","display_name":"nucleophosmin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/p120","display_name":"p120","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nucleolus","display_name":"nucleolus","score":0.8220000267028809},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6859999895095825},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nucleolar-activity","display_name":"nucleolar activity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tumor-grading","display_name":"tumor grading","score":0.546999990940094},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/formalin-fixed-tissue","display_name":"formalin-fixed tissue","score":0.7099999785423279},{"id":"https://openalex.org/keywords/immunohistochemical-markers","display_name":"immunohistochemical markers","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7661656737327576},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.7176399827003479},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.6354831457138062},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6050686240196228},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.535905659198761},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5291935205459595},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5256782174110413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45866623520851135},{"id":"https://openalex.org/C95798472","wikidata":"https://www.wikidata.org/wiki/Q5506326","display_name":"Frozen section procedure","level":2,"score":0.4202043414115906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2856178879737854},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12670093774795532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090243","descriptor_name":"Nucleophosmin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002466","descriptor_name":"Cell Nucleolus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009697","descriptor_name":"Nucleolus Organizer Region","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7542384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7542384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:15287","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/15287/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:21226852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7542384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1490246121","https://openalex.org/W1995479916","https://openalex.org/W2018309032","https://openalex.org/W2019094601","https://openalex.org/W2020515745","https://openalex.org/W2024674112","https://openalex.org/W2025299468","https://openalex.org/W2048618941","https://openalex.org/W2054068403","https://openalex.org/W2055894224","https://openalex.org/W2064134794","https://openalex.org/W2066815321","https://openalex.org/W2070090852","https://openalex.org/W2078125077","https://openalex.org/W2089453517","https://openalex.org/W2091769395","https://openalex.org/W2092338165","https://openalex.org/W2093067136","https://openalex.org/W2098502218","https://openalex.org/W2099242821","https://openalex.org/W2111833149","https://openalex.org/W2127147519","https://openalex.org/W2133663825","https://openalex.org/W2135727395","https://openalex.org/W2139318392","https://openalex.org/W2155885064","https://openalex.org/W2161845913","https://openalex.org/W2166321841","https://openalex.org/W2398802637","https://openalex.org/W2402120402","https://openalex.org/W2415160368","https://openalex.org/W2415729556","https://openalex.org/W2416136691","https://openalex.org/W2425780676","https://openalex.org/W6642111758","https://openalex.org/W6698679602"],"related_works":["https://openalex.org/W96141442","https://openalex.org/W2296767249","https://openalex.org/W1964383297","https://openalex.org/W2358020958","https://openalex.org/W2115920391","https://openalex.org/W3091820154","https://openalex.org/W2466337260","https://openalex.org/W2045225395","https://openalex.org/W2169281631","https://openalex.org/W3150682867"],"abstract_inverted_index":{"The":[0],"expression":[1,233],"of":[2,31,54,60,81,86,124,133,139,160,177,189,230,234,241,255],"two":[3],"specific":[4],"nucleolar":[5,256],"antigens,":[6],"p120":[7,55,125,151,181,210,235],"and":[8,26,33,46,70,88,104,112,183,218,244,252],"B23,":[9,209],"has":[10],"been":[11],"investigated":[12],"in":[13,23,78,96,102,110,113,168,194,199,216,258],"the":[14,79,122,131,172,178,242],"prostatic":[15,35,107,141],"carcinoma":[16,135,173],"cell":[17,89],"line":[18],"LNCaP":[19,83],"as":[20,22,99,101],"well":[21,100],"40":[24,27],"frozen":[25,137],"formalin-fixed":[28,114,217],"tissue":[29,115],"samples":[30],"benign":[32,38,140],"malignant":[34,105],"lesions":[36],"(15":[37],"hyperplasias,":[39],"5":[40,47],"grade":[41,44,48,195,200],"1,":[42],"15":[43],"2,":[45],"3":[49,169,201],"carcinomas).":[50],"In":[51,120,171,206],"vitro,":[52],"immunoreactivity":[53,123],"was":[56,76,94,126,185],"confined":[57],"to":[58,130,197,208,237],"nucleoli":[59,80,132],"proliferating":[61],"cells,":[62,108],"with":[63,239],"virtually":[64],"no":[65],"negative":[66,149],"staining":[67],"during":[68],"S":[69],"G2/M":[71],"phases.":[72,91],"Unlike":[73],"p120,":[74],"B23":[75,93],"expressed":[77],"all":[82,97],"cells":[84,163],"independently":[85],"growth":[87],"cycle":[90],"Hence,":[92],"detectable":[95],"stromal":[98],"normal":[103],"epithelial":[106],"both":[109],"fresh":[111],"sections":[116,138],"after":[117],"microwave":[118],"treatment.":[119],"contrast,":[121],"almost":[127],"completely":[128],"restricted":[129],"prostate":[134],"cells:":[136],"hyperplasia":[142],"(n":[143,152],"=":[144,153,166],"15)":[145],"were":[146,180],"either":[147],"totally":[148],"for":[150,249],"13)":[154],"or":[155],"had":[156],"a":[157,186,227,246],"low":[158],"percentage":[159],"positively":[161],"stained":[162],"(labeling":[164],"index":[165,191],"3.3%":[167],"cases).":[170],"group":[174],"76%":[175],"(19/25)":[176],"specimens":[179],"positive,":[182],"there":[184],"significant":[187],"rise":[188],"labeling":[190],"from":[192],"18.1%":[193],"1":[196],"82.2%":[198],"carcinomas":[202],"(P":[203],"<":[204],"0.001).":[205],"contrast":[207],"could":[211],"not":[212],"be":[213],"reliably":[214],"demonstrated":[215],"paraffin-embedded":[219],"tissue.":[220],"We":[221],"therefore":[222],"conclude":[223],"that":[224],"anti-B23":[225],"is":[226],"general":[228],"marker":[229],"nucleoli,":[231],"whereas":[232],"appears":[236],"correlate":[238],"\"hyperactivity\"":[240],"nucleolus":[243],"provides":[245],"new":[247],"tool":[248],"flow":[250],"cytometrical":[251],"immunohistochemical":[253],"assessment":[254],"activity":[257],"tumor":[259],"pathology.":[260]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}