{"id":"https://openalex.org/W2122674036","doi":"https://doi.org/10.1016/j.celrep.2014.09.042","title":"A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease","display_name":"A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease","publication_year":2014,"publication_date":"2014-10-24","ids":{"openalex":"https://openalex.org/W2122674036","doi":"https://doi.org/10.1016/j.celrep.2014.09.042","mag":"2122674036","pmid":"https://pubmed.ncbi.nlm.nih.gov/25437566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4255334"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2014.09.042","doi":"https://doi.org/10.1016/j.celrep.2014.09.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2014.09.042","pdf_url":"http://www.cell.com/article/S2211124714008250/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124714008250/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084365462","display_name":"Marc Brehme","orcid":"https://orcid.org/0000-0003-0694-331X","observed_orcids":["https://orcid.org/0000-0003-0694-331X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"id":"https://openalex.org/I4210157976","display_name":"Proteostasis Therapeutics (United States)","ror":"https://ror.org/05d0zs426","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Brehme","raw_affiliation_strings":["Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA; Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA","Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA","Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA; Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4210157976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043518525","display_name":"Cindy Voisine","orcid":"https://orcid.org/0000-0001-7165-9636","observed_orcids":["https://orcid.org/0000-0001-7165-9636"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Voisine","raw_affiliation_strings":["Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063781036","display_name":"Thomas Rolland","orcid":"https://orcid.org/0000-0001-6468-8391","observed_orcids":["https://orcid.org/0000-0001-6468-8391"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Rolland","raw_affiliation_strings":["Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Genetics, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112147691","display_name":"Shinichiro Wachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157976","display_name":"Proteostasis Therapeutics (United States)","ror":"https://ror.org/05d0zs426","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinichiro Wachi","raw_affiliation_strings":["Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4210157976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031849162","display_name":"James H. Soper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157976","display_name":"Proteostasis Therapeutics (United States)","ror":"https://ror.org/05d0zs426","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James\u00a0H. Soper","raw_affiliation_strings":["Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4210157976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110108746","display_name":"Yitan Zhu","orcid":"https://orcid.org/0000-0001-5332-6125","observed_orcids":["https://orcid.org/0000-0001-5332-6125"]},"institutions":[{"id":"https://openalex.org/I4210157976","display_name":"Proteostasis Therapeutics (United States)","ror":"https://ror.org/05d0zs426","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yitan Zhu","raw_affiliation_strings":["Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4210157976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071909309","display_name":"Kai Orton","orcid":"https://orcid.org/0000-0003-4050-1873","observed_orcids":["https://orcid.org/0000-0003-4050-1873"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Orton","raw_affiliation_strings":["Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022200558","display_name":"Adriana Villella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157976","display_name":"Proteostasis Therapeutics (United States)","ror":"https://ror.org/05d0zs426","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Villella","raw_affiliation_strings":["Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4210157976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090719251","display_name":"Dan Garza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157976","display_name":"Proteostasis Therapeutics (United States)","ror":"https://ror.org/05d0zs426","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Garza","raw_affiliation_strings":["Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4210157976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040546953","display_name":"Marc Vidal","orcid":"https://orcid.org/0000-0003-3391-5410","observed_orcids":["https://orcid.org/0000-0003-3391-5410"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc Vidal","raw_affiliation_strings":["Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: marc_vidal@dfci.harvard.edu","Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Genetics, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: marc_vidal@dfci.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157976","display_name":"Proteostasis Therapeutics (United States)","ror":"https://ror.org/05d0zs426","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157976"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hui Ge","raw_affiliation_strings":["Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA. Electronic address: hui.ge@novartis.com","Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA. Electronic address: hui.ge@novartis.com","institution_ids":["https://openalex.org/I4210157976"]},{"raw_affiliation_string":"Proteostasis Therapeutics, Inc., Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4210157976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004866198","display_name":"Richard I. Morimoto","orcid":"https://orcid.org/0000-0002-3431-445X","observed_orcids":["https://orcid.org/0000-0002-3431-445X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard\u00a0I. Morimoto","raw_affiliation_strings":["Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA. Electronic address: r-morimoto@northwestern.edu","Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA. Electronic address: r-morimoto@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004866198","https://openalex.org/A5040546953"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579","https://openalex.org/I4210157976"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":12.4576,"has_fulltext":false,"cited_by_count":576,"citation_normalized_percentile":{"value":0.99333298,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"1135","last_page":"1150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteostasis-network","display_name":"proteostasis network","score":0.9359999895095825},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.6899999976158142},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.7279999852180481},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.7059999704360962},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/proteotoxicity","display_name":"proteotoxicity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/atp-dependent-chaperones","display_name":"ATP-dependent chaperones","score":0.7850000262260437},{"id":"https://openalex.org/keywords/atp-independent-chaperones","display_name":"ATP-independent chaperones","score":0.9639999866485596},{"id":"https://openalex.org/keywords/co-chaperones","display_name":"co-chaperones","score":0.8709999918937683},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.5230000019073486},{"id":"https://openalex.org/keywords/polyglutamine","display_name":"polyglutamine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/huntingtin-aggregation","display_name":"huntingtin aggregation","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.931498110294342},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.7919870018959045},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.7919661402702332},{"id":"https://openalex.org/C2776104650","wikidata":"https://www.wikidata.org/wiki/Q2113512","display_name":"Proteotoxicity","level":3,"score":0.7420440316200256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6689552068710327},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.5414777398109436},{"id":"https://openalex.org/C2777174735","wikidata":"https://www.wikidata.org/wiki/Q18047040","display_name":"CLPB","level":4,"score":0.5044728517532349},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49026158452033997},{"id":"https://openalex.org/C2910011555","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin Protein","level":5,"score":0.4855208396911621},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.45564326643943787},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.4546007812023163},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38044577836990356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37803274393081665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33316755294799805},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.322072297334671},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26439303159713745},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.2565068304538727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08332124352455139},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057165","descriptor_name":"Proteostasis Deficiencies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D057165","descriptor_name":"Proteostasis Deficiencies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.celrep.2014.09.042","doi":"https://doi.org/10.1016/j.celrep.2014.09.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2014.09.042","pdf_url":"http://www.cell.com/article/S2211124714008250/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:25437566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25437566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4255334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4255334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a7c4790bcaa740b184e1aecb1dd3a085","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7c4790bcaa740b184e1aecb1dd3a085","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 9, Iss 3, Pp 1135-1150 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2014.09.042","doi":"https://doi.org/10.1016/j.celrep.2014.09.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2014.09.042","pdf_url":"http://www.cell.com/article/S2211124714008250/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G152081809","display_name":"C. elegans Model for Neurodegenerative Diseases of Aging","funder_award_id":"R37AG026647","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4944879654","display_name":"C. Elegans Model for Neurodegenerative Diseases of Aging","funder_award_id":"R01AG026647","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5280339932","display_name":"A Systems Approach to Stress Biology and Proteostasis Networks","funder_award_id":"R01GM038109","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7437889387","display_name":"REGULATION AND EXPRESSION OF THE HSP70 GENE FAMILY","funder_award_id":"R37GM038109","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8106039593","display_name":"Genomic Analysis of Network Perturbations in Human Disease","funder_award_id":"P50HG004233","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2122674036.pdf"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1511237419","https://openalex.org/W1554180547","https://openalex.org/W1588279803","https://openalex.org/W1596657747","https://openalex.org/W1944127002","https://openalex.org/W1967058595","https://openalex.org/W1967912600","https://openalex.org/W1971108880","https://openalex.org/W1975595547","https://openalex.org/W1977537173","https://openalex.org/W1980505864","https://openalex.org/W1980825524","https://openalex.org/W1981899072","https://openalex.org/W1982899653","https://openalex.org/W1992909271","https://openalex.org/W1995920563","https://openalex.org/W1996113127","https://openalex.org/W2011358070","https://openalex.org/W2014484295","https://openalex.org/W2016053737","https://openalex.org/W2025851491","https://openalex.org/W2029399678","https://openalex.org/W2047789918","https://openalex.org/W2050721857","https://openalex.org/W2058238065","https://openalex.org/W2069448508","https://openalex.org/W2076159058","https://openalex.org/W2079838574","https://openalex.org/W2086071706","https://openalex.org/W2086230817","https://openalex.org/W2095785516","https://openalex.org/W2096525273","https://openalex.org/W2096622242","https://openalex.org/W2096966529","https://openalex.org/W2099429272","https://openalex.org/W2102117809","https://openalex.org/W2103813752","https://openalex.org/W2104921590","https://openalex.org/W2107578201","https://openalex.org/W2107644675","https://openalex.org/W2108560778","https://openalex.org/W2109350663","https://openalex.org/W2109502717","https://openalex.org/W2110620844","https://openalex.org/W2112466127","https://openalex.org/W2114926230","https://openalex.org/W2115971557","https://openalex.org/W2126525177","https://openalex.org/W2128679613","https://openalex.org/W2129004089","https://openalex.org/W2135624681","https://openalex.org/W2136714530","https://openalex.org/W2137209191","https://openalex.org/W2140937615","https://openalex.org/W2144467478","https://openalex.org/W2152217159","https://openalex.org/W2155142785","https://openalex.org/W2156079900","https://openalex.org/W2156576736","https://openalex.org/W2160748841","https://openalex.org/W2163671213","https://openalex.org/W2169579807","https://openalex.org/W4231170962","https://openalex.org/W4252368281"],"related_works":["https://openalex.org/W1968892625","https://openalex.org/W2490327928","https://openalex.org/W2913940235","https://openalex.org/W7097078993","https://openalex.org/W7098398976","https://openalex.org/W2138812188","https://openalex.org/W1482870101","https://openalex.org/W3016436937","https://openalex.org/W7099503267","https://openalex.org/W1498622598"],"abstract_inverted_index":{"Chaperones":[0],"are":[1,61,68,127],"central":[2],"to":[3,47,56,118],"the":[4,10,19,44,71,84],"proteostasis":[5],"network":[6,26],"(PN)":[7],"and":[8,15,32,59,65,93,100,113,125,133,135,154],"safeguard":[9],"proteome":[11],"from":[12],"misfolding,":[13],"aggregation,":[14],"proteotoxicity.":[16],"We":[17],"categorized":[18],"human":[20,37,94,120,141],"chaperome":[21,85,148],"of":[22,41,43,73,83,108,122],"332":[23],"genes":[24],"into":[25],"communities":[27],"using":[28],"function,":[29],"localization,":[30],"interactome,":[31],"expression":[33,40],"data":[34],"sets.":[35],"During":[36],"brain":[38,131],"aging,":[39],"32%":[42],"chaperome,":[45],"corresponding":[46,55],"ATP-dependent":[48],"chaperone":[49],"machines,":[50],"is":[51],"repressed,":[52,128],"whereas":[53],"19.5%,":[54],"ATP-independent":[57],"chaperones":[58],"co-chaperones,":[60],"induced.":[62],"These":[63,116,143],"repression":[64],"induction":[66],"clusters":[67],"enhanced":[69,110],"in":[70,90,130,140,152],"brains":[72],"those":[74],"with":[75],"Alzheimer's,":[76],"Huntington's,":[77],"or":[78],"Parkinson's":[79],"disease.":[80,155],"Functional":[81],"properties":[82],"were":[86],"assessed":[87],"by":[88],"perturbation":[89],"C.":[91,104],"elegans":[92,105],"cell":[95],"models":[96],"expressing":[97],"A\u03b2,":[98],"polyglutamine,":[99],"Huntingtin.":[101],"Of":[102],"219":[103],"orthologs,":[106,121],"knockdown":[107],"16":[109],"both":[111],"A\u03b2":[112],"polyQ-associated":[114],"toxicity.":[115],"correspond":[117],"28":[119],"which":[123],"52%":[124],"41%":[126],"respectively,":[129],"aging":[132,153],"disease":[134],"37.5%":[136],"affected":[137],"Huntingtin":[138],"aggregation":[139],"cells.":[142],"results":[144],"identify":[145],"a":[146],"critical":[147],"subnetwork":[149],"that":[150],"functions":[151]},"counts_by_year":[{"year":2026,"cited_by_count":50},{"year":2025,"cited_by_count":47},{"year":2024,"cited_by_count":48},{"year":2023,"cited_by_count":56},{"year":2022,"cited_by_count":56},{"year":2021,"cited_by_count":56},{"year":2020,"cited_by_count":59},{"year":2019,"cited_by_count":54},{"year":2018,"cited_by_count":50},{"year":2017,"cited_by_count":43},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":24}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
