{"id":"https://openalex.org/W2122492414","doi":"https://doi.org/10.1200/jco.2012.47.4288","title":"Cediranib for Metastatic Alveolar Soft Part Sarcoma","display_name":"Cediranib for Metastatic Alveolar Soft Part Sarcoma","publication_year":2013,"publication_date":"2013-04-30","ids":{"openalex":"https://openalex.org/W2122492414","doi":"https://doi.org/10.1200/jco.2012.47.4288","mag":"2122492414","pmid":"https://pubmed.ncbi.nlm.nih.gov/23630200"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.47.4288","doi":"https://doi.org/10.1200/jco.2012.47.4288","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.47.4288","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677840","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003847273","display_name":"Shivaani Kummar","orcid":"https://orcid.org/0000-0001-6906-1627","observed_orcids":["https://orcid.org/0000-0001-6906-1627"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivaani Kummar","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058978836","display_name":"Deborah Emma Allen","orcid":"https://orcid.org/0000-0002-3615-6715","observed_orcids":["https://orcid.org/0000-0002-3615-6715"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Allen","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064141830","display_name":"Anne P. Monks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Monks","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","National Cancer Institute, Bldg 31, Room 3A44,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bldg 31, Room 3A44,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033145217","display_name":"Eric C. Polley","orcid":"https://orcid.org/0000-0002-5152-8740","observed_orcids":["https://orcid.org/0000-0002-5152-8740"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C. Polley","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073401889","display_name":"Curtis D. Hose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis D. Hose","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","National Cancer Institute, Bldg 31, Room 3A44,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bldg 31, Room 3A44,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080736692","display_name":"S. Percy Ivy","orcid":"https://orcid.org/0000-0001-7747-072X","observed_orcids":["https://orcid.org/0000-0001-7747-072X"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Percy Ivy","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ismail B. Turkbey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ismail B. Turkbey","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007831491","display_name":"Scott M. Lawrence","orcid":"https://orcid.org/0000-0002-5297-7978","observed_orcids":["https://orcid.org/0000-0002-5297-7978"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Lawrence","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","National Cancer Institute, Bldg 31, Room 3A44,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bldg 31, Room 3A44,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090468019","display_name":"Robert J. Kinders","orcid":"https://orcid.org/0000-0002-5310-3367","observed_orcids":["https://orcid.org/0000-0002-5310-3367"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Kinders","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","National Cancer Institute, Bldg 31, Room 3A44,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Bldg 31, Room 3A44,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082080836","display_name":"Peter L. Choyke","orcid":"https://orcid.org/0000-0003-1086-8826","observed_orcids":["https://orcid.org/0000-0003-1086-8826"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Choyke","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101715307","display_name":"Richard M Simon","orcid":"https://orcid.org/0000-0003-3558-4598","observed_orcids":["https://orcid.org/0000-0003-3558-4598"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Simon","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044239219","display_name":"Seth M. Steinberg","orcid":"https://orcid.org/0000-0002-8280-551X","observed_orcids":["https://orcid.org/0000-0002-8280-551X"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth M. Steinberg","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041200743","display_name":"James H. Doroshow","orcid":"https://orcid.org/0000-0002-4463-1790","observed_orcids":["https://orcid.org/0000-0002-4463-1790"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Doroshow","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066585382","display_name":"Lee J. Helman","orcid":"https://orcid.org/0000-0001-9553-4475","observed_orcids":["https://orcid.org/0000-0001-9553-4475"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee Helman","raw_affiliation_strings":["Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivaani Kummar, Deborah Allen, Eric C. Polley, S. Percy Ivy, Ismail B. Turkbey, Peter Choyke, Richard Simon, Seth M. Steinberg, James H. Doroshow, and Lee Helman, National Cancer Institute, Bethesda; Anne Monks, Curtis D. Hose, Scott Lawrence, and Robert J. Kinders, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.0511,"has_fulltext":false,"cited_by_count":218,"citation_normalized_percentile":{"value":0.99428345,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"31","issue":"18","first_page":"2296","last_page":"2302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cediranib","display_name":"cediranib","score":0.949999988079071},{"id":"https://openalex.org/keywords/alveolar-soft-part-sarcoma","display_name":"alveolar soft part sarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastatic-sarcoma","display_name":"metastatic sarcoma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/vegfr-tyrosine-kinase-inhibitors","display_name":"VEGFR inhibitors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-receptor","display_name":"vascular endothelial growth factor receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.4909999966621399},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/vasculogenesis","display_name":"vasculogenesis","score":0.6790000200271606},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7839999794960022},{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.7630000114440918},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8801194429397583},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.750795841217041},{"id":"https://openalex.org/C2777666782","wikidata":"https://www.wikidata.org/wiki/Q4063436","display_name":"Alveolar soft part sarcoma","level":3,"score":0.5592122077941895},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.5516369342803955},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.536372184753418},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.5257973074913025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5200319290161133},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5149143934249878},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4356841444969177},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4246925115585327},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38557663559913635},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34660375118255615},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.34492555260658264},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2884712219238281},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28587108850479126},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22932395339012146},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.0872316062450409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018234","descriptor_name":"Sarcoma, Alveolar Soft Part","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1200/jco.2012.47.4288","doi":"https://doi.org/10.1200/jco.2012.47.4288","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.47.4288","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:23630200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23630200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:europepmc.org:3035607","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677840","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3677840","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677840","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.976.1920","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.976.1920","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hwmaint.jco.ascopubs.org/cgi/reprint/31/18/2296.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.981.6261","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.981.6261","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hwmaint.jco.ascopubs.org/cgi/reprint/JCO.2012.47.4288v1.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3677840","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677840","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Oncol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1521411027","display_name":null,"funder_award_id":"No. HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2462534994","display_name":null,"funder_award_id":"Contract No.,HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2474977437","display_name":null,"funder_award_id":"Contract No. HHSN261200800001E.","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3503792436","display_name":null,"funder_award_id":"#HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W4105886","https://openalex.org/W298677108","https://openalex.org/W1512633541","https://openalex.org/W1572876072","https://openalex.org/W1769310585","https://openalex.org/W1971762239","https://openalex.org/W1985429138","https://openalex.org/W1988045521","https://openalex.org/W2007624605","https://openalex.org/W2012921981","https://openalex.org/W2039013742","https://openalex.org/W2085053752","https://openalex.org/W2094337993","https://openalex.org/W2097373408","https://openalex.org/W2106855098","https://openalex.org/W2108921615","https://openalex.org/W2133365073","https://openalex.org/W2137758263","https://openalex.org/W2139248078","https://openalex.org/W2146355396","https://openalex.org/W2147712199","https://openalex.org/W2154056804","https://openalex.org/W2165630767","https://openalex.org/W2169500410","https://openalex.org/W2340136319"],"related_works":["https://openalex.org/W2112129582","https://openalex.org/W2132190370","https://openalex.org/W2517108090","https://openalex.org/W2068633458","https://openalex.org/W2759379512","https://openalex.org/W2894042521","https://openalex.org/W2241521827","https://openalex.org/W2249967442","https://openalex.org/W3162549408","https://openalex.org/W2122492414"],"abstract_inverted_index":{"PURPOSE:":[0],"Alveolar":[1],"soft":[2],"part":[3],"sarcoma":[4],"(ASPS)":[5],"is":[6,26,233],"a":[7,27,46,130,144,210],"rare,":[8],"highly":[9],"vascular":[10,35],"tumor,":[11],"for":[12,20,59,113,193,237],"which":[13],"no":[14],"effective":[15],"standard":[16],"systemic":[17,191],"treatment":[18],"exists":[19],"patients":[21,60,108,128,134,174,238],"with":[22,61,124,143,160,239,244],"unresectable":[23,63],"disease.":[24],"Cediranib":[25],"potent,":[28],"oral":[29],"small-molecule":[30],"inhibitor":[31],"of":[32,50,88,118,126,156,177,190,207,214,222],"all":[33],"three":[34],"endothelial":[36],"growth":[37],"factor":[38],"receptors":[39],"(VEGFRs).":[40],"PATIENTS":[41],"AND":[42],"METHODS:":[43],"We":[44,72],"conducted":[45,236],"phase":[47,229],"II":[48,230],"trial":[49,187,232],"once-daily":[51],"cediranib":[52,89,199,243],"(30":[53],"mg)":[54],"given":[55],"in":[56,78],"28-day":[57],"cycles":[58],"metastatic,":[62],"ASPS":[64,241],"to":[65,180,188],"determine":[66],"the":[67,86,116,140,220],"objective":[68],"response":[69,114,149],"rate":[70,147,213],"(ORR).":[71],"also":[73],"compared":[74],"gene":[75],"expression":[76],"profiles":[77],"pre-":[79],"and":[80,84,93,99,209],"post-treatment":[81],"tumor":[82,91,170],"biopsies":[83,171],"evaluated":[85],"effect":[87],"on":[90,168],"proliferation":[92],"angiogenesis":[94],"using":[95],"positron":[96],"emission":[97],"tomography":[98],"dynamic":[100],"contrast-enhanced":[101],"magnetic":[102],"resonance":[103],"imaging.":[104],"RESULTS:":[105],"Of":[106],"46":[107],"enrolled,":[109],"43":[110,127],"were":[111],"evaluable":[112],"at":[115,153,216],"time":[117],"analysis.":[119],"The":[120],"ORR":[121,206],"was":[122],"35%,":[123],"15":[125],"achieving":[129],"partial":[131],"response.":[132],"Twenty-six":[133],"(60%)":[135],"had":[136],"stable":[137,151],"disease":[138,145,211],"as":[139],"best":[141],"response,":[142],"control":[146,212],"(partial":[148],"+":[150],"disease)":[152],"24":[154,217],"weeks":[155],"84%.":[157],"Microarray":[158],"analysis":[159],"validation":[161],"by":[162],"quantitative":[163],"real-time":[164],"polymerase":[165],"chain":[166],"reaction":[167],"paired":[169],"from":[172],"eight":[173],"demonstrated":[175],"downregulation":[176],"genes":[178],"related":[179],"vasculogenesis.":[181],"CONCLUSION:":[182],"In":[183],"this":[184],"largest":[185],"prospective":[186],"date":[189],"therapy":[192],"metastatic":[194,240],"ASPS,":[195],"we":[196],"observed":[197],"that":[198],"has":[200],"substantial":[201],"single-agent":[202],"activity,":[203],"producing":[204],"an":[205,225],"35%":[208],"84%":[215],"weeks.":[218],"On":[219],"basis":[221],"these":[223],"results,":[224],"open-label,":[226],"multicenter,":[227],"randomized":[228],"registration":[231],"currently":[234],"being":[235],"comparing":[242],"another":[245],"VEGFR":[246],"inhibitor,":[247],"sunitinib.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":8}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}