{"id":"https://openalex.org/W2122485686","doi":"https://doi.org/10.1016/j.febslet.2011.07.034","title":"RNF20\u2013RNF40: A ubiquitin\u2010driven link between gene expression and the DNA damage response","display_name":"RNF20\u2013RNF40: A ubiquitin\u2010driven link between gene expression and the DNA damage response","publication_year":2011,"publication_date":"2011-08-04","ids":{"openalex":"https://openalex.org/W2122485686","doi":"https://doi.org/10.1016/j.febslet.2011.07.034","mag":"2122485686","pmid":"https://pubmed.ncbi.nlm.nih.gov/21827756"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2011.07.034","doi":"https://doi.org/10.1016/j.febslet.2011.07.034","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2011.07.034","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.07.034","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.07.034","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086398854","display_name":"Yosef Shiloh","orcid":"https://orcid.org/0000-0002-1538-6060","observed_orcids":["https://orcid.org/0000-0002-1538-6060"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Yosef Shiloh","raw_affiliation_strings":["The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. yossih@post.tau.ac.il","The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. yossih@post.tau.ac.il","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065872858","display_name":"Efrat Shema","orcid":"https://orcid.org/0000-0002-3718-593X","observed_orcids":["https://orcid.org/0000-0002-3718-593X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Efrat Shema","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013626134","display_name":"Lilach Moyal","orcid":"https://orcid.org/0000-0002-3076-1527","observed_orcids":["https://orcid.org/0000-0002-3076-1527"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lilach Moyal","raw_affiliation_strings":["The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036387444","display_name":"Moshe Oren","orcid":"https://orcid.org/0000-0003-4311-7172","observed_orcids":["https://orcid.org/0000-0003-4311-7172"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Moshe Oren","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086398854"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":{"value":3980,"currency":"USD","value_usd":3980},"fwci":0.644,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.52477685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"585","issue":"18","first_page":"2795","last_page":"2802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.45509999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.45509999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2734000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.1664000004529953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnf20","display_name":"RNF20","score":0.9769999980926514},{"id":"https://openalex.org/keywords/rnf40","display_name":"RNF40","score":1.0},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.972000002861023},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ataxia-telangiectasia-mutated","display_name":"ATM kinase","score":0.6299999952316284},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/chromatin-decondensation","display_name":"chromatin decondensation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tfiis","display_name":"TFIIS","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.7929999828338623},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6741795539855957},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6600762605667114},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6367308497428894},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6364367008209229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6336746215820312},{"id":"https://openalex.org/C2779320353","wikidata":"https://www.wikidata.org/wiki/Q1416887","display_name":"Histone H2B","level":4,"score":0.6147206425666809},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5906196236610413},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5442017912864685},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5419510006904602},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42313721776008606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41339969635009766},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.41049110889434814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3923811912536621},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.312923789024353}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.febslet.2011.07.034","doi":"https://doi.org/10.1016/j.febslet.2011.07.034","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2011.07.034","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.07.034","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:21827756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21827756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.febslet.2011.07.034","doi":"https://doi.org/10.1016/j.febslet.2011.07.034","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.febslet.2011.07.034","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2011.07.034","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3111313494","display_name":"Functional analysis of the p53 tumor suppressor","funder_award_id":"R37CA040099","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3823405994","display_name":null,"funder_award_id":"CA40099","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306740","display_name":"Israel Cancer Research Fund","ror":"https://ror.org/02h43gk75"},{"id":"https://openalex.org/F4320308854","display_name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","ror":"https://ror.org/0001ew531"},{"id":"https://openalex.org/F4320313684","display_name":"Federation of European Biochemical Societies","ror":"https://ror.org/0100zbm77"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122485686.pdf","grobid_xml":"https://content.openalex.org/works/W2122485686.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W104404459","https://openalex.org/W1489183905","https://openalex.org/W1492634884","https://openalex.org/W1514850574","https://openalex.org/W1548983621","https://openalex.org/W1963996414","https://openalex.org/W1964480889","https://openalex.org/W1964922169","https://openalex.org/W1971419576","https://openalex.org/W1971848700","https://openalex.org/W1973030224","https://openalex.org/W1974327959","https://openalex.org/W1974654938","https://openalex.org/W1974755980","https://openalex.org/W1975660840","https://openalex.org/W1976956267","https://openalex.org/W1977434752","https://openalex.org/W1977748078","https://openalex.org/W1978282378","https://openalex.org/W1978780879","https://openalex.org/W1979584856","https://openalex.org/W1980300257","https://openalex.org/W1983218764","https://openalex.org/W1983467866","https://openalex.org/W1984159489","https://openalex.org/W1988524165","https://openalex.org/W1989092936","https://openalex.org/W1998499862","https://openalex.org/W1998592800","https://openalex.org/W1999406663","https://openalex.org/W1999541392","https://openalex.org/W2003391080","https://openalex.org/W2004617021","https://openalex.org/W2006001474","https://openalex.org/W2006031514","https://openalex.org/W2006721912","https://openalex.org/W2008461545","https://openalex.org/W2009403023","https://openalex.org/W2009837566","https://openalex.org/W2010941702","https://openalex.org/W2014179038","https://openalex.org/W2014766736","https://openalex.org/W2020084014","https://openalex.org/W2020809494","https://openalex.org/W2022079791","https://openalex.org/W2022190569","https://openalex.org/W2023348831","https://openalex.org/W2023620387","https://openalex.org/W2027349141","https://openalex.org/W2027996199","https://openalex.org/W2028140379","https://openalex.org/W2028921845","https://openalex.org/W2030197516","https://openalex.org/W2031203839","https://openalex.org/W2032042016","https://openalex.org/W2033172828","https://openalex.org/W2035924891","https://openalex.org/W2038451572","https://openalex.org/W2039778682","https://openalex.org/W2050293032","https://openalex.org/W2050690313","https://openalex.org/W2054938702","https://openalex.org/W2055148721","https://openalex.org/W2056018903","https://openalex.org/W2056179278","https://openalex.org/W2056704195","https://openalex.org/W2058306877","https://openalex.org/W2058471321","https://openalex.org/W2059172839","https://openalex.org/W2059365987","https://openalex.org/W2059698383","https://openalex.org/W2060446536","https://openalex.org/W2060875411","https://openalex.org/W2061455523","https://openalex.org/W2063000913","https://openalex.org/W2068973408","https://openalex.org/W2070867144","https://openalex.org/W2072155586","https://openalex.org/W2073004429","https://openalex.org/W2074353056","https://openalex.org/W2074483662","https://openalex.org/W2077436902","https://openalex.org/W2078544177","https://openalex.org/W2078770765","https://openalex.org/W2083548220","https://openalex.org/W2086333179","https://openalex.org/W2087732089","https://openalex.org/W2088857928","https://openalex.org/W2088983779","https://openalex.org/W2089456325","https://openalex.org/W2090438862","https://openalex.org/W2090571513","https://openalex.org/W2090759699","https://openalex.org/W2094119502","https://openalex.org/W2097565373","https://openalex.org/W2100730597","https://openalex.org/W2102143993","https://openalex.org/W2103395279","https://openalex.org/W2103770333","https://openalex.org/W2106117017","https://openalex.org/W2106624609","https://openalex.org/W2108014213","https://openalex.org/W2110817748","https://openalex.org/W2110867751","https://openalex.org/W2112651502","https://openalex.org/W2114982790","https://openalex.org/W2123243207","https://openalex.org/W2131827278","https://openalex.org/W2132396299","https://openalex.org/W2133063603","https://openalex.org/W2133452708","https://openalex.org/W2135144687","https://openalex.org/W2139633538","https://openalex.org/W2139777089","https://openalex.org/W2140210955","https://openalex.org/W2140886363","https://openalex.org/W2145200068","https://openalex.org/W2146085143","https://openalex.org/W2152385412","https://openalex.org/W2153406517","https://openalex.org/W2162203253","https://openalex.org/W2162951729","https://openalex.org/W2164995160","https://openalex.org/W2166819601","https://openalex.org/W2167756186","https://openalex.org/W2168159728","https://openalex.org/W2169509924","https://openalex.org/W2171045529","https://openalex.org/W7098798001"],"related_works":["https://openalex.org/W4239339278","https://openalex.org/W2912983106","https://openalex.org/W2289506289","https://openalex.org/W2010941702","https://openalex.org/W1659536617","https://openalex.org/W2005780148","https://openalex.org/W2809311691","https://openalex.org/W3083878377","https://openalex.org/W749616215","https://openalex.org/W4311768185"],"abstract_inverted_index":{"The":[0,36,50],"DNA":[1,24],"damage":[2,83,240],"response":[3,52],"(DDR)":[4],"is":[5,53,73,123,237,250,276],"emerging":[6],"as":[7,30],"a":[8,63,76,86,188,267,277],"vast":[9],"signaling":[10],"network":[11],"that":[12,166,205,229,289],"temporarily":[13,91],"modulates":[14],"numerous":[15],"aspects":[16],"of":[17,23,41,65,78,88,106,132,142,170,182,185,220,255,269,280],"cellular":[18,94],"metabolism":[19],"in":[20,68,217,248,290],"the":[21,31,57,82,99,107,133,167,180,191,195,218,233,270,282],"face":[22],"lesions,":[25],"especially":[26],"critical":[27],"ones":[28],"such":[29],"double":[32],"strand":[33],"break":[34],"(DSB).":[35],"DDR":[37,108,271,283],"involves":[38],"extensive":[39],"dynamics":[40],"protein":[42,59,258],"post-translational":[43],"modifications,":[44],"most":[45],"notably":[46],"phosphorylation":[47],"and":[48,85,139,194,209,212,215,272,275],"ubiquitylation.":[49],"DSB":[51,231,256,262],"mobilized":[54],"primarily":[55,125],"by":[56,126],"ATM":[58],"kinase,":[60],"which":[61,247],"phosphorylates":[62],"plethora":[64],"key":[66],"players":[67],"its":[69],"various":[70],"branches.":[71],"It":[72],"based":[74],"on":[75,172],"core":[77],"proteins":[79,89,137],"dedicated":[80],"to":[81,96,150,153,239,285],"response,":[84],"cadre":[87],"borrowed":[90],"from":[92],"other":[93,294],"processes":[95],"help":[97],"meet":[98],"challenge.":[100],"A":[101],"recently":[102],"identified":[103],"novel":[104],"component":[105],"pathway":[109,265],"-":[110,114],"histone":[111,144],"H2B":[112,121,145,234],"monoubiquitylation":[113,122,235],"exemplifies":[115],"this":[116],"principle.":[117],"In":[118,224],"mammalian":[119],"cells,":[120],"driven":[124],"an":[127],"E3":[128],"ubiquitin":[129],"ligase":[130],"composed":[131],"two":[134],"RING":[135],"finger":[136],"RNF20":[138,214],"RNF40.":[140],"Generation":[141],"monoubiquitylated":[143],"(H2Bub)":[146],"has":[147],"been":[148],"known":[149],"be":[151],"coupled":[152],"gene":[154,173],"transcription,":[155],"presumably":[156],"modulating":[157],"chromatin":[158,273],"decondensation":[159],"at":[160],"transcribed":[161],"regions.":[162],"New":[163],"evidence":[164],"indicates":[165],"regulatory":[168,200],"function":[169],"H2Bub":[171],"expression":[174,181],"can":[175],"selectively":[176],"enhance":[177],"or":[178],"suppress":[179],"distinct":[183],"subsets":[184],"genes":[186,204],"through":[187],"mechanism":[189],"involving":[190],"hPAF1":[192],"complex":[193],"TFIIS":[196],"protein.":[197],"This":[198,264],"delicate":[199],"process":[201],"specifically":[202],"affects":[203],"control":[206],"cell":[207],"growth":[208],"genome":[210],"stability,":[211],"places":[213],"RNF40":[216],"realm":[219],"tumor":[221],"suppressor":[222],"proteins.":[223],"parallel,":[225],"it":[226,243],"was":[227],"found":[228],"following":[230],"induction,":[232],"module":[236],"recruited":[238],"sites":[241],"where":[242],"induces":[244],"local":[245],"H2Bub,":[246],"turn":[249],"required":[251],"for":[252],"timely":[253,261],"recruitment":[254],"repair":[257],"and,":[259],"subsequently,":[260],"repair.":[263],"represents":[266],"crossroads":[268],"organization,":[274],"typical":[278],"example":[279],"how":[281],"calls":[284],"action":[286],"functional":[287],"modules":[288],"unprovoked":[291],"cells":[292],"regulate":[293],"processes.":[295]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}