{"id":"https://openalex.org/W2122475397","doi":"https://doi.org/10.1086/313752","title":"Practice Guidelines for the Management of Patients with Histoplasmosis","display_name":"Practice Guidelines for the Management of Patients with Histoplasmosis","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W2122475397","doi":"https://doi.org/10.1086/313752","mag":"2122475397","pmid":"https://pubmed.ncbi.nlm.nih.gov/10770731"},"language":"en","primary_location":{"id":"doi:10.1086/313752","doi":"https://doi.org/10.1086/313752","is_oa":true,"landing_page_url":"https://doi.org/10.1086/313752","pdf_url":"https://academic.oup.com/cid/article-pdf/30/4/688/1167398/30-4-688.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cid/article-pdf/30/4/688/1167398/30-4-688.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072895969","display_name":"Joseph Wheat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158455","display_name":"Larue Carter Hospital","ror":"https://ror.org/02qpa9w62","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210158455"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Wheat","raw_affiliation_strings":["Department of Medicine and Pathology, Indiana University School of Medicine, Indianapolis 46202, USA. lwheat@iupui.edu","Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana","Department of Veterans' Affairs Hospital, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Pathology, Indiana University School of Medicine, Indianapolis 46202, USA. lwheat@iupui.edu","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Veterans' Affairs Hospital, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4210158455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007019135","display_name":"George A. Sarosi","orcid":"https://orcid.org/0000-0002-3525-3417","observed_orcids":["https://orcid.org/0000-0002-3525-3417"]},"institutions":[{"id":"https://openalex.org/I4210158455","display_name":"Larue Carter Hospital","ror":"https://ror.org/02qpa9w62","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210158455"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Sarosi","raw_affiliation_strings":["Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","Department of Veterans' Affairs Hospital, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Veterans' Affairs Hospital, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4210158455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111743773","display_name":"D. S. McKinsey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. McKinsey","raw_affiliation_strings":["Infectious Disease Associates of Kansas City, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Associates of Kansas City, Missouri","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109542312","display_name":"Richard J. Hamill","orcid":"https://orcid.org/0000-0002-0491-9626","observed_orcids":["https://orcid.org/0000-0002-0491-9626"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Hamill","raw_affiliation_strings":["Department of Medicine, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005986898","display_name":"Robert W. Bradsher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Bradsher","raw_affiliation_strings":["Department of Medicine, University of Arkansas School of Medicine, Little Rock"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Arkansas School of Medicine, Little Rock","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014389883","display_name":"P. Johnson","orcid":"https://orcid.org/0000-0001-6663-7520","observed_orcids":["https://orcid.org/0000-0001-6663-7520"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Johnson","raw_affiliation_strings":["University of Texas Medical School at Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical School at Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065762639","display_name":"James E. Loyd","orcid":"https://orcid.org/0000-0002-5042-7390","observed_orcids":["https://orcid.org/0000-0002-5042-7390"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Loyd","raw_affiliation_strings":["Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113613638","display_name":"Carol A. Kauffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Kauffman","raw_affiliation_strings":["Department of Medicine, Veterans Affairs Medical Center, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Veterans Affairs Medical Center, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5072895969"],"corresponding_institution_ids":["https://openalex.org/I4210158455","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":17.6288,"has_fulltext":true,"cited_by_count":374,"citation_normalized_percentile":{"value":0.99616316,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"30","issue":"4","first_page":"688","last_page":"695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histoplasmosis","display_name":"histoplasmosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/histoplasma-capsulatum","display_name":"Histoplasma capsulatum","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.796999990940094},{"id":"https://openalex.org/keywords/liposomal-amphotericin-b","display_name":"liposomal amphotericin B","score":0.9470000267028809},{"id":"https://openalex.org/keywords/amphotericin-b-lipid-complex","display_name":"amphotericin B lipid complex","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ketoconazole","display_name":"ketoconazole","score":0.9240000247955322},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-pulmonary-histoplasmosis","display_name":"chronic pulmonary histoplasmosis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/disseminated-histoplasmosis","display_name":"disseminated histoplasmosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.39500001072883606},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9279999732971191},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8947965502738953},{"id":"https://openalex.org/C2780318139","wikidata":"https://www.wikidata.org/wiki/Q627625","display_name":"Histoplasmosis","level":2,"score":0.8195067048072815},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.7432682514190674},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7373883128166199},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4889027178287506},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4672386944293976},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33151715993881226},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18218395113945007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1777345836162567},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1360914409160614},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0928368866443634}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006287","descriptor_name":"Health Planning Guidelines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006658","descriptor_name":"Histoplasma","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006660","descriptor_name":"Histoplasmosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006660","descriptor_name":"Histoplasmosis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D006660","descriptor_name":"Histoplasmosis","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008480","descriptor_name":"Mediastinitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008480","descriptor_name":"Mediastinitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010493","descriptor_name":"Pericarditis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010493","descriptor_name":"Pericarditis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1086/313752","doi":"https://doi.org/10.1086/313752","is_oa":true,"landing_page_url":"https://doi.org/10.1086/313752","pdf_url":"https://academic.oup.com/cid/article-pdf/30/4/688/1167398/30-4-688.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:10770731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10770731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Guideline"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.322.8708","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.8708","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mycology.adelaide.edu.au/downloads/histoplasmosis.pdf","raw_type":"text"},{"id":"mag:3140766481","doi":null,"is_oa":false,"landing_page_url":"http://bdsp-ehesp.inist.fr/vibad/index.php?action=getRecordDetail&idt=212572","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Clinical Infectious Diseases","raw_type":null}],"best_oa_location":{"id":"doi:10.1086/313752","doi":"https://doi.org/10.1086/313752","is_oa":true,"landing_page_url":"https://doi.org/10.1086/313752","pdf_url":"https://academic.oup.com/cid/article-pdf/30/4/688/1167398/30-4-688.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122475397.pdf","grobid_xml":"https://content.openalex.org/works/W2122475397.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W10462506","https://openalex.org/W60392937","https://openalex.org/W603683707","https://openalex.org/W1973676165","https://openalex.org/W1973699476","https://openalex.org/W1983662954","https://openalex.org/W1990543032","https://openalex.org/W1995491579","https://openalex.org/W2010955960","https://openalex.org/W2012885522","https://openalex.org/W2016637342","https://openalex.org/W2022830148","https://openalex.org/W2024269319","https://openalex.org/W2029513944","https://openalex.org/W2029950196","https://openalex.org/W2030000278","https://openalex.org/W2032580396","https://openalex.org/W2034722106","https://openalex.org/W2036039203","https://openalex.org/W2037683016","https://openalex.org/W2046719836","https://openalex.org/W2046752598","https://openalex.org/W2051241295","https://openalex.org/W2055966210","https://openalex.org/W2070842128","https://openalex.org/W2073813986","https://openalex.org/W2075580040","https://openalex.org/W2081928767","https://openalex.org/W2087153789","https://openalex.org/W2087475143","https://openalex.org/W2092425312","https://openalex.org/W2102038624","https://openalex.org/W2112170775","https://openalex.org/W2112956661","https://openalex.org/W2120520862","https://openalex.org/W2124623086","https://openalex.org/W2126468078","https://openalex.org/W2163658544","https://openalex.org/W2293029534","https://openalex.org/W2315264566","https://openalex.org/W2318259553","https://openalex.org/W2335497076","https://openalex.org/W2394929302","https://openalex.org/W2401851192","https://openalex.org/W2406195143","https://openalex.org/W2417663147"],"related_works":["https://openalex.org/W7096278013","https://openalex.org/W7100063194","https://openalex.org/W4214515343","https://openalex.org/W4385352764","https://openalex.org/W4301666432","https://openalex.org/W3084649021","https://openalex.org/W86603150","https://openalex.org/W2398105167","https://openalex.org/W2398271436","https://openalex.org/W1997277925"],"abstract_inverted_index":{"Objective.":[0],"The":[1,39,54,93,191,686,704,1102,1136,1250,1734,2135,2250,2954,2976,3015,3643,3688,3775,4102,4139,4241],"objective":[2],"of":[3,18,27,50,56,85,90,99,112,132,141,144,171,194,206,222,257,319,376,393,422,452,465,470,513,526,533,556,571,576,616,651,672,679,721,740,853,858,871,902,907,914,932,939,971,984,1009,1038,1045,1088,1110,1127,1138,1270,1290,1333,1345,1388,1415,1426,1440,1455,1469,1483,1485,1498,1509,1550,1590,1647,1679,1685,1718,1782,1828,1894,1915,1933,1938,1953,2011,2024,2045,2075,2111,2205,2224,2294,2353,2359,2370,2407,2451,2498,2546,2568,2626,2635,2672,2737,2773,2806,2823,2832,2854,2866,2948,2956,2969,2987,2990,3007,3030,3067,3164,3184,3212,3227,3230,3236,3238,3254,3300,3309,3346,3356,3403,3422,3480,3512,3579,3596,3603,3613,3624,3634,3641,3665,3691,3739,3789,3791,3830,3852,3860,3893,3923,3949,3985,3988,3994,4024,4054,4070,4078,4110,4115,4126,4171,4173,4179,4213,4216,4219,4236,4243,4247,4281,4286,4291,4301],"this":[4,31,37,246,352,670,1094,3219,3278,3692,4217],"guideline":[5,46],"is":[6,58,212,314,521,561,709,755,774,811,824,838,976,1073,1091,1096,1149,1266,1314,1351,1385,1404,1492,1537,1615,1628,1640,1656,1738,1754,1959,1969,1990,2092,2164,2173,2202,2311,2336,2412,2454,2505,2565,2589,2637,2666,2682,2686,2734,2782,2840,2848,2959,2972,2980,3012,3021,3027,3241,3282,3338,3483,3530,3545,3609,3645,3679,3747,3815,3956,3968,3977,4062,4089,4104,4154,4163,4191,4228,4233,4252,4255,4260],"to":[7,35,59,155,159,262,361,407,445,457,499,530,579,587,628,631,947,956,1098,1107,1177,1204,1231,1247,1280,1328,1364,1411,1422,1432,1436,1447,1465,1477,1481,1525,1569,1582,1744,1922,1948,1971,2067,2100,2125,2140,2166,2174,2234,2278,2283,2399,2422,2462,2478,2513,2540,2660,2668,2725,2898,2978,2982,2995,3005,3038,3070,3280,3292,3315,3328,3431,3467,3520,3593,3683,3698,3770,3772,3778,3840,3900,3907,3931,3962,4045,4085,4146,4221,4269],"provide":[8,124,2661],"recommendations":[9,128,645,875,4283],"for":[10,71,127,129,162,208,217,239,268,270,351,415,646,694,744,851,861,885,891,973,1004,1017,1048,1131,1140,1170,1218,1224,1311,1382,1390,1406,1494,1603,1652,1756,1836,1857,1941,1962,2094,2114,2177,2199,2207,2222,2344,2363,2429,2507,2555,2562,2570,2592,2609,2645,2698,2712,2745,2756,2864,2896,3018,3061,3074,3096,3138,3177,3210,3218,3252,3285,3287,3340,3353,3490,3506,3532,3542,3547,3554,3564,3586,3800,3979,4001,4036,4064,4165,4196,4238,4273,4284,4294,4304],"treating":[11,1141,1942,2115],"patients":[12,72,218,240,564,635,730,892,1005,1049,1059,1183,1225,1275,1304,1318,1407,1460,1561,1591,1632,1758,1783,1795,1817,1829,1867,1895,1901,1946,1963,1975,2025,2046,2077,2095,2122,2208,2244,2348,2371,2424,2489,2508,2571,2593,2693,2699,2713,2794,2926,2991,3097,3178,3286,3413,3491,3507,3548,3587,3826,3868,3884,3894,4005,4065,4127,4277,4287,4295,4305],"with":[13,73,150,219,241,405,424,436,547,565,636,786,831,842,879,1050,1060,1082,1153,1168,1185,1236,1298,1319,1574,1592,1746,1759,1774,1818,1821,1868,1897,1902,1910,1917,1951,1964,1976,2026,2057,2133,2209,2269,2349,2372,2377,2383,2446,2524,2728,2795,2813,2838,2927,2950,2992,3000,3102,3377,3414,3464,3492,3508,3549,3572,3708,3822,3827,3869,3885,3895,3928,3940,3958,3973,4006,4013,4043,4066,4074,4121,4128,4148,4159,4202,4208,4278,4288,4296,4306],"the":[14,45,61,97,110,125,139,142,145,151,237,242,335,343,374,377,391,413,425,440,463,468,471,497,509,524,531,537,554,588,596,623,647,737,753,815,828,836,856,869,937,949,962,969,996,1039,1077,1108,1111,1146,1192,1264,1386,1443,1475,1486,1495,1577,1634,1667,1688,1693,1696,1731,1878,1891,1931,1934,2108,2146,2178,2181,2203,2354,2357,2360,2449,2467,2531,2566,2624,2633,2670,2771,2804,2809,2814,2943,2957,2967,2996,3031,3072,3119,3128,3145,3202,3225,3234,3259,3301,3307,3341,3347,3372,3404,3423,3580,3625,3639,3663,3703,3726,3843,3850,3904,3908,3912,3950,3983,3989,4018,4047,4055,4116,4169,4174,4214,4234,4244,4270],"more":[15,648,791,796,1061,1179,1629,1657,3192,3313,3448,3710,4067,4261],"common":[16,562,649,1630,1669,1676],"forms":[17,131,170,193,221,256],"histoplasmosis.":[19,133,822,1322,1681,1762,1980,2351,4279,4289,4299,4308],"Participants":[20],"and":[21,43,75,88,115,121,167,176,204,215,301,321,332,345,366,370,467,573,593,601,608,656,666,674,803,814,840,866,945,1014,1119,1155,1159,1252,1276,1339,1545,1645,1654,1663,1671,1695,1703,1706,1770,1806,1852,1885,1978,1996,2083,2128,2163,2221,2263,2286,2301,2381,2419,2431,2470,2558,2611,2616,2622,2652,2694,2722,2758,2763,2769,2861,2887,2923,2961,3003,3121,3157,3214,3396,3439,3450,3591,3619,3622,3628,3647,3725,3814,3833,3879,3898,3991,4021,4106,4112,4118,4176,4181,4232],"consensus":[22],"process.":[23],"A":[24,569,614,2481,2784,3736],"working":[25,40],"group":[26,41,2816],"8":[28],"experts":[29],"in":[30,178,316,379,389,448,482,504,523,536,545,563,657,677,711,728,747,782,827,920,1028,1057,1145,1166,1258,1273,1278,1316,1331,1343,1442,1552,1560,1631,1659,1716,1780,1791,1802,1811,1826,1839,1846,1860,1955,1974,2007,2022,2036,2042,2070,2226,2232,2243,2260,2267,2299,2331,2347,2417,2466,2487,2614,2650,2761,2778,2793,2803,2808,2925,2942,2984,3118,3141,3154,3162,3233,3306,3322,3412,3457,3471,3570,3793,3825,3835,3849,3866,3883,3891,4004,4108,4144,4276],"field":[32],"was":[33,101,136,1000,1601,1778,1824,2005,2018],"convened":[34],"develop":[36,1241,2276],"guideline.":[38],"developed":[42,2069],"refined":[44],"through":[47],"a":[48,718,915,1007,1043,1085,1125,1206,1547,1588,2037,2061,2464,2474,2542,2800,2819,3040,3089,3135,3207,3442,3601,3610,3709,3716,3921],"series":[49],"conference":[51],"calls.":[52],"Outcomes.":[53],"goal":[55],"treatment":[57,111,148,235,617,644,924,1169,1387,1521,1737,1909,2204,2391,2411,2567,2634,2865,2999,3017,3211,3237,3463,3661,3686,3732,4012,4147,4235,4275,4282,4285],"eradicate":[60],"infection":[62,474,514,560,1244,2673,3909,3913,4056],"when":[63,3809],"possible,":[64],"although":[65,1287,2966,3191],"chronic":[66,113,226,254,574,602,1242,1320,1391,1722,2475,2742,3247,3717,4297],"suppression":[67],"may":[68,197,438,488,682,697,725,750,761,800,817,935,1105,1116,1240,1461,1708,2275,2341,2484,2913,2934,3311,3349,3368,3398,3446,3733,3919,4186],"be":[69,626,726,762,818,889,918,991,1054,1080,1099,1117,1122,1202,1222,1329,1365,1463,1505,1523,1558,1580,1742,2131,2175,2185,2240,2254,2329,2342,2393,2426,2435,2485,2522,2605,2619,2655,2696,2710,2726,2752,2766,2914,2935,3059,3094,3175,3312,3351,3369,3399,3447,3501,3518,3568,3584,3734,3785,3798,3820,3856,3881,3901,3920,3999,4040,4206],"adequate":[70],"AIDS":[74,994,1154,1593,1977,2027,2447,2491],"other":[76,130,182,500,1182,2488,2985,3085,3129,3290],"serious":[77],"immunosuppressive":[78,549,1643,2271],"disorders.":[79],"Other":[80,253,1682],"important":[81],"outcomes":[82],"are":[83,259,356,359,403,432,619,653,675,690,876,1227,1341,1409,1567,1649,1666,1675,1926,2097,2366,2510,2601,3250,3436,3706,3730,3767,3838],"resolution":[84,1952,3987,4172],"clinical":[86,119,897,1251,1873,2468,2970,3704,3750,3986,4019],"abnormalities":[87,2917],"prevention":[89],"relapse.":[91,2480,2775],"Evidence.":[92],"published":[94,1928],"literature":[95],"on":[96,138,462,688,873,2356,3681,3982,4168],"management":[98,3851],"histoplasmosis":[100,172,258,271,394,447,577,637,652,673,749,834,1027,1144,1158,1393,1604,1943,2746,2807,2833,2867,3514,3614,3897,3925,4203,4259],"reviewed.":[102],"Controlled":[103],"trials":[104],"have":[105,326,340,733,894,1324,2493,2573,2893,3099,3159,3294,3375,3468,3671,3764],"been":[106,251,328,780,967,2119,2894,3049,3160,3276,3455,3469,3488,3807,3864],"conducted":[107],"that":[108,399,431,752,934,981,1467,1765,1881,2390,2663,2983,3390,3486,3552,3656,4049,4081,4092,4258,4266],"address":[109],"pulmonary":[114,227,477,492,559,821,833,1026,1143,1243,1271,1321,1392,3410,3873,3876,4298],"disseminated":[116,229,758,1157,1596,1680,1761,1979,2350,3924,4307],"histoplasmosis,":[117,195,223,1597],"but":[118,324,358,520,621,696,1093,1348,1576,1618,1740,1888,1994,2318,2685,2731,3023,3332,3938],"experience":[120,683,795],"descriptive":[122],"studies":[123,1764,1880,2369],"basis":[126,140,3137,3777,3984,4170],"Value.":[134],"Value":[135],"assigned":[137,154],"strength":[143,857],"evidence":[146,872,2662,4023,4077,4091,4257],"supporting":[147],"recommendations,":[149],"highest":[152],"value":[153],"controlled":[156],"trials,":[157],"according":[158],"conventions":[160],"established":[161],"developing":[163,756],"practice":[164],"guidelines.":[165],"Benefits":[166],"costs.":[168],"Certain":[169],"cause":[173,184,489,2450,4222],"life-threatening":[174],"illnesses":[175],"result":[177,580],"considerable":[179],"morbidity,":[180],"whereas":[181,485,1913],"manifestations":[183,575,1063,1874,3551,3887,3917,4130],"no":[185,896,1927,2150,2533,4090,4256],"symptoms":[186,2215,2578,3435,3633,3990,4141,4175],"or":[187,228,295,307,475,551,584,605,630,700,771,862,929,941,1198,1215,1372,1379,1400,1418,1429,1445,1480,1530,1543,1566,1611,1623,1673,1690,1724,1870,1987,2155,2158,2161,2196,2211,2308,2323,2401,2537,2575,2642,2690,2717,2874,2884,2909,2930,2940,2945,3083,3127,3263,3270,3303,3364,3409,3525,3539,3744,3875,3946,4033,4059,4073,4095,4265],"minor":[188],"self-limited":[189,243,839],"illnesses.":[190],"nonprogressive":[192,522],"however,":[196,1520,3224,3273,3694,4227],"reduce":[198,936,948,3071,4046],"functional":[199],"capacity,":[200],"affecting":[201],"work":[202],"capacity":[203],"quality":[205,870],"life":[207,2646],"several":[209,3635],"months.":[210,2191],"Treatment":[211,265,823,878,1313,1753],"clearly":[213],"beneficial":[214,3470],"cost-effective":[216],"progressive":[220,255,757,1760,2960,3646,3689],"such":[224,401,3320,4239],"as":[225,1721,2448,2688,2741,3186,3503],"infection.":[230,493,741,3433],"It":[231],"remains":[232],"unknown":[233,357],"whether":[234],"improves":[236],"outcome":[238,816,3235,3664,3955],"manifestations,":[244],"since":[245,633,776],"patient":[247,754,830,1078,2147,2532,3473],"population":[248],"has":[249,518,778,965,2117,2230,3048,3274,3454,3487,3805,3863],"not":[250,260,433,734,825,966,1175,1228,1462,1889,1960,1997,2118,2218,2581,2687,2719,2724,2849,2964,3200,3275,3350,3753,3768,3806,3969,4083,4155,4205],"studied.":[252],"responsive":[261,3314],"pharmacologic":[263],"treatment.":[264,3534],"options.":[266],"Options":[267],"therapy":[269,640,768,1068,1187,1457,1748,1820,1923,1949,1968,2021,2033,2056,2142,2225,2346,2365,2378,2665,2733,2744,2979,3011,3101,3249,3281,3293,3343,3355,3453,3505,3605,3676,3780,3796,3804,3967,4097,4153,4190,4293,4303],"include":[272,362,698,1687,2870,2918,3391],"ketoconazole,":[273],"itraconazole,":[274,880,1194,1434,1526,1575,2525,2787,3360,3521,3740,4029],"fluconazole,":[275,2049,2058],"amphotericin":[276,284,290,302,1071,1326,1470,1490,1541,1776,1822,1898,1911,1939,2030,2112,2126,2138,2171,2235,2503,2729,3001,3068,3078,3103,3113,3125,3149,3255,3329,3378,4248],"B":[277,285,291,303,1072,1327,1491,1542,1777,1823,1940,2031,2113,2127,2139,2172,2236,2504,2520,3079,3104,3114,3126,3150,3256,3330,3337,3379,4249],"(Fungizone;":[278],"Bristol-Meyer":[279],"Squibb,":[280],"Princeton,":[281,310],"NJ),":[282],"liposomal":[283,3112],"(AmBisome;":[286],"Fujisawa,":[287],"Deerfield,":[288],"IL),":[289],"colloidal":[292],"suspension":[293],"(ABCD,":[294],"Amphotec;":[296],"Seques,":[297],"Menlo":[298],"Park,":[299],"CA),":[300],"lipid":[304,1040,1487,1936,2109,3130,3146,4245],"complex":[305],"(ABLC,":[306],"Abelcet;":[308],"Liposome,":[309],"NJ).":[311],"Histoplasma":[312,1728,3019,3165],"capsulatum":[313,459,975,2274,2296],"endemic":[315,353],"certain":[317],"areas":[318],"North":[320],"Latin":[322],"America,":[323],"cases":[325,339,1291,1334,1711,2012,3163,3321,3459,4111],"also":[327,1352,2312],"reported":[329,3672],"from":[330,496,581,951,1191,1877,1890,2072,2137,2368,3616,3757,3842],"Europe":[331],"Asia.":[333],"In":[334,1284,1517,1587,1763,2064,2827,3109],"United":[336],"States,":[337],"most":[338,449,634,1274,1518,1668,3051,3653],"occurred":[341,2041],"within":[342,717],"Ohio":[344],"Mississippi":[346],"River":[347],"valleys.":[348],"Precise":[349],"reasons":[350],"distribution":[354],"pattern":[355],"thought":[360],"moderate":[363],"climate,":[364],"humidity,":[365],"soil":[367,380],"characteristics.":[368],"Bird":[369],"bat":[371],"excrement":[372],"enhances":[373],"growth":[375,386],"organism":[378],"by":[381,764,848,988,1354,2473,2692,2881,2937,3106,3401,3903,4010],"accelerating":[382],"sporulation.":[383],"These":[384,3417,3916],"unique":[385],"requirements":[387],"explain,":[388],"part,":[390],"localization":[392],"into":[395,2456,3258],"so-called":[396],"microfoci.":[397],"Activities":[398],"disturb":[400],"sites":[402,430,1684],"associated":[404,841],"exposure":[406,456,466,487,708,793,1246],"H.":[408,458,974,1248,2273,2295,2859,3197],"capsulatum.":[409,1249],"Air":[410],"currents":[411],"carry":[412],"spores":[414],"miles,":[416],"exposing":[417],"individuals":[418,507,2262],"who":[419,893,1064,1163,1226,1408,1562,1594,2028,2047,2078,2096,2216,2245,2492,2509,2572,2579,2594,2600,2700,2714,3098,3179,3244,3474,3588,3762,3837],"were":[420,1875],"unaware":[421],"contact":[423],"contaminated":[426,435],"site.":[427],"Furthermore,":[428],"environmental":[429],"visibly":[434],"droppings":[437],"harbor":[439],"organism,":[441],"making":[442],"it":[443,777,3206,3696],"difficult":[444,3697],"suspect":[446],"cases.":[450,680,4240],"Severity":[451],"illness":[453,837,1265,1655,1920,2469],"after":[454,599,706,899,912,1245,1293,1450,2053,2145,2495,3010,3065,3371,3528,3674,4188],"inhalation":[455],"varies,":[460],"depending":[461],"intensity":[464],"immunity":[469,517],"host.":[472,1031],"Asymptomatic":[473],"mild":[476,2210,2574,3438],"disease":[478,1239,2958],"follows":[479],"low-intensity":[480],"exposures":[481],"healthy":[483],"individuals,":[484],"heavy":[486],"severe":[490,797,1062,1658,1710,1869,1872,1903,1919,2214,2270,2577,3449,3509,3828,3886,4068,4076,4262],"diffuse":[491,787,2888],"Hematogenous":[494],"dissemination":[495,542,1686,4267],"lungs":[498],"tissues":[501],"probably":[502],"occurs":[503,543,1715,3890,4268],"all":[505,1317,1757,3289,3326],"infected":[506],"during":[508,595,736,2280,2818,4230,4250,4263],"first":[510,597,622,738],"2":[511,1132,3333,3363,3565],"weeks":[512,720,746,1133,1454,2564,3783,4003],"before":[515,2414,2900],"specific":[516],"developed,":[519],"majority":[525],"cases,":[527,1719],"which":[528,760,874,979,1472,1639,3133,3204,3682,3794],"leads":[529],"development":[532],"calcified":[534],"granulomas":[535,611],"liver":[538],"and/or":[539,4134],"spleen.":[540],"Progressive":[541,558],"primarily":[544],"those":[546,552,1018,1058,1256,1773,1916,2076,2227,2268,2949,3571,3836,3939],"underlying":[548,566,1237],"disorders":[550],"at":[553,1042,1124,1309,1451,1500,1507,2008,2255,2402,2623,2770,3638],"extremes":[555,1646],"age.":[557],"centrilobular":[567],"emphysema.":[568],"variety":[570,615],"acute":[572,748,832,3711,3896],"appear":[578,1176],"unusual":[582],"inflammatory":[583,1103,3712,3905],"fibrotic":[585,3429,3718],"responses":[586],"infection,":[589,2997],"including":[590,2292],"rheumatologic":[591,4129],"syndromes":[592,3418],"pericarditis":[594,3929,3964,3995,4100],"year":[598,2825],"exposure,":[600],"mediastinal":[603,3424,3513,3581,3598],"inflammation":[604,3421],"fibrosis,":[606],"broncholithiasis,":[607],"enlarging":[609],"parenchymal":[610,2951,3357],"occurring":[612],"later.":[613],"options":[618],"available,":[620],"decision":[624],"must":[625],"made":[627],"treat":[629],"observe,":[632],"recover":[638],"without":[639,1736,2086,2490,3324,3845,3935],"(table":[641,1336,1751,1814,1863,2103,2516,3557],"1).":[642],"Specific":[643],"types":[650,2986],"reviewed":[654],"below":[655],"table":[658],"2.":[659],"Fever,":[660,2902],"chills,":[661],"headache,":[662,2903],"myalgia,":[663],"anorexia,":[664],"cough,":[665,3394],"chest":[667,3392],"pain":[668],"characterize":[669],"form":[671],"seen":[676,1257,2936],"85%\u2013100%":[678],"Patients":[681,785,1152,1235,2445,2599,2748,3243,3630,3761,3927],"pleuritic":[684],"pain.":[685],"findings":[687,1254,1678,3705,3751,3993,4020,4069,4178],"examination":[689],"usually":[691,715,812,2892,4142],"unremarkable,":[692],"except":[693,3284],"fever,":[695],"rales":[699],"pleural":[701],"friction":[702],"rubs.":[703],"course":[705,1087,1208,1497,2545,2955,3644,3690],"low-level":[707],"benign":[710],"immunocompetent":[712,1030,1768],"patients.":[713],"Symptoms":[714,2891,3389],"abate":[716],"few":[719,3443],"onset":[722],"[1].":[723],"Therapy":[724,1958,2453,3516,3972,4158],"helpful":[727,3456,3489,3808,3865],"symptomatic":[729,3590],"whose":[731,2228],"conditions":[732,1644,3374],"improved":[735,2231,3376],"month":[739,901,3091,3556],"Fever":[742,1662],"persisting":[743],">3":[745],"indicate":[751],"disease,":[759,1904],"aborted":[763],"therapy.":[765,2499,2548,3317,3701,3774],"Whether":[766],"antifungal":[767,1186,1747,3231,3316,3604,3658,3675,3700,3773,3936,4210,4274,4292,4302],"hastens":[769],"recovery":[770,810],"prevents":[772,4098],"complications":[773,3511,3829],"unknown,":[775,3022],"never":[779],"studied":[781],"prospective":[783,1879,2038],"trials.":[784],"radiographic":[788,1253,3787,4022],"involvement":[789,1714,2883,2952,3299],"following":[790],"intense":[792],"often":[794,3052,3437,3631,3648,3943],"disease.":[798],"They":[799],"become":[801,2442],"hypoxemic":[802],"even":[804],"require":[805,1065,1232,1412,2101,2219,2514,2582,3384,3944],"ventilatory":[806,1066,1416,2156],"support.":[807],"Without":[808,1262],"treatment,":[809,1263],"slow":[813],"fatal.":[819],"Localized":[820],"indicated":[826,1315,1755],"typical":[829],"because":[835,1076,1414,1425,2736,2853,3029,4212],"minimal":[843],"morbidity":[844],"(EIII;":[845],"see":[846],"article":[847],"Sobel":[849],"[2]":[850],"definitions":[852],"categories":[854],"reflecting":[855,868],"each":[859],"recommendation":[860],"against":[863,2858,3196],"its":[864,943,2738,2855,3139,3216],"use":[865,931,1350,1482,1932,2358,3140,3217],"grades":[867],"based).":[877],"200":[881,952,957,1010,1020,1195,1212,1376,1527,2193,2305,2526,2550,2639,2788,3361,3522,3536,3741,4030],"mg":[882,953,958,1011,1021,1129,1196,1213,1361,1377,1398,1511,1528,1535,1584,1599,1613,1636,1789,1800,1809,1834,1844,1855,1984,2003,2016,2051,2060,2194,2258,2265,2306,2527,2551,2587,2640,2678,2707,2789,2843,3056,3172,3362,3523,3537,3562,3742,4031],"once":[883,959,1022,1197,1214,1378,1529,2195,2307,2641,2680,2844,3524,3538,3743,4032],"daily":[884,955,1013,1023,1130,1217,1381,1585,1600,1637,1835,1856,2017,2198,2259,2266,2529,2554,2561,2644,3541,3563,4035],"6\u201312":[886,1219,3543],"weeks,":[887,1220,3566,3981,4038,4167],"should":[888,990,1053,1201,1504,1579,2184,2239,2253,2392,2425,2434,2604,2618,2654,2695,2751,2765,3174,3500,3583,3819,3855,4204],"considered":[890,3095,3176,3502,3569],"shown":[895,1325],"improvement":[898,3529,3673],"1":[900,985,1037,1285,1294,1484,1553,2824,3472,3801],"observation":[903,1300],"(BIII).":[904,1209,1234,2303,2444,2629,2674,3053,3076,3344,3515,3559,3606,3996,4184],"Blood":[905],"concentrations":[906,983,1439,1573,2375,2397,2416,2613,2649,2760,3117,3153,3229],"itraconazole":[908,940,972,1340,1373,1424,1441,1456,1544,1565,1622,1787,1832,1883,2141,2248,2322,2335,2597,2638,2703,2721,2781,2810,2839],"obtained":[909],"2\u20134":[910,2190],"h":[911],"administration":[913,3253],"dose":[916,950,1044,1578,3044],"could":[917,1121,1221,1557,2143,2328,2709,3517,3567,3797,4039],"monitored":[919,2436,2620,2656,2767],"selected":[921],"situations:":[922],"suspected":[923,2627,2774],"failure,":[925,1705],"concern":[926,4048],"about":[927,1001,1401,1930,2073],"compliance":[928],"absorption,":[930],"medications":[933],"solubility":[938],"accelerate":[942],"metabolism,":[944],"desire":[946],"twice":[954,1012,1199,1216,1380,1531,1988,2197,2309,2528,2560,2643,3526,3540,3745,4034],"daily.":[960,1532],"Although":[961,1302,3434,3652],"\u201ctherapeutic\u201d":[963],"concentration":[964,999,2298],"defined,":[968],"MIC90":[970],".02":[977],"\u00b5g/mL,":[978],"suggests":[980],"serum":[982,2420,2651],"\u00b5g/mL":[986,1003,1016],"measured":[987],"bioassay":[989],"therapeutic.":[992],"Among":[993,1816],"patients,":[995,1347,1519],"median":[997,2820],"plasma":[998],"6":[1002,3319],"receiving":[1006,1019,1633,2602,2749],"dosage":[1008,1126,1468,1476,2183,2252],"\u223c3":[1015],"[3].":[1024],"Diffuse":[1025],"an":[1029,2457,2590,2683,2850,3024],"Amphotericin":[1032,1395,1981,2088,2519,2675,3034,3336,3496,4225],"B,":[1033,1396,1471,1912,1982,2089,2676,2730,3002,3035,3069,3497,4226],"0.7":[1034,1402],"mg/kg/d":[1035,1047,1479,2091,3037,3082],"(or":[1036],"preparations":[1041,1937,4246],"3":[1046,1512,2552,2556,3365],"renal":[1051,1704],"impairment)":[1052],"used":[1055,1074,1203,1223,1559,1602,1882,2176,2241,2330,2711,3050],"initially":[1056],"supportive":[1067],"(AIII).":[1069,1101,4087],"If":[1070,1489,2170,2410,3702],"exclusively":[1075],"cannot":[1079,1563,2246,2595,2701,2715],"treated":[1081,1184,1896,2132,2727,4207],"oral":[1083,2168],"medications,":[1084],"total":[1086,2182,2544,3043],"\u226435":[1089],"mg/kg":[1090,1503,2187,3042],"recommended,":[1092],"situation":[1095],"expected":[1097,3769,3839],"rare":[1100,3960],"response":[1104,1548,2233,2316,2977,3906,4145],"contribute":[1106],"pathogenesis":[1109],"respiratory":[1112,1700],"compromise;":[1113],"thus,":[1114],"corticosteroids":[1115,1139,1165,3465,4050,4086],"helpful,":[1118],"prednisone":[1120],"administered":[1123,1493],"60":[1128],"[4]":[1134],"(CIII).":[1135,3108,3189,3380,3576,3760,3858,3888,4027,4057],"role":[1137,3226],"extensive":[1142],"immunocompromised":[1147,1660,2084,2779],"host":[1148],"less":[1150,1366,1538,1619,1918,2319],"clear.":[1151],"concurrent":[1156],"Pneumocystis":[1160],"carinii":[1161],"pneumonia":[1162],"received":[1164,2029,2048],"conjunction":[1167],"both":[1171],"microbial":[1172],"pathogens":[1173],"did":[1174,3124],"do":[1178,2217,2580,2718,3752],"poorly":[1180],"than":[1181,1370,1540,1621,2321,3123,3194,3428,3715,3911],"only.":[1188],"After":[1189],"discharge":[1190],"hospital,":[1193],"daily,":[1200,1362,1399,1536,2004,2052,2310,2588,2708,2790,3057,3173,3367,3527,3746],"complete":[1205,2541,3039],"12-week":[1207,2459,2543,3737],"Itraconazole":[1210],"alone,":[1211],"sufficiently":[1229,2098,2511],"ill":[1230,2099,2512],"hospitalization":[1233,1413,2102,2515,2536,2583],"lung":[1238],"resemble":[1255],"reactivation":[1259],"tuberculosis":[1260],"[5].":[1261,1301],"progressive,":[1267],"causing":[1268],"loss":[1269,1665],"function":[1272],"death":[1277],"up":[1279,3004],"half":[1281,1906,2074,3006,4109,4125],"[5,":[1282],"6].":[1283],"study,":[1286,2039],"only":[1288,2212,2242,3776,3834,3959],"30%":[1289],"progressed":[1292,1297],"year,":[1295],"79%":[1296],"longer":[1299,2151,2534],"some":[1303,2332,3458,3867],"improve":[1305,1448],"spontaneously,":[1306],"they":[1307,2441,3445],"remain":[1308,3589],"risk":[1310,1650,3073],"recrudescence.":[1312],"Studies":[1323],"effective":[1330,1342,1367,1539,1617,1779,1825,1992,2006,2019,2314],"59%\u2013100%":[1332],"[6\u201314]":[1335],"3).":[1337],"Ketoconazole":[1338,1606,2327],"75%\u201385%":[1344],"case":[1346,3795],"their":[1349],"complicated":[1353],"high":[1355,2830],"relapse":[1356,1973,2040,2284,2384,2628,3009,3075,3245],"rates":[1357,2831],"[11\u201313].":[1358],"Fluconazole,":[1359,1533,2014,2585,2705,3054],"200\u2013400":[1360,1534,2002],"appears":[1363,3899],"(64%":[1368],"response)":[1369],"ketoconazole":[1371,1798,1842],"[14].":[1374,1555],"Itraconazole,":[1375,2001,2192,2549,3190,3535],"12\u201324":[1383],"months,":[1384,2201,3444,3544],"choice":[1389,2206,2569,2636,3209,4237],"(AII).":[1394,1458,2105,2237,2518,2584,2647],"50":[1397,1510,1983,2677],"mg/kg/d,":[1403,3499],"recommended":[1405,2093,2506,2841,3028,3339,3546,3970,3978,4063,4156,4164],"judged":[1410],"insufficiency":[1417],"general":[1419],"debilitation,":[1420],"inability":[1421,1431,1435],"take":[1423,2167,2247,2596,2702],"drug":[1427],"interactions":[1428],"allergies,":[1430],"absorb":[1433,2720],"achieve":[1437,1570,3151],"detectable":[1438,1571,3152],"blood,":[1444],"failure":[1446],"clinically":[1449,2608,2755],"least":[1452,1501,2009,2256,2403],"12":[1453,1837,1858,2563,3782,4037],"Some":[1459,2387],"able":[1464,2165],"tolerate":[1466,2716],"justifies":[1473],"reducing":[1474],"0.5\u20130.6":[1478],"formulations.":[1488],"full":[1496,2179,3182],"therapy,":[1499,2281,2502,2632,3170,3185,3272,3331,3937],"35":[1502,2186,3041],"given":[1506,1985,2188,3087,4041],"doses":[1508],"times":[1513,2553,3366],"weekly,":[1514,1989,2681],"if":[1515,2963,3721,3749],"tolerated.":[1516],"can":[1522,1741,2129,2521],"changed":[1524,3519],"yielded":[1546],"rate":[1549,3729],"64%":[1551],"study":[1554,1589],"Fluconazole":[1556,2238,2847],"receive":[1564],"unable":[1568],"blood":[1572,2153,2300,2617,2764,3120],"increased":[1581],"400\u2013800":[1583,2706],"(BII).":[1586,2249,2338,2598,2704],"had":[1595,3475],"800":[1598,1612,1635,2059,2264,2586,3055,3171],"[15].":[1605,2063,2080,2868],"(200":[1607,2842],"mg,":[1608,1610],"400":[1609,2050,2257],"daily)":[1614,1790,1801,1810,1845,2845],"reasonably":[1616,2313],"well-tolerated":[1620,1998,2320,2689],"fluconazole":[1624,1807,1853,1886,2068,2251,2279,2324,2603,2732,2750,3107,3168,3195],"[12,":[1625,1804,2325],"13].":[1626,2326],"Toxicity":[1627],"dosage,":[1638],"discouraged.":[1641],"Underlying":[1642],"age":[1648],"factors":[1651],"dissemination,":[1653],"individuals.":[1661],"weight":[1664],"symptoms,":[1670],"hepatomegaly":[1672],"splenomegaly":[1674],"physical":[1677,3992,4177],"frequent":[1683],"oropharyngeal":[1689],"gastrointestinal":[1691],"mucosa,":[1692],"skin,":[1694],"adrenal":[1697],"glands.":[1698],"Shock,":[1699],"distress,":[1701],"hepatic":[1702],"coagulopathy":[1707],"complicate":[1709],"[16].":[1712,1944],"CNS":[1713],"5%\u201320%":[1717],"presenting":[1720],"meningitis":[1723,2993,3020,3213,3240,3310],"focal":[1725,2872,2910],"brain":[1726,2873,2944,3122,3302],"lesions.":[1727],"rarely":[1729,3383,3918],"infects":[1730],"spinal":[1732,2875,2946,3304],"cord.":[1733],"mortality":[1735],"80%":[1739],"reduced":[1743,2739],"<25%":[1745],"[6,":[1749,1784],"11\u201322]":[1750],"4).":[1752,1815,1864],"mostly":[1766],"included":[1767],"hosts":[1769,2082,2085],"specifically":[1771],"excluded":[1772,1876],"AIDS,":[1775,1819,3325],"68%\u201392%":[1781],"17,":[1785],"18],":[1786],"(200\u2013400":[1788,1799,1808,1843],"100%":[1792],"(only":[1793,1848],"10":[1794],"studied)":[1796],"[11],":[1797],"56%\u201370%":[1803],"13],":[1805],"86%":[1812],"[14]":[1813],"74%\u201388%":[1827],"[19,":[1830],"20],":[1831],"(400":[1833],"weeks)":[1838,1859],"85%":[1840],"[21],":[1841],"9%":[1847],"11":[1849],"cases)":[1850],"[16],":[1851],"(800":[1854],"74%":[1861],"[15]":[1862,1887],"Of":[1865,1900,3222,3318],"note,":[1866,3223],"moderately":[1871,2213,2576,4075],"[21]":[1884],"retrospective":[1892],"reviews":[1893],"B.":[1899],"nearly":[1905,2043],"died":[1907],"despite":[1908,2998,3181,3246,3600],"98%":[1914],"responded":[1921,3327],"[20].":[1924],"There":[1925,4088,4254],"reports":[1929],"newer":[1935],"Most":[1945,2121,2352],"respond":[1947,2123,3771,3930,4084],"rapidly,":[1950],"fever":[1954],"1\u20132":[1956,4002],"weeks.":[1957,4199],"curative":[1961],"AIDS.":[1965,2087,2373],"Lifelong":[1966],"maintenance":[1967,2020,2476,2631,2664,2743,3169,3248],"needed":[1970],"prevent":[1972,2479],"weekly":[1986],"highly":[1991,2973],"(81%\u201397%)":[1993],"inconvenient":[1995],"[16,":[1999,2379],"23].":[2000],"90%":[2010],"[22].":[2013],"100\u2013400":[2015],"88%":[2023],"induction":[2032,2055,2501,2547],"[24].":[2034],"However,":[2035,3143],"one-third":[2044],"successful":[2054,3354],"day":[2062,3086],"vitro":[2065],"resistance":[2066,2277],"isolates":[2071],"relapsed":[2079,2494,3334],"Immunocompetent":[2081],"0.7\u20131.0":[2090,3498],"2)":[2104,2517],"Experience":[2106,3267],"using":[2107,3268],"formulations":[2110,3131],"histo-plasmosis":[2116],"reported.":[2120],"quickly":[2124],"then":[2130,2471,2559],"itraconazole.":[2134],"transition":[2136],"occur":[2144,4187],"becomes":[2148],"afebrile,":[2149],"requires":[2152,2535],"pressure":[2154],"support":[2157],"iv":[2159,2538,2679],"fluids":[2160],"nutrition,":[2162]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}