{"id":"https://openalex.org/W2122411568","doi":"https://doi.org/10.1152/ajpendo.00101.2009","title":"Brought in by force: AMPK, TBC1D1, and contraction-stimulated glucose transport in skeletal muscle","display_name":"Brought in by force: AMPK, TBC1D1, and contraction-stimulated glucose transport in skeletal muscle","publication_year":2009,"publication_date":"2009-03-03","ids":{"openalex":"https://openalex.org/W2122411568","doi":"https://doi.org/10.1152/ajpendo.00101.2009","mag":"2122411568","pmid":"https://pubmed.ncbi.nlm.nih.gov/19258491"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00101.2009","doi":"https://doi.org/10.1152/ajpendo.00101.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00101.2009","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088487695","display_name":"Philip J. Bilan","orcid":"https://orcid.org/0000-0002-4171-9316","observed_orcids":["https://orcid.org/0000-0002-4171-9316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip J. Bilan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009437708","display_name":"Jonathan D. Schertzer","orcid":"https://orcid.org/0000-0002-1547-5856","observed_orcids":["https://orcid.org/0000-0002-1547-5856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan D. Schertzer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1099,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46073831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"296","issue":"5","first_page":"E965","last_page":"E966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tbc1d1","display_name":"TBC1D1","score":0.996999979019165},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9670000076293945},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.7419999837875366},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.45500001311302185},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.6600000262260437},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6850000023841858},{"id":"https://openalex.org/keywords/muscle-fiber-type","display_name":"muscle fiber type","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8305608630180359},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6278453469276428},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5514456629753113},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.5252681970596313},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.45119166374206543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4489341676235199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42332881689071655},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3925696909427643},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32370322942733765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22869104146957397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1930646002292633},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.16542673110961914},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1597696840763092},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.12100839614868164},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.10313117504119873}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000263","descriptor_name":"Adenylate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpendo.00101.2009","doi":"https://doi.org/10.1152/ajpendo.00101.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00101.2009","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:19258491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19258491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Editorial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.930.7013","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.930.7013","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpendo.physiology.org/content/ajpendo/296/5/E965.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1965133547","https://openalex.org/W2003032553","https://openalex.org/W2017414380","https://openalex.org/W2017931973","https://openalex.org/W2020050304","https://openalex.org/W2031532881","https://openalex.org/W2056000808","https://openalex.org/W2063958537","https://openalex.org/W2090634888","https://openalex.org/W2096012966","https://openalex.org/W2096440265","https://openalex.org/W2113053818","https://openalex.org/W2135704900","https://openalex.org/W2141885300","https://openalex.org/W2150889500","https://openalex.org/W2161532807"],"related_works":["https://openalex.org/W7096172150","https://openalex.org/W2938098774","https://openalex.org/W4213275225","https://openalex.org/W4213449388","https://openalex.org/W7098616065","https://openalex.org/W2131356526","https://openalex.org/W2162834706","https://openalex.org/W2058860541","https://openalex.org/W2056000808","https://openalex.org/W3200836713"],"abstract_inverted_index":{"signaling":[0],"mediator":[1],"described":[2],"to":[3],"regulate":[4],"contraction-stimulated":[5],"glucose":[6,27],"transport":[7,28,50],"in":[8,29,51,107],"skeletal":[9,30,52],"muscle":[10,31,34,53,67,79,94],"(6).":[11],"Thirty":[12],"years":[13],"later,":[14],"the":[15,72,87,93],"discoveries,":[16],"that":[17,33,69,104],"5-AMP-activated":[18],"protein":[19],"kinase":[20],"(AMPK)":[21],"activator":[22],"5-aminoimidazole-4-carboxamide":[23],"1--D-ribofurano-side":[24],"(AICAR)":[25],"stimulated":[26],"and":[32,66,77,85,89,110],"contraction":[35,68],"activated":[36],"AMPK,":[37],"positioned":[38],"this":[39],"cellular":[40],"energy":[41],"sensor":[42],"as":[43],"a":[44,60],"potential":[45],"central":[46],"regulator":[47],"of":[48],"glu-cose":[49],"(5,":[54],"10).":[55],"Subsequent":[56],"research":[57],"has":[58],"unfolded":[59],"complex":[61],"association":[62],"between":[63],"AMPK":[64,82,113],"activation":[65],"depends":[70],"on":[71],"exercise/contrac-tion":[73],"protocol,":[74],"its":[75],"intensity":[76],"duration,":[78],"fiber":[80],"type,":[81],"subunit":[83],"composition,":[84],"even":[86],"strain":[88],"species":[90],"from":[91],"which":[92],"is":[95],"derived":[96],"(2,":[97],"3,":[98],"7,":[99],"13).":[100],"Studies":[101],"have":[102],"suggested":[103],"contraction-induced":[105],"changes":[106],"intracellular":[108],"calcium":[109],"2-containing":[111],"heterotrimeric":[112],"complexes":[114]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}