{"id":"https://openalex.org/W2122392232","doi":"https://doi.org/10.1099/vir.0.023010-0","title":"High levels of HCV core+1 antibodies in HCV patients with hepatocellular carcinoma","display_name":"High levels of HCV core+1 antibodies in HCV patients with hepatocellular carcinoma","publication_year":2011,"publication_date":"2011-02-10","ids":{"openalex":"https://openalex.org/W2122392232","doi":"https://doi.org/10.1099/vir.0.023010-0","mag":"2122392232","pmid":"https://pubmed.ncbi.nlm.nih.gov/21307221"},"language":"en","primary_location":{"id":"doi:10.1099/vir.0.023010-0","doi":"https://doi.org/10.1099/vir.0.023010-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.023010-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108659138","display_name":"Georgia Dalagiorgou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]},{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Dalagiorgou","raw_affiliation_strings":["Democritus University of Thrace Medical School, Alexandroupolis, Greece","Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","1Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","2Democritus University of Thrace Medical School, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Democritus University of Thrace Medical School, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]},{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"1Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"2Democritus University of Thrace Medical School, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044505779","display_name":"Niki Vassilaki","orcid":"https://orcid.org/0000-0001-7992-3438","observed_orcids":["https://orcid.org/0000-0001-7992-3438"]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N. Vassilaki","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020245849","display_name":"Pelagia Foka","orcid":"https://orcid.org/0000-0002-6888-7678","observed_orcids":["https://orcid.org/0000-0002-6888-7678"]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P. Foka","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017072015","display_name":"Anissa Boumlic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR","GR"],"is_corresponding":false,"raw_author_name":"A. Boumlic","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","University of Strasbourg-CNRS FRE 3211, Oncoprotein group, IREBS, Illkirch, France","1Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","3University of Strasbourg-CNRS FRE 3211, Oncoprotein group, IREBS, Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"University of Strasbourg-CNRS FRE 3211, Oncoprotein group, IREBS, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I68947357"]},{"raw_affiliation_string":"1Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"3University of Strasbourg-CNRS FRE 3211, Oncoprotein group, IREBS, Illkirch, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113741702","display_name":"Athanassios Kakkanas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Kakkanas","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090904295","display_name":"Emmanouil Kochlios","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Kochlios","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008709442","display_name":"Shirin Khalili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S. Khalili","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022517231","display_name":"E. Aslanoglou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Aslanoglou","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010908007","display_name":"Stavroula Vouliana Veletza","orcid":"https://orcid.org/0000-0002-5723-5973","observed_orcids":["https://orcid.org/0000-0002-5723-5973"]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S. Veletza","raw_affiliation_strings":["Democritus University of Thrace Medical School, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Democritus University of Thrace Medical School, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086480146","display_name":"Georges Orfanoudakis","orcid":"https://orcid.org/0000-0002-0064-1305","observed_orcids":["https://orcid.org/0000-0002-0064-1305"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Orfanoudakis","raw_affiliation_strings":["University of Strasbourg-CNRS FRE 3211, Oncoprotein group, IREBS, Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Strasbourg-CNRS FRE 3211, Oncoprotein group, IREBS, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071905620","display_name":"Dimitrios Vassilopoulos","orcid":"https://orcid.org/0000-0003-2288-3863","observed_orcids":["https://orcid.org/0000-0003-2288-3863"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Vassilopoulos","raw_affiliation_strings":["Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109386158","display_name":"Stephanos J. Hadziyannis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153759","display_name":"Henry Dunant Hospital","ror":"https://ror.org/05n7t4h40","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210153759"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S. J. Hadziyannis","raw_affiliation_strings":["Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Hepatology, Henry Dunant Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210153759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083845265","display_name":"John S. Koskinas","orcid":"https://orcid.org/0000-0003-4375-4454","observed_orcids":["https://orcid.org/0000-0003-4375-4454"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"J. Koskinas","raw_affiliation_strings":["Second Department of Internal Medicine, Medical School of Athens, Hippokration General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Medical School of Athens, Hippokration General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059174311","display_name":"Penelope Mavromara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P. Mavromara","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8239,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86134969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"92","issue":"6","first_page":"1343","last_page":"1351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8529999852180481},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hcv-core-protein","display_name":"HCV core protein","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hcv-genotype-1a","display_name":"HCV genotype 1a","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hcv-genotype-1b","display_name":"HCV genotype 1b","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hcv-pathogenesis","display_name":"HCV pathogenesis","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7774015665054321},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.7534974813461304},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7482302784919739},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6961443424224854},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5646555423736572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.556744396686554},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5399181842803955},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4814152717590332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44265368580818176},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.42462635040283203},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.411325603723526},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13514330983161926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12168273329734802},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014758","descriptor_name":"Viral Core Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014758","descriptor_name":"Viral Core Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018937","descriptor_name":"Hepatitis C Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018937","descriptor_name":"Hepatitis C Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1099/vir.0.023010-0","doi":"https://doi.org/10.1099/vir.0.023010-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.023010-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:21307221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21307221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W72674982","https://openalex.org/W1580487003","https://openalex.org/W1593744374","https://openalex.org/W1636820287","https://openalex.org/W1969728880","https://openalex.org/W1973417881","https://openalex.org/W1976341528","https://openalex.org/W1982770627","https://openalex.org/W1987731017","https://openalex.org/W1989182531","https://openalex.org/W1997677874","https://openalex.org/W2011221934","https://openalex.org/W2012033859","https://openalex.org/W2015336471","https://openalex.org/W2021199098","https://openalex.org/W2021678525","https://openalex.org/W2023367724","https://openalex.org/W2023492746","https://openalex.org/W2026466058","https://openalex.org/W2029834382","https://openalex.org/W2032043574","https://openalex.org/W2032730113","https://openalex.org/W2033651440","https://openalex.org/W2039422277","https://openalex.org/W2041557163","https://openalex.org/W2052196168","https://openalex.org/W2054886492","https://openalex.org/W2057386135","https://openalex.org/W2059532520","https://openalex.org/W2066116844","https://openalex.org/W2072184294","https://openalex.org/W2074229472","https://openalex.org/W2077103006","https://openalex.org/W2080449573","https://openalex.org/W2089829321","https://openalex.org/W2106129349","https://openalex.org/W2106132583","https://openalex.org/W2109048688","https://openalex.org/W2119010298","https://openalex.org/W2138209618","https://openalex.org/W2149781618","https://openalex.org/W2152464639","https://openalex.org/W2158803332","https://openalex.org/W4239108047"],"related_works":["https://openalex.org/W2736157459","https://openalex.org/W2054886492","https://openalex.org/W2223346954","https://openalex.org/W2883840080","https://openalex.org/W1999602906","https://openalex.org/W7216844424","https://openalex.org/W4289529226","https://openalex.org/W2052196168","https://openalex.org/W4214487875","https://openalex.org/W2587360473"],"abstract_inverted_index":{"The":[0,33],"core":[1],"region":[2],"of":[3,36,53,81,93,141,151,176,191,208,217,223,236],"the":[4,24,59,79,82,91,149,177,192,195,209,214,221,230,234],"hepatitis":[5],"C":[6],"virus":[7,48],"(HCV)":[8],"genome":[9],"possesses":[10],"an":[11,144],"overlapping":[12],"ORF":[13],"that":[14,58],"has":[15],"been":[16],"shown":[17,57],"to":[18,44],"encode":[19],"a":[20,51,132,227],"protein,":[21],"known":[22],"as":[23,41,129,131],"alternate":[25],"reading":[26],"frame":[27],"protein":[28,38,61,138,232],"(ARFP),":[29],"F":[30],"or":[31],"core+1.":[32],"biological":[34],"role":[35,228],"this":[37],"remains":[39],"elusive,":[40],"it":[42],"appears":[43],"be":[45],"non-essential":[46],"for":[47,120,229],"replication.":[49],"However,":[50],"number":[52],"independent":[54],"studies":[55],"have":[56],"ARFP/F/core+1":[60,231],"elicits":[62],"humoral":[63,84],"and":[64,71,125,168],"cellular":[65,75],"immune":[66],"responses":[67],"in":[68,86,96,104,154,159,206,220,233],"HCV-infected":[69,87,108,164,197],"individuals":[70,109,198],"interacts":[72],"with":[73,100,106,157,161,184],"important":[74],"proteins.":[76],"To":[77],"assess":[78],"significance":[80],"core+1":[83,116,152,186],"response":[85],"patients,":[88],"we":[89,147],"examined":[90],"prevalence":[92,150],"anti-core+1":[94,218],"antibodies":[95,153,219],"sera":[97,193],"from":[98,180,194],"patients":[99,156,165,182,225],"hepatocellular":[101],"carcinoma":[102],"(HCC)":[103],"comparison":[105,160],"chronically":[107,163],"without":[110,166],"HCC.":[111,237],"We":[112],"produced":[113],"two":[114],"HCV":[115],"histidine-tagged":[117],"recombinant":[118,136],"proteins":[119],"genotypes":[121],"1a":[122],"(aa":[123,127,139],"11-160)":[124],"1b":[126],"11-144),":[128],"well":[130],"non-tagged":[133],"highly":[134],"purified":[135],"core+1/S":[137],"85-144)":[140],"HCV-1b.":[142],"Using":[143],"in-house":[145],"ELISA,":[146],"tested":[148,199],"45":[155],"HCC":[158,167,181,224],"47":[162],"77":[169],"negative-control":[170],"sera.":[171],"More":[172],"than":[173],"50":[174],"%":[175,190],"serum":[178,222],"samples":[179],"reacted":[183],"all":[185],"antigens,":[187],"whereas":[188],"<26":[189],"non-HCC":[196],"positive.":[200],"No":[201],"core+1-specific":[202],"reactivity":[203],"was":[204],"detected":[205],"any":[207],"control":[210],"samples.":[211],"In":[212],"conclusion,":[213],"high":[215],"occurrence":[216],"suggests":[226],"pathogenesis":[235]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}