{"id":"https://openalex.org/W2122377005","doi":null,"title":"Role of the thymus and T-cells in slow growth of B16 melanoma in old mice.","display_name":"Role of the thymus and T-cells in slow growth of B16 melanoma in old mice.","publication_year":1987,"publication_date":"1987-06-15","ids":{"openalex":"https://openalex.org/W2122377005","mag":"2122377005","pmid":"https://pubmed.ncbi.nlm.nih.gov/3495326"},"language":"en","primary_location":{"id":"pmid:3495326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3495326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071441044","display_name":"Tadaaki Tsuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tsuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085844439","display_name":"Young Tai Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y T Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044207557","display_name":"Gregory W. Siskind","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G W Siskind","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112232317","display_name":"A DeBlasio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A DeBlasio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110273326","display_name":"Rise Schwab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Schwab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005027884","display_name":"William B. Ershler","orcid":"https://orcid.org/0000-0001-8160-7661","observed_orcids":["https://orcid.org/0000-0001-8160-7661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Ershler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110109803","display_name":"Marc E. Weksler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Weksler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.317,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.81702418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"47","issue":"12","first_page":"3097","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-growth-rate","display_name":"tumor growth rate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9639999866485596},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7419999837875366},{"id":"https://openalex.org/keywords/thymectomy","display_name":"thymectomy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antithymocyte-serum","display_name":"antithymocyte serum","score":0.7049999833106995},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.847000002861023},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7599999904632568},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6567044854164124},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6390801072120667},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.5478852987289429},{"id":"https://openalex.org/C2780635560","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplasm","level":2,"score":0.48894181847572327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4425256848335266},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.41535964608192444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3983493149280548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3668466806411743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30504435300827026},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28941839933395386},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28825104236602783},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11171245574951172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3495326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3495326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2122377005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3495326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W155962202","https://openalex.org/W1556941182","https://openalex.org/W1963788239","https://openalex.org/W1965384251","https://openalex.org/W1968746678","https://openalex.org/W1969036594","https://openalex.org/W1994706890","https://openalex.org/W2011260171","https://openalex.org/W2030183133","https://openalex.org/W2034713890","https://openalex.org/W2041216256","https://openalex.org/W2058833328","https://openalex.org/W2064124677","https://openalex.org/W2102916120","https://openalex.org/W2103781389","https://openalex.org/W2105556027","https://openalex.org/W2328559169","https://openalex.org/W2336352690","https://openalex.org/W2402784056","https://openalex.org/W2408977915"],"related_works":["https://openalex.org/W2419537858","https://openalex.org/W7096730680","https://openalex.org/W2078415950","https://openalex.org/W2336352690","https://openalex.org/W2129115996","https://openalex.org/W2416819172","https://openalex.org/W2022169103","https://openalex.org/W1997783564","https://openalex.org/W2115181851","https://openalex.org/W4415604198"],"abstract_inverted_index":{"Clinical":[0],"observations":[1],"suggest":[2],"that":[3,176],"tumors":[4,163],"grow":[5],"more":[6,42],"slowly":[7,43],"in":[8,44,62,87,121,134],"aged":[9],"subjects.":[10],"To":[11],"investigate":[12],"the":[13,22,63,66,88,106,115,131,182],"influence":[14],"of":[15,25,33,74,90,108,118,170,184],"age":[16],"on":[17],"tumor":[18,109,135,186],"growth,":[19],"we":[20],"injected":[21],"same":[23],"number":[24,64],"cultured":[26],"B16":[27,36,161,185],"melanoma":[28,37,119,162],"cells":[29,120,142],"into":[30],"C57BL/6":[31],"mice":[32,56,97,147,157],"various":[34],"ages.":[35],"cells,":[38],"inoculated":[39],"s.c.,":[40],"grew":[41],"old":[45,80,93,144],"(18-20-month-old)":[46],"as":[47,77],"compared":[48,78],"to":[49,69,79,98,148],"young":[50,54,95,128,146,154],"(6-8-week-old)":[51],"mice.":[52,129],"In":[53],"tumor-bearing":[55,81,96],"there":[57],"was":[58,84,111],"a":[59],"significant":[60],"increase":[61],"and":[65,71,94,105,125,150,167],"proliferative":[67,168],"response":[68,89],"phytohemagglutinin":[70],"concanavalin":[72],"A":[73],"splenic":[75],"T-cells":[76,104,177],"animals.":[82,155],"There":[83],"no":[85],"difference":[86,133],"B-lymphocytes":[91],"from":[92,143],"lipopolysaccharide.":[99],"The":[100],"positive":[101],"association":[102],"between":[103],"rate":[107],"growth":[110,117,136,183],"also":[112],"suggested":[113],"by":[114,140],"slower":[116],"thymectomized":[122,124,149],"or":[123,145,178],"anti-theta":[126],"antiserum-treated":[127],"Finally,":[130],"age-associated":[132],"could":[137],"be":[138],"transferred":[139],"spleen":[141],"lethally":[151],"irradiated":[152],"syngeneic":[153],"Young":[156],"with":[158],"rapidly":[159],"growing":[160],"have":[164],"increased":[165],"numbers":[166],"responses":[169],"thymic-derived":[171],"lymphocytes.":[172],"It":[173],"is":[174],"likely":[175],"their":[179],"products":[180],"facilitate":[181],"cells.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
