{"id":"https://openalex.org/W2122372853","doi":"https://doi.org/10.1146/annurev-neuro-071714-033835","title":"Neuronal and Vascular Interactions","display_name":"Neuronal and Vascular Interactions","publication_year":2015,"publication_date":"2015-03-17","ids":{"openalex":"https://openalex.org/W2122372853","doi":"https://doi.org/10.1146/annurev-neuro-071714-033835","mag":"2122372853","pmid":"https://pubmed.ncbi.nlm.nih.gov/25782970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5729758"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-neuro-071714-033835","doi":"https://doi.org/10.1146/annurev-neuro-071714-033835","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-neuro-071714-033835","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-neuro-071714-033835","source":{"id":"https://openalex.org/S131371711","display_name":"Annual Review of Neuroscience","issn_l":"0147-006X","issn":["0147-006X","1545-4126"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-neuro-071714-033835","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012853997","display_name":"Benjamin J. Andreone","orcid":"https://orcid.org/0009-0000-7009-4127","observed_orcids":["https://orcid.org/0009-0000-7009-4127"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J. Andreone","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115;, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115;, ,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058142112","display_name":"Baptiste Lacoste","orcid":"https://orcid.org/0000-0002-1922-8801","observed_orcids":["https://orcid.org/0000-0002-1922-8801"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baptiste Lacoste","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115;, ,","email: bandreone@fas.harvard.edu , Baptiste_Lacoste@hms.harvard.edu , Chenghua_Gu@hms.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115;, ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"email: bandreone@fas.harvard.edu , Baptiste_Lacoste@hms.harvard.edu , Chenghua_Gu@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028273617","display_name":"Chenghua Gu","orcid":"https://orcid.org/0000-0002-4212-7232","observed_orcids":["https://orcid.org/0000-0002-4212-7232","https://orcid.org/0000-0003-4465-9125"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chenghua Gu","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115;, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115;, ,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028273617"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":1.2307,"has_fulltext":true,"cited_by_count":268,"citation_normalized_percentile":{"value":0.78297162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"38","issue":"1","first_page":"25","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-perfusion","display_name":"cerebral perfusion","score":0.6779999732971191},{"id":"https://openalex.org/keywords/cerebral-autoregulation","display_name":"cerebral autoregulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9470000267028809},{"id":"https://openalex.org/keywords/brain-vascularization","display_name":"brain vascularization","score":0.5429999828338623},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.6949999928474426},{"id":"https://openalex.org/keywords/brain-homeostasis","display_name":"brain homeostasis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neurovascular-coupling","display_name":"neurovascular coupling","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7351478338241577},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5683943033218384},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5474562644958496},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5194527506828308},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.5111382603645325},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5105451345443726},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4984126091003418},{"id":"https://openalex.org/C2993270971","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Blood supply","level":2,"score":0.4418376386165619},{"id":"https://openalex.org/C3018998897","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Neuronal circuits","level":2,"score":0.43134137988090515},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.4293667674064636},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4167044162750244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3862415552139282},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3831263780593872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2284616231918335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14418545365333557},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.13484254479408264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12593978643417358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12517470121383667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07794806361198425},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev-neuro-071714-033835","doi":"https://doi.org/10.1146/annurev-neuro-071714-033835","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-neuro-071714-033835","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-neuro-071714-033835","source":{"id":"https://openalex.org/S131371711","display_name":"Annual Review of Neuroscience","issn_l":"0147-006X","issn":["0147-006X","1545-4126"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Neuroscience","raw_type":"journal-article"},{"id":"pmid:25782970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25782970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5729758","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5729758/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1146/annurev-neuro-071714-033835","doi":"https://doi.org/10.1146/annurev-neuro-071714-033835","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-neuro-071714-033835","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-neuro-071714-033835","source":{"id":"https://openalex.org/S131371711","display_name":"Annual Review of Neuroscience","issn_l":"0147-006X","issn":["0147-006X","1545-4126"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3070845776","display_name":"The Role of Semaphorins in Axon and Blood Vessel Guidance","funder_award_id":"R01NS064583","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4646225624","display_name":"New tools for understanding the blood brain barrier","funder_award_id":"DP1NS092473","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122372853.pdf","grobid_xml":"https://content.openalex.org/works/W2122372853.grobid-xml"},"referenced_works_count":154,"referenced_works":["https://openalex.org/W99869719","https://openalex.org/W230768509","https://openalex.org/W768077658","https://openalex.org/W1578782149","https://openalex.org/W1618901679","https://openalex.org/W1731074416","https://openalex.org/W1774266184","https://openalex.org/W1963806203","https://openalex.org/W1964030001","https://openalex.org/W1964544654","https://openalex.org/W1964710036","https://openalex.org/W1967076681","https://openalex.org/W1967291020","https://openalex.org/W1968060691","https://openalex.org/W1969049738","https://openalex.org/W1969449517","https://openalex.org/W1970649851","https://openalex.org/W1972681874","https://openalex.org/W1973418567","https://openalex.org/W1973544766","https://openalex.org/W1973763077","https://openalex.org/W1975857820","https://openalex.org/W1976980661","https://openalex.org/W1977311786","https://openalex.org/W1977940746","https://openalex.org/W1979240985","https://openalex.org/W1980372225","https://openalex.org/W1980783002","https://openalex.org/W1983924090","https://openalex.org/W1985474890","https://openalex.org/W1986546035","https://openalex.org/W1986622894","https://openalex.org/W1986638713","https://openalex.org/W1986873897","https://openalex.org/W1992112653","https://openalex.org/W1992758695","https://openalex.org/W1995037165","https://openalex.org/W1995162194","https://openalex.org/W1996719014","https://openalex.org/W1997423718","https://openalex.org/W2000166086","https://openalex.org/W2001552996","https://openalex.org/W2001726213","https://openalex.org/W2002555098","https://openalex.org/W2004193154","https://openalex.org/W2005215351","https://openalex.org/W2005447528","https://openalex.org/W2005613270","https://openalex.org/W2007834433","https://openalex.org/W2009755276","https://openalex.org/W2010560308","https://openalex.org/W2010856791","https://openalex.org/W2013517841","https://openalex.org/W2014932510","https://openalex.org/W2015551920","https://openalex.org/W2016724180","https://openalex.org/W2017193637","https://openalex.org/W2017912617","https://openalex.org/W2018039955","https://openalex.org/W2022533974","https://openalex.org/W2025061302","https://openalex.org/W2025113219","https://openalex.org/W2025738693","https://openalex.org/W2026449998","https://openalex.org/W2028383367","https://openalex.org/W2032112615","https://openalex.org/W2033261072","https://openalex.org/W2035799281","https://openalex.org/W2039857463","https://openalex.org/W2040490831","https://openalex.org/W2042422091","https://openalex.org/W2042698075","https://openalex.org/W2042883482","https://openalex.org/W2045242267","https://openalex.org/W2045312970","https://openalex.org/W2045482803","https://openalex.org/W2046390311","https://openalex.org/W2050442786","https://openalex.org/W2050589760","https://openalex.org/W2051256781","https://openalex.org/W2052837799","https://openalex.org/W2054868504","https://openalex.org/W2056856515","https://openalex.org/W2060319077","https://openalex.org/W2063659485","https://openalex.org/W2066349780","https://openalex.org/W2068083739","https://openalex.org/W2068400560","https://openalex.org/W2069660393","https://openalex.org/W2069929255","https://openalex.org/W2071901025","https://openalex.org/W2073216243","https://openalex.org/W2074782193","https://openalex.org/W2075143031","https://openalex.org/W2075556735","https://openalex.org/W2077673959","https://openalex.org/W2078261317","https://openalex.org/W2078381356","https://openalex.org/W2078434398","https://openalex.org/W2080828131","https://openalex.org/W2081119206","https://openalex.org/W2085467935","https://openalex.org/W2087666006","https://openalex.org/W2088374090","https://openalex.org/W2091805482","https://openalex.org/W2092474731","https://openalex.org/W2092616115","https://openalex.org/W2092641793","https://openalex.org/W2094567624","https://openalex.org/W2100276489","https://openalex.org/W2107325549","https://openalex.org/W2109290881","https://openalex.org/W2109699895","https://openalex.org/W2112219075","https://openalex.org/W2112917637","https://openalex.org/W2115390024","https://openalex.org/W2121903406","https://openalex.org/W2122670147","https://openalex.org/W2124248841","https://openalex.org/W2126552458","https://openalex.org/W2126858639","https://openalex.org/W2127482795","https://openalex.org/W2128264853","https://openalex.org/W2128854308","https://openalex.org/W2130962254","https://openalex.org/W2135202732","https://openalex.org/W2135780113","https://openalex.org/W2139123746","https://openalex.org/W2140430230","https://openalex.org/W2141659416","https://openalex.org/W2144232916","https://openalex.org/W2144914358","https://openalex.org/W2148992136","https://openalex.org/W2151759589","https://openalex.org/W2152353759","https://openalex.org/W2160381201","https://openalex.org/W2162273085","https://openalex.org/W2162676548","https://openalex.org/W2163234334","https://openalex.org/W2164996701","https://openalex.org/W2167462712","https://openalex.org/W2168468808","https://openalex.org/W2169118010","https://openalex.org/W2169199162","https://openalex.org/W2169800968","https://openalex.org/W2171420142","https://openalex.org/W2273487096","https://openalex.org/W2333281281","https://openalex.org/W2345266925","https://openalex.org/W2412552578","https://openalex.org/W2571918371","https://openalex.org/W2897462549","https://openalex.org/W2912349604","https://openalex.org/W3036895338"],"related_works":["https://openalex.org/W4245236458","https://openalex.org/W4378649436","https://openalex.org/W3037018226","https://openalex.org/W4388247219","https://openalex.org/W4245760333","https://openalex.org/W3038979473","https://openalex.org/W4416914071","https://openalex.org/W4411924575","https://openalex.org/W2797977233","https://openalex.org/W2046388629"],"abstract_inverted_index":{"The":[0],"brain,":[1],"which":[2],"represents":[3],"2%":[4],"of":[5,11,39,72,106,117,128],"body":[6,12],"mass":[7],"but":[8],"consumes":[9],"20%":[10],"energy":[13,22,135],"at":[14],"rest,":[15],"has":[16],"a":[17,67],"limited":[18],"capacity":[19],"to":[20,60,76,109,121,132,137],"store":[21],"and":[23,30,50,74,85,102,113,125],"is":[24],"therefore":[25],"highly":[26],"dependent":[27],"on":[28,44,93],"oxygen":[29],"glucose":[31],"supply":[32,136],"from":[33],"the":[34,57,78,104,115,118,126],"blood":[35,51,112,130],"stream.":[36],"Normal":[37],"functioning":[38],"neural":[40,138],"circuits":[41],"thus":[42],"relies":[43],"adequate":[45],"matching":[46],"between":[47],"metabolic":[48],"needs":[49],"supply.":[52],"Moreover,":[53],"not":[54],"only":[55],"does":[56],"brain":[58,100,123],"need":[59],"be":[61],"densely":[62],"vascularized,":[63],"it":[64],"also":[65],"requires":[66],"tightly":[68],"controlled":[69],"environment":[70],"free":[71],"toxins":[73],"pathogens":[75],"provide":[77],"proper":[79],"chemical":[80],"composition":[81],"for":[82],"synaptic":[83],"transmission":[84],"neuronal":[86],"function.":[87,139],"In":[88],"this":[89],"review,":[90],"we":[91],"focus":[92],"three":[94],"major":[95],"factors":[96],"that":[97],"ensure":[98],"optimal":[99],"perfusion":[101],"function:":[103],"patterning":[105],"vascular":[107],"networks":[108],"efficiently":[110],"deliver":[111],"nutrients,":[114],"function":[116],"blood-brain":[119],"barrier":[120],"maintain":[122],"homeostasis,":[124],"regulation":[127],"cerebral":[129],"flow":[131],"adequately":[133],"couple":[134]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":40},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
