{"id":"https://openalex.org/W2122294534","doi":"https://doi.org/10.1016/j.theriogenology.2003.08.001","title":"The effect of follicle-stimulating hormone on follicular development, granulosa cell apoptosis and steroidogenesis and its mediation by insulin-like growth factor-I in the goat ovary","display_name":"The effect of follicle-stimulating hormone on follicular development, granulosa cell apoptosis and steroidogenesis and its mediation by insulin-like growth factor-I in the goat ovary","publication_year":2003,"publication_date":"2003-10-14","ids":{"openalex":"https://openalex.org/W2122294534","doi":"https://doi.org/10.1016/j.theriogenology.2003.08.001","mag":"2122294534","pmid":"https://pubmed.ncbi.nlm.nih.gov/14580651"},"language":"en","primary_location":{"id":"doi:10.1016/j.theriogenology.2003.08.001","doi":"https://doi.org/10.1016/j.theriogenology.2003.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2003.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045927996","display_name":"Yuansong Yu","orcid":"https://orcid.org/0000-0002-0382-8298","observed_orcids":["https://orcid.org/0000-0002-0382-8298"]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuansong Yu","raw_affiliation_strings":["College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318238","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-6235-0749","observed_orcids":["https://orcid.org/0000-0002-6235-0749"]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029050133","display_name":"Zheng\u2010Bin Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengbin Han","raw_affiliation_strings":["College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085277740","display_name":"Ming\u2010Jiu Luo","orcid":"https://orcid.org/0000-0003-0460-8358","observed_orcids":["https://orcid.org/0000-0003-0460-8358"]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingjiu Luo","raw_affiliation_strings":["College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108356110","display_name":"Zhongle Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongle Chang","raw_affiliation_strings":["College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000223104","display_name":"Jing\u2010He Tan","orcid":"https://orcid.org/0000-0001-6437-6259","observed_orcids":["https://orcid.org/0000-0001-6437-6259"]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinghe Tan","raw_affiliation_strings":["College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai-an City 271018, PR China","institution_ids":["https://openalex.org/I74485261"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000223104"],"corresponding_institution_ids":["https://openalex.org/I74485261"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":4.5466,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.93346602,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"60","issue":"9","first_page":"1691","last_page":"1704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/goat-ovary","display_name":"goat ovary","score":0.8479999899864197},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/granulosa-cell-apoptosis","display_name":"granulosa cell apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9589999914169312},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9800000190734863},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8299999833106995},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/follicular-fluid","display_name":"follicular fluid","score":0.7459999918937683},{"id":"https://openalex.org/keywords/igf-i-mrna-expression","display_name":"IGF-I mRNA expression","score":0.6909999847412109},{"id":"https://openalex.org/keywords/follicle-count","display_name":"follicle count","score":0.4860000014305115},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.6449999809265137},{"id":"https://openalex.org/keywords/ovarian-follicles","display_name":"ovarian follicles","score":0.36399999260902405},{"id":"https://openalex.org/keywords/estradiol-progesterone-ratio","display_name":"estradiol/progesterone ratio","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7451412677764893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7394698262214661},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.7027711272239685},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.6436084508895874},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.6318255066871643},{"id":"https://openalex.org/C2776188440","wikidata":"https://www.wikidata.org/wiki/Q3746826","display_name":"Follicular fluid","level":4,"score":0.6274796724319458},{"id":"https://openalex.org/C2777203538","wikidata":"https://www.wikidata.org/wiki/Q1543282","display_name":"Granulosa cell","level":3,"score":0.6090628504753113},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.5886623859405518},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.555484414100647},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.5348111391067505},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4941563904285431},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4630890190601349},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.43673112988471985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4162137508392334},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.41495558619499207},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4096965193748474},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39827707409858704},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.38146841526031494},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3558802604675293},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22924107313156128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15988829731941223},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.13858211040496826},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.13349094986915588},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09474372863769531},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.040631890296936035},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.theriogenology.2003.08.001","doi":"https://doi.org/10.1016/j.theriogenology.2003.08.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.theriogenology.2003.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S43044067","display_name":"Theriogenology","issn_l":"0093-691X","issn":["0093-691X","1879-3231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"journal-article"},{"id":"pmid:14580651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14580651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theriogenology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1269873","https://openalex.org/W6216114","https://openalex.org/W178183906","https://openalex.org/W1964203795","https://openalex.org/W1966609633","https://openalex.org/W1966998304","https://openalex.org/W1974832873","https://openalex.org/W2010973426","https://openalex.org/W2014514472","https://openalex.org/W2015485462","https://openalex.org/W2016010155","https://openalex.org/W2019621385","https://openalex.org/W2024707038","https://openalex.org/W2035414103","https://openalex.org/W2037242585","https://openalex.org/W2043747649","https://openalex.org/W2061702838","https://openalex.org/W2062564846","https://openalex.org/W2064298474","https://openalex.org/W2070466664","https://openalex.org/W2081041798","https://openalex.org/W2083011227","https://openalex.org/W2087209804","https://openalex.org/W2088951219","https://openalex.org/W2095126398","https://openalex.org/W2099014342","https://openalex.org/W2108446310","https://openalex.org/W2115561646","https://openalex.org/W2117887814","https://openalex.org/W2119427617","https://openalex.org/W2121852257","https://openalex.org/W2139499838","https://openalex.org/W2143713069","https://openalex.org/W2152430865","https://openalex.org/W2154688395","https://openalex.org/W2166329690","https://openalex.org/W2170773973","https://openalex.org/W2325420349","https://openalex.org/W2416718464","https://openalex.org/W2418759574"],"related_works":["https://openalex.org/W1976112070","https://openalex.org/W2064530455","https://openalex.org/W4303648099","https://openalex.org/W2156828451","https://openalex.org/W2289399243","https://openalex.org/W2093860696","https://openalex.org/W2062564846","https://openalex.org/W2029288463","https://openalex.org/W2115561646","https://openalex.org/W2062644214"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}