{"id":"https://openalex.org/W2122208971","doi":"https://doi.org/10.1093/toxsci/kfl175","title":"PI3K, RSK, and mTOR Signal Networks for the GST Gene Regulation","display_name":"PI3K, RSK, and mTOR Signal Networks for the GST Gene Regulation","publication_year":2006,"publication_date":"2006-10-31","ids":{"openalex":"https://openalex.org/W2122208971","doi":"https://doi.org/10.1093/toxsci/kfl175","mag":"2122208971","pmid":"https://pubmed.ncbi.nlm.nih.gov/17122411"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfl175","doi":"https://doi.org/10.1093/toxsci/kfl175","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxsci/kfl175","pdf_url":null,"source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109151051","display_name":"Sang Geon Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. G. Kim","raw_affiliation_strings":["College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, South Korea. sgk@snu.ac.kr","College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151\u2010742, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, South Korea. sgk@snu.ac.kr","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151\u2010742, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101399063","display_name":"Seho Lee","orcid":"https://orcid.org/0000-0001-7415-8191","observed_orcids":["https://orcid.org/0000-0001-7415-8191"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. J. Lee","raw_affiliation_strings":["College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151\u2010742, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151\u2010742, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":0.898,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.66420798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"2","first_page":"206","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/rsk1","display_name":"RSK1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9290000200271606},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.6549999713897705},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.8360000252723694},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytoprotective-agents","display_name":"cytoprotective agents","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pro-oxidants","display_name":"pro-oxidants","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8149999976158142},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7776209115982056},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6359120607376099},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6255191564559937},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5721294283866882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5245466828346252},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5092085599899292},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5071539878845215},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.46783486008644104},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4672887921333313},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.46279382705688477},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.440616637468338},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3343251347541809},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17295986413955688},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019893","descriptor_name":"Ribosomal Protein S6 Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/toxsci/kfl175","doi":"https://doi.org/10.1093/toxsci/kfl175","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxsci/kfl175","pdf_url":null,"source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmid:17122411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17122411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.526.1606","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.526.1606","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://toxsci.oxfordjournals.org/content/96/2/206.full.pdf","raw_type":"text"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/23590","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10371/23590","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1538140157","https://openalex.org/W1561096292","https://openalex.org/W1927958267","https://openalex.org/W1969783942","https://openalex.org/W1971396843","https://openalex.org/W1975067622","https://openalex.org/W1979761686","https://openalex.org/W1980870419","https://openalex.org/W1998128080","https://openalex.org/W1999148207","https://openalex.org/W2005994488","https://openalex.org/W2006923351","https://openalex.org/W2025679749","https://openalex.org/W2026377273","https://openalex.org/W2029022033","https://openalex.org/W2035681090","https://openalex.org/W2036147144","https://openalex.org/W2042126195","https://openalex.org/W2048654549","https://openalex.org/W2052548231","https://openalex.org/W2053063855","https://openalex.org/W2056735841","https://openalex.org/W2065652048","https://openalex.org/W2065661936","https://openalex.org/W2066309898","https://openalex.org/W2074033963","https://openalex.org/W2076613821","https://openalex.org/W2080435498","https://openalex.org/W2081712663","https://openalex.org/W2083287953","https://openalex.org/W2092449641","https://openalex.org/W2098571122","https://openalex.org/W2119347606","https://openalex.org/W2124174146","https://openalex.org/W2124524961","https://openalex.org/W2125378729","https://openalex.org/W2125762200","https://openalex.org/W2126513833","https://openalex.org/W2128489339","https://openalex.org/W2134757689","https://openalex.org/W2135718970","https://openalex.org/W2146283444","https://openalex.org/W2148454550","https://openalex.org/W2150301412","https://openalex.org/W2159820690","https://openalex.org/W2163615146","https://openalex.org/W2165643859","https://openalex.org/W2166593442","https://openalex.org/W2169052484","https://openalex.org/W2169980814","https://openalex.org/W2186542461","https://openalex.org/W2295706507","https://openalex.org/W2346380588","https://openalex.org/W2413475876","https://openalex.org/W4319704909","https://openalex.org/W4406060585"],"related_works":["https://openalex.org/W2187729279","https://openalex.org/W2017016317","https://openalex.org/W2122660076","https://openalex.org/W2094787536","https://openalex.org/W2150115597","https://openalex.org/W7066622223","https://openalex.org/W1990040373","https://openalex.org/W7097380054","https://openalex.org/W2140970860","https://openalex.org/W2095817976"],"abstract_inverted_index":{"The":[0,63],"induction":[1,71,74,96],"of":[2,24,72,93,97,105],"glutathione":[3],"S-transferases":[4],"(GST)":[5],"represents":[6],"not":[7],"only":[8],"cell":[9,61,67],"detoxification":[10],"and":[11,49,66,77],"survival":[12],"but":[13],"also":[14],"cancer":[15],"prevention.":[16],"In":[17],"response":[18],"to":[19,30],"various":[20],"extracellular":[21],"stimuli,":[22],"expression":[23],"the":[25,36,52,57,70,90,94,98],"gene":[26,100],"has":[27],"been":[28],"shown":[29],"be":[31,80],"regulated":[32],"coordinately":[33],"by":[34,75,84,102],"activating":[35],"transcription":[37,58,106],"factors":[38,59,107],"in":[39],"a":[40,103],"transcriptional":[41,95],"or":[42,111],"posttranscriptional":[43],"manner.":[44],"Cytoprotective":[45],"agents":[46],"induce":[47],"GST":[48,73,99],"concomitantly":[50],"activate":[51,56],"PI3K-Akt/ERK-RSK1-mTOR":[53],"pathways":[54],"that":[55,83,108],"favoring":[60],"viability.":[62],"mechanistic":[64],"basis":[65],"signaling":[68],"for":[69],"prooxidants":[76],"toxicants":[78],"may":[79],"different":[81],"from":[82],"cytoprotective":[85],"agents.":[86],"This":[87],"paper":[88],"summarizes":[89],"molecular":[91],"mechanisms":[92],"orchestrated":[101],"series":[104],"recruit":[109],"coactivators":[110],"corepressors.":[112]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
