{"id":"https://openalex.org/W2122097462","doi":"https://doi.org/10.1016/j.ijrobp.2014.02.029","title":"Proton Radiation Therapy for Head and Neck Cancer: A Review of the Clinical Experience to Date","display_name":"Proton Radiation Therapy for Head and Neck Cancer: A Review of the Clinical Experience to Date","publication_year":2014,"publication_date":"2014-05-05","ids":{"openalex":"https://openalex.org/W2122097462","doi":"https://doi.org/10.1016/j.ijrobp.2014.02.029","mag":"2122097462","pmid":"https://pubmed.ncbi.nlm.nih.gov/24837890"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2014.02.029","doi":"https://doi.org/10.1016/j.ijrobp.2014.02.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2014.02.029","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011546832","display_name":"Emma Brey Holliday","orcid":"https://orcid.org/0000-0002-4362-461X","observed_orcids":["https://orcid.org/0000-0002-4362-461X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma B. Holliday","raw_affiliation_strings":["Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001478135","display_name":"Steven Jay Frank","orcid":"https://orcid.org/0000-0001-6517-7884","observed_orcids":["https://orcid.org/0000-0001-6517-7884","https://orcid.org/0000-0003-1020-4966"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven J. Frank","raw_affiliation_strings":["Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: sjfrank@mdanderson.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: sjfrank@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001478135"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":2.65,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.93103448,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"89","issue":"2","first_page":"292","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/bragg-peak","display_name":"Bragg peak","score":0.9539999961853027},{"id":"https://openalex.org/keywords/normal-tissue-sparing","display_name":"normal tissue sparing","score":0.8270000219345093},{"id":"https://openalex.org/keywords/chordoma","display_name":"chordoma","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/sinonasal-tumors","display_name":"sinonasal tumors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/local-control","display_name":"local control","score":0.8730000257492065},{"id":"https://openalex.org/keywords/late-toxicity","display_name":"late toxicity","score":0.671999990940094},{"id":"https://openalex.org/keywords/early-toxicity","display_name":"early toxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9367817640304565},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.8461402058601379},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7495899796485901},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6310006976127625},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.49782848358154297},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49717023968696594},{"id":"https://openalex.org/C2780944729","wikidata":"https://www.wikidata.org/wiki/Q897227","display_name":"Bragg peak","level":3,"score":0.4298710823059082},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4258507490158081},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.39538925886154175},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27443626523017883},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.2302911877632141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19866743683815002},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009669","descriptor_name":"Nose Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D019292","descriptor_name":"Skull Base Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D058958","descriptor_name":"Organs at Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijrobp.2014.02.029","doi":"https://doi.org/10.1016/j.ijrobp.2014.02.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2014.02.029","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},{"id":"pmid:24837890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24837890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation oncology, biology, physics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W204177031","https://openalex.org/W1550943092","https://openalex.org/W1594475165","https://openalex.org/W1965619896","https://openalex.org/W1967375089","https://openalex.org/W1968218090","https://openalex.org/W1979169907","https://openalex.org/W1980014671","https://openalex.org/W1981576515","https://openalex.org/W1983201663","https://openalex.org/W1984301456","https://openalex.org/W1988936862","https://openalex.org/W1989207107","https://openalex.org/W1990381926","https://openalex.org/W1991628107","https://openalex.org/W1992286040","https://openalex.org/W1994460828","https://openalex.org/W1998747684","https://openalex.org/W2015773555","https://openalex.org/W2017673775","https://openalex.org/W2017872025","https://openalex.org/W2024409025","https://openalex.org/W2025555885","https://openalex.org/W2027651392","https://openalex.org/W2029753133","https://openalex.org/W2038274483","https://openalex.org/W2044569420","https://openalex.org/W2046436442","https://openalex.org/W2049584360","https://openalex.org/W2054722721","https://openalex.org/W2054893822","https://openalex.org/W2057016599","https://openalex.org/W2060017885","https://openalex.org/W2066616656","https://openalex.org/W2071696483","https://openalex.org/W2072087143","https://openalex.org/W2072818743","https://openalex.org/W2075121774","https://openalex.org/W2075173808","https://openalex.org/W2081901297","https://openalex.org/W2087859424","https://openalex.org/W2092201288","https://openalex.org/W2095610022","https://openalex.org/W2096267659","https://openalex.org/W2097572956","https://openalex.org/W2097679300","https://openalex.org/W2100232910","https://openalex.org/W2103485856","https://openalex.org/W2108057492","https://openalex.org/W2110998462","https://openalex.org/W2111714525","https://openalex.org/W2112482103","https://openalex.org/W2112915889","https://openalex.org/W2114603477","https://openalex.org/W2114909947","https://openalex.org/W2117830660","https://openalex.org/W2118865293","https://openalex.org/W2119302956","https://openalex.org/W2125919881","https://openalex.org/W2127494183","https://openalex.org/W2129121210","https://openalex.org/W2130443041","https://openalex.org/W2136716437","https://openalex.org/W2137898685","https://openalex.org/W2140110477","https://openalex.org/W2141313402","https://openalex.org/W2144586199","https://openalex.org/W2145944546","https://openalex.org/W2151415400","https://openalex.org/W2160657334","https://openalex.org/W2165468773","https://openalex.org/W2596589910"],"related_works":["https://openalex.org/W2055516646","https://openalex.org/W135473613","https://openalex.org/W4200036212","https://openalex.org/W1985872973","https://openalex.org/W2044130197","https://openalex.org/W3041312056","https://openalex.org/W3197105846","https://openalex.org/W204177031","https://openalex.org/W2750320583","https://openalex.org/W2608005949"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}