{"id":"https://openalex.org/W2122003173","doi":"https://doi.org/10.1093/aje/kws123","title":"Integrating Genetic Association, Genetics of Gene Expression, and Single Nucleotide Polymorphism Set Analysis to Identify Susceptibility Loci for Type 2 Diabetes Mellitus","display_name":"Integrating Genetic Association, Genetics of Gene Expression, and Single Nucleotide Polymorphism Set Analysis to Identify Susceptibility Loci for Type 2 Diabetes Mellitus","publication_year":2012,"publication_date":"2012-08-02","ids":{"openalex":"https://openalex.org/W2122003173","doi":"https://doi.org/10.1093/aje/kws123","mag":"2122003173","pmid":"https://pubmed.ncbi.nlm.nih.gov/22865700","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3499116"},"language":"en","primary_location":{"id":"doi:10.1093/aje/kws123","doi":"https://doi.org/10.1093/aje/kws123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/aje/kws123","pdf_url":"https://academic.oup.com/aje/article-pdf/176/5/423/235536/kws123.pdf","source":{"id":"https://openalex.org/S170967050","display_name":"American Journal of Epidemiology","issn_l":"0002-9262","issn":["0002-9262","1476-6256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/aje/article-pdf/176/5/423/235536/kws123.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107874403","display_name":"Danielle M. Greenawalt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. M. Greenawalt","raw_affiliation_strings":["Department of Genetics, Merck Research Laboratories, Pasteur, Boston, MA 02115, USA. danielle_greenawalt@merck.com","Department of Genetics, Merck Research Laboratories, Pasteur, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Merck Research Laboratories, Pasteur, Boston, MA 02115, USA. danielle_greenawalt@merck.com","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Genetics, Merck Research Laboratories, Pasteur, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048701330","display_name":"Solveig K. Sieberts","orcid":"https://orcid.org/0000-0003-1033-0954","observed_orcids":["https://orcid.org/0000-0003-1033-0954"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I1323236076","display_name":"Sage Bionetworks","ror":"https://ror.org/049ncjx51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1323236076"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. K. Sieberts","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Sage Bionetworks"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Sage Bionetworks","institution_ids":["https://openalex.org/I1323236076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103574131","display_name":"Marilyn C. Cornelis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. C. Cornelis","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079115002","display_name":"Cynthia J. Girman","orcid":"https://orcid.org/0000-0002-5714-174X","observed_orcids":["https://orcid.org/0000-0002-5714-174X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. J. Girman","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Merck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101978852","display_name":"Hua Zhong","orcid":"https://orcid.org/0000-0002-9358-1582","observed_orcids":["https://orcid.org/0000-0002-9358-1582"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I1323236076","display_name":"Sage Bionetworks","ror":"https://ror.org/049ncjx51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1323236076"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Zhong","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Sage Bionetworks"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Sage Bionetworks","institution_ids":["https://openalex.org/I1323236076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088751229","display_name":"Xia Yang","orcid":"https://orcid.org/0000-0002-3971-038X","observed_orcids":["https://orcid.org/0000-0002-3971-038X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I1323236076","display_name":"Sage Bionetworks","ror":"https://ror.org/049ncjx51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1323236076"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Yang","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Sage Bionetworks"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Sage Bionetworks","institution_ids":["https://openalex.org/I1323236076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080308005","display_name":"Justin Guinney","orcid":"https://orcid.org/0000-0003-1477-1888","observed_orcids":["https://orcid.org/0000-0003-1477-1888"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I1323236076","display_name":"Sage Bionetworks","ror":"https://ror.org/049ncjx51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1323236076"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Guinney","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Sage Bionetworks"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Sage Bionetworks","institution_ids":["https://openalex.org/I1323236076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100625029","display_name":"Lu Qi","orcid":"https://orcid.org/0000-0002-8041-7791","observed_orcids":["https://orcid.org/0000-0002-8041-7791"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Qi","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056459536","display_name":"Frank B. Hu","orcid":"https://orcid.org/0000-0002-8233-6274","observed_orcids":["https://orcid.org/0000-0002-8233-6274","https://orcid.org/0000-0002-8412-2261"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. B. Hu","raw_affiliation_strings":["Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics , Merck Research Laboratories , 33 Avenue Louis Pasteur , Boston , MA 02115","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107874403"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4856,"currency":"USD","value_usd":4856},"apc_paid":null,"fwci":2.5055,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.89657668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"176","issue":"5","first_page":"423","last_page":"430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5350000262260437},{"id":"https://openalex.org/keywords/usp36","display_name":"USP36","score":1.0},{"id":"https://openalex.org/keywords/tcf7l2","display_name":"TCF7L2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fat-cell-differentiation","display_name":"fat cell differentiation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gene-set-analysis","display_name":"gene set analysis","score":0.49000000953674316},{"id":"https://openalex.org/keywords/nested-case-control-study","display_name":"nested case-control study","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C39263347","wikidata":"https://www.wikidata.org/wiki/Q14913892","display_name":"TCF7L2","level":5,"score":0.8139622211456299},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7923475503921509},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7706314325332642},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.658725380897522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5932015180587769},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5305507779121399},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5185250043869019},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4563103914260864},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4272417426109314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4197385609149933},{"id":"https://openalex.org/C55060382","wikidata":"https://www.wikidata.org/wiki/Q7675093","display_name":"Tag SNP","level":5,"score":0.41313329339027405},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.237608402967453},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20020025968551636},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0547848641872406}],"mesh":[{"descriptor_ui":"D000071119","descriptor_name":"ADAMTS9 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071119","descriptor_name":"ADAMTS9 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071119","descriptor_name":"ADAMTS9 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071119","descriptor_name":"ADAMTS9 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071119","descriptor_name":"ADAMTS9 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058118","descriptor_name":"Transcription Factor 7-Like 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/aje/kws123","doi":"https://doi.org/10.1093/aje/kws123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/aje/kws123","pdf_url":"https://academic.oup.com/aje/article-pdf/176/5/423/235536/kws123.pdf","source":{"id":"https://openalex.org/S170967050","display_name":"American Journal of Epidemiology","issn_l":"0002-9262","issn":["0002-9262","1476-6256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Epidemiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2752102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3499116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3499116","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3499116","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Epidemiol","raw_type":"Text"},{"id":"pmid:22865700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22865700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of epidemiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/aje/kws123","doi":"https://doi.org/10.1093/aje/kws123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/aje/kws123","pdf_url":"https://academic.oup.com/aje/article-pdf/176/5/423/235536/kws123.pdf","source":{"id":"https://openalex.org/S170967050","display_name":"American Journal of Epidemiology","issn_l":"0002-9262","issn":["0002-9262","1476-6256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Epidemiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1065250665","display_name":"GWAS of Venous Thrombosis","funder_award_id":"U01HG004735","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G1338396984","display_name":null,"funder_award_id":"U01-HG004423","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G1798569254","display_name":null,"funder_award_id":"CA63464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1808327166","display_name":"A Multiethnic Genome-Wide Scan of Prostate Cancer","funder_award_id":"U01HG004726","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G1848479244","display_name":null,"funder_award_id":"U01HG04424","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G214012886","display_name":null,"funder_award_id":"CA136792","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G274415032","display_name":"Study of Addiction: Genetics and Environment","funder_award_id":"U01HG004422","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2761753895","display_name":"Genome-Wide Associations Environmental Interactions in the Lung Health Study","funder_award_id":"U01HG004738","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2837531967","display_name":"International Consortium to Identify Genes and Interactions Controlling Oral Clef","funder_award_id":"U01DE018993","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2848451949","display_name":"Genes and Environment Initiatives in Type 2 Diabetes","funder_award_id":"U01HG004399","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G3100084882","display_name":"GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS","funder_award_id":"U01CA063464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3210234578","display_name":"Genome-wide association studies of prematurity and its complications","funder_award_id":"5u01hg004423-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3627917228","display_name":"Multiethnic Cohort Study of Diet and Cancer","funder_award_id":"R37CA054281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3724153920","display_name":"GWA for Gene-Environment Interaction Effects Influencing CHD","funder_award_id":"U01HG004402","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G3874702986","display_name":"Dental Caries: Whole Genome Association and Gene x Environment Studies","funder_award_id":"U01DE018903","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4344742353","display_name":"MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER","funder_award_id":"R01CA054281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4345993040","display_name":"Genes and Environment Initiative in Glaucoma","funder_award_id":"U01HG004728","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4451534877","display_name":"The Collaborative Genetic Study of Nicotine Dependence","funder_award_id":"P01CA089392","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4477173112","display_name":"GWA Mapping: Maternal Metabolism-Birth Weight Interactions","funder_award_id":"U01HG004415","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4576530895","display_name":"Genome Wide Association Coordinating Center","funder_award_id":"U01HG004446","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5100432211","display_name":"GWAS of longitudinal blood pressure profiles from young adulthood to middle-age","funder_award_id":"U01HG004729","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5147604047","display_name":"A Center for GEI Association Studies","funder_award_id":"U01HG004424","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5648774847","display_name":"Genetic Susceptibility to Cancer in Multiethnic Cohorts","funder_award_id":"R01CA063464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5654214539","display_name":null,"funder_award_id":"CA 54281","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5924991214","display_name":"JH/CIDR Genotyping for Genome-Wide Association Studies","funder_award_id":"U01HG004438","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5938881030","display_name":"Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups","funder_award_id":"U01HG004436","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6695818331","display_name":"FAMILY STUDY OF COCAINE DEPENDENCE","funder_award_id":"R01DA013423","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8225427209","display_name":"A Genome-wide Association Study of Prostate Cancer in African Americans","funder_award_id":"U01CA136792","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8267674335","display_name":null,"funder_award_id":"HHSN268200782096C","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000914127","display_name":"Collaborative Study on the Genetics of Alcoholism (COGA).","funder_award_id":"U10AA008401","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G925122303","display_name":"Genome-Wide Association Studies","funder_award_id":"Z01CP010200","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122003173.pdf","grobid_xml":"https://content.openalex.org/works/W2122003173.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1502936039","https://openalex.org/W1507217056","https://openalex.org/W1965141016","https://openalex.org/W1976844911","https://openalex.org/W1978014946","https://openalex.org/W1978215768","https://openalex.org/W1982380538","https://openalex.org/W1982966896","https://openalex.org/W2012280706","https://openalex.org/W2013196115","https://openalex.org/W2028335133","https://openalex.org/W2041953582","https://openalex.org/W2043842514","https://openalex.org/W2066874799","https://openalex.org/W2083602172","https://openalex.org/W2090808827","https://openalex.org/W2091901410","https://openalex.org/W2107956878","https://openalex.org/W2110065044","https://openalex.org/W2114687295","https://openalex.org/W2117446594","https://openalex.org/W2119586206","https://openalex.org/W2122203297","https://openalex.org/W2124821727","https://openalex.org/W2130410032","https://openalex.org/W2139025111","https://openalex.org/W2139487710","https://openalex.org/W2140742732","https://openalex.org/W2141653244","https://openalex.org/W2147329075","https://openalex.org/W2148564836","https://openalex.org/W2157752701","https://openalex.org/W2159482845","https://openalex.org/W2161633633","https://openalex.org/W2171460953","https://openalex.org/W2172136994","https://openalex.org/W4240204556"],"related_works":["https://openalex.org/W7095243549","https://openalex.org/W2003699592","https://openalex.org/W2139487710","https://openalex.org/W1976588209","https://openalex.org/W2342878310","https://openalex.org/W2012280706","https://openalex.org/W2128970479","https://openalex.org/W2795513215","https://openalex.org/W2141653244","https://openalex.org/W7100581506"],"abstract_inverted_index":{"Large-scale":[0],"genome-wide":[1,93,203],"association":[2],"studies":[3,57,105],"(GWAS)":[4],"have":[5],"identified":[6,164],"over":[7],"40":[8],"genomic":[9],"regions":[10],"significantly":[11,120],"associated":[12,82,121],"with":[13,83],"type":[14,48,124,197,218,242],"2":[15,49,59,125,190,198,219,243],"diabetes":[16,50,126,199,220,244],"mellitus.":[17,245],"However,":[18],"GWAS":[19,52,162],"results":[20,163],"are":[21,131],"not":[22],"always":[23],"straightforward":[24],"to":[25,31,77,91,106,123,134,169],"interpret,":[26],"and":[27,71,100,147,173,207,224,239],"linking":[28],"these":[29,103],"loci":[30,223],"meaningful":[32],"disease":[33],"etiology":[34],"is":[35],"often":[36],"difficult":[37],"without":[38],"extensive":[39],"follow-up":[40],"studies.":[41],"The":[42],"authors":[43,113],"expanded":[44],"on":[45],"previously":[46],"reported":[47],"mellitus":[51,127,221],"from":[53],"the":[54,112,118,135,141,148,161,170,174,186,237],"nested":[55,109],"case-control":[56,110],"of":[58,80,117,160,234,241],"prospective":[60],"US":[61],"cohorts":[62],"by":[63],"incorporating":[64],"expression":[65,132,167],"single":[66],"nucleotide":[67],"polymorphism":[68],"(SNP)":[69],"information":[70],"applying":[72],"SNP":[73,156],"set":[74,157,209],"enrichment":[75,158,165],"analysis":[76,159,210],"identify":[78],"sets":[79],"SNPs":[81,122,133,168],"genes":[84],"that":[85,115],"could":[86],"provide":[87,212],"further":[88],"biologic":[89,178,214],"insight":[90],"traditional":[92],"analysis.":[94],"Using":[95],"data":[96],"collected":[97],"between":[98],"1989":[99],"1994":[101],"in":[102,128,228],"previous":[104],"form":[107],"a":[108],"study,":[111],"found":[114],"3":[116],"most":[119],"their":[129],"study":[130],"lymphocyte":[136],"antigen":[137],"75":[138],"gene":[139,145,154,191,205,208],"(LY75),":[140],"ubiquitin-specific":[142],"peptidase":[143],"36":[144],"(USP36),":[146],"phosphatidylinositol":[149],"transfer":[150],"protein,":[151],"cytoplasmic":[152],"1":[153],"(PITPNC1).":[155],"for":[166,216,236],"macrophage-enriched":[171],"module":[172],"Gene":[175],"Ontology":[176],"(GO)":[177],"process":[179],"fat":[180],"cell":[181],"differentiation":[182],"human,":[183],"which":[184],"includes":[185],"transcription":[187],"factor":[188],"7-like":[189],"(TCF7L2),":[192],"as":[193,195],"well":[194],"other":[196],"mellitus-associated":[200],"genes.":[201],"Integrating":[202],"association,":[204],"expression,":[206],"may":[211,225],"valuable":[213],"support":[215],"potential":[217],"susceptibility":[222],"be":[226],"useful":[227],"identifying":[229],"new":[230],"targets":[231],"or":[232],"pathways":[233],"interest":[235],"treatment":[238],"prevention":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}