{"id":"https://openalex.org/W2121990273","doi":"https://doi.org/10.1002/cne.903030212","title":"GABAergic circuitry in the rostral ventral medulla of the rat and its relationship to descending antinociceptive controls","display_name":"GABAergic circuitry in the rostral ventral medulla of the rat and its relationship to descending antinociceptive controls","publication_year":1991,"publication_date":"1991-01-08","ids":{"openalex":"https://openalex.org/W2121990273","doi":"https://doi.org/10.1002/cne.903030212","mag":"2121990273","pmid":"https://pubmed.ncbi.nlm.nih.gov/2013643"},"language":"en","primary_location":{"id":"doi:10.1002/cne.903030212","doi":"https://doi.org/10.1002/cne.903030212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.903030212","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026445567","display_name":"Hee Jung Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hee Jung Cho","raw_affiliation_strings":["Department of Anatomy, University of California, San Francisco 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of California, San Francisco 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007740596","display_name":"Allan I. Basbaum","orcid":"https://orcid.org/0000-0002-1710-6333","observed_orcids":["https://orcid.org/0000-0002-1710-6333"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan I. Basbaum","raw_affiliation_strings":["Departments of Anatomy and Physiology, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Physiology, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007740596"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.404,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.89556083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"303","issue":"2","first_page":"316","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gabaergic-synapses","display_name":"GABAergic synapses","score":0.9150000214576721},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nucleus-raphe-magnus","display_name":"nucleus raphe magnus","score":0.9240000247955322},{"id":"https://openalex.org/keywords/synaptic-convergence","display_name":"synaptic convergence","score":0.5770000219345093},{"id":"https://openalex.org/keywords/axodendritic-synapses","display_name":"axodendritic synapses","score":0.8360000252723694},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tonic-inhibition","display_name":"tonic inhibition","score":0.45100000500679016},{"id":"https://openalex.org/keywords/gabaergic-terminals","display_name":"GABAergic terminals","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.8397459983825684},{"id":"https://openalex.org/C2781069035","wikidata":"https://www.wikidata.org/wiki/Q1243765","display_name":"Periaqueductal gray","level":4,"score":0.7600363492965698},{"id":"https://openalex.org/C2777603711","wikidata":"https://www.wikidata.org/wiki/Q17143534","display_name":"Nucleus raphe magnus","level":5,"score":0.7390376329421997},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7164817452430725},{"id":"https://openalex.org/C2778110749","wikidata":"https://www.wikidata.org/wiki/Q189033","display_name":"Medulla oblongata","level":3,"score":0.5530378818511963},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5474300384521484},{"id":"https://openalex.org/C17291353","wikidata":"https://www.wikidata.org/wiki/Q6807308","display_name":"Medulla","level":2,"score":0.4725370407104492},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.4626394808292389},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.46006524562835693},{"id":"https://openalex.org/C142642502","wikidata":"https://www.wikidata.org/wiki/Q7455042","display_name":"Serotonergic cell groups","level":5,"score":0.45303261280059814},{"id":"https://openalex.org/C32610206","wikidata":"https://www.wikidata.org/wiki/Q5298804","display_name":"Dorsal raphe nucleus","level":5,"score":0.44366490840911865},{"id":"https://openalex.org/C2777659854","wikidata":"https://www.wikidata.org/wiki/Q3857077","display_name":"Rostral ventromedial medulla","level":5,"score":0.4255863428115845},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3954184651374817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3950079083442688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3857870101928711},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.3282976448535919},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.31995582580566406},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.26420536637306213},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22550255060195923},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.1392984688282013},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10805001854896545},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cne.903030212","doi":"https://doi.org/10.1002/cne.903030212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.903030212","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:2013643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2013643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G636262753","display_name":null,"funder_award_id":"NS21445","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G726581290","display_name":null,"funder_award_id":"NS 14627","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W221359381","https://openalex.org/W1029293373","https://openalex.org/W1594142158","https://openalex.org/W1838045633","https://openalex.org/W1969331221","https://openalex.org/W1970315491","https://openalex.org/W1974164498","https://openalex.org/W1974782548","https://openalex.org/W1975756729","https://openalex.org/W1977742625","https://openalex.org/W1983851668","https://openalex.org/W1990618194","https://openalex.org/W1996185004","https://openalex.org/W2004422735","https://openalex.org/W2009172550","https://openalex.org/W2019207659","https://openalex.org/W2027829039","https://openalex.org/W2033930984","https://openalex.org/W2036761672","https://openalex.org/W2039598635","https://openalex.org/W2040342883","https://openalex.org/W2043756267","https://openalex.org/W2045313047","https://openalex.org/W2045410309","https://openalex.org/W2046302138","https://openalex.org/W2046926887","https://openalex.org/W2055220033","https://openalex.org/W2059445922","https://openalex.org/W2064735411","https://openalex.org/W2068237121","https://openalex.org/W2084325081","https://openalex.org/W2088503298","https://openalex.org/W2089451975","https://openalex.org/W2090691199","https://openalex.org/W2090876805","https://openalex.org/W2115393043","https://openalex.org/W2122363717","https://openalex.org/W2123166542","https://openalex.org/W2137229086","https://openalex.org/W2138512124","https://openalex.org/W2171584675","https://openalex.org/W2215177648","https://openalex.org/W2431435386"],"related_works":["https://openalex.org/W2007284096","https://openalex.org/W2036896908","https://openalex.org/W1996185004","https://openalex.org/W1979514882","https://openalex.org/W1032835256","https://openalex.org/W1977700300","https://openalex.org/W2090408408","https://openalex.org/W4367556819","https://openalex.org/W2061695081","https://openalex.org/W2021846533"],"abstract_inverted_index":{"This":[0],"study":[1,60],"used":[2],"postembedding":[3],"immunocytochemistry":[4],"to":[5,72,150,194],"examine":[6],"the":[7,13,19,24,28,36,55,61,80,84,99,103,109,141,146,165,176,180,195,198,207,211,225],"organization":[8],"of":[9,18,27,38,51,64,95,119,140,155,157,179,201,206,213,224],"GABA-immunoreactive":[10,39,91,120,151],"synapse":[11],"in":[12,79,98,145],"rostral":[14],"ventral":[15],"medulla":[16],"(RVM)":[17],"rat.":[20],"To":[21,59],"determine":[22],"whether":[23],"outflow":[25],"neurons":[26,44,178,223],"RVM":[29,73,181],"are":[30,182,190,219],"under":[31,183],"GABAergic":[32,65,162,185,215],"control,":[33],"we":[34,75],"examined":[35,83],"distribution":[37],"synapses":[40,97,134],"upon":[41,221],"bulbospinal":[42],"projection":[43,177],"that":[45,175,197,218],"were":[46,114,135,148,169],"labelled":[47],"by":[48],"retrograde":[49],"transport":[50],"wheatgerm":[52],"agglutinin-HRP":[53],"from":[54],"cervical":[56],"spinal":[57],"cord.":[58],"possible":[62],"convergence":[63,156],"and":[66,82,90,108,125,128,161,203],"periaqueductal":[67],"gray":[68],"(PAG)":[69],"synaptic":[70],"inputs":[71],"neurons,":[74],"also":[76,170],"made":[77,129],"lesions":[78],"PAG":[81,88,159,209],"relationship":[85],"between":[86],"degenerating":[87,158],"axons":[89],"terminals.":[92,152],"Approximately":[93],"45%":[94],"all":[96],"RVM,":[100],"which":[101],"includes":[102],"midline":[104],"nucleus":[105,110,226],"raphe":[106,227],"magnus":[107],"reticularis":[111],"paragigantocellularis":[112],"lateralis,":[113],"GABA-immunoreactive.":[115],"The":[116,188],"vast":[117],"majority":[118],"terminals":[121,160,163],"contained":[122],"round,":[123],"clear,":[124],"pleomorphic":[126],"vesicles":[127],"symmetrical":[130],"axodendritic":[131],"synapses;":[132],"axoaxonic":[133],"not":[136],"found.":[137,171],"Almost":[138],"50%":[139],"retrogradely":[142],"labeled":[143],"dendrites":[144],"NRM":[147],"postsynaptic":[149],"Several":[153],"examples":[154],"onto":[164],"same":[166],"unlabelled":[167],"dendrite":[168],"These":[172],"data":[173],"indicate":[174],"profound":[184],"inhibitory":[186,216],"control.":[187],"results":[189],"discussed":[191],"with":[192],"regard":[193],"hypothesis":[196],"analgesic":[199],"action":[200],"narcotics":[202],"electrical":[204],"stimulation":[205],"midbrain":[208],"involves":[210],"regulation":[212],"tonic":[214],"controls":[217],"exerted":[220],"spinally-projecting":[222],"magnus.":[228]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}