{"id":"https://openalex.org/W2121968614","doi":"https://doi.org/10.3349/ymj.2010.51.5.692","title":"Impacts of Cytosolic Phospholipase A2, 15-Prostaglandin Dehydrogenase, and Cyclooxygenase-2 Expressions on Tumor Progression in Colorectal Cancer","display_name":"Impacts of Cytosolic Phospholipase A2, 15-Prostaglandin Dehydrogenase, and Cyclooxygenase-2 Expressions on Tumor Progression in Colorectal Cancer","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2121968614","doi":"https://doi.org/10.3349/ymj.2010.51.5.692","mag":"2121968614","pmid":"https://pubmed.ncbi.nlm.nih.gov/20635443","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908865"},"language":"en","primary_location":{"id":"doi:10.3349/ymj.2010.51.5.692","doi":"https://doi.org/10.3349/ymj.2010.51.5.692","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2010.51.5.692","pdf_url":"http://eymj.org/Synapse/Data/PDFData/0069YMJ/ymj-51-692.pdf","source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2121968614"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://eymj.org/Synapse/Data/PDFData/0069YMJ/ymj-51-692.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071757863","display_name":"Sung\u2010Chul Lim","orcid":"https://orcid.org/0000-0001-6179-691X","observed_orcids":["https://orcid.org/0000-0001-6179-691X"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Chul Lim","raw_affiliation_strings":["Department of Pathology, Chosun University, Gwangju, Korea","Research Center for Resistant Cells, Chosun University, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500"]},{"raw_affiliation_string":"Research Center for Resistant Cells, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423285","display_name":"Hoon Cho","orcid":"https://orcid.org/0000-0002-6475-5184","observed_orcids":["https://orcid.org/0000-0002-6475-5184"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hoon Cho","raw_affiliation_strings":["Department of Polymer Science & Engineering, Chosun University, Gwangju, Korea","Research Center for Resistant Cells, Chosun University, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Polymer Science & Engineering, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500"]},{"raw_affiliation_string":"Research Center for Resistant Cells, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003945075","display_name":"Tae Bum Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Bum Lee","raw_affiliation_strings":["Research Center for Resistant Cells, Chosun University, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Resistant Cells, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053917295","display_name":"Cheol Hee Choi","orcid":"https://orcid.org/0000-0002-0400-8224","observed_orcids":["https://orcid.org/0000-0002-0400-8224"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Cheol Hee Choi","raw_affiliation_strings":["Research Center for Resistant Cells, Chosun University, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Resistant Cells, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108196280","display_name":"Young\u2010Don Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]},{"id":"https://openalex.org/I4210101795","display_name":"Chosun University Hospital","ror":"https://ror.org/0131gn249","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I152238500","https://openalex.org/I4210101795"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Don Min","raw_affiliation_strings":["Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500","https://openalex.org/I4210101795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337397","display_name":"Sung Soo Kim","orcid":"https://orcid.org/0000-0002-5190-227X","observed_orcids":["https://orcid.org/0000-0002-5190-227X"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]},{"id":"https://openalex.org/I4210101795","display_name":"Chosun University Hospital","ror":"https://ror.org/0131gn249","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I152238500","https://openalex.org/I4210101795"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Soo Kim","raw_affiliation_strings":["Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500","https://openalex.org/I4210101795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033703113","display_name":"Kyung Jong Kim","orcid":"https://orcid.org/0000-0001-8984-2180","observed_orcids":["https://orcid.org/0000-0001-8984-2180"]},"institutions":[{"id":"https://openalex.org/I152238500","display_name":"Chosun University","ror":"https://ror.org/01zt9a375","country_code":"KR","type":"education","lineage":["https://openalex.org/I152238500"]},{"id":"https://openalex.org/I4210101795","display_name":"Chosun University Hospital","ror":"https://ror.org/0131gn249","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I152238500","https://openalex.org/I4210101795"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyung Jong Kim","raw_affiliation_strings":["Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea","institution_ids":["https://openalex.org/I152238500","https://openalex.org/I4210101795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033703113"],"corresponding_institution_ids":["https://openalex.org/I152238500","https://openalex.org/I4210101795"],"apc_list":{"value":700,"currency":"USD","value_usd":700},"apc_paid":{"value":700,"currency":"USD","value_usd":700},"fwci":3.8103,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92337165,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"51","issue":"5","first_page":"692","last_page":"692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cytosolic-phospholipase-a2","display_name":"cytosolic phospholipase A2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/15-hydroxyprostaglandin-dehydrogenase","display_name":"15-hydroxyprostaglandin dehydrogenase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/microsomal-prostaglandin-e2-synthase-1","display_name":"microsomal prostaglandin E2 synthase-1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/prostaglandin-e2-synthesis","display_name":"prostaglandin E2 synthesis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-invasion-depth","display_name":"depth of invasion","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.741567075252533},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.6494463682174683},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5955653786659241},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5925503373146057},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5823231339454651},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5745145678520203},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5478555560112},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5397741198539734},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.48698100447654724},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4492078721523285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43473803997039795},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4303128719329834},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.42453569173812866},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40419620275497437},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38340115547180176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3705369830131531},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3620098829269409},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.2826586961746216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18771669268608093}],"mesh":[{"descriptor_ui":"D000071876","descriptor_name":"Prostaglandin-E Synthases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006911","descriptor_name":"Hydroxyprostaglandin Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054513","descriptor_name":"Group IV Phospholipases A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3349/ymj.2010.51.5.692","doi":"https://doi.org/10.3349/ymj.2010.51.5.692","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2010.51.5.692","pdf_url":"http://eymj.org/Synapse/Data/PDFData/0069YMJ/ymj-51-692.pdf","source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},{"id":"pmid:20635443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20635443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2908865","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2908865/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Med J","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.353.5645","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.353.5645","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7e/6f/Yonsei_Med_J_2010_Sep_1_51(5)_692-699.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3349/ymj.2010.51.5.692","doi":"https://doi.org/10.3349/ymj.2010.51.5.692","is_oa":true,"landing_page_url":"https://doi.org/10.3349/ymj.2010.51.5.692","pdf_url":"http://eymj.org/Synapse/Data/PDFData/0069YMJ/ymj-51-692.pdf","source":{"id":"https://openalex.org/S107862393","display_name":"Yonsei Medical Journal","issn_l":"0513-5796","issn":["0513-5796","1976-2437"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319467","host_organization_name":"Yonsei University College of Medicine","host_organization_lineage":["https://openalex.org/P4310319467"],"host_organization_lineage_names":["Yonsei University College of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yonsei Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321199","display_name":"Chosun University","ror":"https://ror.org/01zt9a375"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2121968614.pdf","grobid_xml":"https://content.openalex.org/works/W2121968614.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1530740124","https://openalex.org/W1567766289","https://openalex.org/W1981144967","https://openalex.org/W1984435481","https://openalex.org/W1990078462","https://openalex.org/W1995595142","https://openalex.org/W1997241564","https://openalex.org/W2001258296","https://openalex.org/W2011698701","https://openalex.org/W2014306540","https://openalex.org/W2015930054","https://openalex.org/W2023688484","https://openalex.org/W2037010823","https://openalex.org/W2039281687","https://openalex.org/W2042855560","https://openalex.org/W2049433363","https://openalex.org/W2049807639","https://openalex.org/W2054137985","https://openalex.org/W2058118671","https://openalex.org/W2060196303","https://openalex.org/W2060800275","https://openalex.org/W2064206697","https://openalex.org/W2069516278","https://openalex.org/W2069547811","https://openalex.org/W2076787572","https://openalex.org/W2077641423","https://openalex.org/W2080149121","https://openalex.org/W2088927230","https://openalex.org/W2091799702","https://openalex.org/W2094402002","https://openalex.org/W2095721808","https://openalex.org/W2101843033","https://openalex.org/W2120673934","https://openalex.org/W2121948155","https://openalex.org/W2143199916","https://openalex.org/W2145218740","https://openalex.org/W2146942822","https://openalex.org/W2147247243","https://openalex.org/W2155913937","https://openalex.org/W2156566729","https://openalex.org/W2157341902","https://openalex.org/W2165191737","https://openalex.org/W2166101368","https://openalex.org/W2167029659","https://openalex.org/W2466731807","https://openalex.org/W2626800913"],"related_works":["https://openalex.org/W1980686215","https://openalex.org/W2060800275","https://openalex.org/W4385980533","https://openalex.org/W2040448591","https://openalex.org/W1195394210","https://openalex.org/W1985290606","https://openalex.org/W1592538062","https://openalex.org/W1567766289","https://openalex.org/W100837395"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1],"addition":[2,176],"to":[3,9,33,36,48,177],"cyclooxygenase-2":[4],"(COX-2)":[5],"which":[6],"is":[7],"related":[8,35],"prostaglandin":[10,22],"E2":[11,23],"synthesis,":[12],"other":[13,88],"enzymes":[14],"such":[15],"as":[16,92,94,96,195,197],"cytosolic":[17],"phospholipase":[18],"A2":[19],"(cPLA2),":[20],"microsomal":[21],"synthase-1":[24],"(mPGES-1),":[25],"and":[26,56,68,81,115,139,155,173,182,193],"15-prostaglandin":[27],"dehydrogenase":[28],"(15-PGDH)":[29],"have":[30,200],"been":[31],"suggested":[32],"be":[34,186],"carcinogenesis":[37],"of":[38,44,52,121,134],"colorectal":[39,189],"cancer":[40],"(CRC).":[41],"The":[42,119,167],"aim":[43],"this":[45],"study":[46,169],"was":[47,102,129,160],"investigate":[49],"the":[50,132,145,149],"roles":[51],"cPLA2,":[53,64,138],"COX-2,":[54,65,178],"mPGES-1,":[55,66,174],"15-PGDH":[57,112,158,184,194],"in":[58,78,104,107,110,113,117,148,175,188,204],"tumor":[59,97,136,205],"progression.":[60,206],"MATERIALS":[61],"AND":[62],"METHODS:":[63],"15-PGDH,":[67],"vascular":[69],"endothelial":[70],"growth":[71],"factor":[72],"(VEGF)":[73],"expressions":[74,83],"were":[75,84],"immunohistochemically":[76],"examined":[77],"89":[79],"CRC,":[80],"their":[82],"compared":[85],"with":[86,124,131,163],"each":[87],"or":[89],"clinicopathologic":[90],"parameters":[91],"well":[93,196],"VEGF":[95,116,125,140,143,164],"progression":[98],"parameters.":[99],"RESULTS:":[100],"cPLA2":[101,122,154,172,192],"expressed":[103],"54.5%,":[105],"COX-2":[106,127,198],"80.5%,":[108],"mPGES-1":[109],"96.4%,":[111],"46.1%,":[114],"65.9%.":[118],"expression":[120,128,147,159],"correlated":[123,130,162],"expression.":[126,165],"depth":[133],"invasion,":[135],"stage,":[137],"expressions.":[141],"Moreover,":[142],"revealed":[144],"highest":[146],"tissues":[150],"positive":[151],"for":[152],"both":[153],"COX-2.":[156],"Furthermore,":[157,191],"inversely":[161],"CONCLUSION:":[166],"present":[168],"demonstrates":[170],"that":[171,183],"are":[179],"constitutively":[180],"overexpressed,":[181],"might":[185],"attenuated":[187],"cancer.":[190],"could":[199],"an":[201],"important":[202],"role":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}