{"id":"https://openalex.org/W2121965026","doi":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","title":"Regulation of Neurite Outgrowth by Integrin Activation","display_name":"Regulation of Neurite Outgrowth by Integrin Activation","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2121965026","doi":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","mag":"2121965026","pmid":"https://pubmed.ncbi.nlm.nih.gov/10964960","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6772972"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.20-17-06551.2000","doi":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","pdf_url":"http://www.jneurosci.org/content/jneuro/20/17/6551.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jneurosci.org/content/jneuro/20/17/6551.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110261633","display_name":"Jonathan K. Ivins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan K. Ivins","raw_affiliation_strings":["Department of Developmental and Cell Biology and the Developmental Biology Center, University of California at Irvine, Irvine, California 92697, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology and the Developmental Biology Center, University of California at Irvine, Irvine, California 92697, and","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007016006","display_name":"Peter D. Yurchenco","orcid":"https://orcid.org/0000-0003-0387-2317","observed_orcids":["https://orcid.org/0000-0003-0387-2317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter D. Yurchenco","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","Department of Pathology & Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030125759","display_name":"Arthur D. Lander","orcid":"https://orcid.org/0000-0002-4380-5525","observed_orcids":["https://orcid.org/0000-0002-4380-5525"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur D. Lander","raw_affiliation_strings":["Department of Developmental and Cell Biology and the Developmental Biology Center, University of California at Irvine, Irvine, California 92697, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology and the Developmental Biology Center, University of California at Irvine, Irvine, California 92697, and","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2605,"has_fulltext":true,"cited_by_count":150,"citation_normalized_percentile":{"value":0.94096961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"17","first_page":"6551","last_page":"6560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9890000224113464},{"id":"https://openalex.org/keywords/integrin-activation","display_name":"integrin activation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/laminin-1","display_name":"laminin-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/retinal-neurons","display_name":"retinal neurons","score":0.9430000185966492},{"id":"https://openalex.org/keywords/integrin-alpha6beta1","display_name":"alpha6beta1 integrin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/integrin-alpha1beta1","display_name":"alpha1beta1 integrin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/r-ras","display_name":"R-Ras","score":0.7519999742507935},{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":0.7210000157356262},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.7799999713897705},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.9639999866485596},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.9298039674758911},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6521289348602295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5112044811248779},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5002250671386719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36534547805786133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24510687589645386},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1507299244403839},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12823158502578735},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10817086696624756}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020703","descriptor_name":"ras GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1523/jneurosci.20-17-06551.2000","doi":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","pdf_url":"http://www.jneurosci.org/content/jneuro/20/17/6551.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6772972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6772972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:10964960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10964960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.4564","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.4564","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/20/17/6551.full.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt6819q9r4","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6819q9r4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 20, iss 17","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6819q9r4","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6819q9r4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroscience, vol 20, iss 17","raw_type":"article"},{"id":"pmh:qt6819q9r4","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/6819q9r4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ivins, JK; Yurchenco, PD; & Lander, AD. (2000). Regulation of neurite outgrowth by integrin activation. Journal of Neuroscience, 20(17), 6551 - 6560. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6819q9r4","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.20-17-06551.2000","doi":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-17-06551.2000","pdf_url":"http://www.jneurosci.org/content/jneuro/20/17/6551.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3373189446","display_name":"MECHANISMS OF NEURONAL GUIDANCE","funder_award_id":"5r01ns036049-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G536394663","display_name":null,"funder_award_id":"NS 36049","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2121965026.pdf","grobid_xml":"https://content.openalex.org/works/W2121965026.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W51726501","https://openalex.org/W69038043","https://openalex.org/W214799791","https://openalex.org/W1565494103","https://openalex.org/W1583466448","https://openalex.org/W1672471316","https://openalex.org/W1796606757","https://openalex.org/W1875275624","https://openalex.org/W1910696330","https://openalex.org/W1964340993","https://openalex.org/W1965676841","https://openalex.org/W1968690892","https://openalex.org/W1970380611","https://openalex.org/W1977517182","https://openalex.org/W1978591458","https://openalex.org/W1979065547","https://openalex.org/W1980952363","https://openalex.org/W1981462495","https://openalex.org/W1988645163","https://openalex.org/W1989046246","https://openalex.org/W1991184627","https://openalex.org/W1992733780","https://openalex.org/W1994767290","https://openalex.org/W1994811935","https://openalex.org/W2006940700","https://openalex.org/W2007442170","https://openalex.org/W2007991972","https://openalex.org/W2008517901","https://openalex.org/W2010547112","https://openalex.org/W2014643665","https://openalex.org/W2017594099","https://openalex.org/W2030340102","https://openalex.org/W2030410158","https://openalex.org/W2030422302","https://openalex.org/W2031325850","https://openalex.org/W2037466352","https://openalex.org/W2041082867","https://openalex.org/W2048450716","https://openalex.org/W2051997170","https://openalex.org/W2053947462","https://openalex.org/W2058452008","https://openalex.org/W2060136332","https://openalex.org/W2060623940","https://openalex.org/W2064540868","https://openalex.org/W2067666083","https://openalex.org/W2069032610","https://openalex.org/W2070090561","https://openalex.org/W2074830772","https://openalex.org/W2079892535","https://openalex.org/W2086386772","https://openalex.org/W2091314328","https://openalex.org/W2093229003","https://openalex.org/W2106291035","https://openalex.org/W2107012136","https://openalex.org/W2110909340","https://openalex.org/W2116596989","https://openalex.org/W2116607514","https://openalex.org/W2128667409","https://openalex.org/W2156735951","https://openalex.org/W2168918180","https://openalex.org/W2171774959","https://openalex.org/W2403581377","https://openalex.org/W2403914133"],"related_works":["https://openalex.org/W2156735951","https://openalex.org/W2108041673","https://openalex.org/W2064540868","https://openalex.org/W7161752104","https://openalex.org/W1672471316","https://openalex.org/W2051153674","https://openalex.org/W1941658825","https://openalex.org/W1945584896","https://openalex.org/W2058690121","https://openalex.org/W2137230105"],"abstract_inverted_index":{"During":[0],"late-embryonic":[1,80,161],"development,":[2],"retinal":[3,81,142],"neurons":[4,102,163,181,233],"lose":[5],"the":[6,14,21,36,50,73,138,151,157,207,224],"ability":[7,229],"to":[8,41,131,145,164],"attach":[9],"and":[10,63,96,105,236],"extend":[11],"neurites":[12],"on":[13,84,110,117],"extracellular":[15,56],"matrix":[16],"molecule":[17],"laminin-1":[18],"(LN-1),":[19],"despite":[20],"fact":[22],"that":[23,35,48,119,171,201],"they":[24],"retain":[25],"expression":[26,66],"of":[27,39,53,58,67,72,141,153,159,177,210,223,227],"integrin":[28,94,154,173],"receptors":[29],"for":[30,108,242],"LN-1.":[31],"Here":[32],"we":[33],"show":[34],"developmental":[37,139,203],"loss":[38,140,226],"responsiveness":[40,144],"LN-1":[42,85,118,165],"can":[43],"be":[44,238],"reversed":[45,137],"by":[46,93,149,169,231],"treatments":[47,170],"increase":[49],"activation":[51,208],"state":[52,209],"integrins.":[54],"Both":[55],"application":[57],"Mn(2+)":[59],"(at":[60],"micromolar":[61],"concentrations)":[62],"viral-mediated":[64],"neuronal":[65,211],"a":[68,132,202,218,239],"constitutively":[69],"active":[70],"form":[71],"ras-related":[74],"GTPase":[75],"R-ras":[76],"(R-ras(38V))":[77],"potently":[78],"promoted":[79],"neurite":[82],"outgrowth":[83,90,109],"substrata.":[86],"In":[87],"both":[88],"cases,":[89],"was":[91],"mediated":[92],"alpha6beta1":[95],"not":[97,188],"alpha3beta1,":[98],"even":[99],"though":[100],"these":[101],"express":[103],"alpha3beta1":[104],"use":[106],"it":[107],"other":[111,160],"laminin":[112],"isoforms,":[113],"as":[114,116],"well":[115],"has":[120],"been":[121],"proteolytically":[122],"or":[123,192],"conformationally":[124],"activated":[125],"(Ivins":[126],"et":[127],"al.,":[128],"1998).":[129],"Mn(2+)-and":[130],"much":[133],"lesser":[134],"extent":[135],"R-ras(38V)-also":[136],"neuron":[143],"type":[146],"IV":[147],"collagen,":[148],"promoting":[150],"function":[152],"alpha1beta1.":[155],"Interestingly,":[156],"responses":[158],"CNS":[162,215,232],"were":[166,186],"also":[167],"enhanced":[168,189],"activate":[172],"function,":[174],"but":[175],"those":[176],"peripheral":[178],"nervous":[179],"system":[180],"(dorsal":[182],"root":[183],"ganglion":[184],"neurons)":[185,191],"either":[187],"(embryonic":[190],"only":[193],"modestly":[194],"improved":[195],"(adult":[196],"neurons).":[197],"These":[198],"results":[199],"suggest":[200],"decline":[204,219],"occurs":[205],"in":[206],"integrins,":[212],"particularly":[213],"among":[214],"neurons.":[216],"Such":[217],"may":[220,237],"underlie":[221],"some":[222],"intrinsic":[225],"regenerative":[228],"sustained":[230],"during":[234],"development":[235],"valid":[240],"target":[241],"therapeutic":[243],"intervention.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}