{"id":"https://openalex.org/W2121925266","doi":"https://doi.org/10.1261/rna.045708.114","title":"Bloodstream form Trypanosoma brucei do not require mRPN1 for gRNA processing","display_name":"Bloodstream form Trypanosoma brucei do not require mRPN1 for gRNA processing","publication_year":2014,"publication_date":"2014-11-17","ids":{"openalex":"https://openalex.org/W2121925266","doi":"https://doi.org/10.1261/rna.045708.114","mag":"2121925266","pmid":"https://pubmed.ncbi.nlm.nih.gov/25404564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4274635"},"language":"en","primary_location":{"id":"doi:10.1261/rna.045708.114","doi":"https://doi.org/10.1261/rna.045708.114","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.045708.114","pdf_url":"http://rnajournal.cshlp.org/content/21/1/28.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://rnajournal.cshlp.org/content/21/1/28.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058529494","display_name":"Jason Carnes","orcid":"https://orcid.org/0000-0001-7302-1935","observed_orcids":["https://orcid.org/0000-0001-7302-1935"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Carnes","raw_affiliation_strings":["Seattle Biomedical Research Institute, Seattle, Washington 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Biomedical Research Institute, Seattle, Washington 98109, USA","institution_ids":["https://openalex.org/I1294824412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072226461","display_name":"Melissa L. Lerch","orcid":"https://orcid.org/0000-0002-6077-0563","observed_orcids":["https://orcid.org/0000-0002-6077-0563"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Lerch","raw_affiliation_strings":["Seattle Biomedical Research Institute, Seattle, Washington 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Biomedical Research Institute, Seattle, Washington 98109, USA","institution_ids":["https://openalex.org/I1294824412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051858995","display_name":"Irina Kurtz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Kurtz","raw_affiliation_strings":["Seattle Biomedical Research Institute, Seattle, Washington 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Biomedical Research Institute, Seattle, Washington 98109, USA","institution_ids":["https://openalex.org/I1294824412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046125174","display_name":"Ken Stuart","orcid":"https://orcid.org/0000-0002-4064-9758","observed_orcids":["https://orcid.org/0000-0002-4064-9758"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ken Stuart","raw_affiliation_strings":["Seattle Biomedical Research Institute, Seattle, Washington 98109, USA ken.stuart@sbri.org","Seattle Biomedical Research Institute , Seattle, Washington 98109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Biomedical Research Institute, Seattle, Washington 98109, USA ken.stuart@sbri.org","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"Seattle Biomedical Research Institute , Seattle, Washington 98109, USA","institution_ids":["https://openalex.org/I1294824412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046125174"],"corresponding_institution_ids":["https://openalex.org/I1294824412"],"apc_list":null,"apc_paid":null,"fwci":0.7047,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72605835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"21","issue":"1","first_page":"28","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mitochondrial-rna-processing","display_name":"mitochondrial RNA processing","score":0.6769999861717224},{"id":"https://openalex.org/keywords/rna-editing","display_name":"RNA editing","score":0.7760000228881836},{"id":"https://openalex.org/keywords/minicircles","display_name":"minicircles","score":0.7049999833106995},{"id":"https://openalex.org/keywords/maxicircles","display_name":"maxicircles","score":0.7670000195503235},{"id":"https://openalex.org/keywords/polycistronic-transcripts","display_name":"polycistronic transcripts","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gene-knockout","display_name":"gene knockout","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C97702854","wikidata":"https://www.wikidata.org/wiki/Q4039747","display_name":"Guide RNA","level":5,"score":0.9266265034675598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8772685527801514},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.8313494920730591},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6028457283973694},{"id":"https://openalex.org/C55204905","wikidata":"https://www.wikidata.org/wiki/Q6865202","display_name":"Minicircle","level":3,"score":0.5193420648574829},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.4993150234222412},{"id":"https://openalex.org/C2777028655","wikidata":"https://www.wikidata.org/wiki/Q415601","display_name":"Endonuclease","level":3,"score":0.492180734872818},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46878066658973694},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45036906003952026},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.41883713006973267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33967167139053345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32956427335739136},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.28246617317199707},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.20595219731330872}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017394","descriptor_name":"RNA, Guide, Kinetoplastida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1261/rna.045708.114","doi":"https://doi.org/10.1261/rna.045708.114","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.045708.114","pdf_url":"http://rnajournal.cshlp.org/content/21/1/28.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4274635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4274635","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"Text"},{"id":"pmid:25404564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25404564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:rna:21/1/28","doi":null,"is_oa":false,"landing_page_url":"http://rnajournal.cshlp.org/cgi/content/short/21/1/28","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1261/rna.045708.114","doi":"https://doi.org/10.1261/rna.045708.114","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.045708.114","pdf_url":"http://rnajournal.cshlp.org/content/21/1/28.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2544788652","display_name":null,"funder_award_id":"AI014102","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4397572012","display_name":"MITOCHONDRIAL DNA OF NORMAL AND MUTANT TRYPANOSOMES","funder_award_id":"R37AI014102","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000247817","display_name":null,"funder_award_id":"AI014102","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000915763","display_name":"Mitochondrial DNA of Normal and Mutant Trypanosomes","funder_award_id":"R01AI014102","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2121925266.pdf","grobid_xml":"https://content.openalex.org/works/W2121925266.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1970146598","https://openalex.org/W2004864204","https://openalex.org/W2006563536","https://openalex.org/W2008506448","https://openalex.org/W2011368420","https://openalex.org/W2012786494","https://openalex.org/W2017642141","https://openalex.org/W2023037868","https://openalex.org/W2043673604","https://openalex.org/W2043828851","https://openalex.org/W2051023465","https://openalex.org/W2051075703","https://openalex.org/W2052004935","https://openalex.org/W2062885653","https://openalex.org/W2076589041","https://openalex.org/W2084211101","https://openalex.org/W2085444198","https://openalex.org/W2090046658","https://openalex.org/W2091577013","https://openalex.org/W2096993626","https://openalex.org/W2104258472","https://openalex.org/W2108244474","https://openalex.org/W2108951078","https://openalex.org/W2116350092","https://openalex.org/W2119535917","https://openalex.org/W2126114647","https://openalex.org/W2128972342","https://openalex.org/W2134028524","https://openalex.org/W2135655270","https://openalex.org/W2138699994","https://openalex.org/W2138859947","https://openalex.org/W2145594096","https://openalex.org/W2149548143","https://openalex.org/W2152645648","https://openalex.org/W2156598833","https://openalex.org/W2160942775","https://openalex.org/W2164277023","https://openalex.org/W2165555600","https://openalex.org/W2168881521","https://openalex.org/W2170082865","https://openalex.org/W2171895257","https://openalex.org/W2171910259"],"related_works":["https://openalex.org/W2164277023","https://openalex.org/W2096993626","https://openalex.org/W3007303552","https://openalex.org/W2011368420","https://openalex.org/W2156598833","https://openalex.org/W2071587518","https://openalex.org/W2142128688","https://openalex.org/W2260623803","https://openalex.org/W3110862604","https://openalex.org/W2160178067"],"abstract_inverted_index":{"Mitochondrial":[0],"RNA":[1,41,65,76],"processing":[2,77,85,109,125],"in":[3,74,107,110,123,126,154],"the":[4,60,119],"kinetoplastid":[5],"parasite":[6],"Trypanosoma":[7],"brucei":[8],"involves":[9],"numerous":[10],"specialized":[11],"catalytic":[12],"activities":[13],"that":[14,24,32,63,132,148],"are":[15],"incompletely":[16],"understood.":[17],"The":[18,81],"mitochondrial":[19,75,86],"genome":[20],"consists":[21],"of":[22,37,55,121,135],"maxicircles":[23],"primarily":[25],"encode":[26,33],"rRNAs":[27],"and":[28,30,53,130],"mRNAs,":[29],"minicircles":[31],"a":[34],"diverse":[35],"array":[36],"guide":[38],"RNAs":[39],"(gRNAs).":[40],"editing":[42,66],"uses":[43],"these":[44],"gRNAs":[45],"as":[46],"templates":[47],"to":[48,104],"recode":[49],"mRNAs":[50],"by":[51,137],"insertion":[52],"deletion":[54],"uridine":[56],"(U)":[57],"residues.":[58],"While":[59],"multiprotein":[61],"complex":[62],"catalyzes":[64],"has":[67],"been":[68],"extensively":[69],"studied,":[70],"other":[71],"players":[72],"involved":[73,106,153],"have":[78],"remained":[79],"enigmatic.":[80],"proteins":[82],"required":[83],"for":[84],"polycistronic":[87],"transcripts":[88],"into":[89],"mature":[90],"species":[91],"was":[92,102],"essentially":[93],"unknown":[94],"until":[95],"an":[96],"RNase":[97],"III":[98],"endonuclease,":[99],"called":[100],"mRPN1,":[101],"reported":[103],"be":[105,152],"gRNA":[108,124,143,155],"procyclic":[111],"form":[112,128],"parasites.":[113],"In":[114],"this":[115],"work,":[116],"we":[117],"examine":[118],"role":[120],"mRPN1":[122,136],"bloodstream":[127],"parasites,":[129],"show":[131],"complete":[133],"elimination":[134],"gene":[138],"knockout":[139],"does":[140],"not":[141],"alter":[142],"maturation.":[144],"These":[145],"results":[146],"indicate":[147],"another":[149],"enzyme":[150],"must":[151],"processing.":[156]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
