{"id":"https://openalex.org/W2121908950","doi":"https://doi.org/10.3346/jkms.2014.29.9.1188","title":"2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Cell-Specific Drug Transporters With Acquired Cisplatin Resistance in Cisplatin Sensitive Cancer Cells","display_name":"2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Cell-Specific Drug Transporters With Acquired Cisplatin Resistance in Cisplatin Sensitive Cancer Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2121908950","doi":"https://doi.org/10.3346/jkms.2014.29.9.1188","mag":"2121908950","pmid":"https://pubmed.ncbi.nlm.nih.gov/25246735"},"language":"en","primary_location":{"id":"doi:10.3346/jkms.2014.29.9.1188","doi":"https://doi.org/10.3346/jkms.2014.29.9.1188","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.2014.29.9.1188","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-29-1188.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-29-1188.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065914070","display_name":"Tuvshinjargal Gotovdorj","orcid":"https://orcid.org/0000-0001-6174-2022","observed_orcids":["https://orcid.org/0000-0001-6174-2022"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tuvshinjargal Gotovdorj","raw_affiliation_strings":["Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea","Molecular, Cellular and Developmental Biology, Division of Biomedical Science, Graduate School, Korea University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6174-2022","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Molecular, Cellular and Developmental Biology, Division of Biomedical Science, Graduate School, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057461466","display_name":"Eunil Lee","orcid":"https://orcid.org/0000-0003-1524-5046","observed_orcids":["https://orcid.org/0000-0003-1524-5046"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunil Lee","raw_affiliation_strings":["Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea","Department of Public Health, Graduate School, Korea University, Seoul, Korea","Graduate School of Public Health, Korea University, Seoul, Korea","Molecular, Cellular and Developmental Biology, Division of Biomedical Science, Graduate School, Korea University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1524-5046","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Public Health, Graduate School, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Graduate School of Public Health, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Molecular, Cellular and Developmental Biology, Division of Biomedical Science, Graduate School, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073512440","display_name":"Yongchul Lim","orcid":"https://orcid.org/0000-0001-9195-0623","observed_orcids":["https://orcid.org/0000-0001-9195-0623"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yongchul Lim","raw_affiliation_strings":["Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-9195-0623","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035763384","display_name":"E. Jeong","orcid":"https://orcid.org/0000-0003-1080-0506","observed_orcids":["https://orcid.org/0000-0003-1080-0506"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Jeong Cha","raw_affiliation_strings":["Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1080-0506","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071078693","display_name":"Daeho Kwon","orcid":"https://orcid.org/0000-0003-1314-2537","observed_orcids":["https://orcid.org/0000-0003-1314-2537"]},"institutions":[{"id":"https://openalex.org/I89079967","display_name":"Catholic Kwandong University","ror":"https://ror.org/05n486907","country_code":"KR","type":"education","lineage":["https://openalex.org/I89079967"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Daeho Kwon","raw_affiliation_strings":["Department of Microbiology, College of Medicine, Kwandong University, Gangneung, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1314-2537","affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Medicine, Kwandong University, Gangneung, Korea","institution_ids":["https://openalex.org/I89079967"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eunyoung Hong","orcid":"https://orcid.org/0000-0002-0329-8004","observed_orcids":["https://orcid.org/0000-0002-0329-8004"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunyoung Hong","raw_affiliation_strings":["Department of Public Health, Graduate School, Korea University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-0329-8004","affiliations":[{"raw_affiliation_string":"Department of Public Health, Graduate School, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101408207","display_name":"Yun Jeong Kim","orcid":"https://orcid.org/0000-0003-0870-4320","observed_orcids":["https://orcid.org/0000-0003-0870-4320"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YunJeong Kim","raw_affiliation_strings":["Graduate School of Public Health, Korea University, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-0870-4320","affiliations":[{"raw_affiliation_string":"Graduate School of Public Health, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031332042","display_name":"Min-Yeong Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Yeong Oh","raw_affiliation_strings":["Graduate School of Public Health, Korea University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Public Health, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":900000,"currency":"KRW","value_usd":690},"apc_paid":{"value":900000,"currency":"KRW","value_usd":690},"fwci":0.2872,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.61782575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"29","issue":"9","first_page":"1188","last_page":"1188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-3-7-8-tetrachlorodibenzo-p-dioxin","display_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin","score":0.996999979019165},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9300000071525574},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.7540000081062317},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.6890000104904175},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8389999866485596},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/abcc3","display_name":"ABCC3","score":0.722000002861023},{"id":"https://openalex.org/keywords/abcc5","display_name":"ABCC5","score":0.968999981880188},{"id":"https://openalex.org/keywords/major-vault-protein","display_name":"major vault protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gastric-cancer-cells","display_name":"gastric cancer cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/colon-cancer-cells","display_name":"colon cancer cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/brain-cancer-cells","display_name":"brain cancer cells","score":0.7070000171661377},{"id":"https://openalex.org/keywords/lymphoma-cells","display_name":"lymphoma cells","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.9153575301170349},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5952876210212708},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.553402304649353},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5110384225845337},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5076380968093872},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4574006199836731},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4103521704673767},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39971232414245605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38281404972076416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3011719286441803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27093398571014404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17687755823135376},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.16172334551811218},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12257784605026245},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10366538166999817}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000072317","descriptor_name":"Polychlorinated Dibenzodioxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000099187","descriptor_name":"Major Vault Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020394","descriptor_name":"Vault Ribonucleoprotein Particles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020394","descriptor_name":"Vault Ribonucleoprotein Particles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020394","descriptor_name":"Vault Ribonucleoprotein Particles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020394","descriptor_name":"Vault Ribonucleoprotein Particles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020394","descriptor_name":"Vault Ribonucleoprotein Particles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020394","descriptor_name":"Vault Ribonucleoprotein Particles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"Multidrug Resistance-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"Multidrug Resistance-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"Multidrug Resistance-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"Multidrug Resistance-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033722","descriptor_name":"Equilibrative-Nucleoside Transporter 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033722","descriptor_name":"Equilibrative-Nucleoside Transporter 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033722","descriptor_name":"Equilibrative-Nucleoside Transporter 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033722","descriptor_name":"Equilibrative-Nucleoside Transporter 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033722","descriptor_name":"Equilibrative-Nucleoside Transporter 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033722","descriptor_name":"Equilibrative-Nucleoside Transporter 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044949","descriptor_name":"Kaempferols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3346/jkms.2014.29.9.1188","doi":"https://doi.org/10.3346/jkms.2014.29.9.1188","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.2014.29.9.1188","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-29-1188.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},{"id":"pmid:25246735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25246735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean medical science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4168170","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4168170","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Korean Med Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3346/jkms.2014.29.9.1188","doi":"https://doi.org/10.3346/jkms.2014.29.9.1188","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.2014.29.9.1188","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-29-1188.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G998565979","display_name":null,"funder_award_id":"20090091416","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2121908950.pdf","grobid_xml":"https://content.openalex.org/works/W2121908950.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W42625690","https://openalex.org/W1498903889","https://openalex.org/W1831079403","https://openalex.org/W1832759482","https://openalex.org/W1954721684","https://openalex.org/W1965213576","https://openalex.org/W1966178564","https://openalex.org/W1967759358","https://openalex.org/W1967875039","https://openalex.org/W1970122162","https://openalex.org/W1972279589","https://openalex.org/W1982217309","https://openalex.org/W1988795813","https://openalex.org/W1990729534","https://openalex.org/W1992839043","https://openalex.org/W1993184426","https://openalex.org/W2005580407","https://openalex.org/W2006715022","https://openalex.org/W2012163265","https://openalex.org/W2017046846","https://openalex.org/W2022484334","https://openalex.org/W2037303548","https://openalex.org/W2044911368","https://openalex.org/W2073392285","https://openalex.org/W2078144803","https://openalex.org/W2085560810","https://openalex.org/W2088109617","https://openalex.org/W2090705949","https://openalex.org/W2099575771","https://openalex.org/W2100642393","https://openalex.org/W2104711019","https://openalex.org/W2127286396","https://openalex.org/W2127480567","https://openalex.org/W2135244846","https://openalex.org/W2141035582","https://openalex.org/W2143453349","https://openalex.org/W2152210401","https://openalex.org/W2157199556","https://openalex.org/W2162067613","https://openalex.org/W2162400904","https://openalex.org/W2164277862","https://openalex.org/W2167907964","https://openalex.org/W4230518990"],"related_works":["https://openalex.org/W2091461259","https://openalex.org/W2406608798","https://openalex.org/W2080420195","https://openalex.org/W2406596433","https://openalex.org/W2066496973","https://openalex.org/W2460036924","https://openalex.org/W1971929983","https://openalex.org/W2133246771","https://openalex.org/W3101286845","https://openalex.org/W2086452998"],"abstract_inverted_index":{"2,3,7,8-tetrachlorodibenzo-p-dioxin":[0],"(TCDD)":[1],"can":[2],"induce":[3],"drug":[4,29,182],"transporter":[5,154],"genes":[6,115,155],"such":[7],"as":[8],"the":[9,23,108,111,133,140,170],"ATP-binding":[10],"cassette":[11],"G":[12],"member":[13],"2":[14],"(ABCG2),":[15],"which":[16,75],"contributes":[17],"to":[18,46],"multidrug":[19],"resistance.":[20],"We":[21],"investigated":[22],"effect":[24],"of":[25,35,42,92,110,120,135,181],"TCDD":[26,87,175],"pretreatment":[27],"on":[28],"transporters":[30],"induction":[31,180],"from":[32],"cancer":[33,62,178],"cells":[34,63,74,102],"various":[36],"origins.":[37],"Cell":[38],"viabilities":[39],"after":[40,83],"treatment":[41,85],"cisplatin":[43,49,54,60,172],"were":[44,165],"measured":[45],"evaluate":[47],"acquiring":[48,171],"resistance":[50,55,173],"by":[51,174],"TCDD.":[52],"Acquring":[53],"was":[56,96],"found":[57,97],"only":[58],"in":[59,80,98,107,116,125,143,146,150],"senstivie":[61],"including":[64,156],"gastric":[65],"SNU601,":[66],"colon":[67],"LS180,":[68],"brain":[69],"CRT-MG":[70,151],"and":[71,88,100,119,138,163],"lymphoma":[72],"Jurkat":[73],"showed":[76],"a":[77,104],"significant":[78],"increase":[79,91,106,142],"cell":[81,144],"viability":[82,145],"combined":[84],"with":[86,103,177],"cisplatin.":[89],"High":[90],"ABCG2":[93,136],"gene":[94],"expression":[95,109,137],"SNU601":[99,117],"LS180":[101,126,147],"mild":[105],"ABCC3,":[112],"ABCC5,and":[113],"SLC29A2":[114],"cells,":[118,152],"major":[121],"vault":[122],"protein":[123],"(MVP)":[124],"cells.":[127,148],"The":[128],"AhR":[129],"inhibitor":[130],"kaempferol":[131],"suppressed":[132],"upregulation":[134],"reversed":[139],"TCDD-induced":[141],"However,":[149],"other":[153],"ABCC1,":[157],"ABCC5,":[158],"ABCA3,":[159],"ABCA2,":[160],"ABCB4,":[161],"ABCG1,":[162],"SLC29A1":[164],"up-regulated.":[166],"These":[167],"findings":[168],"suggested":[169],"associated":[176],"cell-type-specific":[179],"transporters.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2025-10-10T00:00:00"}