{"id":"https://openalex.org/W2121763014","doi":"https://doi.org/10.1016/s1359-6349(09)70447-1","title":"1235 A phase-I study of the combination of intravenous reovirus (REOLYSIN \u00ae) and gemcitabine in patients with advanced cancer","display_name":"1235 A phase-I study of the combination of intravenous reovirus (REOLYSIN \u00ae) and gemcitabine in patients with advanced cancer","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2121763014","doi":"https://doi.org/10.1016/s1359-6349(09)70447-1","mag":"2121763014"},"language":"en","primary_location":{"id":"doi:10.1016/s1359-6349(09)70447-1","doi":"https://doi.org/10.1016/s1359-6349(09)70447-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1359-6349(09)70447-1","pdf_url":null,"source":{"id":"https://openalex.org/S13410216","display_name":"European Journal of Cancer Supplements","issn_l":"1359-6349","issn":["1359-6349","1878-1217"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Supplements","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078332643","display_name":"Martijn P. Lolkema","orcid":"https://orcid.org/0000-0003-0466-2928","observed_orcids":["https://orcid.org/0000-0003-0466-2928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.P. Lolkema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072284989","display_name":"Kevin Joseph Harrington","orcid":"https://orcid.org/0000-0002-6014-348X","observed_orcids":["https://orcid.org/0000-0002-6014-348X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Harrington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035271696","display_name":"JEFF EVANS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012989377","display_name":"Hendrik\u2010Tobias Arkenau","orcid":"https://orcid.org/0000-0002-2015-1549","observed_orcids":["https://orcid.org/0000-0002-2015-1549","https://orcid.org/0000-0003-0372-0540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.T. Arkenau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052216285","display_name":"Patricia Roxburgh","orcid":"https://orcid.org/0000-0001-9869-591X","observed_orcids":["https://orcid.org/0000-0001-9869-591X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Roxburgh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067959211","display_name":"Rebecca Morrison","orcid":"https://orcid.org/0000-0001-6337-1771","observed_orcids":["https://orcid.org/0000-0001-6337-1771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Morrison","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006401570","display_name":"Victoria Roulstone","orcid":"https://orcid.org/0000-0003-4141-8123","observed_orcids":["https://orcid.org/0000-0003-4141-8123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Roulstone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111811615","display_name":"Matthew C. Coffey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Coffey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087028329","display_name":"Karl L. Mettinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Mettinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. de Bono","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"2","first_page":"131","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule-association","display_name":"microtubule association","score":0.7820000052452087},{"id":"https://openalex.org/keywords/microtubule-binding-protein","display_name":"microtubule-binding protein","score":0.7950000166893005},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6990000009536743},{"id":"https://openalex.org/keywords/synonymous-mutations","display_name":"synonymous mutations","score":0.5789999961853027},{"id":"https://openalex.org/keywords/ntpase-activity","display_name":"NTPase activity","score":0.824999988079071},{"id":"https://openalex.org/keywords/viral-rna-synthesis","display_name":"viral RNA synthesis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/viral-factories","display_name":"viral factories","score":0.5120000243186951},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.8303244113922119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5865994095802307},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5024075508117676},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.4904598891735077},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47191861271858215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4478342831134796},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19341787695884705},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.030891746282577515}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1359-6349(09)70447-1","doi":"https://doi.org/10.1016/s1359-6349(09)70447-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1359-6349(09)70447-1","pdf_url":null,"source":{"id":"https://openalex.org/S13410216","display_name":"European Journal of Cancer Supplements","issn_l":"1359-6349","issn":["1359-6349","1878-1217"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Supplements","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070985249","https://openalex.org/W1799953230","https://openalex.org/W3134501918","https://openalex.org/W2010822166","https://openalex.org/W7099604956","https://openalex.org/W2122776465","https://openalex.org/W2037483660","https://openalex.org/W2154344559","https://openalex.org/W2110811665","https://openalex.org/W2006331766"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
