{"id":"https://openalex.org/W2121745542","doi":"https://doi.org/10.1046/j.1524-4725.2003.29150.x","title":"A Randomized, Double-Blind, Multicenter Comparison of the Efficacy and Tolerability of Restylane Versus Zyplast for the Correction of Nasolabial Folds","display_name":"A Randomized, Double-Blind, Multicenter Comparison of the Efficacy and Tolerability of Restylane Versus Zyplast for the Correction of Nasolabial Folds","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2121745542","doi":"https://doi.org/10.1046/j.1524-4725.2003.29150.x","mag":"2121745542","pmid":"https://pubmed.ncbi.nlm.nih.gov/12786700"},"language":"en","primary_location":{"id":"doi:10.1046/j.1524-4725.2003.29150.x","doi":"https://doi.org/10.1046/j.1524-4725.2003.29150.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1524-4725.2003.29150.x","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015184186","display_name":"Rhoda S. Narins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118537","display_name":"Dermatology Surgery & Laser Center","ror":"https://ror.org/02ebbs344","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210118537"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rhoda S. Narins","raw_affiliation_strings":["Dermatology and Laser Center, White Plains, New York, USA. rsnmd@worldnet.att.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology and Laser Center, White Plains, New York, USA. rsnmd@worldnet.att.net","institution_ids":["https://openalex.org/I4210118537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109246992","display_name":"Fredric S Brandt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fredric Brandt","raw_affiliation_strings":["Frederic S. Brandt Dermatology & Assoc., Coral Gables, Florida","Frederic S. Brandt Dermatology & Assoc., Coral Gables, Florida,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frederic S. Brandt Dermatology & Assoc., Coral Gables, Florida","institution_ids":[]},{"raw_affiliation_string":"Frederic S. Brandt Dermatology & Assoc., Coral Gables, Florida,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Leyden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086113","display_name":"KGL Skin Study Center","ror":"https://ror.org/00j9wfd65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Leyden","raw_affiliation_strings":["Skin Study Center, Broomall, Pennsylvania","Skin Study Center, Broomall, Pennsylvania,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skin Study Center, Broomall, Pennsylvania","institution_ids":["https://openalex.org/I4210086113"]},{"raw_affiliation_string":"Skin Study Center, Broomall, Pennsylvania,","institution_ids":["https://openalex.org/I4210086113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103100736","display_name":"Z. Paul Lorenc","orcid":"https://orcid.org/0000-0002-5119-8825","observed_orcids":["https://orcid.org/0000-0002-5119-8825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z. Paul Lorenc","raw_affiliation_strings":["Lorenc Aesthetic Plastic Surgery, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lorenc Aesthetic Plastic Surgery, New York,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Rubin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Rubin","raw_affiliation_strings":["Lasky Clinic, Beverly Hills, California","Lasky Clinic, Beverly Hills, California, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lasky Clinic, Beverly Hills, California","institution_ids":[]},{"raw_affiliation_string":"Lasky Clinic, Beverly Hills, California, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103083388","display_name":"STACY R. SMITH","orcid":"https://orcid.org/0000-0002-4384-6888","observed_orcids":["https://orcid.org/0000-0002-4384-6888"]},"institutions":[{"id":"https://openalex.org/I4210118537","display_name":"Dermatology Surgery & Laser Center","ror":"https://ror.org/02ebbs344","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210118537"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stacy Smith","raw_affiliation_strings":["Dermatology and Laser Center, White Plains, New York","Therapeutics Inc., La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology and Laser Center, White Plains, New York","institution_ids":["https://openalex.org/I4210118537"]},{"raw_affiliation_string":"Therapeutics Inc., La Jolla, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015184186","https://openalex.org/A5103083388"],"corresponding_institution_ids":["https://openalex.org/I4210118537"],"apc_list":null,"apc_paid":null,"fwci":26.8676,"has_fulltext":false,"cited_by_count":562,"citation_normalized_percentile":{"value":0.99914174,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"29","issue":"6","first_page":"588","last_page":"595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12301","display_name":"Facial Nerve Paralysis Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasolabial-fold-correction","display_name":"nasolabial fold correction","score":0.8080000281333923},{"id":"https://openalex.org/keywords/restylane","display_name":"Restylane","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8370000123977661},{"id":"https://openalex.org/keywords/bovine-collagen","display_name":"bovine collagen","score":0.9919999837875366},{"id":"https://openalex.org/keywords/facial-soft-tissue-augmentation","display_name":"facial soft tissue augmentation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dermal-fillers","display_name":"dermal fillers","score":0.6959999799728394},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.4959999918937683},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.9459999799728394},{"id":"https://openalex.org/keywords/injection-site-reactions","display_name":"injection site reactions","score":0.7889999747276306},{"id":"https://openalex.org/keywords/wrinkle-severity-rating-scale","display_name":"Wrinkle Severity Rating Scale","score":0.9520000219345093},{"id":"https://openalex.org/keywords/global-aesthetic-improvement-scale","display_name":"Global Aesthetic Improvement Scale","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.9520840048789978},{"id":"https://openalex.org/C2777872592","wikidata":"https://www.wikidata.org/wiki/Q349185","display_name":"Wrinkle","level":2,"score":0.7588350176811218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.682133674621582},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.609532356262207},{"id":"https://openalex.org/C2775935860","wikidata":"https://www.wikidata.org/wiki/Q1425611","display_name":"Nasolabial fold","level":2,"score":0.541102409362793},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4687621295452118},{"id":"https://openalex.org/C2909121775","wikidata":"https://www.wikidata.org/wiki/Q5174008","display_name":"Cosmetic Techniques","level":2,"score":0.4589698016643524},{"id":"https://openalex.org/C2779758324","wikidata":"https://www.wikidata.org/wiki/Q5428567","display_name":"Facial rejuvenation","level":2,"score":0.45782431960105896},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40534508228302},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.32119670510292053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2031252682209015},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003357","descriptor_name":"Cosmetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003357","descriptor_name":"Cosmetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003357","descriptor_name":"Cosmetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008046","descriptor_name":"Lip","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008046","descriptor_name":"Lip","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008046","descriptor_name":"Lip","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009666","descriptor_name":"Nose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009666","descriptor_name":"Nose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009666","descriptor_name":"Nose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1046/j.1524-4725.2003.29150.x","doi":"https://doi.org/10.1046/j.1524-4725.2003.29150.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1524-4725.2003.29150.x","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},{"id":"doi:10.1097/00042728-200306000-00006","doi":"https://doi.org/10.1097/00042728-200306000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00042728-200306000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},{"id":"pmid:12786700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12786700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.861.8852","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.861.8852","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.therapeuticsinc.com/news_publications/documents/Restylane_publication_001.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1964540098","https://openalex.org/W1987393062","https://openalex.org/W1993554726","https://openalex.org/W2005162306","https://openalex.org/W2005825565","https://openalex.org/W2009544323","https://openalex.org/W2062513135","https://openalex.org/W2064613915","https://openalex.org/W2082440478","https://openalex.org/W2083583736","https://openalex.org/W2087451216","https://openalex.org/W2101952242","https://openalex.org/W2114813556","https://openalex.org/W2118322752","https://openalex.org/W2154602069","https://openalex.org/W2401002595","https://openalex.org/W4241296793"],"related_works":["https://openalex.org/W2384270240","https://openalex.org/W2251083773","https://openalex.org/W2415225343","https://openalex.org/W1994629037","https://openalex.org/W2956628452","https://openalex.org/W2130052028","https://openalex.org/W2409715102","https://openalex.org/W4389323325","https://openalex.org/W4250920356","https://openalex.org/W3187354904"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bovine":[1],"collagen":[2,59,85,188,226],"is":[3,228],"extensively":[4],"used":[5],"for":[6,61,127,209],"facial":[7],"soft":[8],"tissue":[9],"augmentation":[10],"but":[11],"provides":[12,218],"only":[13],"temporary":[14],"correction":[15,29],"and":[16,30,36,43,83,116,139,141,161,181,193,201,227],"can":[17],"cause":[18],"hypersensitivity":[19],"reactions.":[20],"Hyaluronic":[21],"acid":[22,49,81,133,145,175,217],"derivatives":[23],"potentially":[24],"offer":[25],"improved":[26],"longevity":[27],"of":[28,34,45,57,63,89,183,195,203],"a":[31,110,219],"reduced":[32],"risk":[33],"immunogenicity":[35],"hypersensitivity.":[37],"OBJECTIVE:":[38],"To":[39],"compare":[40],"the":[41,90,210],"efficacy":[42],"safety":[44],"nonanimal":[46],"stabilized":[47,215],"hyaluronic":[48,80,132,144,174,216],"gel":[50,82,134,146,176],"(Restylane;":[51],"Q-Med,":[52],"Uppsala,":[53],"Sweden)":[54],"with":[55,71,79,131,136],"that":[56,173],"bovine":[58,84,137,187,225],"(Zyplast)":[60],"treatment":[62,78],"nasolabial":[64,73],"folds.":[65],"METHODS:":[66],"One":[67],"hundred":[68],"thirty-eight":[69],"patients":[70,140],"prominent":[72],"folds":[74],"were":[75,93,107,207],"randomized":[76],"to":[77,100,147],"on":[86],"contralateral":[87],"sides":[88],"face.":[91],"Treatments":[92],"repeated":[94],"at":[95,113,167],"2-week":[96],"intervals,":[97],"as":[98],"required,":[99],"achieve":[101],"\"optimal":[102,128],"cosmetic":[103,129,153],"result\"":[104,130],"(baseline).":[105],"Outcomes":[106],"evaluated":[108],"by":[109],"blinded":[111],"investigator":[112],"2,":[114],"4,":[115],"6":[117,168],"months":[118,169],"after":[119,170],"baseline.":[120],"RESULTS:":[121],"Less":[122],"injection":[123],"volume":[124],"was":[125,177,189],"required":[126],"than":[135,224],"collagen,":[138],"investigators":[142],"judged":[143],"be":[148],"more":[149,220],"effective":[150],"in":[151,179,191],"maintaining":[152],"correction.":[154],"The":[155,198],"investigator-based":[156],"Wrinkle":[157],"Severity":[158],"Rating":[159],"Scale":[160,165],"Global":[162],"Aesthetic":[163],"Improvement":[164],"assessments":[166],"baseline":[171],"indicated":[172],"superior":[178,190],"56.9%":[180],"62.0%":[182],"patients,":[184,196],"respectively,":[185],"whereas":[186],"9.5%":[192],"8.0%":[194],"respectively.":[197],"frequency,":[199],"intensity,":[200],"duration":[202],"local":[204],"injection-site":[205],"reactions":[206],"similar":[208],"two":[211],"products.":[212],"CONCLUSION:":[213],"Nonanimal":[214],"durable":[221],"aesthetic":[222],"improvement":[223],"well":[229],"tolerated.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":23}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
