{"id":"https://openalex.org/W2121566985","doi":"https://doi.org/10.1093/jac/dkq458","title":"Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment","display_name":"Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment","publication_year":2010,"publication_date":"2010-12-31","ids":{"openalex":"https://openalex.org/W2121566985","doi":"https://doi.org/10.1093/jac/dkq458","mag":"2121566985","pmid":"https://pubmed.ncbi.nlm.nih.gov/21196489","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3019088"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkq458","doi":"https://doi.org/10.1093/jac/dkq458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkq458","pdf_url":"https://academic.oup.com/jac/article-pdf/66/2/265/2141723/dkq458.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jac/article-pdf/66/2/265/2141723/dkq458.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076699359","display_name":"Linos Vandekerckhove","orcid":"https://orcid.org/0000-0002-8600-1631","observed_orcids":["https://orcid.org/0000-0002-8600-1631"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"L. Vandekerckhove","raw_affiliation_strings":["Department of General Internal Medicine, Infectious Diseases and Psychosomatic Medicine, University Hospital Ghent, Ghent, Belgium. linos.vandekerckhove@ugent.be","AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium","Department of General Internal Medicine, Infectious Diseases and Psychosomatic Medicine, University Hospital Ghent, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Infectious Diseases and Psychosomatic Medicine, University Hospital Ghent, Ghent, Belgium. linos.vandekerckhove@ugent.be","institution_ids":["https://openalex.org/I2801227569"]},{"raw_affiliation_string":"AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]},{"raw_affiliation_string":"Department of General Internal Medicine, Infectious Diseases and Psychosomatic Medicine, University Hospital Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025728078","display_name":"Chris Verhofstede","orcid":"https://orcid.org/0000-0002-0645-1174","observed_orcids":["https://orcid.org/0000-0002-0645-1174"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C. Verhofstede","raw_affiliation_strings":["AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031219315","display_name":"Els Demecheleer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E. Demecheleer","raw_affiliation_strings":["AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107842158","display_name":"St\u00e9phane De Wit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S. De Wit","raw_affiliation_strings":["Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium","institution_ids":["https://openalex.org/I4210154425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074588238","display_name":"\u00c9ric Florence","orcid":"https://orcid.org/0000-0002-7004-9120","observed_orcids":["https://orcid.org/0000-0002-7004-9120","https://orcid.org/0000-0001-8317-7917"]},"institutions":[{"id":"https://openalex.org/I78281549","display_name":"Instituut voor Tropische Geneeskunde","ror":"https://ror.org/03xq4x896","country_code":"BE","type":"funder","lineage":["https://openalex.org/I78281549"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E. Florence","raw_affiliation_strings":["Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium","institution_ids":["https://openalex.org/I78281549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067774407","display_name":"Katrien Fransen","orcid":"https://orcid.org/0000-0003-2127-4599","observed_orcids":["https://orcid.org/0000-0003-2127-4599"]},"institutions":[{"id":"https://openalex.org/I78281549","display_name":"Instituut voor Tropische Geneeskunde","ror":"https://ror.org/03xq4x896","country_code":"BE","type":"funder","lineage":["https://openalex.org/I78281549"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"K. Fransen","raw_affiliation_strings":["AIDS Reference Laboratory, Institute of Tropical Medicine, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Reference Laboratory, Institute of Tropical Medicine, Antwerp, Belgium","institution_ids":["https://openalex.org/I78281549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036459628","display_name":"Michel P. Moutschen","orcid":"https://orcid.org/0000-0002-6405-1785","observed_orcids":["https://orcid.org/0000-0002-6405-1785"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Moutschen","raw_affiliation_strings":["Immunology and Infectious Diseases Unit, GIGA-Research, University of Liege, Liege-Sart Tilman, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology and Infectious Diseases Unit, GIGA-Research, University of Liege, Liege-Sart Tilman, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045084331","display_name":"Wendy Mostmans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Mostmans","raw_affiliation_strings":["Virco BVBA, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virco BVBA, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080832138","display_name":"Kabamba Kabeya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154425","display_name":"Centre Hospitalier Universitaire de Saint-Pierre","ror":"https://ror.org/05cmp5q80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210154425"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"K. Kabeya","raw_affiliation_strings":["Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium","institution_ids":["https://openalex.org/I4210154425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018207343","display_name":"N Mackie","orcid":"https://orcid.org/0009-0003-6502-8063","observed_orcids":["https://orcid.org/0009-0003-6502-8063"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Mackie","raw_affiliation_strings":["Imperial College Healthcare National Health Service Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Healthcare National Health Service Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022619099","display_name":"Jean R. Plum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Plum","raw_affiliation_strings":["AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Reference Laboratory, University Hospital Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Vaira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"D. Vaira","raw_affiliation_strings":["Immunology and Infectious Diseases Unit, GIGA-Research, University of Liege, Liege-Sart Tilman, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology and Infectious Diseases Unit, GIGA-Research, University of Liege, Liege-Sart Tilman, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054798384","display_name":"Karen Van Baelen","orcid":"https://orcid.org/0000-0002-5700-3574","observed_orcids":["https://orcid.org/0000-0002-5700-3574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Van Baelen","raw_affiliation_strings":["Virco BVBA, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virco BVBA, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046409769","display_name":"Ina Vandenbroucke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Vandenbroucke","raw_affiliation_strings":["Virco BVBA, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virco BVBA, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050421096","display_name":"Veerle Van Eygen","orcid":"https://orcid.org/0000-0001-8804-1613","observed_orcids":["https://orcid.org/0000-0001-8804-1613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Van Eygen","raw_affiliation_strings":["Virco BVBA, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virco BVBA, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047207289","display_name":"Herwig G. Van Marck","orcid":"https://orcid.org/0000-0002-5198-5335","observed_orcids":["https://orcid.org/0000-0002-5198-5335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Van Marck","raw_affiliation_strings":["Virco BVBA, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virco BVBA, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053029618","display_name":"Dirk Vogelaers","orcid":"https://orcid.org/0000-0002-7707-285X","observed_orcids":["https://orcid.org/0000-0002-7707-285X"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"D. Vogelaers","raw_affiliation_strings":["Department of General Internal Medicine, Infectious Diseases and Psychosomatic Medicine, University Hospital Ghent, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Infectious Diseases and Psychosomatic Medicine, University Hospital Ghent, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054324011","display_name":"Anna Mar\u00eda Geretti","orcid":"https://orcid.org/0000-0002-3670-6588","observed_orcids":["https://orcid.org/0000-0002-3670-6588"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]},{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. M. Geretti","raw_affiliation_strings":["University College Medical School and Royal Free Hampstead National Health Service Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Medical School and Royal Free Hampstead National Health Service Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I169248724","https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070724386","display_name":"Lieven J. Stuyver","orcid":"https://orcid.org/0000-0001-7818-9390","observed_orcids":["https://orcid.org/0000-0001-7818-9390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. J. Stuyver","raw_affiliation_strings":["Virco BVBA, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virco BVBA, Beerse, Belgium","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5076699359"],"corresponding_institution_ids":["https://openalex.org/I2801227569"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":{"value":2869,"currency":"GBP","value_usd":3784},"fwci":2.6856,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89235799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"66","issue":"2","first_page":"265","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.21860000491142273,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-tropism","display_name":"HIV-1 tropism","score":0.9760000109672546},{"id":"https://openalex.org/keywords/maraviroc","display_name":"maraviroc","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ccr5-antagonist","display_name":"CCR5 antagonist","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ultra-deep-sequencing","display_name":"ultra-deep sequencing","score":0.7850000262260437},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2778899366","wikidata":"https://www.wikidata.org/wiki/Q421369","display_name":"Maraviroc","level":3,"score":0.9876203536987305},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.7081557512283325},{"id":"https://openalex.org/C37044404","wikidata":"https://www.wikidata.org/wiki/Q5009692","display_name":"CCR5 receptor antagonist","level":5,"score":0.6900924444198608},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6240772008895874},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5455957055091858},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5415693521499634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5386971831321716},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4769767224788666},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.44003167748451233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3443076014518738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3414386212825775},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22722643613815308},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11780902743339539},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10189792513847351},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000077592","descriptor_name":"Maraviroc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056189","descriptor_name":"Viral Tropism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1093/jac/dkq458","doi":"https://doi.org/10.1093/jac/dkq458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkq458","pdf_url":"https://academic.oup.com/jac/article-pdf/66/2/265/2141723/dkq458.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3019088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3019088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Antimicrob Chemother","raw_type":"Text"},{"id":"pmid:21196489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21196489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Comparative Study"},{"id":"pmh:oai:archive.ugent.be:1206204","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/1206204","pdf_url":"https://biblio.ugent.be/publication/1206204/file/1207738.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0305-7453","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:art.torvergata.it:2108/410685","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2108/410685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/169323","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/169323","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of antimicrobial chemotherapy, 66 (2","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkq458v1","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkq458v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/110799","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/110799","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Antimicrobial Chemotherapy, 66 (2), 265-72 (2011)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1093/jac/dkq458","doi":"https://doi.org/10.1093/jac/dkq458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkq458","pdf_url":"https://academic.oup.com/jac/article-pdf/66/2/265/2141723/dkq458.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2121566985.pdf","grobid_xml":"https://content.openalex.org/works/W2121566985.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W101727076","https://openalex.org/W115823608","https://openalex.org/W1426208733","https://openalex.org/W1563310348","https://openalex.org/W1606409921","https://openalex.org/W1767400858","https://openalex.org/W1989062156","https://openalex.org/W1998818310","https://openalex.org/W2048448752","https://openalex.org/W2103467105","https://openalex.org/W2122589684","https://openalex.org/W2126897429","https://openalex.org/W2133194323","https://openalex.org/W2150001263","https://openalex.org/W2154729337","https://openalex.org/W2155447554","https://openalex.org/W2161416666","https://openalex.org/W2168709956","https://openalex.org/W2169054534","https://openalex.org/W2169186537","https://openalex.org/W2297631951","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W188945215","https://openalex.org/W2982393384","https://openalex.org/W60051277","https://openalex.org/W2806768040","https://openalex.org/W2804263557","https://openalex.org/W1953735714","https://openalex.org/W2328584320","https://openalex.org/W2128056683","https://openalex.org/W2943916759","https://openalex.org/W969587007"],"abstract_inverted_index":{"BACKGROUND:":[0],"Determination":[1],"of":[2,11,19,62,73,83,130,236,250],"HIV-1":[3],"tropism":[4,22,33,67,77,122,133,140,239,245],"is":[5],"a":[6,63,112,131,200,205,242],"pre-requisite":[7],"to":[8,119,137,170],"the":[9,17,29,71,81,121,128,138,171,180,185,234,248],"use":[10,235],"CCR5":[12,145],"antagonists.":[13],"This":[14,124],"study":[15],"evaluated":[16],"potential":[18],"population":[20,86,99,195,197,237],"genotypic":[21,238],"tests":[23,34],"(GTTs)":[24],"in":[25,36,60,117],"clinical":[26,228],"practice,":[27],"and":[28,95,101,153,184,187,204,215],"correlation":[30],"with":[31,193,224],"phenotypic":[32],"(PTTs)":[35],"patients":[37,59],"accessing":[38],"routine":[39],"HIV":[40],"care.":[41],"METHODS:":[42],"Forty-nine":[43],"consecutive":[44],"plasma":[45],"samples":[46,143,162,183],"for":[47,150,166,244],"which":[48],"an":[49,216],"original":[50],"Trofile(TM)":[51,194],"assay":[52],"was":[53,68,110,115],"performed":[54,116],"were":[55,144,155],"obtained":[56,79],"from":[57,80,227],"triple-class-experienced":[58],"need":[61],"therapy":[64],"change.":[65],"Viral":[66],"defined":[69],"as":[70,157,241],"consensus":[72,109],"three":[74],"or":[75],"more":[76],"calls":[78],"combination":[82],"two":[84],"independent":[85],"PTT":[87,114],"assays":[88],"(Trofile":[89],"Biosciences,":[90],"San":[91],"Francisco,":[92],"CA,":[93],"USA,":[94],"Virco,":[96],"Beerse,":[97],"Belgium),":[98],"GTTs":[100,102,198],"based":[103],"on":[104],"ultra-deep":[105],"sequencing.":[106],"If":[107],"no":[108],"reached,":[111],"clonal":[113],"order":[118],"finalize":[120],"call.":[123,134],"two-step":[125],"approach":[126],"allowed":[127],"definition":[129],"reference":[132,139],"RESULTS:":[135],"According":[136],"result,":[141],"35/49":[142],"tropic":[146],"(R5)":[147],"(patients":[148],"eligible":[149,165],"maraviroc":[151,167],"treatment)":[152],"14/49":[154],"assigned":[156],"non-R5":[158,161],"tropic.":[159],"The":[160],"[patients":[163],"not":[164],"treatment":[168],"according":[169],"FDA/European":[172],"Medicines":[173],"Agency":[174],"(EMEA)":[175],"label]":[176],"group":[177],"included":[178],"both":[179],"CXCR4":[181],"(X4)":[182],"dual":[186],"mixed":[188],"CCR5/CXCR4":[189],"(R5/X4)":[190],"samples.":[191],"Compared":[192],"PTTs,":[196],"showed":[199],"higher":[201,206],"sensitivity":[202],"(97%)":[203],"negative":[207],"predictive":[208,219],"value":[209],"(91%),":[210],"but":[211],"almost":[212],"equal":[213,217],"specificity":[214],"positive":[218],"value.":[220],"CONCLUSIONS:":[221],"In":[222],"line":[223],"recent":[225],"reports":[226],"trial":[229],"data,":[230],"our":[231],"data":[232],"support":[233],"testing":[240],"tool":[243],"determination":[246],"before":[247],"start":[249],"maraviroc.":[251]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}