{"id":"https://openalex.org/W2121005801","doi":null,"title":"Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance.","display_name":"Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance.","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2121005801","mag":"2121005801","pmid":"https://pubmed.ncbi.nlm.nih.gov/11064488"},"language":"en","primary_location":{"id":"pmid:11064488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11064488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Mount Sinai journal of medicine, New York","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000238308","display_name":"IGOR I. GALYNKER","orcid":"https://orcid.org/0000-0001-8083-9479","observed_orcids":["https://orcid.org/0000-0001-8083-9479","https://orcid.org/0009-0001-4122-1470"]},"institutions":[{"id":"https://openalex.org/I1287643137","display_name":"Mount Sinai Beth Israel","ror":"https://ror.org/01742jq13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287643137","https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I I Galynker","raw_affiliation_strings":["Department of Psychiatry, Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003, USA","Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003, USA","institution_ids":["https://openalex.org/I1287643137"]},{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062277804","display_name":"Sniezyna Watras Gans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Watras-Ganz","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085444481","display_name":"Christian R. Miner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Miner","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019146461","display_name":"Richard N. Rosenthal","orcid":"https://orcid.org/0000-0002-6011-809X","observed_orcids":["https://orcid.org/0000-0002-6011-809X"]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R N Rosenthal","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080704496","display_name":"Don C. Des Jarlais","orcid":"https://orcid.org/0000-0002-0157-8168","observed_orcids":["https://orcid.org/0000-0002-0157-8168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Des Jarlais","raw_affiliation_strings":["Global Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053165768","display_name":"Beverly L. Richman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B L Richman","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019337347","display_name":"Edythe D. London","orcid":"https://orcid.org/0000-0003-3577-7808","observed_orcids":["https://orcid.org/0000-0003-3577-7808"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E London","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2741,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.89001258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"67","issue":"5-6","first_page":"381","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9860000014305115},{"id":"https://openalex.org/keywords/methadone-maintenance-treatment","display_name":"methadone maintenance treatment","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anterior-cingulate-cortex","display_name":"anterior cingulate cortex","score":0.9190000295639038},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.6650000214576721},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2778140631","wikidata":"https://www.wikidata.org/wiki/Q2026938","display_name":"Opiate","level":3,"score":0.8512263894081116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7389971613883972},{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.7163347005844116},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5368216037750244},{"id":"https://openalex.org/C2778903061","wikidata":"https://www.wikidata.org/wiki/Q17156814","display_name":"Methadone maintenance","level":3,"score":0.5136067867279053},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.4901221692562103},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.4644335210323334},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.44304946064949036},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.44257956743240356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.442336767911911},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3824571967124939},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09903281927108765}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11064488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11064488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Mount Sinai journal of medicine, New York","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.454.7401","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.454.7401","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.drugpolicy.org/docUploads/meth381.pdf","raw_type":"text"},{"id":"mag:2121005801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11064488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G82511758","display_name":"ASSERTIVE OUTREACH FOR SUBSTANCE DEPENDENT MENTALLY ILL","funder_award_id":"R01DA009431","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1508846850","https://openalex.org/W1773001224","https://openalex.org/W1967981329","https://openalex.org/W1968280685","https://openalex.org/W1969436218","https://openalex.org/W1974610494","https://openalex.org/W1974965561","https://openalex.org/W1978136073","https://openalex.org/W1980315117","https://openalex.org/W1984897162","https://openalex.org/W2000526996","https://openalex.org/W2005581629","https://openalex.org/W2009257194","https://openalex.org/W2030258997","https://openalex.org/W2033127662","https://openalex.org/W2047670385","https://openalex.org/W2047912148","https://openalex.org/W2049707473","https://openalex.org/W2050443628","https://openalex.org/W2056532414","https://openalex.org/W2073902466","https://openalex.org/W2087917230","https://openalex.org/W2092941291","https://openalex.org/W2093155685","https://openalex.org/W2108038806","https://openalex.org/W2110965393","https://openalex.org/W2113443500","https://openalex.org/W2132284897","https://openalex.org/W2149860264","https://openalex.org/W2270174414","https://openalex.org/W2336027753","https://openalex.org/W4240267522"],"related_works":["https://openalex.org/W2057972821","https://openalex.org/W1983274014","https://openalex.org/W2093253429","https://openalex.org/W2041576679","https://openalex.org/W1963744902","https://openalex.org/W4233455880","https://openalex.org/W2050523253","https://openalex.org/W6981397607","https://openalex.org/W4388802165","https://openalex.org/W2099881958"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,13,151],"long-term":[2],"effects":[3],"of":[4,15,27,98,137,153,165],"opiate":[5,28,168,195],"use":[6,42,103,196],"on":[7],"human":[8,23],"brain":[9,34,164],"are":[10,192],"not":[11,88,146],"known.":[12],"goal":[14],"this":[16,154],"preliminary":[17],"study":[18,155],"was":[19,62,116],"to":[20,64,180,185,194,198],"determine":[21,186],"whether":[22,45,187],"subjects":[24,78,87,100,132],"with":[25,38],"histories":[26],"dependence":[29],"have":[30],"persistent":[31],"differences":[32,191],"in":[33,73,109,111,130,162,205],"function":[35],"as":[36],"compared":[37],"individuals":[39],"without":[40,101],"substance":[41,102],"disorders,":[43],"and":[44,94,121,139,184],"methadone":[46,81,90],"maintenance":[47,82,91],"reverses":[48],"or":[49,197],"ameliorates":[50],"the":[51,66,112,119,143,163,188],"potential":[52],"abnormality.":[53],"METHOD:":[54],"Positron":[55],"emission":[56],"tomographic":[57],"(PET)":[58],"[18F]fluorodeoxyglucose":[59],"(FDG)":[60],"method":[61],"used":[63],"compare":[65],"regional":[67],"cerebral":[68],"metabolic":[69],"rate":[70],"for":[71],"glucose(rCMRglc)":[72],"three":[74],"groups:":[75],"four":[76,85],"opiate-dependent":[77,86],"currently":[79],"receiving":[80,89],"therapy":[83,92],"(MM),":[84],"(MW),":[93],"a":[95,166,203],"comparison":[96],"group":[97],"five":[99],"disorders.":[104],"RESULTS:":[105],"A":[106],"significant":[107],"difference":[108,144],"rCMRglc":[110,190],"anterior":[113],"cingulate":[114],"gyrus":[115],"found":[117],"between":[118,135],"MW":[120,138],"Control":[122,140],"groups":[123],"(Mann-Whitney":[124],"U=2.0,":[125],"p=0.05).":[126],"Generally":[127],"speaking,":[128],"rCMRglc's":[129],"MM":[131],"were":[133],"intermediate":[134],"those":[136],"groups,":[141],"although":[142],"did":[145],"reach":[147],"statistical":[148],"significance.":[149],"CONCLUSIONS:":[150],"results":[152,183],"suggest":[156],"that":[157,201],"neurobiological":[158],"abnormalities":[159,200],"can":[160],"persist":[161],"chronic":[167],"user":[169],"several":[170],"years":[171],"after":[172],"detoxification":[173],"from":[174],"methadone.":[175],"Future":[176],"research":[177],"is":[178],"needed":[179],"replicate":[181],"these":[182],"observed":[189],"related":[193],"neurochemical":[199],"play":[202],"role":[204],"developing":[206],"addictive":[207],"behavior.":[208]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}