{"id":"https://openalex.org/W2120882909","doi":"https://doi.org/10.1371/journal.pone.0044622","title":"Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent","display_name":"Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent","publication_year":2012,"publication_date":"2012-09-13","ids":{"openalex":"https://openalex.org/W2120882909","doi":"https://doi.org/10.1371/journal.pone.0044622","mag":"2120882909","pmid":"https://pubmed.ncbi.nlm.nih.gov/23028567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3441567"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0044622","doi":"https://doi.org/10.1371/journal.pone.0044622","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044622","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044622&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044622&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091065841","display_name":"Xinggang Wu","orcid":"https://orcid.org/0000-0001-6163-0493","observed_orcids":["https://orcid.org/0000-0001-6163-0493"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xinggang Wu","raw_affiliation_strings":["School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030929661","display_name":"Lai\u2010Ming Yung","orcid":"https://orcid.org/0000-0002-3650-2980","observed_orcids":["https://orcid.org/0000-0002-3650-2980"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lai-Ming Yung","raw_affiliation_strings":["Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083579737","display_name":"Wai Hang Cheng","orcid":"https://orcid.org/0000-0002-3408-9184","observed_orcids":["https://orcid.org/0000-0002-3408-9184"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Wai-Hang Cheng","raw_affiliation_strings":["School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017833659","display_name":"Paul B. Yu","orcid":"https://orcid.org/0000-0003-2145-4944","observed_orcids":["https://orcid.org/0000-0003-2145-4944"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul B. Yu","raw_affiliation_strings":["Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036703144","display_name":"Jodie L. Babitt","orcid":"https://orcid.org/0000-0003-1228-1551","observed_orcids":["https://orcid.org/0000-0003-1228-1551"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jodie L. Babitt","raw_affiliation_strings":["Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105935846","display_name":"Herbert Yih-Fuu Lin","orcid":"https://orcid.org/0009-0008-4774-0627","observed_orcids":["https://orcid.org/0009-0008-4774-0627"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Y. Lin","raw_affiliation_strings":["Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Anemia Signaling Research, Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100736595","display_name":"Yin Yan Xia","orcid":"https://orcid.org/0000-0003-0315-7532","observed_orcids":["https://orcid.org/0000-0003-0315-7532"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Yin Xia","raw_affiliation_strings":["Jinan University-The Chinese University of Hong Kong Key Laboratory for Regenerative Medicine, Ministry of Education, Guangzhou, China","School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China","Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinan University-The Chinese University of Hong Kong Key Laboratory for Regenerative Medicine, Ministry of Education, Guangzhou, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I177725633"]},{"raw_affiliation_string":"School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China","institution_ids":["https://openalex.org/I4210116924"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100736595"],"corresponding_institution_ids":["https://openalex.org/I159948400","https://openalex.org/I177725633","https://openalex.org/I4210116924"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.451,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.93113611,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"9","first_page":"e44622","last_page":"e44622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepcidin","display_name":"hepcidin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bmp6","display_name":"BMP6","score":1.0},{"id":"https://openalex.org/keywords/smad1-5-8-phosphorylation","display_name":"Smad1/5/8 phosphorylation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/id1","display_name":"Id1","score":0.7509999871253967},{"id":"https://openalex.org/keywords/iron-regulation","display_name":"iron regulation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hemojuvelin","display_name":"hemojuvelin","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.9927675724029541},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6192718744277954},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.594231903553009},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5868493914604187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5537645220756531},{"id":"https://openalex.org/C181628713","wikidata":"https://www.wikidata.org/wiki/Q14903748","display_name":"Bone morphogenetic protein 6","level":5,"score":0.544224739074707},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49806976318359375},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.49021750688552856},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.43591418862342834},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42542269825935364},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4208434224128723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39870432019233704},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3869014382362366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3764948546886444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3699873089790344},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21320819854736328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16858112812042236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12644413113594055},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.12294483184814453},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07290828227996826},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013454","descriptor_name":"Sulfoxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051798","descriptor_name":"Inhibitor of Differentiation Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051898","descriptor_name":"Smad1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051902","descriptor_name":"Smad5 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051904","descriptor_name":"Smad8 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055415","descriptor_name":"Bone Morphogenetic Protein 4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055418","descriptor_name":"Bone Morphogenetic Protein 6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D064451","descriptor_name":"Hepcidins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0044622","doi":"https://doi.org/10.1371/journal.pone.0044622","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044622","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044622&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2452218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3441567","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3441567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3441567","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23028567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23028567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.769.3775","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.769.3775","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/87/25/pone.0044622.PMC3441567.pdf","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/10498784","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10498784","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4cdc57d9cda04969952c3737b2f75ada","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4cdc57d9cda04969952c3737b2f75ada","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 9, p e44622 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0044622","doi":"https://doi.org/10.1371/journal.pone.0044622","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044622","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044622&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1207668284","display_name":"Molecular and cellular mechanisms of heterotopic ossification","funder_award_id":"R01AR057374","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4537218895","display_name":"Mechanisms of action of hemojuvelin","funder_award_id":"R01DK071837","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8158644483","display_name":"Regulation of Iron Homeostasis by BMP Signaling","funder_award_id":"R01DK087727","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120882909.pdf","grobid_xml":"https://content.openalex.org/works/W2120882909.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1645591373","https://openalex.org/W1707148630","https://openalex.org/W1761222131","https://openalex.org/W1965254560","https://openalex.org/W1965288056","https://openalex.org/W1977767277","https://openalex.org/W1979482280","https://openalex.org/W1992880469","https://openalex.org/W1997562107","https://openalex.org/W1999203566","https://openalex.org/W2009988274","https://openalex.org/W2012836529","https://openalex.org/W2024408363","https://openalex.org/W2025063713","https://openalex.org/W2030400155","https://openalex.org/W2049912996","https://openalex.org/W2050656944","https://openalex.org/W2050833520","https://openalex.org/W2059080581","https://openalex.org/W2064708319","https://openalex.org/W2065585203","https://openalex.org/W2066937360","https://openalex.org/W2068313428","https://openalex.org/W2069594569","https://openalex.org/W2098200075","https://openalex.org/W2103263770","https://openalex.org/W2107072141","https://openalex.org/W2117133328","https://openalex.org/W2118753068","https://openalex.org/W2120066253","https://openalex.org/W2134420180","https://openalex.org/W2137616957","https://openalex.org/W2140534638","https://openalex.org/W2142374658","https://openalex.org/W2154568166","https://openalex.org/W2163487646","https://openalex.org/W2166920557","https://openalex.org/W2167404536","https://openalex.org/W2519905081"],"related_works":["https://openalex.org/W7095529879","https://openalex.org/W2085329459","https://openalex.org/W2141687032","https://openalex.org/W7098212578","https://openalex.org/W2761872170","https://openalex.org/W4313385927","https://openalex.org/W772279174","https://openalex.org/W2050656944","https://openalex.org/W2902140922","https://openalex.org/W2774189642"],"abstract_inverted_index":{"Hepcidin":[0,24,59],"is":[1,25,33,52,60,107,114,199],"an":[2,86],"antimicrobial":[3],"peptide,":[4],"which":[5],"also":[6,61,108],"negatively":[7],"regulates":[8],"iron":[9,14,20,36,81],"in":[10,28,57,85,103,112,128,137,156,181,202,205,213,215],"circulation":[11],"by":[12,35,63,71,110,188],"controlling":[13],"absorption":[15],"from":[16,22,83],"dietary":[17],"sources":[18],"and":[19,39,77,131,136,163,173,183,207],"release":[21,82],"macrophages.":[23,64,140],"synthesized":[26],"mainly":[27],"the":[29,120,167,189],"liver,":[30],"where":[31],"hepcidin":[32,55,69,79,101,106,126,154,179,197,211],"regulated":[34,109,200],"loading,":[37],"inflammation":[38],"hypoxia.":[40],"Recently,":[41],"we":[42,118],"have":[43,66,94,150],"demonstrated":[44],"that":[45,68,78,96,143,196,208],"bone":[46],"morphogenetic":[47],"protein":[48],"(BMP)-hemojuvelin":[49],"(HJV)-SMAD":[50],"signaling":[51,124],"central":[53],"for":[54],"regulation":[56],"hepatocytes.":[58],"expressed":[62],"Studies":[65],"shown":[67,95],"expression":[70,102,127,155,180,198,212],"macrophages":[72,84,113,157,203,214],"increases":[73],"following":[74],"bacterial":[75],"infection,":[76],"decreases":[80],"autocrine":[87],"and/or":[88],"paracrine":[89],"manner.":[90,219],"Although":[91],"previous":[92],"studies":[93],"lipopolysaccharide":[97],"(LPS)":[98],"can":[99],"induce":[100],"macrophages,":[104,182],"whether":[105],"BMPs":[111,209],"still":[115],"unknown.":[116],"Therefore,":[117],"examined":[119],"effects":[121],"of":[122,169],"BMP":[123],"on":[125,153],"RAW":[129],"264.7":[130],"J774":[132],"macrophage":[133],"cell":[134],"lines,":[135],"primary":[138],"peritoneal":[139],"We":[141],"found":[142],"BMP4":[144,172],"or":[145],"BMP6":[146,174],"alone":[147],"did":[148],"not":[149],"any":[151],"effect":[152],"although":[158],"they":[159],"stimulated":[160],"Smad1/5/8":[161],"phosphorylation":[162],"Id1":[164],"expression.":[165],"In":[166],"presence":[168],"LPS,":[170],"however,":[171],"were":[175],"able":[176],"to":[177],"stimulate":[178],"this":[184],"stimulation":[185],"was":[186],"abolished":[187],"NF-\u03baB":[190],"inhibitor":[191],"Ro1069920.":[192],"These":[193],"results":[194],"suggest":[195],"differently":[201],"than":[204],"hepatocytes,":[206],"regulate":[210],"a":[216],"LPS-NF-\u03baB":[217],"dependent":[218]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
