{"id":"https://openalex.org/W2120809799","doi":"https://doi.org/10.1016/s0022-5347(01)64097-7","title":"NEPHRECTOMY BEFORE INTERLEUKIN-2 THERAPY FOR PATIENTS WITH METASTATIC RENAL CELL CARCINOMA","display_name":"NEPHRECTOMY BEFORE INTERLEUKIN-2 THERAPY FOR PATIENTS WITH METASTATIC RENAL CELL CARCINOMA","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2120809799","doi":"https://doi.org/10.1016/s0022-5347(01)64097-7","mag":"2120809799","pmid":"https://pubmed.ncbi.nlm.nih.gov/9334580"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(01)64097-7","doi":"https://doi.org/10.1016/s0022-5347(01)64097-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)64097-7","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063808159","display_name":"Mark L. Fallick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L. Fallick","raw_affiliation_strings":["From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052233","display_name":"David F. McDermott","orcid":"https://orcid.org/0000-0002-2675-5095","observed_orcids":["https://orcid.org/0000-0002-2675-5095","https://orcid.org/0000-0001-6978-0867"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. McDermott","raw_affiliation_strings":["From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110358649","display_name":"D LaRock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis LaRock","raw_affiliation_strings":["From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John P. Long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Long","raw_affiliation_strings":["From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052526230","display_name":"Michael B. Atkins","orcid":"https://orcid.org/0000-0003-3901-9924","observed_orcids":["https://orcid.org/0000-0003-3901-9924"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Atkins","raw_affiliation_strings":["From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology and Division of Hematology/Oncology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":4.6587,"has_fulltext":false,"cited_by_count":158,"citation_normalized_percentile":{"value":0.94633199,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"158","issue":"5","first_page":"1691","last_page":"1695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/il-2-immunotherapy","display_name":"IL-2 immunotherapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/radical-nephrectomy","display_name":"radical nephrectomy","score":0.6840000152587891},{"id":"https://openalex.org/keywords/patient-selection-criteria","display_name":"patient selection criteria","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cytoreductive-surgery","display_name":"cytoreductive surgery","score":0.8600000143051147},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5230000019073486},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4909999966621399},{"id":"https://openalex.org/keywords/cytokine-therapy","display_name":"cytokine therapy","score":0.6700000166893005},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9596565961837769},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.8791182041168213},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.7542896270751953},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7007989883422852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4312877953052521},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.42484280467033386},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4100460112094879},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.34640181064605713},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.34112346172332764},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20813551545143127}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(01)64097-7","doi":"https://doi.org/10.1016/s0022-5347(01)64097-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)64097-7","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:9334580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9334580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W68714234","https://openalex.org/W71294735","https://openalex.org/W97326833","https://openalex.org/W1949493533","https://openalex.org/W2026493131","https://openalex.org/W2033760269","https://openalex.org/W2051828182","https://openalex.org/W2079565466","https://openalex.org/W2114180295","https://openalex.org/W2116323453","https://openalex.org/W2123914905","https://openalex.org/W2133988080","https://openalex.org/W2137288715","https://openalex.org/W2141924395","https://openalex.org/W2149724818","https://openalex.org/W2167951448","https://openalex.org/W2223317700","https://openalex.org/W2398385928","https://openalex.org/W2406002349","https://openalex.org/W2409576273","https://openalex.org/W2417076109","https://openalex.org/W4247719573","https://openalex.org/W4301452248"],"related_works":["https://openalex.org/W2167951448","https://openalex.org/W2399984187","https://openalex.org/W1995098380","https://openalex.org/W2470660931","https://openalex.org/W2033316540","https://openalex.org/W2727025259","https://openalex.org/W4323874204","https://openalex.org/W319745172","https://openalex.org/W2467532659","https://openalex.org/W2617953282"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,228,322],"management":[2],"of":[3,16,79,116,140,203,238,246,272,286,324],"metastatic":[4],"renal":[5],"cell":[6,155],"carcinoma":[7],"remains":[8],"challenging":[9],"and":[10,75,130,133,169,189,244,264,334],"controversial.":[11],"There":[12],"is":[13,332],"some":[14],"evidence":[15],"improved":[17],"response":[18,188,256],"to":[19,40,55,178,253,281],"interleukin-2":[20],"(IL-2)":[21],"based":[22,95],"immunotherapy":[23,41,74,96,183,247,311],"in":[24,147,197,326,338],"patients":[25,50,68,80,146,165,231,290,317,327],"who":[26,295],"undergo":[27],"nephrectomy":[28,72,106,194,243,305],"before":[29,73,310],"systemic":[30,57,109,320],"treatment.":[31,287,321],"However,":[32],"recent":[33],"reports":[34],"have":[35],"suggested":[36],"that":[37,316],"surgery":[38],"prior":[39],"may":[42],"not":[43,52],"be":[44,53,307],"an":[45,224],"efficient":[46],"strategy,":[47],"since":[48],"many":[49],"will":[51,318],"able":[54],"receive":[56,319],"treatment":[58,103],"after":[59,211],"nephrectomy.":[60,212],"We":[61],"describe":[62],"our":[63,77,90],"criteria":[64,101,168,304],"for":[65,71,102],"determining":[66],"which":[67],"are":[69,158,291,296],"candidates":[70],"present":[76],"series":[78],"treated":[81,171,222,328],"with":[82,93,104,172,223,260,329],"this":[83,173,330],"approach.":[84,174],"MATERIALS":[85],"AND":[86],"METHODS:":[87],"Based":[88],"on":[89],"initial":[91,105],"experience":[92],"IL-2":[94,325],"we":[97],"developed":[98],"certain":[99],"inclusion":[100],"followed":[107,177],"by":[108],"immunotherapy,":[110],"including":[111,293],"greater":[112],"than":[113,152],"75%":[114],"debulking":[115],"tumor":[117],"burden":[118],"possible,":[119],"no":[120],"central":[121],"nervous":[122],"system,":[123],"bone":[124],"or":[125,142],"liver":[126],"metastases,":[127],"adequate":[128],"pulmonary":[129,217],"cardiac":[131],"function,":[132],"Eastern":[134],"Cooperative":[135],"Oncology":[136],"Group":[137],"performance":[138],"status":[139],"0":[141],"1.":[143],"In":[144],"addition,":[145],"whom":[148],"biopsies":[149],"show":[150],"other":[151],"predominantly":[153],"clear":[154],"type":[156],"histology":[157],"excluded.":[159],"From":[160],"1991":[161],"through":[162],"1996,":[163],"28":[164],"met":[166],"these":[167,302],"were":[170,176],"Patients":[175],"determine":[179],"the":[180,273,284,314],"number":[181],"receiving":[182],"as":[184,186],"well":[185],"overall":[187],"survival":[190,271],"rates.":[191],"RESULTS:":[192],"Radical":[193],"was":[195,221,248,258,276],"performed":[196,309],"all":[198],"patients.":[199,341],"One":[200],"patient":[201,214],"died":[202],"respiratory":[204],"failure":[205],"from":[206,283],"disease":[207,297],"progression":[208],"1":[209,236,252,280],"month":[210],"Another":[213],"had":[215],"poor":[216],"function":[218],"and,":[219],"therefore,":[220],"alternative":[225],"cytokine":[226],"therapy.":[227],"remaining":[229],"26":[230],"(93%)":[232],"received":[233],"at":[234],"least":[235],"course":[237],"IL-2.":[239],"Median":[240],"interval":[241],"between":[242],"initiation":[245,285],"1.5":[249],"months":[250,278],"(range":[251,279],"3).":[254],"Overall":[255],"rate":[257],"39%":[259],"5":[261],"complete":[262],"(18%)":[263],"6":[265],"partial":[266],"(21%)":[267],"responses.":[268],"Actuarial":[269],"median":[270],"entire":[274],"group":[275],"20.5":[277],"66)":[282],"Currently":[288],"13":[289],"alive,":[292],"8":[294],"and/or":[298],"progression-free.":[299],"CONCLUSIONS:":[300],"Using":[301],"strict":[303],"can":[306],"effectively":[308],"without":[312],"compromising":[313],"likelihood":[315],"activity":[323],"approach":[331],"encouraging":[333],"justifies":[335],"its":[336],"consideration":[337],"properly":[339],"selected":[340]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
