{"id":"https://openalex.org/W2120804323","doi":"https://doi.org/10.1177/0284185115590434","title":"Effects of gadolinium-based contrast agent concentrations (0.5 M or 1.0 M) on the diagnostic performance of magnetic resonance imaging examinations: systematic review of the literature","display_name":"Effects of gadolinium-based contrast agent concentrations (0.5 M or 1.0 M) on the diagnostic performance of magnetic resonance imaging examinations: systematic review of the literature","publication_year":2015,"publication_date":"2015-06-12","ids":{"openalex":"https://openalex.org/W2120804323","doi":"https://doi.org/10.1177/0284185115590434","mag":"2120804323","pmid":"https://pubmed.ncbi.nlm.nih.gov/26071496"},"language":"en","primary_location":{"id":"doi:10.1177/0284185115590434","doi":"https://doi.org/10.1177/0284185115590434","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0284185115590434","pdf_url":null,"source":{"id":"https://openalex.org/S160113820","display_name":"Acta Radiologica","issn_l":"0284-1851","issn":["0284-1851","1600-0455"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Radiologica","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076364603","display_name":"Eric Lancelot","orcid":"https://orcid.org/0000-0003-2751-9147","observed_orcids":["https://orcid.org/0000-0003-2751-9147"]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Eric Lancelot","raw_affiliation_strings":["GUERBET, Villepinte, France","1 GUERBET, Villepinte, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GUERBET, Villepinte, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"1 GUERBET, Villepinte, France","institution_ids":["https://openalex.org/I120615911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036888556","display_name":"John M. Froehlich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Froehlich","raw_affiliation_strings":["GUERBET AG, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GUERBET AG, Z\u00fcrich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Oliver Heine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Heine","raw_affiliation_strings":["GUERBET GmbH, Sulzbach/Taunus, Germany","3 GUERBET GmbH, Sulzbach/Taunus, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GUERBET GmbH, Sulzbach/Taunus, Germany","institution_ids":[]},{"raw_affiliation_string":"3 GUERBET GmbH, Sulzbach/Taunus, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012391695","display_name":"Pierre Desch\u00e9","orcid":"https://orcid.org/0000-0002-2389-0697","observed_orcids":["https://orcid.org/0000-0002-2389-0697"]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Desch\u00e9","raw_affiliation_strings":["GUERBET, Villepinte, France","1 GUERBET, Villepinte, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GUERBET, Villepinte, France","institution_ids":["https://openalex.org/I120615911"]},{"raw_affiliation_string":"1 GUERBET, Villepinte, France","institution_ids":["https://openalex.org/I120615911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076364603"],"corresponding_institution_ids":["https://openalex.org/I120615911"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0145,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.05485232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"57","issue":"11","first_page":"1334","last_page":"1343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.7163000106811523,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.2531999945640564,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium-based-contrast-agents","display_name":"gadolinium-based contrast agents","score":1.0},{"id":"https://openalex.org/keywords/contrast-agent-concentration","display_name":"contrast agent concentration","score":0.7200000286102295},{"id":"https://openalex.org/keywords/gadobutrol","display_name":"gadobutrol","score":0.8939999938011169},{"id":"https://openalex.org/keywords/diagnostic-performance","display_name":"diagnostic performance","score":0.6449999809265137},{"id":"https://openalex.org/keywords/image-quality","display_name":"image quality","score":0.6370000243186951},{"id":"https://openalex.org/keywords/contrast-to-noise-ratio","display_name":"contrast-to-noise ratio","score":0.9070000052452087},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.9900000095367432},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.919471025466919},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7508757710456848},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.6409087181091309},{"id":"https://openalex.org/C2776875665","wikidata":"https://www.wikidata.org/wiki/Q2570844","display_name":"Gadobutrol","level":3,"score":0.6048981547355652},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5494012236595154},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.49415162205696106},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0284185115590434","doi":"https://doi.org/10.1177/0284185115590434","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0284185115590434","pdf_url":null,"source":{"id":"https://openalex.org/S160113820","display_name":"Acta Radiologica","issn_l":"0284-1851","issn":["0284-1851","1600-0455"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Radiologica","raw_type":"journal-article"},{"id":"pmid:26071496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26071496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta radiologica (Stockholm, Sweden : 1987)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1574591622","https://openalex.org/W1964765606","https://openalex.org/W1967287397","https://openalex.org/W1977769806","https://openalex.org/W1987948368","https://openalex.org/W1991456059","https://openalex.org/W2002441805","https://openalex.org/W2012769412","https://openalex.org/W2016755131","https://openalex.org/W2019604413","https://openalex.org/W2023491304","https://openalex.org/W2030003406","https://openalex.org/W2040015513","https://openalex.org/W2042109245","https://openalex.org/W2048771127","https://openalex.org/W2058710711","https://openalex.org/W2062756130","https://openalex.org/W2088566311","https://openalex.org/W2104004877","https://openalex.org/W2114297037","https://openalex.org/W2114739044","https://openalex.org/W2122639169","https://openalex.org/W2124888186","https://openalex.org/W2137780847","https://openalex.org/W2144256084","https://openalex.org/W2149201105","https://openalex.org/W2157725482","https://openalex.org/W2165699345","https://openalex.org/W2322781671"],"related_works":["https://openalex.org/W2162993889","https://openalex.org/W4394694232","https://openalex.org/W2317318223","https://openalex.org/W2010665254","https://openalex.org/W1977769806","https://openalex.org/W2039663415","https://openalex.org/W4200257640","https://openalex.org/W3161488038","https://openalex.org/W4318935406","https://openalex.org/W3189193962"],"abstract_inverted_index":{"Background":[0],"To":[1,20],"date":[2],"there":[3],"is":[4,10],"no":[5],"agreement":[6],"as":[7],"to":[8],"what":[9],"the":[11,58,116,137,145,209],"optimal":[12],"concentration":[13],"for":[14,35,110,142,154,190],"gadolinium-based":[15],"contrast":[16],"agents":[17],"(GBCAs).":[18],"Purpose":[19],"assess":[21],"whether":[22],"diagnostic":[23,59,199,237],"performance":[24],"differences":[25,149,215],"exist":[26],"between":[27,52,150,216],"0.5":[28,118,217],"M":[29,32,119,122,192,218,221],"and":[30,41,54,82,97,120,165,168,187,219],"1.0":[31,121,191,220],"GBCAs":[33,123,151,222],"used":[34],"magnetic":[36],"resonance":[37],"imaging":[38,74],"(MRI).":[39],"Material":[40],"Methods":[42],"A":[43],"PubMed":[44],"literature":[45],"search":[46],"identified":[47,204],"21":[48],"clinical":[49],"studies":[50,100,179,207],"published":[51],"2005":[53],"2013":[55],"which":[56],"evaluated":[57],"efficacy":[60,238],"of":[61,64,69,115,144,157,171,177,211],"both":[62],"types":[63],"GBCAs.":[65,146],"Study":[66],"design,":[67],"type":[68],"procedure,":[70],"GBCA":[71],"administration":[72],"mode,":[73],"performances,":[75],"impact":[76,197],"on":[77,91,198],"patient":[78],"management,":[79],"study":[80],"limitations,":[81],"biases":[83,202],"were":[84,101,124,152,203,223],"analyzed.":[85],"No":[86,147],"statistical":[87],"test":[88],"was":[89],"performed":[90,240],"pooled":[92],"data.":[93],"Results":[94],"Sixteen":[95],"comparative":[96],"five":[98],"non-comparative":[99],"analyzed,":[102],"involving":[103],"2183":[104],"patients":[105],"who":[106],"underwent":[107],"MRI":[108],"procedures":[109],"various":[111],"indications.":[112],"In":[113],"67%":[114],"studies,":[117],"injected":[125],"at":[126],"equimolar":[127,242],"gadolinium":[128],"amounts":[129],"per":[130],"kg":[131],"body":[132],"weight.":[133],"Only":[134],"33%":[135],"applied":[136],"same":[138],"molar":[139],"flow":[140],"rate":[141],"delivery":[143,182,228],"significant":[148],"reported":[153],"23":[155],"out":[156,170,176],"27":[158],"qualitative":[159],"endpoints":[160],"(mainly":[161],"image":[162],"quality,":[163],"lesion,":[164],"vessel":[166],"visualization)":[167],"29":[169],"40":[172],"quantitative":[173],"endpoints.":[174],"Three":[175],"four":[178],"with":[180],"non-equimolar":[181,227],"rates":[183],"showed":[184],"better":[185],"contrast-to-noise":[186],"signal-to-noise":[188],"ratios":[189],"gadobutrol,":[193],"without":[194],"showing":[195],"an":[196],"performance.":[200],"Methodological":[201],"in":[205],"several":[206],"impairing":[208],"interpretation":[210],"comparisons.":[212],"Conclusion":[213],"Imaging":[214],"essentially":[224],"observed":[225],"under":[226,241],"rates.":[229],"However,":[230],"they":[231],"did":[232],"not":[233],"result":[234],"into":[235],"greater":[236],"when":[239],"conditions.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
